Prss40 (protease, serine, 40) - Rat Genome Database

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Gene: Prss40 (protease, serine, 40) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prss40
Name: protease, serine, 40
RGD ID: 1561330
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space; INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC316318; RGD1561330; serine protease 40; similar to TESP2; Tesp2; testicular serine protease 2
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,258,081 - 44,266,893 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl944,258,088 - 44,266,893 (-)EnsemblGRCr8
mRatBN7.2936,762,170 - 36,770,979 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,762,173 - 36,770,979 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx945,259,087 - 45,267,892 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0950,390,263 - 50,399,068 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0948,672,189 - 48,680,988 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0941,061,116 - 41,069,929 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,061,116 - 41,069,929 (-)Ensemblrn6Rnor6.0
Rnor_5.0940,731,239 - 40,739,928 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4933,297,863 - 33,305,899 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera934,548,166 - 34,555,665 (-)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
Additional References at PubMed
PMID:21873635  


Genomics

Variants

.
Variants in Prss40
67 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:92
Interacting mature miRNAs:98
Transcripts:ENSRNOT00000018758
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 1 7 2 1 2 6 2 7 2 28 1 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000018758   ⟹   ENSRNOP00000018758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl944,258,088 - 44,266,893 (-)Ensembl
mRatBN7.2 Ensembl936,762,173 - 36,770,979 (-)Ensembl
Rnor_6.0 Ensembl941,061,116 - 41,069,929 (-)Ensembl
RefSeq Acc Id: NM_001108209   ⟹   NP_001101679
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,258,088 - 44,266,893 (-)NCBI
mRatBN7.2936,762,173 - 36,770,979 (-)NCBI
Rnor_6.0941,061,116 - 41,069,929 (-)NCBI
Rnor_5.0940,731,239 - 40,739,928 (-)NCBI
RGSC_v3.4933,297,863 - 33,305,899 (-)RGD
Celera934,548,166 - 34,555,665 (-)RGD
Sequence:
RefSeq Acc Id: XM_039083559   ⟹   XP_038939487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,258,081 - 44,266,827 (-)NCBI
mRatBN7.2936,762,170 - 36,770,913 (-)NCBI
RefSeq Acc Id: XM_063267143   ⟹   XP_063123213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,258,081 - 44,266,816 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001101679 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939487 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123213 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99304 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018758
  ENSRNOP00000018758.5
RefSeq Acc Id: NP_001101679   ⟸   NM_001108209
- Peptide Label: precursor
- UniProtKB: D3ZR46 (UniProtKB/TrEMBL),   A6INA6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018758   ⟸   ENSRNOT00000018758
RefSeq Acc Id: XP_038939487   ⟸   XM_039083559
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063123213   ⟸   XM_063267143
- Peptide Label: isoform X1
Protein Domains
Peptidase S1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561330 AgrOrtholog
BioCyc Gene G2FUF-27856 BioCyc
Ensembl Genes ENSRNOG00000014001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018758 ENTREZGENE
  ENSRNOT00000018758.7 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1 UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin-like_Pept_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:316318 UniProtKB/TrEMBL
NCBI Gene 316318 ENTREZGENE
PANTHER PROTEASE, SERINE 47 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Prss40 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014001 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A6INA6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZR46 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Prss40  protease, serine, 40  Tesp2  testicular serine protease 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-29 Tesp2  testicular serine protease 2  RGD1561330_predicted  similar to TESP2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561330_predicted  similar to TESP2 (predicted)  LOC316318  similar to TESP2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC316318  similar to TESP2      Symbol and Name status set to provisional 70820 PROVISIONAL