Rpl8l1 (ribosomal protein L8 like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rpl8l1 (ribosomal protein L8 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rpl8l1 (Ensembl: AC129049.1)
Name: ribosomal protein L8 like 1
RGD ID: 1561333
Description: Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to be located in cytoplasm and ribosome. Predicted to be part of cytosolic large ribosomal subunit. Orthologous to human RPL8 (ribosomal protein L8).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 60S ribosomal protein L8-like; large ribosomal subunit protein uL2-like; LOC499374; RGD1561333; Rpl8; similar to 60S ribosomal protein L8
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81261,861,754 - 261,862,610 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1261,861,764 - 261,862,609 (+)EnsemblGRCr8
mRatBN7.21251,920,614 - 251,921,456 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1251,920,610 - 251,921,471 (+)EnsemblmRatBN7.2
Rnor_6.01273,563,411 - 273,564,250 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01280,975,521 - 280,976,330 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41258,942,068 - 258,942,877 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1247,580,628 - 247,581,467 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22082260  


Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000048691
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1600390Niddm64Non-insulin dependent diabetes mellitus QTL 640.003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1257624997270518180Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
1598839Rf56Renal function QTL 56renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1255849111270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 12 65 34 30 18 56 18 6 158 85 6 57 42 51 12 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000048691   ⟹   ENSRNOP00000047328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1251,920,610 - 251,921,471 (+)Ensembl
Rnor_6.0 Ensembl1273,563,441 - 273,564,214 (+)Ensembl
RefSeq Acc Id: XM_039101440   ⟹   XP_038957368
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81261,861,754 - 261,862,610 (+)NCBI
mRatBN7.21251,920,614 - 251,921,456 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038957368 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047328
  ENSRNOP00000047328.2
RefSeq Acc Id: XP_038957368   ⟸   XM_039101440
- UniProtKB: D4A6W6 (UniProtKB/TrEMBL),   A6HSE4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000047328   ⟸   ENSRNOT00000048691
Protein Domains
Large ribosomal subunit protein uL2 C-terminal   Large ribosomal subunit protein uL2 RNA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A6W6-F1-model_v2 AlphaFold D4A6W6 1-257 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690990
Promoter ID:EPDNEW_R1511
Type:multiple initiation site
Name:AC129049_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01273,563,406 - 273,563,466EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561333 AgrOrtholog
BioCyc Gene G2FUF-55407 BioCyc
Ensembl Genes ENSRNOG00000031381 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048691 ENTREZGENE
  ENSRNOT00000048691.5 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.30 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  4.10.950.10 UniProtKB/TrEMBL
InterPro NA-bd_OB-fold UniProtKB/TrEMBL
  Rbsml_prot_L2_RNA-bd_dom UniProtKB/TrEMBL
  Rib_L2_dom2 UniProtKB/TrEMBL
  Ribosomal_L2 UniProtKB/TrEMBL
  Ribosomal_L2_arc UniProtKB/TrEMBL
  Ribosomal_L2_C UniProtKB/TrEMBL
  Ribosomal_L2_CS UniProtKB/TrEMBL
  Ribosomal_L2_dom3 UniProtKB/TrEMBL
  Translation_prot_SH3-like_sf UniProtKB/TrEMBL
NCBI Gene 499374 ENTREZGENE
PANTHER 60S RIBOSOMAL PROTEIN L8 UniProtKB/TrEMBL
  PTHR13691 UniProtKB/TrEMBL
Pfam Ribosomal_L2_C UniProtKB/TrEMBL
PhenoGen Rpl8l1 PhenoGen
PIRSF Ribosomal_L2 UniProtKB/TrEMBL
PROSITE RIBOSOMAL_L2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031381 RatGTEx
SMART Ribosomal_L2 UniProtKB/TrEMBL
  Ribosomal_L2_C UniProtKB/TrEMBL
Superfamily-SCOP SSF50104 UniProtKB/TrEMBL
  SSF50249 UniProtKB/TrEMBL
UniProt A6HSE4 ENTREZGENE, UniProtKB/TrEMBL
  D4A6W6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-19 Rpl8l1  ribosomal protein L8 like 1  Rpl8  ribosomal protein L8 like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-19 Rpl8  ribosomal protein L8 like 1  RGD1561333  similar to 60S ribosomal protein L8  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1561333  similar to 60S ribosomal protein L8   RGD1561333_predicted  similar to 60S ribosomal protein L8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561333_predicted  similar to 60S ribosomal protein L8 (predicted)  LOC499374  similar to 60S ribosomal protein L8  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499374  similar to 60S ribosomal protein L8      Symbol and Name status set to provisional 70820 PROVISIONAL