Rup2 (urinary protein 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rup2 (urinary protein 2) Rattus norvegicus
Analyze
Symbol: Rup2
Name: urinary protein 2
RGD ID: 1561250
Description: Predicted to be located in extracellular region; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: liver regeneration-related protein LRRG05; RUP-1; UP-1; urinary protein 1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8843,547,875 - 43,551,456 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl843,549,809 - 43,700,211 (-)EnsemblGRCr8
mRatBN7.2835,336,764 - 35,340,345 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl835,336,764 - 35,489,103 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx839,362,186 - 39,365,767 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0837,645,238 - 37,648,819 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0835,508,119 - 35,511,700 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0841,657,662 - 41,661,223 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl841,657,566 - 41,661,238 (+)Ensemblrn6Rnor6.0
Rnor_5.0841,643,250 - 41,646,811 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4836,680,096 - 36,683,657 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera838,811,835 - 38,813,381 (-)NCBICelera
Cytogenetic Map8q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11565799   PMID:11840564   PMID:12477932  


Genomics

Variants

.
Variants in Rup2
44 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:15
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000042860
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
61337Bp22Blood pressure QTL 225.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625851589833Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625867378345Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
70206Alc20Alcohol consumption QTL 202drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)83910625849610361Rat

Markers in Region
RH142417  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 9 12 32 52 53 31 23 31 3 114 50 18 22 22 22

Sequence


Ensembl Acc Id: ENSRNOT00000042860   ⟹   ENSRNOP00000050106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl835,336,764 - 35,340,345 (-)Ensembl
Rnor_6.0 Ensembl841,657,566 - 41,661,238 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072224   ⟹   ENSRNOP00000065475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl843,549,809 - 43,551,456 (-)Ensembl
mRatBN7.2 Ensembl835,485,518 - 35,489,103 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122112   ⟹   ENSRNOP00000111117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl843,698,560 - 43,700,211 (-)Ensembl
RefSeq Acc Id: NM_001034950   ⟹   NP_001030122
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8843,547,875 - 43,551,456 (-)NCBI
mRatBN7.2835,336,764 - 35,340,345 (-)NCBI
Rnor_6.0841,657,662 - 41,661,223 (+)NCBI
Rnor_5.0841,643,250 - 41,646,811 (+)NCBI
RGSC_v3.4836,680,096 - 36,683,657 (+)RGD
Celera838,811,835 - 38,813,381 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001030122 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF15598 (Get FASTA)   NCBI Sequence Viewer  
  AAP97738 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050106.3
  ENSRNOP00000065475
GenBank Protein P81827 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001030122   ⟸   NM_001034950
- Peptide Label: precursor
- UniProtKB: Q53ZD7 (UniProtKB/Swiss-Prot),   P81827 (UniProtKB/Swiss-Prot),   H8Y6J4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000050106   ⟸   ENSRNOT00000042860
Ensembl Acc Id: ENSRNOP00000065475   ⟸   ENSRNOT00000072224
Ensembl Acc Id: ENSRNOP00000111117   ⟸   ENSRNOT00000122112
Protein Domains
UPAR/Ly6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P81827-F1-model_v2 AlphaFold P81827 1-101 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695869
Promoter ID:EPDNEW_R6393
Type:initiation region
Name:Rup2_1
Description:urinary protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0841,657,644 - 41,657,704EPDNEW

Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-31138 BioCyc
Ensembl Genes ENSRNOG00000045799 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000084687 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000042860.6 UniProtKB/Swiss-Prot
  ENSRNOT00000072224 ENTREZGENE
IMAGE_CLONE IMAGE:7323589 IMAGE-MGC_LOAD
InterPro LY6_UPA_recep-like UniProtKB/Swiss-Prot
KEGG Report rno:619560 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156491 IMAGE-MGC_LOAD
NCBI Gene 619560 ENTREZGENE
Pfam UPAR_LY6 UniProtKB/Swiss-Prot
PhenoGen Rup2 PhenoGen
RatGTEx ENSRNOG00000045799 RatGTEx
  ENSRNOG00000084687 RatGTEx
UniProt H8Y6J4 ENTREZGENE, UniProtKB/TrEMBL
  P81827 ENTREZGENE
  Q53ZD7 ENTREZGENE
  UP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q53ZD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Rup2  urinary protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL