Herc6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6) - Rat Genome Database

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Gene: Herc6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6) Rattus norvegicus
Analyze
Symbol: Herc6
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
RGD ID: 1561739
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within hematopoietic progenitor cell differentiation and response to bacterium. Predicted to be active in cytoplasm. Orthologous to human HERC6 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 6); INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hect domain and RLD 6; potential ubiquitin ligase; probable E3 ubiquitin-protein ligase HERC6
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8488,854,612 - 88,897,043 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl488,854,640 - 88,896,993 (-)EnsemblGRCr8
mRatBN7.2487,524,470 - 87,566,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl487,524,493 - 87,581,744 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx492,746,445 - 92,788,704 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0488,521,840 - 88,564,101 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0486,884,872 - 86,927,193 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0488,606,851 - 88,649,424 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl488,607,518 - 88,649,216 (-)Ensemblrn6Rnor6.0
Rnor_5.04153,429,540 - 153,491,797 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4487,278,557 - 87,343,287 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera482,289,544 - 82,332,364 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6alpha-methylprednisolone  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folpet  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
prednisolone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
trametinib  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19028597   PMID:23012479   PMID:24029230  


Genomics

Comparative Map Data
Herc6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8488,854,612 - 88,897,043 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl488,854,640 - 88,896,993 (-)EnsemblGRCr8
mRatBN7.2487,524,470 - 87,566,895 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl487,524,493 - 87,581,744 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx492,746,445 - 92,788,704 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0488,521,840 - 88,564,101 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0486,884,872 - 86,927,193 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0488,606,851 - 88,649,424 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl488,607,518 - 88,649,216 (-)Ensemblrn6Rnor6.0
Rnor_5.04153,429,540 - 153,491,797 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4487,278,557 - 87,343,287 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera482,289,544 - 82,332,364 (-)NCBICelera
Cytogenetic Map4q24NCBI
HERC6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38488,378,852 - 88,443,097 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl488,378,739 - 88,443,098 (+)Ensemblhg38GRCh38
GRCh37489,300,004 - 89,364,249 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,518,915 - 89,583,272 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34489,657,197 - 89,721,426NCBI
Celera486,596,361 - 86,660,787 (+)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef485,051,870 - 85,116,214 (+)NCBIHuRef
CHM1_1489,276,425 - 89,340,723 (+)NCBICHM1_1
T2T-CHM13v2.0491,709,824 - 91,774,756 (+)NCBIT2T-CHM13v2.0
Herc6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39657,557,977 - 57,642,121 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl657,557,985 - 57,641,617 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38657,580,992 - 57,665,136 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl657,581,000 - 57,664,632 (+)Ensemblmm10GRCm38
MGSCv37657,530,986 - 57,615,130 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36657,530,994 - 57,615,130 (+)NCBIMGSCv36mm8
Celera658,333,270 - 58,408,797 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.82NCBI
HERC6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2386,383,628 - 86,447,450 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1486,646,107 - 86,709,920 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0480,669,642 - 80,733,409 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1491,393,215 - 91,456,399 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl491,393,415 - 91,455,756 (+)EnsemblpanPan2panpan1.1
HERC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,624,883 - 11,751,305 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,694,963 - 11,750,719 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3230,203,843 - 30,259,601 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03211,748,514 - 11,804,925 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,748,556 - 11,804,342 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,831,645 - 11,886,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03211,656,819 - 11,712,063 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,204,467 - 28,260,972 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Herc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530129,650,996 - 29,692,797 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936685863,212 - 911,202 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936685863,198 - 916,774 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERC6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8130,594,939 - 130,665,145 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18130,594,941 - 130,665,591 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HERC6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,739,524 - 36,803,493 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl736,739,566 - 36,803,915 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603715,490,201 - 15,555,183 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Herc6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1683,428,035 - 83,482,939 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Herc6
253 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:622
Count of miRNA genes:265
Interacting mature miRNAs:324
Transcripts:ENSRNOT00000058626
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48279077797183061Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat

Markers in Region
D4Rat230  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8488,862,296 - 88,862,538 (+)Marker Load Pipeline
mRatBN7.2487,532,151 - 87,532,391 (+)MAPPERmRatBN7.2
Rnor_6.0488,614,531 - 88,614,772NCBIRnor6.0
Rnor_5.04153,437,220 - 153,437,461UniSTSRnor5.0
RGSC_v3.4487,286,221 - 87,286,462UniSTSRGSC3.4
RGSC_v3.4487,286,220 - 87,286,462RGDRGSC3.4
Celera482,297,124 - 82,297,361UniSTS
RGSC_v3.1487,529,692 - 87,529,933RGD
RH 3.4 Map4543.3RGD
RH 3.4 Map4543.3UniSTS
SHRSP x BN Map443.1UniSTS
SHRSP x BN Map443.1RGD
Cytogenetic Map4q24UniSTS
D4Got76  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,565,881 - 87,566,036 (+)MAPPERmRatBN7.2
Rnor_6.0488,648,263 - 88,648,417NCBIRnor6.0
Rnor_5.04153,470,963 - 153,471,117UniSTSRnor5.0
RGSC_v3.4487,319,952 - 87,320,107RGDRGSC3.4
RGSC_v3.4487,319,953 - 87,320,107UniSTSRGSC3.4
Celera482,331,206 - 82,331,352UniSTS
RGSC_v3.1487,563,435 - 87,563,589RGD
RH 3.4 Map4548.7RGD
RH 3.4 Map4548.7UniSTS
Cytogenetic Map4q24UniSTS
RH140011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2487,524,568 - 87,524,748 (+)MAPPERmRatBN7.2
mRatBN7.2147,310,743 - 47,310,923 (+)MAPPERmRatBN7.2
Rnor_6.0147,634,121 - 47,634,300NCBIRnor6.0
Rnor_6.0488,606,950 - 88,607,129NCBIRnor6.0
Rnor_5.04153,429,639 - 153,429,818UniSTSRnor5.0
Rnor_5.0148,934,508 - 48,934,687UniSTSRnor5.0
RGSC_v3.4487,278,640 - 87,278,819UniSTSRGSC3.4
RGSC_v3.4141,530,041 - 41,530,220UniSTSRGSC3.4
Celera142,994,731 - 42,994,910UniSTS
Celera482,289,643 - 82,289,822UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 162 91 90 59 92 59 6 355 191 11 141 81 91 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000058626   ⟹   ENSRNOP00000055422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl488,854,640 - 88,896,993 (-)Ensembl
mRatBN7.2 Ensembl487,524,493 - 87,581,744 (-)Ensembl
Rnor_6.0 Ensembl488,607,518 - 88,649,216 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000163441   ⟹   ENSRNOP00000101074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl488,854,640 - 88,896,993 (-)Ensembl
RefSeq Acc Id: NM_001012474   ⟹   NP_001012492
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8488,854,633 - 88,896,993 (-)NCBI
mRatBN7.2487,524,486 - 87,566,846 (-)NCBI
RefSeq Acc Id: XM_039108687   ⟹   XP_038964615
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8488,854,612 - 88,886,007 (-)NCBI
mRatBN7.2487,524,470 - 87,555,909 (-)NCBI
RefSeq Acc Id: XM_039108689   ⟹   XP_038964617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8488,854,612 - 88,878,223 (-)NCBI
mRatBN7.2487,524,470 - 87,548,070 (-)NCBI
RefSeq Acc Id: XR_005503613
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8488,856,554 - 88,897,043 (-)NCBI
mRatBN7.2487,526,398 - 87,566,895 (-)NCBI
Ensembl Acc Id: ENSRNOP00000055422   ⟸   ENSRNOT00000058626
RefSeq Acc Id: XP_038964615   ⟸   XM_039108687
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038964617   ⟸   XM_039108689
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001012492   ⟸   NM_001012474
- UniProtKB: Q5U2P8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101074   ⟸   ENSRNOT00000163441
Protein Domains
HECT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LPM8-F1-model_v2 AlphaFold F1LPM8 1-1027 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693092
Promoter ID:EPDNEW_R3609
Type:initiation region
Name:Herc6_1
Description:HECT and RLD domain containing E3 ubiquitin protein ligase familymember 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0488,649,216 - 88,649,276EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561739 AgrOrtholog
BioCyc Gene G2FUF-44664 BioCyc
Ensembl Genes ENSRNOG00000023969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058626 ENTREZGENE
  ENSRNOT00000058626.6 UniProtKB/TrEMBL
  ENSRNOT00000163441.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108839 IMAGE-MGC_LOAD
InterPro E3A/B/C-like UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  Reg_chr_condens UniProtKB/TrEMBL
  Reg_csome_cond/b-lactamase_inh UniProtKB/TrEMBL
  Signaling_Regulatory_Domain UniProtKB/TrEMBL
  Ub-ligase/GTPase-reg UniProtKB/TrEMBL
MGC_CLONE MGC:94832 IMAGE-MGC_LOAD
NCBI Gene 362376 ENTREZGENE
PANTHER BTK-BINDING PROTEIN-RELATED UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE HERC6-RELATED UniProtKB/TrEMBL
  LIGASE, PUTATIVE-RELATED UniProtKB/TrEMBL
  UBIQUITIN-PROTEIN LIGASE E3A-RELATED UniProtKB/TrEMBL
  UBIQUITIN-PROTEIN LIGASE E3C UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  WD40_RLD UniProtKB/TrEMBL
PhenoGen Herc6 PhenoGen
PRINTS RCCNDNSATION UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  RCC1_2 UniProtKB/TrEMBL
  RCC1_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023969 RatGTEx
SMART HECTc UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/TrEMBL
UniProt A0ABK0LLE2_RAT UniProtKB/TrEMBL
  A6K134_RAT UniProtKB/TrEMBL
  A6K135_RAT UniProtKB/TrEMBL
  F1LPM8_RAT UniProtKB/TrEMBL
  Q5U2P8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-17 Herc6  HECT and RLD domain containing E3 ubiquitin protein ligase family member 6  Herc6  hect domain and RLD 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 Herc6  hect domain and RLD 6  Herc6  potential ubiquitin ligase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 Herc6  potential ubiquitin ligase      Symbol and Name status set to provisional 70820 PROVISIONAL