Cfap73 (cilia and flagella associated protein 73) - Rat Genome Database

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Pathways
Gene: Cfap73 (cilia and flagella associated protein 73) Rattus norvegicus
Analyze
Symbol: Cfap73
Name: cilia and flagella associated protein 73
RGD ID: 1561303
Description: Predicted to be located in cilium. Orthologous to human CFAP73 (cilia and flagella associated protein 73); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ccdc42b; cilia- and flagella-associated protein 73; coiled-coil domain containing 42B; coiled-coil domain-containing protein 42B; hypothetical LOC304509; LOC304509; RGD1561303
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,589,297 - 41,597,334 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1241,589,526 - 41,596,245 (+)EnsemblGRCr8
mRatBN7.21235,928,892 - 35,935,664 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,928,854 - 35,935,973 (+)EnsemblmRatBN7.2
Rnor_6.01241,463,015 - 41,469,926 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,463,922 - 41,468,617 (+)Ensemblrn6Rnor6.0
Rnor_5.01243,321,876 - 43,328,912 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41237,096,535 - 37,102,545 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1237,589,488 - 37,596,399 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cilium  (IEA)
cytoskeleton  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Cfap73
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,589,297 - 41,597,334 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1241,589,526 - 41,596,245 (+)EnsemblGRCr8
mRatBN7.21235,928,892 - 35,935,664 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,928,854 - 35,935,973 (+)EnsemblmRatBN7.2
Rnor_6.01241,463,015 - 41,469,926 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,463,922 - 41,468,617 (+)Ensemblrn6Rnor6.0
Rnor_5.01243,321,876 - 43,328,912 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41237,096,535 - 37,102,545 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1237,589,488 - 37,596,399 (+)NCBICelera
Cytogenetic Map12q16NCBI
CFAP73
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812113,149,724 - 113,159,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12113,149,716 - 113,159,526 (+)Ensemblhg38GRCh38
GRCh3712113,587,529 - 113,597,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612112,072,046 - 112,079,110 (+)NCBIBuild 36Build 36hg18NCBI36
Celera12113,214,654 - 113,224,070 (+)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12110,600,362 - 110,609,794 (+)NCBIHuRef
CHM1_112113,555,926 - 113,565,344 (+)NCBICHM1_1
T2T-CHM13v2.012113,126,368 - 113,135,920 (+)NCBIT2T-CHM13v2.0
Cfap73
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395120,766,400 - 120,772,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5120,766,400 - 120,772,300 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385120,628,335 - 120,634,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5120,628,335 - 120,634,235 (-)Ensemblmm10GRCm38
MGSCv375121,078,344 - 121,084,244 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365121,078,344 - 121,084,244 (-)NCBIMGSCv36mm8
Celera5117,713,580 - 117,719,410 (-)NCBICelera
Cytogenetic Map5FNCBI
Cfap73
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554829,486,264 - 9,493,331 (+)Ensembl
ChiLan1.0NW_0049554829,486,245 - 9,493,876 (+)NCBIChiLan1.0ChiLan1.0
CFAP73
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210121,237,856 - 121,247,790 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112121,234,238 - 121,244,161 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012110,753,961 - 110,764,103 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112114,137,330 - 114,145,179 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12114,137,330 - 114,145,162 (+)EnsemblpanPan2panpan1.1
CFAP73
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12610,542,631 - 10,554,075 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2610,542,817 - 10,552,384 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2610,662,941 - 10,676,754 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02610,785,035 - 10,798,704 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,784,351 - 10,795,641 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12610,758,712 - 10,772,527 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,821,528 - 10,835,198 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,870,292 - 10,884,103 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cfap73
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118148,558,225 - 148,564,016 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366683,057,231 - 3,062,784 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFAP73
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1438,642,993 - 38,651,446 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11438,642,414 - 38,650,518 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,101,658 - 41,109,991 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CFAP73
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111108,384,472 - 108,409,066 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11108,400,031 - 108,408,129 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037136,687,158 - 136,697,102 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfap73
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,279,228 - 19,285,448 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474719,279,223 - 19,294,123 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cfap73
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11633,193,486 - 33,199,479 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cfap73
25 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH137589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,934,781 - 35,934,977 (+)MAPPERmRatBN7.2
Rnor_6.01241,469,711 - 41,469,906NCBIRnor6.0
Rnor_5.01243,327,812 - 43,328,007UniSTSRnor5.0
RGSC_v3.41237,102,354 - 37,102,549UniSTSRGSC3.4
Celera1237,596,184 - 37,596,379UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 8 50 109 56 55 24 48 24 6 205 130 9 81 35 70 31 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000089378   ⟹   ENSRNOP00000071474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,589,526 - 41,596,245 (+)Ensembl
mRatBN7.2 Ensembl1235,928,854 - 35,935,973 (+)Ensembl
Rnor_6.0 Ensembl1241,463,922 - 41,468,617 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170356   ⟹   ENSRNOP00000102551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,589,526 - 41,595,412 (+)Ensembl
RefSeq Acc Id: XM_039089885   ⟹   XP_038945813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,589,297 - 41,596,247 (+)NCBI
mRatBN7.21235,928,892 - 35,935,664 (+)NCBI
RefSeq Acc Id: XM_222198   ⟹   XP_222198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,589,297 - 41,597,334 (+)NCBI
mRatBN7.21235,928,892 - 35,935,664 (+)NCBI
Rnor_6.01241,463,015 - 41,469,926 (+)NCBI
Rnor_5.01243,321,876 - 43,328,912 (+)NCBI
RGSC_v3.41237,096,535 - 37,102,545 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001418689 (Get FASTA)   NCBI Sequence Viewer  
  NP_001418690 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945813 (Get FASTA)   NCBI Sequence Viewer  
  XP_222198 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13772 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000071474
  ENSRNOP00000071474.2
  ENSRNOP00000102551.1
RefSeq Acc Id: XP_222198   ⟸   XM_222198
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000071474   ⟸   ENSRNOT00000089378
RefSeq Acc Id: XP_038945813   ⟸   XM_039089885
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000102551   ⟸   ENSRNOT00000170356
Protein Domains
DUF4200

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K0J5-F1-model_v2 AlphaFold A0A0G2K0J5 1-280 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561303 AgrOrtholog
BioCyc Gene G2FUF-19185 BioCyc
Ensembl Genes ENSRNOG00000056407 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089378 ENTREZGENE
  ENSRNOT00000089378.3 UniProtKB/TrEMBL
  ENSRNOT00000170356.1 UniProtKB/TrEMBL
InterPro CFAP_domain-containing UniProtKB/TrEMBL
  DUF4200 UniProtKB/TrEMBL
NCBI Gene 304509 ENTREZGENE
PANTHER CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 73 UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam DUF4200 UniProtKB/TrEMBL
PhenoGen Cfap73 PhenoGen
RatGTEx ENSRNOG00000056407 RatGTEx
UniProt A0A0G2K0J5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L1X2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-26 Cfap73  cilia and flagella associated protein 73  Ccdc42b  coiled-coil domain containing 42B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Ccdc42b  coiled-coil domain containing 42B  RGD1561303  RGD1561303  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561303  RGD1561303   RGD1561303_predicted  RGD1561303 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561303_predicted  RGD1561303 (predicted)  LOC304509  hypothetical LOC304509  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC304509  hypothetical LOC304509      Symbol and Name status set to provisional 70820 PROVISIONAL