Mslnl (mesothelin-like) - Rat Genome Database

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Gene: Mslnl (mesothelin-like) Rattus norvegicus
Analyze
Symbol: Mslnl
Name: mesothelin-like
RGD ID: 1561732
Description: Predicted to be involved in cell-matrix adhesion. Predicted to be located in membrane. Predicted to be active in cell surface. Orthologous to human MSLNL (mesothelin like); INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC363554; mesothelin-like protein; RGD1561732; similar to hypothetical protein 4732467B22
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,260,084 - 15,276,190 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,263,955 - 15,276,490 (+)EnsemblGRCr8
mRatBN7.21014,755,344 - 14,771,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,759,311 - 14,771,675 (+)EnsemblmRatBN7.2
Rnor_6.01015,103,047 - 15,119,427 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,108,072 - 15,119,183 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,915,768 - 14,932,148 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,003,704 - 15,016,864 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,424,767 - 14,441,024 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell surface  (IBA)
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Mslnl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,260,084 - 15,276,190 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1015,263,955 - 15,276,490 (+)EnsemblGRCr8
mRatBN7.21014,755,344 - 14,771,673 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,759,311 - 14,771,675 (+)EnsemblmRatBN7.2
Rnor_6.01015,103,047 - 15,119,427 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,108,072 - 15,119,183 (+)Ensemblrn6Rnor6.0
Rnor_5.01014,915,768 - 14,932,148 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41015,003,704 - 15,016,864 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1014,424,767 - 14,441,024 (+)NCBICelera
Cytogenetic Map10q12NCBI
MSLNL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3816769,428 - 781,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl16769,428 - 782,054 (-)Ensemblhg38GRCh38
GRCh3716819,428 - 831,996 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3616759,429 - 772,927 (-)NCBIBuild 36Build 36hg18NCBI36
Celera161,019,315 - 1,032,813 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef16741,405 - 753,969 (-)NCBIHuRef
CHM1_116819,368 - 831,946 (-)NCBICHM1_1
T2T-CHM13v2.016774,138 - 786,707 (-)NCBIT2T-CHM13v2.0
Mslnl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,952,477 - 25,967,328 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,955,016 - 25,967,304 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381725,733,503 - 25,748,354 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,736,042 - 25,748,330 (+)Ensemblmm10GRCm38
MGSCv371725,872,985 - 25,885,275 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361725,463,640 - 25,475,930 (+)NCBIMGSCv36mm8
Celera1726,268,346 - 26,280,661 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.84NCBI
MSLNL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,825,470 - 39,827,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,820,917 - 39,827,531 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha641,084,585 - 41,092,188 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0640,163,040 - 40,170,643 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,164,029 - 40,170,643 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,851,671 - 39,859,274 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,811,884 - 39,819,488 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,290,761 - 40,298,364 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100519473
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,016,457 - 41,025,590 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1341,021,665 - 41,025,766 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,452,319 - 41,459,418 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mslnl
104 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:44
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000060286
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH130788  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,771,328 - 14,771,532 (+)MAPPERmRatBN7.2
Rnor_6.01015,119,083 - 15,119,286NCBIRnor6.0
Rnor_5.01014,931,804 - 14,932,007UniSTSRnor5.0
RGSC_v3.41015,016,518 - 15,016,721UniSTSRGSC3.4
Celera1014,440,680 - 14,440,883UniSTS
RH 3.4 Map10170.3UniSTS
Cytogenetic Map10q12UniSTS
BE099462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,771,980 - 14,772,159 (+)MAPPERmRatBN7.2
Rnor_6.01015,119,735 - 15,119,913NCBIRnor6.0
Rnor_5.01014,932,456 - 14,932,634UniSTSRnor5.0
RGSC_v3.41015,017,170 - 15,017,348UniSTSRGSC3.4
Celera1014,441,332 - 14,441,510UniSTS
RH 3.4 Map10154.3UniSTS
Cytogenetic Map10q12-q21UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 9 65 162 80 79 48 88 48 6 329 186 11 141 76 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000060286   ⟹   ENSRNOP00000057036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1015,263,955 - 15,276,490 (+)Ensembl
mRatBN7.2 Ensembl1014,759,311 - 14,771,675 (+)Ensembl
Rnor_6.0 Ensembl1015,108,072 - 15,119,183 (+)Ensembl
RefSeq Acc Id: XM_008767615   ⟹   XP_008765837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,260,084 - 15,276,190 (+)NCBI
mRatBN7.21014,755,344 - 14,771,673 (+)NCBI
Rnor_6.01015,104,750 - 15,119,427 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039087109   ⟹   XP_038943037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,260,084 - 15,272,592 (+)NCBI
mRatBN7.21014,755,344 - 14,768,074 (+)NCBI
RefSeq Acc Id: XM_063270020   ⟹   XP_063126090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81015,260,084 - 15,276,190 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008765837 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943037 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126090 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03948 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057036
  ENSRNOP00000057036.3
RefSeq Acc Id: XP_008765837   ⟸   XM_008767615
- Peptide Label: isoform X2
- UniProtKB: D4AB62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057036   ⟸   ENSRNOT00000060286
RefSeq Acc Id: XP_038943037   ⟸   XM_039087109
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063126090   ⟸   XM_063270020
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AB62-F1-model_v2 AlphaFold D4AB62 1-686 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561732 AgrOrtholog
BioCyc Gene G2FUF-25764 BioCyc
Ensembl Genes ENSRNOG00000039339 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060286 ENTREZGENE
  ENSRNOT00000060286.5 UniProtKB/TrEMBL
Gene3D-CATH 1.20.970.40 UniProtKB/TrEMBL
InterPro Mesothelin UniProtKB/TrEMBL
  Stereocilin_related UniProtKB/TrEMBL
KEGG Report rno:363554 UniProtKB/TrEMBL
NCBI Gene 363554 ENTREZGENE
PANTHER PTHR23412 UniProtKB/TrEMBL
  PTHR23412:SF15 UniProtKB/TrEMBL
Pfam Mesothelin UniProtKB/TrEMBL
PhenoGen Mslnl PhenoGen
RatGTEx ENSRNOG00000039339 RatGTEx
UniProt D4AB62 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Mslnl  mesothelin-like  RGD1561732  similar to hypothetical protein 4732467B22   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561732  similar to hypothetical protein 4732467B22   RGD1561732_predicted  similar to hypothetical protein 4732467B22 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561732_predicted  similar to hypothetical protein 4732467B22 (predicted)  LOC363554  similar to hypothetical protein 4732467B22  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363554  similar to hypothetical protein 4732467B22      Symbol and Name status set to provisional 70820 PROVISIONAL