Tmem81 (transmembrane protein 81) - Rat Genome Database

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Gene: Tmem81 (transmembrane protein 81) Rattus norvegicus
Analyze
Symbol: Tmem81
Name: transmembrane protein 81
RGD ID: 1561544
Description: Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in sperm-egg recognition. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM81 (transmembrane protein 81); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC498229; similar to RIKEN cDNA 4930429O20
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,491,808 - 46,494,239 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1346,491,802 - 46,494,236 (+)EnsemblGRCr8
mRatBN7.21343,939,677 - 43,942,108 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,939,630 - 43,942,113 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1346,546,661 - 46,549,092 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01347,834,791 - 47,837,222 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,095,498 - 45,097,929 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01349,277,722 - 49,280,153 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,277,722 - 49,280,151 (+)Ensemblrn6Rnor6.0
Rnor_5.01354,353,122 - 54,355,553 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41345,392,327 - 45,394,758 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1344,274,257 - 44,276,688 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
sperm-egg recognition  (IEA,ISO,ISS)

Cellular Component
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Comparative Map Data
Tmem81
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81346,491,808 - 46,494,239 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1346,491,802 - 46,494,236 (+)EnsemblGRCr8
mRatBN7.21343,939,677 - 43,942,108 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,939,630 - 43,942,113 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1346,546,661 - 46,549,092 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01347,834,791 - 47,837,222 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,095,498 - 45,097,929 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01349,277,722 - 49,280,153 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1349,277,722 - 49,280,151 (+)Ensemblrn6Rnor6.0
Rnor_5.01354,353,122 - 54,355,553 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41345,392,327 - 45,394,758 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1344,274,257 - 44,276,688 (+)NCBICelera
Cytogenetic Map13q13NCBI
TMEM81
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381205,083,129 - 205,084,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1205,083,129 - 205,084,460 (-)Ensemblhg38GRCh38
GRCh371205,052,257 - 205,053,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361203,318,880 - 203,320,211 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1178,187,174 - 178,188,505 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1176,217,507 - 176,218,838 (-)NCBIHuRef
CHM1_11206,475,588 - 206,476,919 (-)NCBICHM1_1
T2T-CHM13v2.01204,347,508 - 204,348,839 (-)NCBIT2T-CHM13v2.0
Tmem81
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,433,968 - 132,436,382 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,433,968 - 132,436,377 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381132,506,230 - 132,508,644 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,506,230 - 132,508,639 (+)Ensemblmm10GRCm38
MGSCv371134,402,807 - 134,405,216 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361134,333,776 - 134,336,183 (+)NCBIMGSCv36mm8
Celera1135,114,902 - 135,117,311 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.42NCBI
Tmem81
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540640,865,574 - 40,867,602 (-)NCBIChiLan1.0ChiLan1.0
TMEM81
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2144,290,735 - 44,293,592 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1144,255,926 - 44,258,871 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01180,685,214 - 180,686,789 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11184,971,622 - 184,973,091 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,972,046 - 184,972,813 (-)EnsemblpanPan2panpan1.1
TMEM81
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1381,604,068 - 1,606,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl381,604,288 - 1,605,254 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha381,698,271 - 1,700,811 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0381,600,560 - 1,603,099 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl381,600,780 - 1,601,746 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1381,596,814 - 1,599,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,987,987 - 1,990,521 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0382,188,141 - 2,190,678 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem81
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934470,051,590 - 70,055,201 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365577,291,797 - 7,295,484 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM81
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl965,780,934 - 65,781,891 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1965,780,520 - 65,782,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2972,006,389 - 72,007,704 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM81
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12524,255,997 - 24,258,150 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2524,256,951 - 24,257,718 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605525,011,579 - 25,014,457 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem81
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,047,323 - 6,049,616 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248076,048,422 - 6,049,961 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem81
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1103,342,997 - 3,344,982 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem81
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:172
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000035335
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131186625456866254Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134627292251216694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132485392569853925Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131244842147969993Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131746828262468282Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131238432057384320Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134373632747969993Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13600200847359539Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132433543255601132Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131244842148744906Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134599007750392939Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132624480871244808Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133379409660914504Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)13308875548088755Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132624480871244808Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131771133662711336Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131186625456866254Rat

Markers in Region
RH129466  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21343,938,849 - 43,939,063 (+)MAPPERmRatBN7.2
Rnor_6.01349,276,895 - 49,277,108NCBIRnor6.0
Rnor_5.01354,352,295 - 54,352,508UniSTSRnor5.0
RGSC_v3.41345,391,500 - 45,391,713UniSTSRGSC3.4
Celera1344,273,430 - 44,273,643UniSTS
RH 3.4 Map13114.3UniSTS
Cytogenetic Map13q13UniSTS
AW254008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21343,941,899 - 43,942,030 (+)MAPPERmRatBN7.2
Rnor_6.01349,279,945 - 49,280,075NCBIRnor6.0
Rnor_5.01354,355,345 - 54,355,475UniSTSRnor5.0
RGSC_v3.41345,394,550 - 45,394,680UniSTSRGSC3.4
Celera1344,276,480 - 44,276,610UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 161 91 90 59 89 59 6 352 188 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000035335   ⟹   ENSRNOP00000034105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1346,491,802 - 46,494,236 (+)Ensembl
mRatBN7.2 Ensembl1343,939,630 - 43,942,113 (+)Ensembl
Rnor_6.0 Ensembl1349,277,722 - 49,280,151 (+)Ensembl
RefSeq Acc Id: NM_001017490   ⟹   NP_001017490
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81346,491,808 - 46,494,239 (+)NCBI
mRatBN7.21343,939,677 - 43,942,108 (+)NCBI
Rnor_6.01349,277,722 - 49,280,153 (+)NCBI
Rnor_5.01354,353,122 - 54,355,553 (+)NCBI
RGSC_v3.41345,392,327 - 45,394,758 (+)RGD
Celera1344,274,257 - 44,276,688 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001017490 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79284 (Get FASTA)   NCBI Sequence Viewer  
  EDM09794 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034105
  ENSRNOP00000034105.3
GenBank Protein Q6AXW8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001017490   ⟸   NM_001017490
- Peptide Label: precursor
- UniProtKB: Q6AXW8 (UniProtKB/Swiss-Prot),   A6IC53 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034105   ⟸   ENSRNOT00000035335
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXW8-F1-model_v2 AlphaFold Q6AXW8 1-262 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698814
Promoter ID:EPDNEW_R9338
Type:multiple initiation site
Name:Tmem81_1
Description:transmembrane protein 81
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01349,277,743 - 49,277,803EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561544 AgrOrtholog
BioCyc Gene G2FUF-18314 BioCyc
Ensembl Genes ENSRNOG00000028752 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000035335 ENTREZGENE
  ENSRNOT00000035335.4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134237 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  TMEM81 UniProtKB/Swiss-Prot
KEGG Report rno:498229 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94412 IMAGE-MGC_LOAD
NCBI Gene 498229 ENTREZGENE
PANTHER PTHR35670 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 81 UniProtKB/Swiss-Prot
PhenoGen Tmem81 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028752 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A6IC53 ENTREZGENE, UniProtKB/TrEMBL
  Q6AXW8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Tmem81  transmembrane protein 81  LOC498229  similar to RIKEN cDNA 4930429O20  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC498229  similar to RIKEN cDNA 4930429O20      Symbol and Name status set to provisional 70820 PROVISIONAL