Glb1l3 (galactosidase, beta 1-like 3) - Rat Genome Database

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Gene: Glb1l3 (galactosidase, beta 1-like 3) Rattus norvegicus
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Symbol: Glb1l3
Name: galactosidase, beta 1-like 3
RGD ID: 1561462
Description: Predicted to enable beta-galactosidase activity. Predicted to be involved in galactose catabolic process. Predicted to be active in vacuole. Orthologous to human GLB1L3 (galactosidase beta 1 like 3); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-galactosidase-1-like protein 3; galactosidase, beta 1 like 3; LOC500961; similar to hypothetical protein BC008326
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8833,454,914 - 33,496,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl833,454,914 - 33,496,641 (-)EnsemblGRCr8
mRatBN7.2825,179,165 - 25,220,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl825,179,165 - 25,220,904 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx829,237,730 - 29,279,461 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0827,532,023 - 27,573,752 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0825,395,446 - 25,437,166 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0827,865,452 - 27,907,726 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl827,865,350 - 27,907,911 (-)Ensemblrn6Rnor6.0
Rnor_5.0827,885,459 - 27,927,733 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4826,448,446 - 26,490,267 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera826,737,742 - 26,779,469 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
vacuole  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334  


Genomics

Comparative Map Data
Glb1l3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8833,454,914 - 33,496,641 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl833,454,914 - 33,496,641 (-)EnsemblGRCr8
mRatBN7.2825,179,165 - 25,220,904 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl825,179,165 - 25,220,904 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx829,237,730 - 29,279,461 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0827,532,023 - 27,573,752 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0825,395,446 - 25,437,166 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0827,865,452 - 27,907,726 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl827,865,350 - 27,907,911 (-)Ensemblrn6Rnor6.0
Rnor_5.0827,885,459 - 27,927,733 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4826,448,446 - 26,490,267 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera826,737,742 - 26,779,469 (-)NCBICelera
Cytogenetic Map8q13NCBI
GLB1L3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811134,275,767 - 134,325,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11134,274,245 - 134,319,579 (+)Ensemblhg38GRCh38
GRCh3711134,146,273 - 134,189,458 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611133,652,266 - 133,694,667 (+)NCBIBuild 36Build 36hg18NCBI36
Celera11131,319,141 - 131,362,133 (+)NCBICelera
Cytogenetic Map11q25NCBI
HuRef11130,101,037 - 130,144,384 (+)NCBIHuRef
CHM1_111134,033,014 - 134,076,147 (+)NCBICHM1_1
T2T-CHM13v2.011134,314,651 - 134,366,918 (+)NCBIT2T-CHM13v2.0
Glb1l3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39926,729,249 - 26,773,394 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl926,729,249 - 26,772,186 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38926,817,953 - 26,862,099 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl926,817,953 - 26,860,890 (-)Ensemblmm10GRCm38
MGSCv37926,625,538 - 26,668,408 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36926,567,399 - 26,610,336 (-)NCBIMGSCv36mm8
Celera924,077,263 - 24,119,785 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map911.67NCBI
GLB1L3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29134,998,067 - 135,044,186 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111136,097,272 - 136,143,364 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011129,126,472 - 129,172,535 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111132,985,554 - 133,029,890 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11132,987,384 - 133,029,890 (+)EnsemblpanPan2panpan1.1
GLB1L3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.15805,531 - 846,125 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl5805,653 - 846,126 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha5925,741 - 967,403 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.05760,724 - 802,389 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.15793,717 - 835,155 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.05795,014 - 836,740 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.05832,260 - 874,005 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
GLB1L3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl960,918,345 - 60,940,093 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1960,917,137 - 60,940,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2967,540,330 - 67,560,798 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLB1L3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11125,359,514 - 125,400,427 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1125,360,454 - 125,400,409 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666043647,520 - 688,581 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glb1l3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1822,584,541 - 22,628,034 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Glb1l3
335 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:24
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000010045
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 4 43 72 66 65 35 21 35 3 149 80 55 18 85 30

Sequence


Ensembl Acc Id: ENSRNOT00000010045   ⟹   ENSRNOP00000010045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl833,454,914 - 33,496,641 (-)Ensembl
mRatBN7.2 Ensembl825,179,165 - 25,220,904 (-)Ensembl
Rnor_6.0 Ensembl827,865,350 - 27,907,911 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118955   ⟹   ENSRNOP00000091712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl833,454,914 - 33,496,641 (-)Ensembl
mRatBN7.2 Ensembl825,179,165 - 25,220,904 (-)Ensembl
RefSeq Acc Id: NM_001024358   ⟹   NP_001019529
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8833,454,914 - 33,496,641 (-)NCBI
mRatBN7.2825,179,165 - 25,220,904 (-)NCBI
Rnor_6.0827,865,452 - 27,907,726 (-)NCBI
Rnor_5.0827,885,459 - 27,927,733 (-)NCBI
RGSC_v3.4826,448,446 - 26,490,267 (-)RGD
Celera826,737,742 - 26,779,469 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001019529 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH83665 (Get FASTA)   NCBI Sequence Viewer  
  EDL83349 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010045
GenBank Protein Q5XIL5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001019529   ⟸   NM_001024358
- Peptide Label: precursor
- UniProtKB: Q5XIL5 (UniProtKB/Swiss-Prot),   F1LQ73 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010045   ⟸   ENSRNOT00000010045
Ensembl Acc Id: ENSRNOP00000091712   ⟸   ENSRNOT00000118955
Protein Domains
Beta-galactosidase 1-like first all-beta   Beta-galactosidase galactose-binding   Glycoside hydrolase 35 catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIL5-F1-model_v2 AlphaFold Q5XIL5 1-631 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561462 AgrOrtholog
BioCyc Gene G2FUF-31311 BioCyc
Ensembl Genes ENSRNOG00000031469 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000010045 ENTREZGENE
Gene3D-CATH Galactose-binding domain-like UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7135489 IMAGE-MGC_LOAD
InterPro B-gal_1-like UniProtKB/Swiss-Prot
  BetaGal1-like_ABD1 UniProtKB/Swiss-Prot
  BetaGal_gal-bd UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
  Gly_Hdrlase_35_cat UniProtKB/Swiss-Prot
  Glyco_hydro_35_CS UniProtKB/Swiss-Prot
  Glycoside_Hdrlase_35 UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
KEGG Report rno:500961 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94507 IMAGE-MGC_LOAD
NCBI Gene 500961 ENTREZGENE
PANTHER PTHR23421 UniProtKB/Swiss-Prot
Pfam BetaGal_ABD_1 UniProtKB/Swiss-Prot
  BetaGal_gal-bd UniProtKB/Swiss-Prot
  Glyco_hydro_35 UniProtKB/Swiss-Prot
PhenoGen Glb1l3 PhenoGen
PIRSF B-gal UniProtKB/Swiss-Prot
PRINTS GLHYDRLASE35 UniProtKB/Swiss-Prot
PROSITE GLYCOSYL_HYDROL_F35 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000031469 RatGTEx
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot
  SSF51445 UniProtKB/Swiss-Prot
UniProt A0A8I6AGN4_RAT UniProtKB/TrEMBL
  F1LQ73 ENTREZGENE, UniProtKB/TrEMBL
  GLBL3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Glb1l3  galactosidase, beta 1-like 3  LOC500961  similar to hypothetical protein BC008326  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500961  similar to hypothetical protein BC008326      Symbol and Name status set to provisional 70820 PROVISIONAL