Fam81b (family with sequence similarity 81, member B) - Rat Genome Database

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Gene: Fam81b (family with sequence similarity 81, member B) Rattus norvegicus
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Symbol: Fam81b
Name: family with sequence similarity 81, member B
RGD ID: 1561830
Description: Orthologous to human FAM81B (family with sequence similarity 81 member B); INTERACTS WITH bisphenol A; gentamycin; lead diacetate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC309925; RGD1561830; similar to hypothetical protein FLJ25333
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr827,482,297 - 7,602,438 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl27,502,278 - 7,644,862 (-)EnsemblGRCr8
mRatBN7.225,750,678 - 5,870,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl25,771,240 - 5,879,440 (-)EnsemblmRatBN7.2
Rnor_6.023,004,688 - 3,134,667 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl23,025,217 - 3,124,543 (-)Ensemblrn6Rnor6.0
Rnor_5.023,002,990 - 3,131,311 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.423,327,645 - 3,401,619 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera22,213,891 - 2,343,705 (-)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21630459  


Genomics

Comparative Map Data
Fam81b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr827,482,297 - 7,602,438 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl27,502,278 - 7,644,862 (-)EnsemblGRCr8
mRatBN7.225,750,678 - 5,870,580 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl25,771,240 - 5,879,440 (-)EnsemblmRatBN7.2
Rnor_6.023,004,688 - 3,134,667 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl23,025,217 - 3,124,543 (-)Ensemblrn6Rnor6.0
Rnor_5.023,002,990 - 3,131,311 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.423,327,645 - 3,401,619 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera22,213,891 - 2,343,705 (-)NCBICelera
Cytogenetic Map2q11NCBI
FAM81B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38595,391,366 - 95,450,441 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl595,391,366 - 95,450,454 (+)Ensemblhg38GRCh38
GRCh37594,727,070 - 94,786,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36594,752,804 - 94,811,900 (+)NCBIBuild 36Build 36hg18NCBI36
Celera590,605,428 - 90,664,550 (+)NCBICelera
Cytogenetic Map5q15NCBI
HuRef589,917,160 - 89,976,256 (+)NCBIHuRef
CHM1_1594,159,684 - 94,218,781 (+)NCBICHM1_1
T2T-CHM13v2.0595,885,697 - 95,951,364 (+)NCBIT2T-CHM13v2.0
Fam81b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391376,349,827 - 76,427,034 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1376,349,827 - 76,453,191 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381376,201,708 - 76,278,915 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1376,201,708 - 76,305,072 (-)Ensemblmm10GRCm38
MGSCv371376,339,156 - 76,391,415 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361376,667,696 - 76,719,969 (-)NCBIMGSCv36mm8
Celera1378,519,845 - 78,603,287 (-)NCBICelera
Cytogenetic Map13C1NCBI
cM Map1340.96NCBI
Fam81b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541817,078,296 - 17,127,502 (-)Ensembl
ChiLan1.0NW_00495541817,080,146 - 17,126,868 (-)NCBIChiLan1.0ChiLan1.0
FAM81B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2419,930,968 - 19,995,147 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1518,085,748 - 18,148,759 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0519,905,433 - 19,965,168 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1520,049,972 - 20,108,165 (-)NCBIPanPan1.1PanPan1.1panPan2
FAM81B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1314,116,761 - 14,171,527 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl314,116,773 - 14,172,051 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha315,455,493 - 15,510,339 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0313,996,761 - 14,051,685 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl313,996,781 - 14,051,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1313,959,549 - 14,014,381 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0313,957,102 - 14,011,964 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0314,156,556 - 14,211,412 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fam81b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213169,716,750 - 169,778,905 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365237,902,362 - 7,963,768 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365237,902,197 - 7,964,338 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM81B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2102,009,457 - 102,067,142 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12102,005,565 - 102,066,291 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22105,760,659 - 105,820,934 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM81B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1489,278,901 - 89,333,098 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl489,279,730 - 89,333,310 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604937,928,937 - 37,978,277 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam81b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474314,041,539 - 14,094,619 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474314,038,314 - 14,093,731 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Fam81b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13220,844,566 - 220,943,208 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Fam81b
539 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:25
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000036547
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2142977529Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat

Markers in Region
RH138225  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.225,772,888 - 5,773,137 (+)MAPPERmRatBN7.2
Rnor_6.023,026,850 - 3,027,098NCBIRnor6.0
Rnor_5.023,025,075 - 3,025,323UniSTSRnor5.0
RGSC_v3.423,329,112 - 3,329,360UniSTSRGSC3.4
Celera22,236,051 - 2,236,299UniSTS
Cytogenetic Map2q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 10 29 137 55 54 23 96 23 6 253 148 2 127 64 77 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000036547   ⟹   ENSRNOP00000032467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl27,503,250 - 7,602,772 (-)Ensembl
mRatBN7.2 Ensembl25,771,240 - 5,879,440 (-)Ensembl
Rnor_6.0 Ensembl23,025,217 - 3,124,543 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000144991   ⟹   ENSRNOP00000111366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl27,503,779 - 7,644,862 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000158493   ⟹   ENSRNOP00000108478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl27,502,278 - 7,643,277 (-)Ensembl
RefSeq Acc Id: XM_039103385   ⟹   XP_038959313
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr827,503,114 - 7,602,438 (-)NCBI
mRatBN7.225,771,162 - 5,870,580 (-)NCBI
RefSeq Acc Id: XM_039103386   ⟹   XP_038959314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr827,482,297 - 7,602,438 (-)NCBI
mRatBN7.225,750,678 - 5,870,580 (-)NCBI
RefSeq Acc Id: XM_039103387   ⟹   XP_038959315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr827,503,114 - 7,602,400 (-)NCBI
mRatBN7.225,771,162 - 5,870,525 (-)NCBI
RefSeq Acc Id: XM_039103388   ⟹   XP_038959316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr827,503,114 - 7,602,402 (-)NCBI
mRatBN7.225,771,162 - 5,870,536 (-)NCBI
Ensembl Acc Id: ENSRNOP00000032467   ⟸   ENSRNOT00000036547
RefSeq Acc Id: XP_038959314   ⟸   XM_039103386
- Peptide Label: isoform X1
- UniProtKB: F1M276 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959313   ⟸   XM_039103385
- Peptide Label: isoform X1
- UniProtKB: F1M276 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959316   ⟸   XM_039103388
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038959315   ⟸   XM_039103387
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000111366   ⟸   ENSRNOT00000144991
Ensembl Acc Id: ENSRNOP00000108478   ⟸   ENSRNOT00000158493

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M276-F1-model_v2 AlphaFold F1M276 1-369 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691038
Promoter ID:EPDNEW_R1561
Type:multiple initiation site
Name:Fam81b_1
Description:family with sequence similarity 81, member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.023,124,528 - 3,124,588EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561830 AgrOrtholog
BioCyc Gene G2FUF-55081 BioCyc
Ensembl Genes ENSRNOG00000026845 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036547 ENTREZGENE
  ENSRNOT00000036547.8 UniProtKB/TrEMBL
  ENSRNOT00000144991.1 UniProtKB/TrEMBL
  ENSRNOT00000158493.1 UniProtKB/TrEMBL
InterPro FAM81 UniProtKB/TrEMBL
NCBI Gene 309925 ENTREZGENE
PANTHER PTHR22420 UniProtKB/TrEMBL
  PTHR22420:SF5 UniProtKB/TrEMBL
PhenoGen Fam81b PhenoGen
RatGTEx ENSRNOG00000026845 RatGTEx
UniProt A0ABK0LK69_RAT UniProtKB/TrEMBL
  A0ABK0M0N9_RAT UniProtKB/TrEMBL
  F1M276 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Fam81b  family with sequence similarity 81, member B  RGD1561830_predicted  similar to hypothetical protein FLJ25333 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561830_predicted  similar to hypothetical protein FLJ25333 (predicted)  LOC309925  similar to hypothetical protein FLJ25333  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC309925  similar to hypothetical protein FLJ25333      Symbol and Name status set to provisional 70820 PROVISIONAL