Lrrc73 (leucine rich repeat containing 73) - Rat Genome Database

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Gene: Lrrc73 (leucine rich repeat containing 73) Rattus norvegicus
Analyze
Symbol: Lrrc73
Name: leucine rich repeat containing 73
RGD ID: 1561390
Description: Orthologous to human LRRC73 (leucine rich repeat containing 73); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC501101; leucine-rich repeat-containing protein 73; NOD3-like protein; nod3l; uncharacterized protein C6orf154 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,223,735 - 22,227,867 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl922,223,152 - 22,226,736 (-)EnsemblGRCr8
mRatBN7.2914,726,157 - 14,730,144 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,726,158 - 14,729,158 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx923,310,400 - 23,313,401 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,372,557 - 28,375,892 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,673,788 - 26,676,789 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,111,176 - 17,115,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,111,177 - 17,114,177 (-)Ensemblrn6Rnor6.0
Rnor_5.0916,007,853 - 16,010,854 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4910,288,726 - 10,291,727 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera912,473,479 - 12,476,480 (-)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19103603  


Genomics

Comparative Map Data
Lrrc73
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8922,223,735 - 22,227,867 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl922,223,152 - 22,226,736 (-)EnsemblGRCr8
mRatBN7.2914,726,157 - 14,730,144 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,726,158 - 14,729,158 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx923,310,400 - 23,313,401 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0928,372,557 - 28,375,892 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,673,788 - 26,676,789 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0917,111,176 - 17,115,249 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl917,111,177 - 17,114,177 (-)Ensemblrn6Rnor6.0
Rnor_5.0916,007,853 - 16,010,854 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4910,288,726 - 10,291,727 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera912,473,479 - 12,476,480 (-)NCBICelera
Cytogenetic Map9q12NCBI
LRRC73
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,506,968 - 43,510,346 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl643,506,965 - 43,510,388 (-)Ensemblhg38GRCh38
GRCh37643,474,706 - 43,478,084 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,582,685 - 43,586,402 (-)NCBIBuild 36Build 36hg18NCBI36
Celera645,026,328 - 45,030,045 (-)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef643,192,739 - 43,196,116 (-)NCBIHuRef
CHM1_1643,477,835 - 43,481,213 (-)NCBICHM1_1
T2T-CHM13v2.0643,335,707 - 43,339,085 (-)NCBIT2T-CHM13v2.0
Lrrc73
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,564,896 - 46,568,242 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,564,457 - 46,568,241 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381746,254,165 - 46,257,316 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,253,531 - 46,257,315 (+)Ensemblmm10GRCm38
MGSCv371746,391,114 - 46,394,265 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361745,717,565 - 45,720,897 (+)NCBIMGSCv36mm8
Celera1749,687,303 - 49,690,415 (+)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Lrrc73
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,337,538 - 9,340,360 (-)Ensembl
ChiLan1.0NW_0049554379,337,538 - 9,340,360 (-)NCBIChiLan1.0ChiLan1.0
LRRC73
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2558,007,171 - 58,010,579 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1653,876,968 - 53,879,790 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0643,099,036 - 43,102,493 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1644,390,150 - 44,393,531 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,390,150 - 44,393,531 (-)EnsemblpanPan2panpan1.1
LRRC73
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,969,115 - 11,971,858 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,969,142 - 11,971,854 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1211,995,324 - 11,998,148 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01212,452,751 - 12,455,575 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,452,778 - 12,455,560 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,978,177 - 11,981,001 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01212,065,066 - 12,067,890 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01212,158,558 - 12,161,382 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lrrc73
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,462,814 - 47,465,644 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,494,558 - 16,497,384 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,494,564 - 16,497,388 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC73
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,501,970 - 38,504,917 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1738,499,381 - 38,504,803 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2744,083,021 - 44,086,361 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC73
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,651,715 - 28,652,434 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1728,649,100 - 28,652,163 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604443,562,363 - 43,567,652 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc73
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,135,274 - 16,138,073 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475416,135,206 - 16,138,079 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lrrc73
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1483,612,367 - 83,615,493 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lrrc73
41 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:110
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000061185
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9671488829567695Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat

Markers in Region
RH142084  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,726,279 - 14,726,475 (+)MAPPERmRatBN7.2
Rnor_6.0917,111,299 - 17,111,494NCBIRnor6.0
Rnor_5.0916,007,976 - 16,008,171UniSTSRnor5.0
RGSC_v3.4910,288,849 - 10,289,044UniSTSRGSC3.4
Celera912,473,602 - 12,473,797UniSTS
RH 3.4 Map961.9UniSTS
Cytogenetic Map9q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 158 56 55 24 79 24 6 293 176 10 138 69 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000061185   ⟹   ENSRNOP00000057899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl922,223,736 - 22,226,736 (-)Ensembl
mRatBN7.2 Ensembl914,726,158 - 14,729,158 (-)Ensembl
Rnor_6.0 Ensembl917,111,177 - 17,114,177 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142162   ⟹   ENSRNOP00000099824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl922,223,152 - 22,226,736 (-)Ensembl
RefSeq Acc Id: NM_001024360   ⟹   NP_001019531
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,223,735 - 22,226,736 (-)NCBI
mRatBN7.2914,726,157 - 14,729,158 (-)NCBI
Rnor_6.0917,111,176 - 17,114,177 (-)NCBI
Rnor_5.0916,007,853 - 16,010,854 (-)NCBI
RGSC_v3.4910,288,726 - 10,291,727 (-)RGD
Celera912,473,479 - 12,476,480 (-)RGD
Sequence:
RefSeq Acc Id: XM_008766878   ⟹   XP_008765100
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,223,735 - 22,227,867 (-)NCBI
mRatBN7.2914,726,157 - 14,730,144 (-)NCBI
Rnor_6.0917,111,176 - 17,115,249 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039084064   ⟹   XP_038939992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,223,735 - 22,226,503 (-)NCBI
mRatBN7.2914,726,157 - 14,728,925 (-)NCBI
RefSeq Acc Id: XM_063267579   ⟹   XP_063123649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8922,224,030 - 22,227,867 (-)NCBI
RefSeq Acc Id: NP_001019531   ⟸   NM_001024360
- UniProtKB: A1A5L6 (UniProtKB/Swiss-Prot),   Q587K4 (UniProtKB/Swiss-Prot),   A6JIS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765100   ⟸   XM_008766878
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000057899   ⟸   ENSRNOT00000061185
RefSeq Acc Id: XP_038939992   ⟸   XM_039084064
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063123649   ⟸   XM_063267579
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000099824   ⟸   ENSRNOT00000142162

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q587K4-F1-model_v2 AlphaFold Q587K4 1-316 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696528
Promoter ID:EPDNEW_R7051
Type:single initiation site
Name:Lrrc73_1
Description:leucine rich repeat containing 73
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0917,114,256 - 17,114,316EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561390 AgrOrtholog
BioCyc Gene G2FUF-28212 BioCyc
Ensembl Genes ENSRNOG00000039856 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000061185 ENTREZGENE
  ENSRNOT00000061185.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7133504 IMAGE-MGC_LOAD
InterPro LRR-containing_regulator UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:501101 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156522 IMAGE-MGC_LOAD
NCBI Gene 501101 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT-CONTAINING PROTEIN 34 UniProtKB/Swiss-Prot
  LEUCINE-RICH REPEAT-CONTAINING PROTEIN 73 UniProtKB/Swiss-Prot
PhenoGen Lrrc73 PhenoGen
RatGTEx ENSRNOG00000039856 RatGTEx
SMART LRR_RI UniProtKB/Swiss-Prot
Superfamily-SCOP RNI-like UniProtKB/Swiss-Prot
UniProt A0ABK0LF97_RAT UniProtKB/TrEMBL
  A1A5L6 ENTREZGENE
  A6JIS4 ENTREZGENE, UniProtKB/TrEMBL
  LRC73_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A1A5L6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-12-06 Lrrc73  leucine rich repeat containing 73  nod3l  NOD3-like protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 nod3l  NOD3-like protein      Symbol and Name status set to provisional 70820 PROVISIONAL