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Gene: Arhgap30 (Rho GTPase activating protein 30) Rattus norvegicus

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Symbol:

Arhgap30

Name:

Rho GTPase activating protein 30

RGD ID:

1561419

Description:

Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of Rho protein signal transduction and small GTPase-mediated signal transduction. Orthologous to human ARHGAP30 (Rho GTPase activating protein 30); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC498282; RGD1561419; rho GTPase-activating protein 30; similar to RIKEN cDNA 6030405P05 gene

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ARHGAP30 (Rho GTPase activating protein 30)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Arhgap30 (Rho GTPase activating protein 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Arhgap30 (Rho GTPase activating protein 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ARHGAP30 (Rho GTPase activating protein 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ARHGAP30 (Rho GTPase activating protein 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Arhgap30 (Rho GTPase activating protein 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ARHGAP30 (Rho GTPase activating protein 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ARHGAP30 (Rho GTPase activating protein 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Arhgap30 (Rho GTPase activating protein 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Arhgap30 (Rho GTPase activating protein 30)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	FH (fumarate hydratase)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ARHGAP30 (Rho GTPase activating protein 30)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Arhgap30 (Rho GTPase activating protein 30)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkeyp-68b7.12	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkeyp-68b7.12	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkeyp-68b7.12	Alliance	DIOPT (OrthoFinder\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	si:dkeyp-68b7.12	Alliance	DIOPT (OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CdGAPr	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Caenorhabditis elegans (roundworm):	rrc-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector)
Caenorhabditis elegans (roundworm):	rrc-1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	arhgap30	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	arhgap30	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,354,448 - 86,376,552 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	86,354,547 - 86,376,888 (+)	Ensembl				GRCr8
mRatBN7.2	13	83,822,290 - 83,843,634 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,822,283 - 83,854,885 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	86,328,054 - 86,349,397 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,726,262 - 87,747,611 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,962,056 - 84,983,508 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,774,764 - 89,796,113 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,774,764 - 89,796,113 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	94,402,339 - 94,423,830 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	87,295,074 - 87,335,018 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	83,452,743 - 83,474,223 (+)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

polycystic ovary syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

cocaine (EXP)

curcumin (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dimethylarsinic acid (ISO)

dimethylselenide (ISO)

diquat (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

iron dichloride (ISO)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (ISO)

lidocaine (EXP)

methylarsonic acid (ISO)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

nitrates (ISO)

okadaic acid (ISO)

ozone (ISO)

reactive oxygen species (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of Rho protein signal transduction (IEA,ISO)

signal transduction (IEA)

small GTPase-mediated signal transduction (IBA)

Molecular Function

GTPase activator activity (IBA,IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Arhgap30
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	86,354,448 - 86,376,552 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	86,354,547 - 86,376,888 (+)	Ensembl				GRCr8
mRatBN7.2	13	83,822,290 - 83,843,634 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,822,283 - 83,854,885 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	86,328,054 - 86,349,397 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,726,262 - 87,747,611 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,962,056 - 84,983,508 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,774,764 - 89,796,113 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,774,764 - 89,796,113 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	94,402,339 - 94,423,830 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	87,295,074 - 87,335,018 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	83,452,743 - 83,474,223 (+)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

ARHGAP30
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	161,046,946 - 161,069,891 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	161,046,946 - 161,069,970 (-)	Ensembl			hg38	GRCh38
GRCh37	1	161,016,736 - 161,039,681 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	159,283,356 - 159,306,384 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	134,083,996 - 134,106,943 (-)	NCBI		Celera
Cytogenetic Map	1	q23.3	NCBI
HuRef	1	132,374,664 - 132,397,174 (-)	NCBI		HuRef
CHM1_1	1	162,412,931 - 162,436,004 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	160,184,453 - 160,207,382 (-)	NCBI		T2T-CHM13v2.0

Arhgap30
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	171,216,528 - 171,237,808 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	171,216,522 - 171,237,866 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	171,388,960 - 171,410,240 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	171,388,954 - 171,410,298 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	173,319,091 - 173,340,371 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	173,225,687 - 173,246,915 (+)	NCBI		MGSCv36	mm8
Celera	1	173,840,100 - 173,861,435 (+)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	79.39	NCBI

Arhgap30
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	12,823,254 - 12,840,405 (-)	Ensembl
ChiLan1.0	NW_004955468	12,822,489 - 12,840,705 (-)	NCBI	ChiLan1.0	ChiLan1.0

ARHGAP30
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	88,782,113 - 88,804,970 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	88,472,444 - 88,495,287 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	136,459,485 - 136,482,384 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	140,372,824 - 140,395,323 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	140,372,824 - 140,395,323 (-)	Ensembl			panPan2	panpan1.1

ARHGAP30
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	21,395,102 - 21,412,047 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	21,395,373 - 21,412,047 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	21,469,030 - 21,485,960 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	21,512,820 - 21,529,763 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	21,513,079 - 21,528,997 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	21,400,917 - 21,417,843 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	21,814,839 - 21,831,760 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	22,224,163 - 22,241,096 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Arhgap30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	7,152,594 - 7,171,119 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936903	361,076 - 379,595 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARHGAP30
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	89,375,526 - 89,394,244 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	89,375,486 - 89,394,190 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	97,379,662 - 97,389,035 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARHGAP30
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	2,922,593 - 2,942,563 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	2,922,935 - 2,941,817 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	1,958,942 - 1,980,534 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arhgap30
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	300,212 - 317,073 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624794	299,877 - 317,859 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Arhgap30
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	50,559,842 - 50,580,108 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Arhgap30
104 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	96
Count of miRNA genes:	68
Interacting mature miRNAs:	81
Transcripts:	ENSRNOT00000005619
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298066	Bp159	Blood pressure QTL 159		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	48639634	93639634	Rat
10755495	Bp387	Blood pressure QTL 387	3.78		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	37216241	90057603	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	38975045	103588154	Rat
8655951	Rf63	Renal function QTL 63	12.2		blood urea nitrogen amount (VT:0005265)	plasma urea nitrogen level (CMO:0000586)	13	71610804	109350286	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	83286150	109350286	Rat
8655945	Rf61	Renal function QTL 61	3.6		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	13	71610804	89333251	Rat
71119	Thym2	Thymus enlargement QTL 2	3.8		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	13	48749814	87285480	Rat
1331783	Bp221	Blood pressure QTL 221	3.72886		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	71610804	89333251	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	72984506	99745408	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	67635937	109350286	Rat
1300166	Kidm6	Kidney mass QTL 6	3.93		kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	13	71610804	89333251	Rat
619615	Bp80	Blood pressure QTL 80		0.0354	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	7421791	87286911	Rat
1581573	Uae36	Urinary albumin excretion QTL 36			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
724564	Uae11	Urinary albumin excretion QTL 11	5.7		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	13	47354258	94285672	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	21120177	109350286	Rat
738027	Lnnr6	Liver neoplastic nodule remodeling QTL 6	3.3		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	65613454	109350286	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	68983334	109350286	Rat
738026	Lnnr5	Liver neoplastic nodule remodeling QTL 5	3.29		liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number (CMO:0001461)	13	62424592	88113509	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	67635937	109350286	Rat
1576318	Schws5	Schwannoma susceptibility QTL 5		0.0351	nervous system integrity trait (VT:0010566)	post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)	13	64497900	109350286	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	11081740	103588154	Rat
1581554	Pur11	Proteinuria QTL 11			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	6002008	88706694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	64375743	109350286	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	103588154	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	67635937	109350286	Rat

Markers in Region

D13Rat185

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	13	86,364,861 - 86,365,053 (+)	Marker Load Pipeline
mRatBN7.2	13	83,832,419 - 83,832,611 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	89,784,900 - 89,785,091	NCBI	Rnor6.0
Rnor_5.0	13	94,412,075 - 94,412,266	UniSTS	Rnor5.0
RGSC_v3.4	13	87,323,804 - 87,323,996	RGD	RGSC3.4
RGSC_v3.4	13	87,323,805 - 87,323,996	UniSTS	RGSC3.4
Celera	13	83,463,010 - 83,463,201	UniSTS
RGSC_v3.1	13	87,512,689 - 87,512,880	RGD
RH 3.4 Map	13	554.9	UniSTS
RH 3.4 Map	13	554.9	RGD
RH 2.0 Map	13	606.3	RGD
SHRSP x BN Map	13	39.6598	RGD
Cytogenetic Map	13	q24	UniSTS

RH133926

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	13	86,376,398 - 86,376,608 (+)	Marker Load Pipeline
mRatBN7.2	13	83,843,957 - 83,844,167 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	89,796,437 - 89,796,646	NCBI	Rnor6.0
Rnor_5.0	13	94,423,612 - 94,423,821	UniSTS	Rnor5.0
RGSC_v3.4	13	87,335,342 - 87,335,551	UniSTS	RGSC3.4
Celera	13	83,474,547 - 83,474,756	UniSTS
RH 3.4 Map	13	554.9	UniSTS
Cytogenetic Map	13	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	159	91	90	59	92	59	6	356	192	11	137	81	92	31	12	12

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC125857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005619 ⟹ ENSRNOP00000005619

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	13	86,354,547 - 86,376,888 (+)	Ensembl
mRatBN7.2 Ensembl	13	83,822,283 - 83,854,885 (+)	Ensembl
Rnor_6.0 Ensembl	13	89,774,764 - 89,796,113 (+)	Ensembl

RefSeq Acc Id:

NM_001109077 ⟹ NP_001102547

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,354,733 - 86,376,075 (+)	NCBI
mRatBN7.2	13	83,822,290 - 83,843,634 (+)	NCBI
Rnor_6.0	13	89,774,764 - 89,796,113 (+)	NCBI
Rnor_5.0	13	94,402,339 - 94,423,830 (+)	NCBI
RGSC_v3.4	13	87,295,074 - 87,335,018 (+)	RGD
Celera	13	83,452,743 - 83,474,223 (+)	RGD

Sequence:

show sequence

ACTACTGACTGGGATTCCATGGGGGACTGGTAGGTCAAAGGTCTTGGGGGACAGAGGTCCGGGG
GGCTCTGGCCATGAAGTCTCGACAAAAAGGAAAGAAGAAAGGCAGCTCCAAGGAACGGGTGTTT
GGGTGTGACCTACGGGAGCATCTACAACAGTCCGGCCAGGAAGTGCCCCAGGTGCTACGGAGCT
GTGCAGAGTTTGTGCAAGAGTATGGAGTGGTGGATGGAATCTACCGCCTCTCAGGGGTCTCCTC
TAACATCCAGAAGCTCCGGCAGGAGTTTGAGGCTGAGAGGAAGCCAGACCTGCGGCGGGACGTT
TACCTCCAGGACATCCACTGTGTCTCCTCCTTGTGCAAGGCCTATTTCAGAGAACTACCAGATC
CCCTCCTCACTTACCGGCTCTATGACAAATTTGCTGAGGCAGTGGCTGTGCAGCTAGAGCCAGA
ACGCTTGGTCAAGATCCTAGAAGTACTTCAAGAACTCCCTGTCCCAAACTACAGGACGCTGGAG
TTCCTTATGCGCCACTTGGTCCACATGGCCTCATTTAGTGCCCAAACCAACATGCATGCCCGCA
ATTTGGCGATTGTGTGGGCCCCCAACCTGCTGAGGTCTAAGGACATAGAAGCCTCGGGCTTCAA
TGGGACAGCAGCATTCATGGAGGTTCGTGTGCAGTCCATTGTTGTGGAGTTCATCCTCACCCAT
GTGGACCAGCTCTTTAGGGGTGATTCCCTCTCTGCTGGTGTAGATTTGGAGAGTGGATGGAAAT
CACTTCCAGGGGCCCGGGCCTCAGGCAGCGCTGAGGACCTCATGCCCACACCTCTTTCCTACCA
CTTGCCTAGCATCTTGCAGGCTGGGGATGGACCGCCACAGATCCGACCGTACCATACTATCATT
GAGATTGCAGAACACAAGAGAAAGGGGTCATTGAAGGTCAGGAAATGGCGCTCTATCTTCAATT
TGGGTCGCTCTGGACACGAGACAAAACGTAAACTTCCATTGAGGACTGAGGACAGGGAAGAAAA
ATCCAGTAAGGGGACACTGCGACCTGCTAAGAGCATGGACTCACTGAGTGCTGCTGCTGGAGTC
AGTGACGAGCCAGAGGGGCTGGTGGGCTCCAGCAGTTCTCAGCCAAGCTCACTGATGATTGAGA
GCTTGGAGAATAGTTCTATGGATGCAGCAGAAGGTGAACAGGAGCCCGAAGCAGAGGCACTGGG
TAGTGCAAATTCTGAGCCAGGAACTCCACAAGCTGGGCGGTCGGCTGTTCGGGCCTTAGGTAGC
AGTCGAGCCGAGCGTTGTGCTGGTGTCCACATCTCAGACCCCTACAACGTCAACCTCCCTCTGC
ACATAACCTCTATCCTCAGTGTACCTCCAAACATCATCTCTAACGTCTCCTTGGTCAGGCTCAC
CCGTGGCCTTGAGTGCCCTGCTCTACAAGCCCGGCCAAGCCCTGCTTCAGGTCCTGGCCCAGGC
CCAGGCCTTGGCCCTGGCCCCCCAGATGAGAAATCAGAGGCAAGATCAGTCCCAGGCCCCCTGG
ATGACTTGAGCCCTATGGACATGGCTCCTGCCCTGGAGGACTCCTTGTCCCAGGAGGTGCAGGA
TTCCTTCTCCTTCCTAGAGGATTTGAGCAGCTCAGAGCCTGAGTGGGTGGGGGTGGAGGATAGG
GAGGTGGCCAAGGCAGAAGCCGCAGAAGCAACAGGAGCAGCAGGAGCAGCAGGAGCAGCAGCTT
TCTCCCTTGGGGAGGATGACCCTGGGATGGGCTACCTGGAGGAGCTCCTGAGAGTTGGGCCTCA
GGTGGAAGAGTTCTCTGTGGAGCCACCCCTGGATGATCTGTCTCTGGATGATGCACAATATGTC
CTGGCTCCTAACTGCTGTTCCCTTGATTCTGCTAGTCCTGACGTAGAAGAGGACTATGGGGAAG
AAGTCTTCTTGAGTGCCTATGATGATCTGAGTCCCCTTCTGGGGCCTAAACCCATCAACTGGGA
AGGTGTAGGGAGTCTGGAGGAAGAGACAGCAAGGTGTGGGAAACAATCTCCAACACAGGCTGAA
GAAGAACAGGCATGCTGGGAAACTGGGCAGGACACAGAGGCTGAGCCCCAAAGCACATCAGATA
ACAGGGAAGAAGCCGAGTCAGCTCCAGAGACTGAGATTGAGGCTGGAAAGCCTGATGAGAAAGG
AGGGGAGGCTGAAAGAAGCCAAGAGGTGATGGGTAGTTTGGAAGAAGGGAATGGGGAAGAGCTA
GAGGCCAAGGAAGAAAATTCCAAAGGTCAAGAGGCTGAAAGTATAGAGGAGATCAAGGATATGG
GCAAAACAAGAGAACAGGGTAGAGATGAGGAGAGAGAGATCGAGAGAAAAGGAGGAGCCGAGAA
AGGAGAGGACACCCCAGTAGAATCTGAGCTGGATCCAGAGCATATGCCCCAGGAATACCTGGTT
CCTGAGGAGAGCTGGGTTGTTATTCATAAACATGAGGCTGAGAAAGGCAGAGAGGGTGATATCA
GACTGAGGAGGAAGAGTGACCATAAGTCAAGAGAAGACCAAGGACACGGTGAAGACAGTAGAAG
TCCAGAAGAAGGTGATAATGGGAAGGAAGTGGATAACAGCAAGGAACAAAAAAGCATAGATGTA
GAAACTGAAGGCATGAGAGGTGTTGGTGTCCACTTAGAAGAGGGGGGCCTCTCTGAAGGGCCAG
GTGTCGAGTTACTGAGGGTTGCCAGCACAGAAGAAATCAATGAAACCTCTGAAATGGAACAAGC
CCCCGTACAGCCATCTGAAATGGAAGGGATGGAGGCTGAGGGACAGCTCAACCCTGAGACATGT
GACATGTATTCTTGTCCCTGTGGGTCAACTGGTGGTGTGGGCATGCGTCTGGCTTCCACCCTAG
TTCAGGTCCGACAGGTCCGTTCTGTTCCTGTAGTGCCCCCCAAACCACAGTTTGCCAAGATGCC
CAGTGCAATGTGTAGCAAGATCCACATAGCACCAGCAAACCCATGTCCAAGGCCTGGTAGGCTT
GATGGGACTCCTGGAGAAAAATGGAGTTCTCGAGCTTCCTGGAGGAATGGAGGTAGTCTTTCTT
TTGATGCTGCTGTGGCCCTGGCCCGGGAACGCCAGAGGACCGAAGCTCAGGGAGTTCGGCGGAC
CCAGACCTGTACTGGAGGTGGGGATTATAGCCTCAATTCCAGAACCTCTCCTTGTAGCATGATC
CCTGCCCATTCTTCCCGGCCCTTTAGCTGTCTGGAGCTCCCACCTGATGCCATAGAAGGGTCTG
AGCCCAGGAGTCGGTTTAGTCTGCCCCCTAGAGAGCTTCACCCTGCTGTACCTCTTGTGGTCCC
TCAGCGCCAGACATATGCATTTGAAACACAGACCAATCATGGGAAAGATGAAAGGGTGTGATGA
AGACTGGACAAGAAGGACCAAGAAATCATCACCAATCTCTGGAGTACTTGCCTAACTATCTTTG
ATGCCTTAGCAGCTGTGATGTCTAATTCCATAGGCTTGGGTCCTCCAGTTACTTGTTTTGACCT
TAGGAGGCACTGCCTTGGTGGGTGTACTTGAGTTTGTGTTAGACACAAAAAGCACTTATGTCTT
AGCAGAGTCTTAAGGAATATAAAAGATCTTGTTTCCATGGAACTGTGTTATTAGCCAAAACATA
GGGAAGGTAGAAGCTTACGGTTTT

hide sequence

RefSeq Acc Id:

XM_063272545 ⟹ XP_063128615

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	86,354,448 - 86,376,552 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001102547	(Get FASTA)	NCBI Sequence Viewer
	XP_063128615	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL94647	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005619
	ENSRNOP00000005619.7

RefSeq Acc Id:

NP_001102547 ⟸ NM_001109077

- UniProtKB:

A6JFZ1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKSRQKGKKKGSSKERVFGCDLREHLQQSGQEVPQVLRSCAEFVQEYGVVDGIYRLSGVSSNIQ
KLRQEFEAERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVAVQLEPERLV
KILEVLQELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEASGFNGTA
AFMEVRVQSIVVEFILTHVDQLFRGDSLSAGVDLESGWKSLPGARASGSAEDLMPTPLSYHLPS
ILQAGDGPPQIRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSGHETKRKLPLRTEDREEKSSK
GTLRPAKSMDSLSAAAGVSDEPEGLVGSSSSQPSSLMIESLENSSMDAAEGEQEPEAEALGSAN
SEPGTPQAGRSAVRALGSSRAERCAGVHISDPYNVNLPLHITSILSVPPNIISNVSLVRLTRGL
ECPALQARPSPASGPGPGPGLGPGPPDEKSEARSVPGPLDDLSPMDMAPALEDSLSQEVQDSFS
FLEDLSSSEPEWVGVEDREVAKAEAAEATGAAGAAGAAAFSLGEDDPGMGYLEELLRVGPQVEE
FSVEPPLDDLSLDDAQYVLAPNCCSLDSASPDVEEDYGEEVFLSAYDDLSPLLGPKPINWEGVG
SLEEETARCGKQSPTQAEEEQACWETGQDTEAEPQSTSDNREEAESAPETEIEAGKPDEKGGEA
ERSQEVMGSLEEGNGEELEAKEENSKGQEAESIEEIKDMGKTREQGRDEEREIERKGGAEKGED
TPVESELDPEHMPQEYLVPEESWVVIHKHEAEKGREGDIRLRRKSDHKSREDQGHGEDSRSPEE
GDNGKEVDNSKEQKSIDVETEGMRGVGVHLEEGGLSEGPGVELLRVASTEEINETSEMEQAPVQ
PSEMEGMEAEGQLNPETCDMYSCPCGSTGGVGMRLASTLVQVRQVRSVPVVPPKPQFAKMPSAM
CSKIHIAPANPCPRPGRLDGTPGEKWSSRASWRNGGSLSFDAAVALARERQRTEAQGVRRTQTC
TGGGDYSLNSRTSPCSMIPAHSSRPFSCLELPPDAIEGSEPRSRFSLPPRELHPAVPLVVPQRQ
TYAFETQTNHGKDERV

hide sequence

Ensembl Acc Id:

ENSRNOP00000005619 ⟸ ENSRNOT00000005619

RefSeq Acc Id:	XP_063128615 ⟸ XM_063272545
- Peptide Label:	isoform X1
- UniProtKB:	D3ZCI3 (UniProtKB/TrEMBL)

Protein Domains

Rho-GAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZCI3-F1-model_v2	AlphaFold	D3ZCI3	1-1104	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561419	AgrOrtholog
BioCyc Gene	G2FUF-17369	BioCyc
Ensembl Genes	ENSRNOG00000004192	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005619	ENTREZGENE
	ENSRNOT00000005619.9	UniProtKB/TrEMBL
Gene3D-CATH	1.10.555.10	UniProtKB/TrEMBL
InterPro	PX-Rho_GAP	UniProtKB/TrEMBL
	Rho_GTPase_activation_prot	UniProtKB/TrEMBL
	RhoGAP	UniProtKB/TrEMBL
KEGG Report	rno:498282	UniProtKB/TrEMBL
NCBI Gene	498282	ENTREZGENE
PANTHER	CDC42 GTPASE-ACTIVATING PROTEIN	UniProtKB/TrEMBL
	RHO GTPASE-ACTIVATING PROTEIN 30	UniProtKB/TrEMBL
Pfam	RhoGAP	UniProtKB/TrEMBL
PhenoGen	Arhgap30	PhenoGen
PROSITE	RHOGAP	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004192	RatGTEx
SMART	RhoGAP	UniProtKB/TrEMBL
Superfamily-SCOP	Rho_GAP	UniProtKB/TrEMBL
UniProt	A6JFZ1	ENTREZGENE, UniProtKB/TrEMBL
	D3ZCI3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-29	Arhgap30	Rho GTPase activating protein 30	RGD1561419_predicted	similar to RIKEN cDNA 6030405P05 gene (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1561419_predicted	similar to RIKEN cDNA 6030405P05 gene (predicted)	LOC498282	similar to RIKEN cDNA 6030405P05 gene	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC498282	similar to RIKEN cDNA 6030405P05 gene			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD