Mtcp1 (mature T-cell proliferation 1) - Rat Genome Database

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Gene: Mtcp1 (mature T-cell proliferation 1) Rattus norvegicus
Analyze
Symbol: Mtcp1 (Ensembl: Cmc4)
Name: mature T-cell proliferation 1 (Ensembl:C-X9-C motif containing 4)
RGD ID: 1561352
Description: Predicted to be located in mitochondrion. Orthologous to human MTCP1 (mature T cell proliferation 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC498814; RGD1561352; similar to p13MTCP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818142,416 - 144,482 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl18140,152 - 146,517 (+)EnsemblGRCr8
mRatBN7.218126,189 - 130,123 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.018411,159 - 411,934 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18411,455 - 411,849 (-)Ensemblrn6Rnor6.0
Rnor_5.018456,394 - 457,178 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.418108,513 - 109,372 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera18119,280 - 122,065 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10983986   PMID:14651853   PMID:18614015  


Genomics

Comparative Map Data
Mtcp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818142,416 - 144,482 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl18140,152 - 146,517 (+)EnsemblGRCr8
mRatBN7.218126,189 - 130,123 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.018411,159 - 411,934 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18411,455 - 411,849 (-)Ensemblrn6Rnor6.0
Rnor_5.018456,394 - 457,178 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.418108,513 - 109,372 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera18119,280 - 122,065 (+)NCBICelera
Cytogenetic Map18p13NCBI
MTCP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X155,064,034 - 155,071,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX155,064,034 - 155,147,937 (-)Ensemblhg38GRCh38
GRCh37X154,292,309 - 154,299,411 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,943,080 - 153,952,830 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X153,853,605 - 153,863,243NCBI
CeleraX154,451,026 - 154,458,264 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,838,199 - 142,844,484 (-)NCBIHuRef
CHM1_1X154,203,936 - 154,211,174 (-)NCBICHM1_1
T2T-CHM13v2.0X153,300,442 - 153,307,544 (-)NCBIT2T-CHM13v2.0
Mtcp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,454,048 - 74,460,190 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,454,050 - 74,460,194 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X75,410,442 - 75,416,584 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,410,444 - 75,416,588 (-)Ensemblmm10GRCm38
MGSCv37X72,650,185 - 72,661,882 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X71,657,566 - 71,669,263 (-)NCBIMGSCv36mm8
CeleraX66,806,837 - 66,818,531 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.22NCBI
Mtcp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594614,422 - 620,142 (+)Ensembl
ChiLan1.0NW_004955594614,422 - 620,142 (+)NCBIChiLan1.0ChiLan1.0
MTCP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X155,041,845 - 155,116,409 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X155,043,512 - 155,120,868 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X144,542,898 - 144,550,059 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X154,379,475 - 154,385,472 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX154,382,737 - 154,385,472 (-)EnsemblpanPan2panpan1.1
MTCP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X123,071,076 - 123,080,695 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX123,074,956 - 123,080,793 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX108,064,456 - 108,074,093 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X126,198,629 - 126,208,271 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX126,202,521 - 126,208,421 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,946,517 - 121,956,155 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,468,959 - 124,478,594 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X124,189,658 - 124,199,294 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mtcp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,976,098 - 119,982,416 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936927334,894 - 341,072 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936927334,017 - 341,016 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTCP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,377,350 - 125,381,178 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X125,372,941 - 125,377,910 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,105,105 - 143,110,085 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTCP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,351,336 - 129,358,601 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX129,352,805 - 129,353,322 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606567,326,930 - 67,336,569 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mtcp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624963215,462 - 218,187 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624963212,524 - 218,187 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mtcp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11534,781,383 - 34,784,805 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mtcp1
19 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:105
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000033663
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18115642423Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat

Markers in Region
RH133812  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr818142,963 - 143,152 (+)Marker Load Pipeline
mRatBN7.218128,606 - 128,796 (-)MAPPERmRatBN7.2
Rnor_6.018411,407 - 411,596NCBIRnor6.0
Rnor_5.018456,657 - 456,846UniSTSRnor5.0
RGSC_v3.418108,766 - 108,955UniSTSRGSC3.4
Celera18121,628 - 121,817UniSTS
RH 3.4 Map1835.0UniSTS
Cytogenetic Map18p13UniSTS
RH143328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218126,103 - 126,340 (-)MAPPERmRatBN7.2
Rnor_6.018413,545 - 413,781NCBIRnor6.0
Rnor_5.018458,206 - 458,442UniSTSRnor5.0
RGSC_v3.418107,067 - 107,303UniSTSRGSC3.4
Celera18119,145 - 119,381UniSTS
RH 3.4 Map1835.1UniSTS
Cytogenetic Map18p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 90 89 58 92 58 6 354 192 10 139 80 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000033663   ⟹   ENSRNOP00000035452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl18411,455 - 411,849 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084138   ⟹   ENSRNOP00000072400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl18140,152 - 146,517 (+)Ensembl
RefSeq Acc Id: XM_039097394   ⟹   XP_038953322
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818142,416 - 144,482 (+)NCBI
mRatBN7.218126,189 - 130,123 (+)NCBI
RefSeq Acc Id: XM_574098   ⟹   XP_574098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818142,416 - 144,482 (+)NCBI
mRatBN7.218126,189 - 129,830 (+)NCBI
Rnor_6.018411,159 - 411,934 (-)NCBI
Rnor_5.018456,394 - 457,178 (-)NCBI
RGSC_v3.418108,513 - 109,372 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_038953322 (Get FASTA)   NCBI Sequence Viewer  
  XP_574098 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86647 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072400
  ENSRNOP00000072400.3
RefSeq Acc Id: XP_574098   ⟸   XM_574098
- Sequence:
Ensembl Acc Id: ENSRNOP00000035452   ⟸   ENSRNOT00000033663
RefSeq Acc Id: XP_038953322   ⟸   XM_039097394
Ensembl Acc Id: ENSRNOP00000072400   ⟸   ENSRNOT00000084138

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3B6-F1-model_v2 AlphaFold D4A3B6 1-93 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561352 AgrOrtholog
BioCyc Gene G2FUF-8442 BioCyc
Ensembl Genes ENSRNOG00000024071 Ensembl
  ENSRNOG00000056435 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084138 ENTREZGENE
  ENSRNOT00000084138.3 UniProtKB/TrEMBL
Gene3D-CATH CytochromE C oxidase copper chaperone UniProtKB/TrEMBL
InterPro Cys_alpha_HP_mot_SF UniProtKB/TrEMBL
  MTCP1 UniProtKB/TrEMBL
NCBI Gene 498814 ENTREZGENE
PANTHER CX9C MOTIF-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  CX9C MOTIF-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
Pfam MTCP1 UniProtKB/TrEMBL
PhenoGen Mtcp1 PhenoGen
PROSITE CHCH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024071 RatGTEx
  ENSRNOG00000056435 RatGTEx
Superfamily-SCOP Cysteine alpha-hairpin motif UniProtKB/TrEMBL
UniProt A0A0G2K2W2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-29 Mtcp1  mature T-cell proliferation 1  RGD1561352_predicted  similar to p13MTCP1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561352_predicted  similar to p13MTCP1 (predicted)  LOC498814  similar to p13MTCP1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498814  similar to p13MTCP1      Symbol and Name status set to provisional 70820 PROVISIONAL