Epc2l1 (enhancer of polycomb homolog 2 (Drosophila)-like 1) - Rat Genome Database

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Gene: Epc2l1 (enhancer of polycomb homolog 2 (Drosophila)-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Epc2l1 (Ensembl: AC142154.1)
Name: enhancer of polycomb homolog 2 (Drosophila)-like 1
RGD ID: 1561337
Description: Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of piccolo histone acetyltransferase complex. Orthologous to human EPC2 (enhancer of polycomb homolog 2); INTERACTS WITH poly(I:C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: enhancer of polycomb homolog 2-like; LOC499105; RGD1561337; similar to enhancer of polycomb homolog 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,059,649 - 91,062,367 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl191,059,702 - 91,062,128 (-)EnsemblGRCr8
mRatBN7.2181,931,963 - 81,934,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl181,932,016 - 81,934,442 (-)EnsemblmRatBN7.2
Rnor_6.0183,435,507 - 83,438,226 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0184,689,768 - 84,692,444 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4181,704,073 - 81,706,499 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera176,357,228 - 76,359,760 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
poly(I:C)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Epc2l1
15 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 17 47 66 126 92 10 46 27 32 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000072193   ⟹   ENSRNOP00000093544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl191,059,702 - 91,062,128 (-)Ensembl
mRatBN7.2 Ensembl181,932,016 - 81,934,442 (-)Ensembl
RefSeq Acc Id: NM_001408769   ⟹   NP_001395698
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,059,649 - 91,062,367 (-)NCBI
mRatBN7.2181,931,963 - 81,934,681 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001395698 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093544
  ENSRNOP00000093544.1
Ensembl Acc Id: ENSRNOP00000093544   ⟸   ENSRNOT00000072193
RefSeq Acc Id: NP_001395698   ⟸   NM_001408769
- UniProtKB: A0A8I6AJU0 (UniProtKB/TrEMBL)
Protein Domains
Enhancer of polycomb C-terminal   Enhancer of polycomb-like N-terminal

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561337 AgrOrtholog
BioCyc Gene G2FUF-60342 BioCyc
Ensembl Genes ENSRNOG00000050758 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072193 ENTREZGENE
  ENSRNOT00000072193.3 UniProtKB/TrEMBL
InterPro Enhancer_polycomb UniProtKB/TrEMBL
  Enhancer_polycomb-like_N UniProtKB/TrEMBL
  Enhancer_polycomb_C UniProtKB/TrEMBL
NCBI Gene 499105 ENTREZGENE
PANTHER PTHR14898 UniProtKB/TrEMBL
Pfam E_Pc_C UniProtKB/TrEMBL
  EPL1 UniProtKB/TrEMBL
PhenoGen Epc2l1 PhenoGen
RatGTEx ENSRNOG00000050758 RatGTEx
UniProt A0A8I6AJU0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Epc2l1  enhancer of polycomb homolog 2 (Drosophila)-like 1  RGD1561337  similar to enhancer of polycomb homolog 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561337  similar to enhancer of polycomb homolog 2   RGD1561337_predicted  similar to enhancer of polycomb homolog 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561337_predicted  similar to enhancer of polycomb homolog 2 (predicted)  LOC499105  similar to enhancer of polycomb homolog 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499105  similar to enhancer of polycomb homolog 2      Symbol and Name status set to provisional 70820 PROVISIONAL