Mfsd4b2l2 (major facilitator superfamily domain containing 4B2 like 2) - Rat Genome Database

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Gene: Mfsd4b2l2 (major facilitator superfamily domain containing 4B2 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Mfsd4b2l2 (Ensembl: RGD1561777)
Name: major facilitator superfamily domain containing 4B2 like 2 (Ensembl:similar to Na+ dependent glucose transporter 1)
RGD ID: 1561777
Description: Predicted to enable glucose transmembrane transporter activity. Predicted to be involved in glucose transmembrane transport. Predicted to be located in membrane. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; furan; tetrachloromethane.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC499463; RGD1561777; similar to Na+ dependent glucose transporter 1; sodium-dependent glucose transporter 1C
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,923,703 - 44,948,921 (-)NCBIGRCr8
mRatBN7.22043,369,151 - 43,394,397 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,371,903 - 43,394,510 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02045,040,743 - 45,054,597 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2045,042,770 - 45,053,640 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02046,763,044 - 46,797,949 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42044,124,181 - 44,152,886 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2044,084,304 - 44,108,502 (-)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Mfsd4b2l2
262 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:75
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000072256
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

Markers in Region
RH140534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22043,393,972 - 43,394,118 (+)MAPPERmRatBN7.2
Rnor_6.02045,077,655 - 45,077,800NCBIRnor6.0
Rnor_5.02046,797,616 - 46,797,761UniSTSRnor5.0
RGSC_v3.42044,146,431 - 44,146,576UniSTSRGSC3.4
Celera2044,107,832 - 44,107,977UniSTS
RH 3.4 Map20467.3UniSTS
Cytogenetic Map20q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 15 15 15
Low 2 6 36 26 3 26 8 11 1 29 19 11 8
Below cutoff 1 37 5 14 44 6 19

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000072256   ⟹   ENSRNOP00000066666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2043,371,903 - 43,394,510 (-)Ensembl
Rnor_6.0 Ensembl2045,042,770 - 45,053,640 (-)Ensembl
RefSeq Acc Id: XM_039099168   ⟹   XP_038955096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,923,703 - 44,948,921 (-)NCBI
mRatBN7.22043,369,151 - 43,394,397 (-)NCBI
RefSeq Acc Id: XM_039099169   ⟹   XP_038955097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,923,703 - 44,948,893 (-)NCBI
mRatBN7.22043,369,151 - 43,394,358 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038955096 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955097 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066666.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000066666   ⟸   ENSRNOT00000072256
RefSeq Acc Id: XP_038955096   ⟸   XM_039099168
- UniProtKB: M0RAV5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955097   ⟸   XM_039099169
- UniProtKB: M0RAV5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RAV5-F1-model_v2 AlphaFold M0RAV5 1-344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561777 AgrOrtholog
BioCyc Gene G2FUF-3455 BioCyc
Ensembl Genes ENSRNOG00000050425 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072256.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/TrEMBL
InterPro MFS UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/TrEMBL
NCBI Gene 499463 ENTREZGENE
PANTHER MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING 4B4 UniProtKB/TrEMBL
  SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/TrEMBL
PhenoGen Mfsd4b2l2 PhenoGen
RatGTEx ENSRNOG00000050425 RatGTEx
Superfamily-SCOP MFS_gen_substrate_transporter UniProtKB/TrEMBL
UniProt M0RAV5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Mfsd4b2l2  major facilitator superfamily domain containing 4B2 like 2  RGD1561777  similar to Na+ dependent glucose transporter 1  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1561777  similar to Na+ dependent glucose transporter 1   RGD1561777_predicted  similar to Na+ dependent glucose transporter 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561777_predicted  similar to Na+ dependent glucose transporter 1 (predicted)  LOC499463  similar to Na+ dependent glucose transporter 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499463  similar to Na+ dependent glucose transporter 1      Symbol and Name status set to provisional 70820 PROVISIONAL