Bri3bp (Bri3 binding protein) - Rat Genome Database

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Gene: Bri3bp (Bri3 binding protein) Rattus norvegicus
Analyze
Symbol: Bri3bp
Name: Bri3 binding protein
RGD ID: 1561711
Description: Predicted to be located in membrane. Predicted to be active in mitochondrion. Orthologous to human BRI3BP (BRI3 binding protein); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BRI3-binding protein; LOC498176; similar to BRI3-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,838,098 - 36,849,919 (-)NCBIGRCr8
mRatBN7.21231,176,742 - 31,188,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,173,971 - 31,188,572 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,347,442 - 32,359,299 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01232,958,867 - 32,970,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,010,791 - 32,022,648 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,576,018 - 36,587,839 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,576,020 - 36,587,839 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,445,350 - 38,457,171 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,270,907 - 32,282,728 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1232,871,267 - 32,883,085 (-)NCBICelera
Cytogenetic Map12q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 77 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bri3bpRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of BRI3BP mRNA]CTDPMID:31150632
Bri3bpRat(1->4)-beta-D-glucan multiple interactionsISOBri3bp (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of BRI3BP mRNACTDPMID:36331819
Bri3bpRat1,2-dimethylhydrazine increases expressionISOBri3bp (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of BRI3BP mRNACTDPMID:22206623
Bri3bpRat17alpha-ethynylestradiol multiple interactionsISOBri3bp (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRI3BP mRNACTDPMID:17942748
Bri3bpRat17beta-estradiol multiple interactionsISOBRI3BP (Homo sapiens)6480464[Estradiol binds to ESR2 protein] which results in increased expression of BRI3BP mRNACTDPMID:20404318
Bri3bpRat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of BRI3BP mRNACTDPMID:26496021
Bri3bpRat17beta-estradiol increases expressionISOBRI3BP (Homo sapiens)6480464Estradiol results in increased expression of BRI3BP mRNACTDPMID:23019147
Bri3bpRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionISOBRI3BP (Homo sapiens)64804642 more ...CTDPMID:19095052
Bri3bpRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOBri3bp (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRI3BP mRNACTDPMID:17942748
Bri3bpRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of BRI3BP mRNACTDPMID:21215274
Bri3bpRat2-methylcholine affects expressionISOBRI3BP (Homo sapiens)6480464beta-methylcholine affects the expression of BRI3BP mRNACTDPMID:21179406
Bri3bpRat3,4-methylenedioxymethamphetamine increases expressionISOBri3bp (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of BRI3BP mRNACTDPMID:20188158
Bri3bpRat3-methylcholanthrene increases expressionISOBri3bp (Mus musculus)6480464Methylcholanthrene results in increased expression of BRI3BP mRNACTDPMID:25926378
Bri3bpRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of BRI3BP mRNACTDPMID:30047161
Bri3bpRataflatoxin B1 decreases expressionISOBri3bp (Mus musculus)6480464Aflatoxin B1 results in decreased expression of BRI3BP mRNACTDPMID:19770486
Bri3bpRatamitrole increases expressionEXP 6480464Amitrole results in increased expression of BRI3BP mRNACTDPMID:30047161
Bri3bpRataristolochic acid A increases expressionISOBRI3BP (Homo sapiens)6480464aristolochic acid I results in increased expression of BRI3BP mRNACTDPMID:33212167
Bri3bpRatarsane affects methylationISOBRI3BP (Homo sapiens)6480464Arsenic affects the methylation of BRI3BP geneCTDPMID:25304211
Bri3bpRatarsenic atom affects methylationISOBRI3BP (Homo sapiens)6480464Arsenic affects the methylation of BRI3BP geneCTDPMID:25304211
Bri3bpRatbenzo[a]pyrene decreases expressionISOBri3bp (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of BRI3BP mRNACTDPMID:19770486

1 to 20 of 77 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bri3bpRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Bri3bpRatmitochondrion located_inISOBRI3BP (Homo sapiens)1624291 PMID:17943721RGDPMID:17943721
Bri3bpRatmitochondrion located_inIEAUniProtKB:Q8WY22 and ensembl:ENSP000003407611600115GO_REF:0000107EnsemblGO_REF:0000107
Bri3bpRatmitochondrion located_inIEAInterPro:IPR0333671600115GO_REF:0000002InterProGO_REF:0000002
Bri3bpRatmitochondrion is_active_inIBAPANTHER:PTN008630955 and UniProtKB:Q8WY221600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Bri3bpRatprotein binding enablesISOBRI3BP (Homo sapiens)1624291UniProtKB:A6NJY4 more ...RGDPMID:11860200 more ...


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
PMID:17943721  



Bri3bp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81236,838,098 - 36,849,919 (-)NCBIGRCr8
mRatBN7.21231,176,742 - 31,188,563 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,173,971 - 31,188,572 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1232,347,442 - 32,359,299 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01232,958,867 - 32,970,726 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,010,791 - 32,022,648 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,576,018 - 36,587,839 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,576,020 - 36,587,839 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01238,445,350 - 38,457,171 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41232,270,907 - 32,282,728 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1232,871,267 - 32,883,085 (-)NCBICelera
Cytogenetic Map12q14NCBI
BRI3BP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812124,993,645 - 125,051,167 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12124,993,645 - 125,031,231 (+)EnsemblGRCh38hg38GRCh38
GRCh3712125,478,191 - 125,515,777 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612124,044,147 - 124,076,302 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412124,003,073 - 124,035,229NCBI
Celera12125,079,837 - 125,113,892 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12122,460,787 - 122,474,086 (+)NCBIHuRef
CHM1_112125,299,491 - 125,331,625 (+)NCBICHM1_1
T2T-CHM13v2.012124,998,843 - 125,059,692 (+)NCBIT2T-CHM13v2.0
Bri3bp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395125,518,632 - 125,537,949 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5125,518,632 - 125,537,434 (+)EnsemblGRCm39 Ensembl
GRCm385125,441,568 - 125,460,885 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5125,441,568 - 125,460,370 (+)EnsemblGRCm38mm10GRCm38
MGSCv375125,921,938 - 125,941,255 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365125,730,944 - 125,750,261 (+)NCBIMGSCv36mm8
Celera5122,463,614 - 122,482,895 (+)NCBICelera
Cytogenetic Map5G1.1NCBI
cM Map564.21NCBI
Bri3bp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554824,710,937 - 4,716,534 (-)NCBIChiLan1.0ChiLan1.0
BRI3BP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210133,080,656 - 133,120,590 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112133,077,046 - 133,116,968 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012122,587,345 - 122,627,273 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112126,891,051 - 126,904,267 (+)NCBIpanpan1.1PanPan1.1panPan2
BRI3BP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1264,938,835 - 4,961,552 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha265,093,905 - 5,121,184 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0265,176,412 - 5,203,707 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl265,180,807 - 5,203,707 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1265,114,537 - 5,141,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0265,203,968 - 5,231,236 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0265,157,906 - 5,185,163 (-)NCBIUU_Cfam_GSD_1.0
Bri3bp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118159,065,004 - 159,091,049 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936558392,985 - 401,751 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936558392,685 - 401,569 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRI3BP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1428,180,103 - 28,202,072 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11428,180,130 - 28,202,106 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21429,887,796 - 29,904,793 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BRI3BP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111120,351,911 - 120,384,626 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037124,895,679 - 124,933,257 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bri3bp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474724,078,187 - 24,095,925 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474724,078,274 - 24,093,028 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Bri3bp
53 total Variants

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:176
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000001295
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 53 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat

1 to 10 of 53 rows
RH135352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21231,177,062 - 31,177,257 (+)MAPPERmRatBN7.2
Rnor_6.01236,576,339 - 36,576,533NCBIRnor6.0
Rnor_5.01238,445,671 - 38,445,865UniSTSRnor5.0
RGSC_v3.41232,271,228 - 32,271,422UniSTSRGSC3.4
Celera1232,871,588 - 32,871,782UniSTS
RH 3.4 Map12471.9UniSTS
Cytogenetic Map12q14UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001295   ⟹   ENSRNOP00000001295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1236,576,020 - 36,587,839 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104714   ⟹   ENSRNOP00000092844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1231,173,971 - 31,188,572 (-)Ensembl
RefSeq Acc Id: NM_001017487   ⟹   NP_001017487
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81236,838,098 - 36,849,919 (-)NCBI
mRatBN7.21231,176,742 - 31,188,563 (-)NCBI
Rnor_6.01236,576,018 - 36,587,839 (-)NCBI
Rnor_5.01238,445,350 - 38,457,171 (-)NCBI
RGSC_v3.41232,270,907 - 32,282,728 (-)RGD
Celera1232,871,267 - 32,883,085 (-)RGD
Sequence:
Protein RefSeqs NP_001017487 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85334 (Get FASTA)   NCBI Sequence Viewer  
  EDM13552 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000092844
  ENSRNOP00000092844.1
RefSeq Acc Id: NP_001017487   ⟸   NM_001017487
- Peptide Label: precursor
- UniProtKB: Q5U3Z5 (UniProtKB/TrEMBL),   A0A8I6AHD0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001295   ⟸   ENSRNOT00000001295
Ensembl Acc Id: ENSRNOP00000092844   ⟸   ENSRNOT00000104714

Name Modeler Protein Id AA Range Protein Structure
AF-Q5U3Z5-F1-model_v2 AlphaFold Q5U3Z5 1-253 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698600
Promoter ID:EPDNEW_R9124
Type:initiation region
Name:Bri3bp_1
Description:Bri3 binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01236,587,907 - 36,587,967EPDNEW


1 to 18 of 18 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19388 BioCyc
Ensembl Genes ENSRNOG00000000979 Ensembl
  ENSRNOG00000063640 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000104714 ENTREZGENE
  ENSRNOT00000104714.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7301029 IMAGE-MGC_LOAD
InterPro BRI3BP UniProtKB/TrEMBL
KEGG Report rno:498176 UniProtKB/TrEMBL
MGC_CLONE MGC:105518 IMAGE-MGC_LOAD
NCBI Gene 498176 ENTREZGENE
PANTHER BRI3-BINDING PROTEIN UniProtKB/TrEMBL
  PTHR31253 UniProtKB/TrEMBL
Pfam BRI3BP UniProtKB/TrEMBL
PhenoGen Bri3bp PhenoGen
RatGTEx ENSRNOG00000000979 RatGTEx
  ENSRNOG00000063640 RatGTEx
UniProt A0A8I6AHD0 ENTREZGENE, UniProtKB/TrEMBL
  Q5U3Z5 ENTREZGENE, UniProtKB/TrEMBL
1 to 18 of 18 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Bri3bp  Bri3 binding protein  LOC498176  similar to BRI3-binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC498176  similar to BRI3-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL