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Gene: Grhl2 (grainyhead-like transcription factor 2) Rattus norvegicus

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Symbol:

Grhl2

Name:

grainyhead-like transcription factor 2

RGD ID:

1561191

Description:

Predicted to enable several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and identical protein binding activity. Predicted to be involved in several processes, including bicellular tight junction assembly; epithelial cell differentiation; and nervous system development. Predicted to act upstream of or within several processes, including embryonic morphogenesis; face development; and lung lobe morphogenesis. Predicted to be located in cell-cell junction. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2); INTERACTS WITH 3-methylfuran; atrazine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

grainyhead-like 2; grainyhead-like 2 (Drosophila); grainyhead-like protein 2 homolog; LOC299979; RGD1561191; similar to BOM

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GRHL2 (grainyhead like transcription factor 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Grhl2 (grainyhead like transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Grhl2 (grainyhead like transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GRHL2 (grainyhead like transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GRHL2 (grainyhead like transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Grhl2 (grainyhead like transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GRHL2 (grainyhead like transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GRHL2 (grainyhead like transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Grhl2 (grainyhead like transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Grhl2 (grainyhead like transcription factor 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GRHL2 (grainyhead like transcription factor 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Grhl2 (grainyhead like transcription factor 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grhl2b (grainyhead-like transcription factor 2b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	grhl2a (grainyhead-like transcription factor 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	grh-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	grh	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	grh	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	grhl2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	70,280,360 - 70,415,277 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	70,285,310 - 70,415,274 (+)	Ensembl				GRCr8
mRatBN7.2	7	68,400,287 - 68,530,269 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	68,400,477 - 68,530,258 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	70,281,213 - 70,410,713 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	72,483,713 - 72,613,205 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	72,351,732 - 72,481,228 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	76,058,623 - 76,197,360 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	76,059,386 - 76,197,856 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	76,188,138 - 76,317,845 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	72,742,859 - 72,872,351 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	65,469,270 - 65,597,175 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nonsyndromic deafness 28 (ISO)

corneal dystrophy (ISO)

ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

posterior polymorphous corneal dystrophy 4 (ISO)

sensorineural hearing loss (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

3-methylfuran (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

aldehydo-D-glucose (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (ISO)

calcitriol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

copper atom (EXP)

copper(0) (EXP)

D-glucose (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

furan (EXP)

gentamycin (EXP)

glucose (ISO)

lamivudine (ISO)

mercury dibromide (ISO)

panobinostat (ISO)

paracetamol (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior neural tube closure (ISO)

bicellular tight junction assembly (IEA,ISO)

biological_process (ND)

brain development (IBA,ISO)

camera-type eye development (ISO)

cardiac ventricle morphogenesis (ISO)

cell adhesion (IEA,ISO)

cell junction assembly (IEA,ISO)

DNA-templated transcription (IEA)

embryonic cranial skeleton morphogenesis (ISO)

embryonic digit morphogenesis (ISO)

embryonic organ development (ISO)

epidermis development (IEA,ISO)

epithelial cell morphogenesis (IEA,ISO)

epithelial cell morphogenesis involved in placental branching (ISO)

epithelium migration (IEA,ISO)

face development (ISO)

in utero embryonic development (ISO)

keratinocyte differentiation (IEA,ISO)

lung epithelial cell differentiation (IEA,ISO)

lung lobe morphogenesis (ISO)

multicellular organism growth (ISO)

neural tube closure (ISO)

neural tube development (IBA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of gene expression (ISO)

regulation of transcription by RNA polymerase II (IBA,IEA,ISO)

respiratory tube development (ISO)

Cellular Component

cell-cell junction (IEA,ISO)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO)

Molecular Function

chromatin binding (IEA,ISO)

chromatin DNA binding (IEA,ISO)

DNA binding (IEA)

DNA-binding transcription activator activity (IEA,ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (IBA,IEA,ISO)

DNA-binding transcription factor activity (IEA,ISO)

DNA-binding transcription factor binding (IEA,ISO)

identical protein binding (IEA,ISO)

intronic transcription regulatory region sequence-specific DNA binding (IEA,ISO)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

sequence-specific DNA binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28.	Peters LM, etal., Hum Mol Genet. 2002 Nov 1;11(23):2877-85.
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:12477932	PMID:19015635	PMID:20654612	PMID:20938050	PMID:20978075	PMID:21081122	PMID:21262862	PMID:21377456	PMID:21515572	PMID:22696678	PMID:22955271	PMID:23254293
PMID:23814079	PMID:25152456	PMID:25758223	PMID:29309642

Genomics

Comparative Map Data

Grhl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	70,280,360 - 70,415,277 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	70,285,310 - 70,415,274 (+)	Ensembl				GRCr8
mRatBN7.2	7	68,400,287 - 68,530,269 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	68,400,477 - 68,530,258 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	70,281,213 - 70,410,713 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	72,483,713 - 72,613,205 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	72,351,732 - 72,481,228 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	76,058,623 - 76,197,360 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	76,059,386 - 76,197,856 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	76,188,138 - 76,317,845 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	72,742,859 - 72,872,351 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	65,469,270 - 65,597,175 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

GRHL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	101,492,439 - 101,681,200 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	101,492,439 - 101,669,726 (+)	Ensembl			hg38	GRCh38
GRCh37	8	102,504,667 - 102,681,954 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	102,574,162 - 102,750,995 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	8	102,574,161 - 102,750,995	NCBI
Celera	8	98,689,599 - 98,866,864 (+)	NCBI		Celera
Cytogenetic Map	8	q22.3	NCBI
HuRef	8	97,702,727 - 97,879,982 (+)	NCBI		HuRef
CHM1_1	8	102,544,909 - 102,722,208 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	8	102,618,140 - 102,807,085 (+)	NCBI		T2T-CHM13v2.0

Grhl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	37,233,065 - 37,363,813 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	37,233,280 - 37,363,813 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	15	37,232,821 - 37,363,569 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	37,233,036 - 37,363,569 (+)	Ensembl			mm10	GRCm38
MGSCv37	15	37,162,791 - 37,293,324 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	15	37,177,836 - 37,308,152 (+)	NCBI		MGSCv36	mm8
Celera	15	37,856,086 - 37,983,260 (+)	NCBI		Celera
Cytogenetic Map	15	B3.1	NCBI
cM Map	15	14.84	NCBI

Grhl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	26,401,363 - 26,533,297 (+)	Ensembl
ChiLan1.0	NW_004955417	26,401,337 - 26,533,297 (+)	NCBI	ChiLan1.0	ChiLan1.0

GRHL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	118,838,709 - 119,023,205 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	94,375,363 - 94,559,131 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	98,129,147 - 98,308,120 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	100,295,531 - 100,471,830 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	100,308,575 - 100,471,830 (+)	Ensembl			panPan2	panpan1.1

GRHL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	3,204,898 - 3,362,533 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	3,204,925 - 3,362,096 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	3,204,498 - 3,362,392 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	3,362,118 - 3,520,180 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	3,362,467 - 3,520,176 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	3,205,577 - 3,363,466 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	3,318,462 - 3,476,089 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	3,335,250 - 3,493,208 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Grhl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	34,430,577 - 34,577,590 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936470	41,859,035 - 42,002,844 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936470	41,856,683 - 41,961,666 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GRHL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	35,371,136 - 35,564,919 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	35,368,788 - 35,565,394 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	38,263,513 - 38,412,524 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GRHL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	96,340,459 - 96,526,366 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	96,342,189 - 96,526,363 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666039	44,151,564 - 44,338,050 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Grhl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624763	18,784,187 - 18,916,358 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624763	18,784,815 - 18,916,358 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Grhl2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	210,734,885 - 210,857,307 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Grhl2
466 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	398
Count of miRNA genes:	215
Interacting mature miRNAs:	280
Transcripts:	ENSRNOT00000009337
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	45113903	90113903	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	26638057	71638057	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	24179478	86817926	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	51700643	96700643	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	31770293	110435881	Rat
1298525	Cm1	Cardiac mass QTL 1	2.7		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	7	56625161	101625161	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	39845902	84845902	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	32998702	77998702	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	46307490	127866166	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	36178764	81178764	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	55498584	105834451	Rat
1559283	Emca4	Estrogen-induced mammary cancer QTL 4	3.7		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	7	63889858	108889858	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	10112916	99900612	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	48475049	93475049	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	36178764	81178764	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	40540077	123682549	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	49682832	115766396	Rat
1298528	Bp169	Blood pressure QTL 169		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	62963207	107963207	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	21541977	86817926	Rat
1576303	Ept7	Estrogen-induced pituitary tumorigenesis QTL 7	3.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	7	63889858	108889858	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	49682832	115766396	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	49682832	115766396	Rat
2303582	Gluco53	Glucose level QTL 53	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	7	48603087	93603087	Rat
61439	Cia8	Collagen induced arthritis QTL 8	5.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	7	27182914	72182914	Rat

Markers in Region

BM386398

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	7	76,187,274 - 76,187,477	UniSTS	Rnor5.0
RGSC_v3.4	7	72,741,661 - 72,741,864	UniSTS	RGSC3.4
Celera	7	65,468,072 - 65,468,275	UniSTS
RH 3.4 Map	7	639.71	UniSTS
Cytogenetic Map	7	q22	UniSTS

AU049954

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	142,562,402 - 142,563,515 (+)	MAPPER	mRatBN7.2
mRatBN7.2	7	68,408,109 - 68,408,391 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	76,067,763 - 76,068,042	NCBI	Rnor6.0
Rnor_6.0	5	148,443,517 - 148,444,629	NCBI	Rnor6.0
Rnor_5.0	7	76,195,778 - 76,196,057	UniSTS	Rnor5.0
Rnor_5.0	5	152,161,294 - 152,162,406	UniSTS	Rnor5.0
RGSC_v3.4	5	149,247,861 - 149,248,973	UniSTS	RGSC3.4
RGSC_v3.4	7	72,750,150 - 72,750,429	UniSTS	RGSC3.4
Celera	7	65,476,902 - 65,477,181	UniSTS
Celera	5	141,029,800 - 141,030,912	UniSTS
Cytogenetic Map	7	q22	UniSTS
Cytogenetic Map	5	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	10	40	141	91	90	59	61	59	6	295	131	10	120	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001134527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009337 ⟹ ENSRNOP00000009337

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	70,285,510 - 70,415,270 (+)	Ensembl
mRatBN7.2 Ensembl	7	68,400,477 - 68,530,258 (+)	Ensembl
Rnor_6.0 Ensembl	7	76,059,386 - 76,197,856 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079692 ⟹ ENSRNOP00000069927

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	70,285,310 - 70,415,274 (+)	Ensembl
mRatBN7.2 Ensembl	7	68,433,180 - 68,530,258 (+)	Ensembl
Rnor_6.0 Ensembl	7	76,092,503 - 76,194,570 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000126945 ⟹ ENSRNOP00000109008

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	70,368,343 - 70,415,269 (+)	Ensembl

RefSeq Acc Id:

NM_001134527 ⟹ NP_001127999

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	70,285,510 - 70,415,271 (+)	NCBI
mRatBN7.2	7	68,400,477 - 68,530,259 (+)	NCBI
Rnor_6.0	7	76,059,451 - 76,197,350 (+)	NCBI
Rnor_5.0	7	76,188,138 - 76,317,845 (+)	NCBI
RGSC_v3.4	7	72,742,859 - 72,872,351 (+)	RGD
Celera	7	65,469,270 - 65,597,175 (+)	RGD

Sequence:

show sequence

AGCAGAATTACCTGTAGCTCTTGTTCTGCCATCTCGGGCGCTCTCACACACCTTCACCTGCACA
GACTTGAAAGTCCAGTTTCACCAGAGGCTGAGGCTCCAGGAAAAGGGGAGCGAGTTCATTGGAT
CAAACATGTCACAAGAGTCGGACAATAATAAAAGACTAGTGGCCTTGGTGCCCATGCCCAGTGA
CCCTCCCTTCAACACCCGAAGAGCCTACACAAGTGAGGATGAGGCCTGGAAGTCGTATCTGGAG
AACCCCCTGACGGCAGCCACCAAGGCAATGATGAGCATCAATGGGGATGAGGACAGTGCTGCTG
CCCTGGGCCTTCTCTATGACTACTACAAGGTTCCTCGAGACAAGAGACTTCTGTCTGTGAGCAA
AGCAAGCGACAGCCAAGAAGACGAGGAAAAAAGAAACTGTCTTGGCACCAGCGAAGCCCAGATC
AACTTGAGCGGAGGCGAGAACCGAGTGCAGGTTCTGAAGACCGTCCCTGTGAACCTCTGCCTGA
GTCAAGACCACATGGAGAATTCGAAGCGTGAGCAGTACAGCGTGTCCATCACTGAGAGCCCCGC
CGTCATCCCCGTGTCGGGCATCACGGTGGTGAAAGCTGAGGATTTCACGCCCGTGTTCATGGCG
CCCCCGGTGCACTATCCCCGCGCGGACGGTGGCGAGGAGCAGCGCGTGGTTATCTTTGAACAGA
CTCAGTATGACCTGCCCTCCATAGCCAGCCACAGCTCCTATCTAAAGGACGACCAGCGCAGCAC
GCCCGACAGCACCTACAGCGAGAGCTTCAAGGACGGCGCCCCGGAGAAATTTCGGAGTACTTCT
GTTGGTGCTGATGAGTATACATATGACCAGACGGGGAGTGGTACATTTCAGTACACCCTGGAAG
CCACCAAATCTCTCCGGCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAATT
CTATGCCATAACACTCAGTGAGACTGGAGACAACAAATGCTTCCGACACCCCATCAGCAAAGTC
AGGAGTGTAGTGATGGTGGTCTTTAGTGAAGACAAAAACCGAGACGAACAGCTGAAGTACTGGA
AGTACTGGCACTCCCGGCAGCACACTGCTAAGCAGAGGGTCCTTGACATTGCTGATTACAAGGA
AAGCTTCAACACCATCGGGAACATTGAAGAGATCGCATACAATGCCGTTTCCTTCACCTGGGAT
GTGAATGAGGAGGCGAAGATCTTCATCACCGTGAACTGCTTGAGTACAGATTTCTCCTCCCAGA
AGGGTGTGAAAGGACTTCCTCTGATGATTCAGATCGACACGTACAGCTATAACAACCGCAGCAA
TAAACCCATCCACAGAGCGTACTGCCAGATCAAGGTCTTCTGCGACAAGGGAGCAGAAAGAAAA
ATCCGGGATGAAGAGAGGAAGCAGAACAGGAAGAAAGGGAAGGGCCAGGCCTCCCAAACCCAGT
GCAGCAATTCCTCTGATGGGAAGATGGCCGCCATACCGTTACAGAAGAAGAGTGACATCACGTA
CTTCAAAACCATGCCCGACCTGCACTCACAGCCTGTGCTCTTCATACCAGATGTTCACTTTGCC
AACCTGCAGAGGACTGGACAGGTCTATTACAACACCGATGATGAGCGAGAAGGCAGCAGTGTCC
TCGTTAAACGGATGTTCAGGCCCATGGAAGAGGAATTTGGTCCAACACCGTCTAAGCAGATTAA
AGAAGAAAACGTAAAGCGAGTGCTTTTATACGTGAGGAAGGAGAACGATGACGTGTTCGATGCT
CTGATGCTGAAATCGCCCACAGTGAAGGGCCTGATGGAAGCGCTGTCTGAGAAGTACGGGCTGC
CGGTGGAGAAGATCACAAAGCTTTATAAGAAGAGCAAAAAGGGAATCCTGGTCAACATGGACGA
CAACATCATTGAGCACTATTCAAATGAGGACACCTTCATTCTCAACATGGAGAGCATGGTGGAA
GGCTTCAAGATCACATTGATGGAGATCTGAACCCTGATGGAGTCCCTGACAGGAGCTTTTGGTG
CACTCCTTCCTGGGAGAGATGTGATCTCTGCCGCCCCAGAACCTGGAGACCCATCTCACCCTCC
TCACAAGACTGTTACAAGACTGCTGGGAAGGGGACGGGGCCCAAGGCCCAGTAACAGACTTCCT
TCCACTCTTCCAAGCTCCCTCTGGAGCTGAAGCCTGAGCCCCTCAGCAGATTCTTTGAGCCTGG
TAGGCCCTTATTTATTGCCCATTCTTTCCCCAAGAGCCCTCCAGGACTCTGCAAGTTACTGAGA
GCTCCATGGGAGACCTCCAGAGTTTCCCCTTCAAGGGCAGCAGCAGCAGCAGCAGCAGCAAGTC
CACTGATCTCGAGCCTGGGGAGCTGGTGTGTCCTTTTCTTACCTCTCCTCATTTCTTGAGTGGA
TGGACCAGATGAGCTGCTTCTTGGTGCAGTCTTCATGGATGGAGTAAGAAGGACCCCAAACCTC
AGATTGCTCTGAGGAAGGTCATTTTGCTAAATACCTCCAGGGGACTCTCAGCAAATAGCCACTG
ACCGCGTTCGGGAAGACTGCACTACCATGTCAGCTTATTGAACACGAGAAAGAGTGTGCCTGAC
GACCATGTACATAATCTGTACATAACATTGCAGTAATATATTTACCTGTGGTTTGTGGGCATGT
TTACTGCCATTGGCCTGGAGGAGACACACTGGAGATTCAGAGCGTTCTGCTCTACCCAAGGGGA
GGTTAGAGAAGTGGCCTCTGGGATGTCATGTGATGGTGGTGAACACCTGGATGGACTCTCCACC
GGGCCATGCCTGAGGACTTGTTTCCCCAGAGCCCTCTCTCCTCAAACATGACTCTCCCTCGAGG
CTATGGCGTTTTATCTCATGGTGATATGTTGCCTAAGCTCGTCCTTTGAGCTGTCTGGGAAAGG
ACATAACTGTCAGTGCCTTCTCTAGCTTTGGTATGGGGCATCTCTTGAGCCTTGCGCAAAATCT
ATGCAGAGATTTTCGCTGGGGCCCTGTCACTGGGACCTGCTGCAGAACTGCTTGGCCGACACGG
GAATCCTGGACACGGTAGCACCCCGCAGTTTACAAGCATGTCCTTCATCTCAAGTGGCCCCTTT
AAAAGTCCAACTGCAGCGTTGTGAATCGAGCCAGCAGCTCTGCTGGGCTGTGAACAGCAGACAG
TGCTTTGCCTTGCTTCTGACAGGAAGAAGTGAGGCTATCCACCCTGGCTGTGGGAAGCTTGGGA
GCCCTTGCACTTCTGAAACCAACTCTGGGAGGCACTGGAGAGCTAAGGCTGTTTCATCCTCTCC
TCACCCTTGGAAGGTCCAGAGAAAATGGCTTACCCAAACAGTCATGAAAGCGTGCCCCATCGTG
AGCCTCTGTTCTCTTTGAGAGAACAGGTCAGTAGTTCTGTTAGGGTTAAGGACTGGTATGTGCC
CCTGGGGCTGAGCACTATTAGTTTGGAGAGCCAGACACATCCCATCCCAAGGCCTAGATAATGA
AACAGCTTTTATGGAAAGGTCTAAATTTGTCTGTGAAGCACTTTGATGTCTTACCTGGAGGCTC
TGCTCTCCAGCCCCTTGCTCTACCTGCCCCCGAGGCCCAGAGCAGCTGAGGCTGACTCCAGCCC
AGCTACTGCTCTTCCAAGCTGCAGAGAAATTGAATGGGATGGGGAGTAGGTGCCGTAACCAAGA
GGATCCCAAAGGGTAGCAGGGGGCACCTTTCTGAGAGCCCACTGGGCTCCTTATCCTTCTTCCT
GTTGCCAAAGGTTTGCATCCAGGGCTCTGCTCTATTCCAGCTCTGCACTCCAAATGCCAGTCCT
TGAAACTAGCAGCCTAGGGACCCTCCAGGGTACTAGTGGATCTCTGATCTAAGACGGACAAACT
CCGTGTTGGAAATATACGCTCTGTGCGCTTCCTGTGCTGTAGCACTTGGGCTTAGCTGCAAACG
TGACCTTAGGGATGGGCTCAGGGTTCCAGAGCAGGGAGACAGATCTGTAGCAACCCGACAGGCG
ACCAGCTCTTCTCTCTGGTCTGTCTGGAAAATTACTGGTCCCACTGGGTCCGGAGACAAACCAG
AGCCGGCTCTCCCTTTGTCCTGAGTCCCTACTCTATGAGGTAGCCATTGCCAGAAGAGGGGATA
GGAAGGCACGAGGAGCAGTGGAGCGTCAGGTCCAGGAGTGTCTGCTGGTGGATCTCCATTCAGC
TCGTCGCTCACTGCGTCCGCTGAGCTTTGCTGAGCATCACCTCCTGAACAAAAACACTCAAAGA
AAAGTTTGCCTTGTCCTGAACTAATCTCACCCAAACAAGGAACTTTTTTATTTTTTATTTTTTG
GTAATCCATAAAAGAGGGGGACACATGGAGCAGGTATTTATTTCCTTCTATGTCTCCACATTGT
TGAAACTTCCGCGGTGTTTAGAGATTGGAACCAGTAGAGAAATGCACGGTGGCTACCACTGTGA
AGTTGGTTCCTAAAAGACTAAGGCACGTCCCAGCGCAGAAACCCGGGAAGTTTGAAATGAATTA
AAACATTTTCCTTCATATTTTAATAGTCATGAAAATGCAACAGGAAAAGAGGGTTTGTGCCAAA
TTCTAAGAATGGCCCTTTCTGAAAGACAAGCAGGGGAGACTCGTGTGTATAATCTGCTCCCACA
TAAAAAGAGTAAATGTAACTTAATAGTTTTGTAAATGGGAGAGGGGGGATCTATAAACTATAAA
TATGTTATTTTATTTTTTGTACATTTTTAAGAAGAAAAAATAAATATTCACAACATGAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAA

hide sequence

RefSeq Acc Id:

XM_006241552 ⟹ XP_006241614

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	70,280,360 - 70,415,277 (+)	NCBI
mRatBN7.2	7	68,400,287 - 68,530,269 (+)	NCBI
Rnor_6.0	7	76,058,623 - 76,197,360 (+)	NCBI
Rnor_5.0	7	76,188,138 - 76,317,845 (+)	NCBI

Sequence:

show sequence

TTCTCCATCAAAGCCTCGCCGCACTTCATAGATCCAGCTCAGGAAAGGTCGCTCGACTGTTTGA
AAACTGAAAACGACCTGCTATCTTCTATGCATCAGAGCACGAGAAGAGTTTGTTGTGGATAAGA
ATGCTAACAATGCAATTACGCAAGAGACCCGGCAATCTCTGTTTCTTTCCCACTCTTAGCATAG
CGTAACTCTAGCTCCCTGACTCTTCTGCCCGTCACTCAGTTCTCGTCCAGCGGGTGTCAAGTGG
CAGGTGGTGAACTGGCCATTTGGTTCCGGGTGGCTTGTTGATTCCTGGGTTCAGCCCTCGATCG
TCCTTCGGTTTGACCCGCAGTACCTAGTGTCTGCAGGCGGTGCTCCCTGCTCCTTCTCTCCCAT
CACCTCTACCCCAGCCCCTAGTCAGGGAAGAAAGTCGAAAGTGGGTAGAAGTCAGCTCGCAGAG
TCTCCAGCGTGTCACCGCTCCACTCAGGTAAACTTCACAGTGAGTGACCTGCACTTGGAGAAGG
GCCTTACCTGAGCGCGCCTCTACCAATGGCAGCTCACCTGAGGGAGCTCCGTAGCCAATCACCG
CGCAGCTCGGCCCTCGGGCTTGTACCCTTTAGTGAAAGAATTCAGCGCCTTGCGAGAAAGTTAC
CTGTGGCCGCCCAAGTCCGCCACTTTGCGCTCTGTGTCTGCCCATTGCCGCGATCCGGGAGGAC
TCCGCGCCGCCGGGCCGCCTCCGAGCGCGGGCCCCATGTGAGGGCTCCCTCCCCCCCATCCCAC
CTTTCCGGCTAGGTGAGGGCGCGAGCGAGCGGGCGAGCGAGAGTGGTGAGGGGGGACGAAAGCA
GAATTACCTGTAGCTCTTGTTCTGCCATCTCGGGCGCTCTCACACACCTTCACCTGCACAGACT
TGAAAGTCCAGTTTCACCAGAGGCTGAGGCTCCAGGAAAAGGGGAGCGAGTTCATTGGATCAAA
CATGTCACAAGAGTCGGACAATAATAAAAGACTAGTGGCCTTGGTGCCCATGCCCAGTGACCCT
CCCTTCAACACCCGAAGAGCCTACACAAGTGAGGATGAGGCCTGGAAGTCGTATCTGGAGAACC
CCCTGACGGCAGCCACCAAGGCAATGATGAGCATCAATGGGGATGAGGACAGTGCTGCTGCCCT
GGGCCTTCTCTATGACTACTACAAGGTTCCTCGAGACAAGAGACTTCTGTCTGTGAGCAAAGCA
AGCGACAGCCAAGAAGACGAGGAAAAAAGAAACTGTCTTGGCACCAGCGAAGCCCAGATCAACT
TGAGCGGAGGCGAGAACCGAGTGCAGGTTCTGAAGACCGTCCCTGTGAACCTCTGCCTGAGTCA
AGACCACATGGAGAATTCGAAGCGTGAGCAGTACAGCGTGTCCATCACTGAGAGCCCCGCCGTC
ATCCCCGTGTCGGGCATCACGGTGGTGAAAGCTGAGGATTTCACGCCCGTGTTCATGGCGCCCC
CGGTGCACTATCCCCGCGCGGACGGTGGCGAGGAGCAGCGCGTGGTTATCTTTGAACAGACTCA
GTATGACCTGCCCTCCATAGCCAGCCACAGCTCCTATCTAAAGGACGACCAGCGCAGCACGCCC
GACAGCACCTACAGCGAGAGCTTCAAGGACGGCGCCCCGGAGAAATTTCGGAGTACTTCTGTTG
GTGCTGATGAGTATACATATGACCAGACGGGGAGTGGTACATTTCAGTACACCCTGGAAGCCAC
CAAATCTCTCCGGCAGAAGCAGGGGGAGGGCCCCATGACCTACCTCAACAAAGGACAATTCTAT
GCCATAACACTCAGTGAGACTGGAGACAACAAATGCTTCCGACACCCCATCAGCAAAGTCAGGA
GTGTAGTGATGGTGGTCTTTAGTGAAGACAAAAACCGAGACGAACAGCTGAAGTACTGGAAGTA
CTGGCACTCCCGGCAGCACACTGCTAAGCAGAGGGTCCTTGACATTGCTGATTACAAGGAAAGC
TTCAACACCATCGGGAACATTGAAGAGATCGCATACAATGCCGTTTCCTTCACCTGGGATGTGA
ATGAGGAGGCGAAGATCTTCATCACCGTGAACTGCTTGAGTACAGATTTCTCCTCCCAGAAGGG
TGTGAAAGGACTTCCTCTGATGATTCAGATCGACACGTACAGCTATAACAACCGCAGCAATAAA
CCCATCCACAGAGCGTACTGCCAGATCAAGGTCTTCTGCGACAAGGGAGCAGAAAGAAAAATCC
GGGATGAAGAGAGGAAGCAGAACAGGAAGAAAGGGAAGGGCCAGGCCTCCCAAACCCAGTGCAG
CAATTCCTCTGATGGGAAGATGGCCGCCATACCGTTACAGAAGAAGAGTGACATCACGTACTTC
AAAACCATGCCCGACCTGCACTCACAGCCTGTGCTCTTCATACCAGATGTTCACTTTGCCAACC
TGCAGAGGACTGGACAGGTCTATTACAACACCGATGATGAGCGAGAAGGCAGTGTCCTCGTTAA
ACGGATGTTCAGGCCCATGGAAGAGGAATTTGGTCCAACACCGTCTAAGCAGATTAAAGAAGAA
AACGTAAAGCGAGTGCTTTTATACGTGAGGAAGGAGAACGATGACGTGTTCGATGCTCTGATGC
TGAAATCGCCCACAGTGAAGGGCCTGATGGAAGCGCTGTCTGAGAAGTACGGGCTGCCGGTGGA
GAAGATCACAAAGCTTTATAAGAAGAGCAAAAAGGGAATCCTGGTCAACATGGACGACAACATC
ATTGAGCACTATTCAAATGAGGACACCTTCATTCTCAACATGGAGAGCATGGTGGAAGGCTTCA
AGATCACATTGATGGAGATCTGAACCCTGATGGAGTCCCTGACAGGAGCTTTTGGTGCACTCCT
TCCTGGGAGAGATGTGATCTCTGCCGCCCCAGAACCTGGAGACCCATCTCACCCTCCTCACAAG
ACTGTTACAAGACTGCTGGGAAGGGGACGGGGCCCAAGGCCCAGTAACAGACTTCCTTCCACTC
TTCCAAGCTCCCTCTGGAGCTGAAGCCTGAGCCCCTCAGCAGATTCTTTGAGCCTGGTAGGCCC
TTATTTATTGCCCATTCTTTCCCCAAGAGCCCTCCAGGACTCTGCAAGTTACTGAGAGCTCCAT
GGGAGACCTCCAGAGTTTCCCCTTCAAGGGCAGCAGCAGCAGCAGCAGCAGCAAGTCCACTGAT
CTCGAGCCTGGGGAGCTGGTGTGTCCTTTTCTTACCTCTCCTCATTTCTTGAGTGGATGGACCA
GATGAGCTGCTTCTTGGTGCAGTCTTCATGGATGGAGTAAGAAGGACCCCAAACCTCAGATTGC
TCTGAGGAAGGTCATTTTGCTAAATACCTCCAGGGGACTCTCAGCAAATAGCCACTGACCGCGT
TCGGGAAGACTGCACTACCATGTCAGCTTATTGAACACGAGAAAGAGTGTGCCTGACGACCATG
TACATAATCTGTACATAACATTGCAGTAATATATTTACCTGTGGTTTGTGGGCATGTTTACTGC
CATTGGCCTGGAGGAGACACACTGGAGATTCAGAGCGTTCTGCTCTACCCAAGGGGAGGTTAGA
GAAGTGGCCTCTGGGATGTCATGTGATGGTGGTGAACACCTGGATGGACTCTCCACCGGGCCAT
GCCTGAGGACTTGTTTCCCCAGAGCCCTCTCTCCTCAAACATGACTCTCCCTCGAGGCTATGGC
GTTTTATCTCATGGTGATATGTTGCCTAAGCTCGTCCTTTGAGCTGTCTGGGAAAGGACATAAC
TGTCAGTGCCTTCTCTAGCTTTGGTATGGGGCATCTCTTGAGCCTTGCGCAAAATCTATGCAGA
GATTTTCGCTGGGGCCCTGTCACTGGGACCTGCTGCAGAACTGCTTGGCCGACACGGGAATCCT
GGACACGGTAGCACCCCGCAGTTTACAAGCATGTCCTTCATCTCAAGTGGCCCCTTTAAAAGTC
CAACTGCAGCGTTGTGAATCGAGCCAGCAGCTCTGCTGGGCTGTGAACAGCAGACAGTGCTTTG
CCTTGCTTCTGACAGGAAGAAGTGAGGCTATCCACCCTGGCTGTGGGAAGCTTGGGAGCCCTTG
CACTTCTGAAACCAACTCTGGGAGGCACTGGAGAGCTAAGGCTGTTTCATCCTCTCCTCACCCT
TGGAAGGTCCAGAGAAAATGGCTTACCCAAACAGTCATGAAAGCGTGCCCCATCGTGAGCCTCT
GTTCTCTTTGAGAGAACAGGTCAGTAGTTCTGTTAGGGTTAAGGACTGGTATGTGCCCCTGGGG
CTGAGCACTATTAGTTTGGAGAGCCAGACACATCCCATCCCAAGGCCTAGATAATGAAACAGCT
TTTATGGAAAGGTCTAAATTTGTCTGTGAAGCACTTTGATGTCTTACCTGGAGGCTCTGCTCTC
CAGCCCCTTGCTCTACCTGCCCCCGAGGCCCAGAGCAGCTGAGGCTGACTCCAGCCCAGCTACT
GCTCTTCCAAGCTGCAGAGAAATTGAATGGGATGGGGAGTAGGTGCCGTAACCAAGAGGATCCC
AAAGGGTAGCAGGGGGCACCTTTCTGAGAGCCCACTGGGCTCCTTATCCTTCTTCCTGTTGCCA
AAGGTTTGCATCCAGGGCTCTGCTCTATTCCAGCTCTGCACTCCAAATGCCAGTCCTTGAAACT
AGCAGCCTAGGGACCCTCCAGGGTACTAGTGGATCTCTGATCTAAGACGGACAAACTCCGTGTT
GGAAATATACGCTCTGTGCGCTTCCTGTGCTGTAGCACTTGGGCTTAGCTGCAAACGTGACCTT
AGGGATGGGCTCAGGGTTCCAGAGCAGGGAGACAGATCTGTAGCAACCCGACAGGCGACCAGCT
CTTCTCTCTGGTCTGTCTGGAAAATTACTGGTCCCACTGGGTCCGGAGACAAACCAGAGCCGGC
TCTCCCTTTGTCCTGAGTCCCTACTCTATGAGGTAGCCATTGCCAGAAGAGGGGATAGGAAGGC
ACGAGGAGCAGTGGAGCGTCAGGTCCAGGAGTGTCTGCTGGTGGATCTCCATTCAGCTCGTCGC
TCACTGCGTCCGCTGAGCTTTGCTGAGCATCACCTCCTGAACAAAAACACTCAAAGAAAAGTTT
GCCTTGTCCTGAACTAATCTCACCCAAACAAGGAACTTTTTTATTTTTTATTTTTTGGTAATCC
ATAAAAGAGGGGGACACATGGAGCAGGTATTTATTTCCTTCTATGTCTCCACATTGTTGAAACT
TCCGCGGTGTTTAGAGATTGGAACCAGTAGAGAAATGCACGGTGGCTACCACTGTGAAGTTGGT
TCCTAAAAGACTAAGGCACGTCCCAGCGCAGAAACCCGGGAAGTTTGAAATGAATTAAAACATT
TTCCTTCATATTTTAATAGTCATGAAAATGCAACAGGAAAAGAGGGTTTGTGCCAAATTCTAAG
AATGGCCCTTTCTGAAAGACAAGCAGGGGAGACTCGTGTGTATAATCTGCTCCCACATAAAAAG
AGTAAATGTAACTTAATAGTTTTGTAAATGGGAGAGGGGGGATCTATAAACTATAAATATGTTA
TTTTATTTTTTGTACATTTTTAAGAAGAAAAAATAAATATTCACAACATGAGTCAAACAGC

hide sequence

RefSeq Acc Id:

XM_039078802 ⟹ XP_038934730

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	70,280,360 - 70,415,277 (+)	NCBI
mRatBN7.2	7	68,400,309 - 68,530,269 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001127999	(Get FASTA)	NCBI Sequence Viewer
	XP_006241614	(Get FASTA)	NCBI Sequence Viewer
	XP_038934730	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68688	(Get FASTA)	NCBI Sequence Viewer
	EDM16380	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009337
	ENSRNOP00000009337.5
	ENSRNOP00000069927
	ENSRNOP00000069927.3
	ENSRNOP00000109008.1

RefSeq Acc Id:

NP_001127999 ⟸ NM_001134527

- UniProtKB:

B5DEI9 (UniProtKB/TrEMBL), A0A0G2JWL5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAAL
GLLYDYYKVPRDKRLLSVSKASDSQEDEEKRNCLGTSEAQINLSGGENRVQVLKTVPVNLCLSQ
DHMENSKREQYSVSITESPAVIPVSGITVVKAEDFTPVFMAPPVHYPRADGGEEQRVVIFEQTQ
YDLPSIASHSSYLKDDQRSTPDSTYSESFKDGAPEKFRSTSVGADEYTYDQTGSGTFQYTLEAT
KSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKY
WHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKG
VKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCS
NSSDGKMAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGSSVLV
KRMFRPMEEEFGPTPSKQIKEENVKRVLLYVRKENDDVFDALMLKSPTVKGLMEALSEKYGLPV
EKITKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKITLMEI

hide sequence

RefSeq Acc Id:	XP_006241614 ⟸ XM_006241552
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JWL5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAAL GLLYDYYKVPRDKRLLSVSKASDSQEDEEKRNCLGTSEAQINLSGGENRVQVLKTVPVNLCLSQ DHMENSKREQYSVSITESPAVIPVSGITVVKAEDFTPVFMAPPVHYPRADGGEEQRVVIFEQTQ YDLPSIASHSSYLKDDQRSTPDSTYSESFKDGAPEKFRSTSVGADEYTYDQTGSGTFQYTLEAT KSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKY WHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKG VKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQTQCS NSSDGKMAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGSVLVK RMFRPMEEEFGPTPSKQIKEENVKRVLLYVRKENDDVFDALMLKSPTVKGLMEALSEKYGLPVE KITKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKITLMEI hide sequence

Ensembl Acc Id:

ENSRNOP00000069927 ⟸ ENSRNOT00000079692

Ensembl Acc Id:

ENSRNOP00000009337 ⟸ ENSRNOT00000009337

RefSeq Acc Id:	XP_038934730 ⟸ XM_039078802
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2JWL5 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000109008 ⟸ ENSRNOT00000126945

Protein Domains

Grh/CP2 DB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B5DEI9-F1-model_v2	AlphaFold	B5DEI9	1-626	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695296

Promoter ID:

EPDNEW_R5821

Type:

single initiation site

Name:

Grhl2_1

Description:

grainyhead-like transcription factor 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	76,059,390 - 76,059,450	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1561191	AgrOrtholog
BioCyc Gene	G2FUF-33632	BioCyc
Ensembl Genes	ENSRNOG00000007000	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009337	ENTREZGENE
	ENSRNOT00000009337.8	UniProtKB/TrEMBL
	ENSRNOT00000079692	ENTREZGENE
	ENSRNOT00000079692.3	UniProtKB/TrEMBL
	ENSRNOT00000126945.1	UniProtKB/TrEMBL
InterPro	CP2	UniProtKB/TrEMBL
	GRHL1/CP2_C	UniProtKB/TrEMBL
	TF_CP2-like	UniProtKB/TrEMBL
KEGG Report	rno:299979	UniProtKB/TrEMBL
NCBI Gene	299979	ENTREZGENE
PANTHER	GRAINYHEAD-LIKE PROTEIN 2 HOMOLOG	UniProtKB/TrEMBL
	TRANSCRIPTION FACTOR CP2	UniProtKB/TrEMBL
Pfam	CP2	UniProtKB/TrEMBL
	GRHL1_C	UniProtKB/TrEMBL
PhenoGen	Grhl2	PhenoGen
PROSITE	GRH_CP2_DB	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007000	RatGTEx
UniProt	A0A0G2JWL5	ENTREZGENE, UniProtKB/TrEMBL
	A0ABK0LE26_RAT	UniProtKB/TrEMBL
	B5DEI9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-11	Grhl2	grainyhead-like transcription factor 2	Grhl2	grainyhead-like 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1561191_predicted	similar to BOM (predicted)	LOC299979	similar to BOM	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC299979	similar to BOM			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

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