Rapgef5 (Rap guanine nucleotide exchange factor 5) - Rat Genome Database

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Gene: Rapgef5 (Rap guanine nucleotide exchange factor 5) Rattus norvegicus
Analyze
Symbol: Rapgef5
Name: Rap guanine nucleotide exchange factor 5
RGD ID: 1561668
Description: Predicted to enable GTP-dependent protein binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in nucleus. Predicted to be active in plasma membrane. Orthologous to human RAPGEF5 (Rap guanine nucleotide exchange factor 5); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: guanine nucleotide exchange factor; guanine nucleotide exchange factor for Rap1-like; LOC100361497; LOC500748; M-Ras-regulated Rap GEF; MR-GEF; Mrgef; Rap guanine nucleotide exchange factor (GEF) 5; RGD1562891; rMR-GEF; similar to Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86144,588,162 - 144,822,908 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6144,580,976 - 144,822,908 (+)EnsemblGRCr8
mRatBN7.26138,445,184 - 138,679,943 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6138,437,991 - 138,679,936 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6141,880,425 - 142,115,425 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06138,497,846 - 138,732,849 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06139,052,896 - 139,287,512 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06145,387,890 - 145,625,243 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6145,546,595 - 145,625,236 (+)Ensemblrn6Rnor6.0
Rnor_5.06154,308,057 - 154,541,118 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46144,949,908 - 145,030,090 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6136,254,550 - 136,332,824 (+)NCBICelera
Cytogenetic Map6q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO)
plasma membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Bithell A, etal., Brain Res Dev Brain Res 2003 Dec 19;146(1-2):107-18.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10486569   PMID:10934204   PMID:17725712  


Genomics

Comparative Map Data
Rapgef5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86144,588,162 - 144,822,908 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6144,580,976 - 144,822,908 (+)EnsemblGRCr8
mRatBN7.26138,445,184 - 138,679,943 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6138,437,991 - 138,679,936 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6141,880,425 - 142,115,425 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06138,497,846 - 138,732,849 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06139,052,896 - 139,287,512 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06145,387,890 - 145,625,243 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6145,546,595 - 145,625,236 (+)Ensemblrn6Rnor6.0
Rnor_5.06154,308,057 - 154,541,118 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46144,949,908 - 145,030,090 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6136,254,550 - 136,332,824 (+)NCBICelera
Cytogenetic Map6q33NCBI
RAPGEF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38722,118,236 - 22,357,154 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl722,118,236 - 22,357,154 (-)Ensemblhg38GRCh38
GRCh37722,157,854 - 22,396,773 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36722,124,433 - 22,363,058 (-)NCBIBuild 36Build 36hg18NCBI36
Celera722,143,557 - 22,382,091 (-)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef722,043,471 - 22,243,092 (-)NCBIHuRef
CHM1_1722,158,708 - 22,397,156 (-)NCBICHM1_1
T2T-CHM13v2.0722,254,475 - 22,493,270 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2722,209,210 - 22,447,742 (-)NCBI
Rapgef5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912117,480,146 - 117,723,472 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12117,480,099 - 117,723,472 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812117,516,526 - 117,759,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12117,516,479 - 117,759,737 (+)Ensemblmm10GRCm38
MGSCv3712118,754,952 - 118,995,451 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612117,958,488 - 118,198,654 (+)NCBIMGSCv36mm8
MGSCv3612111,717,001 - 111,958,157 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1263.06NCBI
Rapgef5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541024,525,748 - 24,716,372 (-)Ensembl
ChiLan1.0NW_00495541024,525,748 - 24,716,151 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2626,984,630 - 27,225,479 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1775,309,356 - 75,550,210 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0722,806,855 - 23,047,663 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1722,118,332 - 22,317,650 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl722,122,434 - 22,317,650 (-)EnsemblpanPan2panpan1.1
RAPGEF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11435,979,393 - 36,208,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1435,982,444 - 36,209,214 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1435,520,950 - 35,750,469 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01435,904,738 - 36,135,155 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1435,904,768 - 36,135,551 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11436,024,971 - 36,254,867 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01435,721,839 - 35,951,074 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01436,057,456 - 36,287,333 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rapgef5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511880,185,677 - 80,381,255 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365467,864,608 - 8,051,356 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365467,860,795 - 8,051,351 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl990,958,078 - 91,578,992 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1990,958,078 - 91,232,256 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29100,401,677 - 100,899,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12135,894,481 - 36,132,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2135,940,360 - 36,133,715 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604268,454,107 - 68,689,515 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247398,427,796 - 8,610,694 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247398,388,172 - 8,614,469 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rapgef5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17118,371,912 - 118,602,313 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:850
Count of miRNA genes:319
Interacting mature miRNAs:431
Transcripts:ENSRNOT00000007112
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
BE108572  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,511,279 - 138,511,450 (+)MAPPERmRatBN7.2
Rnor_6.06145,456,623 - 145,456,793NCBIRnor6.0
Rnor_5.06154,373,928 - 154,374,098UniSTSRnor5.0
RGSC_v3.46144,858,798 - 144,858,968UniSTSRGSC3.4
Celera6136,164,170 - 136,164,340UniSTS
RH 3.4 Map6928.8UniSTS
Cytogenetic Map6q33UniSTS
BE119908  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26138,497,684 - 138,497,870 (+)MAPPERmRatBN7.2
Rnor_6.06145,441,165 - 145,441,350NCBIRnor6.0
Rnor_5.06154,361,345 - 154,361,530UniSTSRnor5.0
RGSC_v3.46144,846,623 - 144,846,808UniSTSRGSC3.4
Celera6136,150,814 - 136,150,999UniSTS
RH 3.4 Map6928.8UniSTS
Cytogenetic Map6q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 89 59 6 352 189 11 144 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000007112   ⟹   ENSRNOP00000007112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6144,580,976 - 144,822,908 (+)Ensembl
mRatBN7.2 Ensembl6138,437,991 - 138,679,936 (+)Ensembl
Rnor_6.0 Ensembl6145,546,595 - 145,625,236 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099532   ⟹   ENSRNOP00000087882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6144,588,115 - 144,822,901 (+)Ensembl
mRatBN7.2 Ensembl6138,445,188 - 138,679,936 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117361   ⟹   ENSRNOP00000087207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6144,744,742 - 144,819,302 (+)Ensembl
mRatBN7.2 Ensembl6138,601,774 - 138,676,337 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000132894   ⟹   ENSRNOP00000101105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6144,616,359 - 144,822,908 (+)Ensembl
RefSeq Acc Id: NM_001047915   ⟹   NP_001041380
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86144,744,742 - 144,822,908 (+)NCBI
mRatBN7.26138,601,774 - 138,679,943 (+)NCBI
Rnor_6.06145,546,595 - 145,625,241 (+)NCBI
Rnor_5.06154,308,057 - 154,541,118 (+)NCBI
RGSC_v3.46144,949,908 - 145,030,090 (+)RGD
Celera6136,254,550 - 136,332,824 (+)RGD
Sequence:
RefSeq Acc Id: NM_001395143   ⟹   NP_001382072
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86144,588,162 - 144,822,908 (+)NCBI
mRatBN7.26138,445,184 - 138,679,943 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001041380 (Get FASTA)   NCBI Sequence Viewer  
  NP_001382072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR83745 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087207
  ENSRNOP00000087882
GenBank Protein P83900 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001041380   ⟸   NM_001047915
- Peptide Label: isoform 1
- UniProtKB: P83900 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007112   ⟸   ENSRNOT00000007112
Ensembl Acc Id: ENSRNOP00000087882   ⟸   ENSRNOT00000099532
Ensembl Acc Id: ENSRNOP00000087207   ⟸   ENSRNOT00000117361
RefSeq Acc Id: NP_001382072   ⟸   NM_001395143
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A853 (UniProtKB/TrEMBL),   F1M888 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000101105   ⟸   ENSRNOT00000132894
Protein Domains
DEP   N-terminal Ras-GEF   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P83900-F1-model_v2 AlphaFold P83900 1-580 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561668 AgrOrtholog
BioCyc Gene G2FUF-35484 BioCyc
Ensembl Genes ENSRNOG00000005271 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000099532 ENTREZGENE
  ENSRNOT00000117361 ENTREZGENE
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot
InterPro Ras-like_GEF UniProtKB/Swiss-Prot
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot
  Ras_G-nucl-exch_fac_CS UniProtKB/Swiss-Prot
  Ras_GEF_dom UniProtKB/Swiss-Prot
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot
  RasGRF_CDC25 UniProtKB/Swiss-Prot
  Ubiquitin-rel_dom UniProtKB/Swiss-Prot
KEGG Report rno:362799 UniProtKB/Swiss-Prot
NCBI Gene 362799 ENTREZGENE
PANTHER PTHR23113 UniProtKB/Swiss-Prot
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5 UniProtKB/Swiss-Prot
Pfam RasGEF UniProtKB/Swiss-Prot
  RasGEF_N UniProtKB/Swiss-Prot
PhenoGen Rapgef5 PhenoGen
PROSITE RASGEF UniProtKB/Swiss-Prot
  RASGEF_CAT UniProtKB/Swiss-Prot
  RASGEF_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005271 RatGTEx
SMART RasGEF UniProtKB/Swiss-Prot
  RasGEFN UniProtKB/Swiss-Prot
Superfamily-SCOP Ras_GEF UniProtKB/Swiss-Prot
  SSF54236 UniProtKB/Swiss-Prot
UniProt A0A8I6A853 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GFS5_RAT UniProtKB/TrEMBL
  A0ABK0L832_RAT UniProtKB/TrEMBL
  F1M888 ENTREZGENE, UniProtKB/TrEMBL
  P83900 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Rapgef5  Rap guanine nucleotide exchange factor 5  Rapgef5  Rap guanine nucleotide exchange factor (GEF) 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Rapgef5  Rap guanine nucleotide exchange factor (GEF) 5  LOC100361497  guanine nucleotide exchange factor for Rap1-like  Data merged from RGD:2320068 737654 PROVISIONAL
2010-05-05 LOC100361497  guanine nucleotide exchange factor for Rap1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-01-09 Rapgef5  Rap guanine nucleotide exchange factor (GEF) 5  RGD1562891_predicted  similar to Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (predicted)  Data merged from RGD:1562891 1643240 APPROVED
2006-03-10 RGD1562891_predicted  similar to Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (predicted)    similar to Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1562891_predicted  similar to Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (predicted)  LOC500748  similar to Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 Rapgef5  Rap guanine nucleotide exchange factor (GEF) 5      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-02-09 LOC500748  similar to Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF)      Symbol and Name status set to provisional 70820 PROVISIONAL