Tmem186 (transmembrane protein 186) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tmem186 (transmembrane protein 186) Rattus norvegicus
Analyze
Symbol: Tmem186
Name: transmembrane protein 186
RGD ID: 1561167
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human TMEM186 (transmembrane protein 186); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aconitine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC114379; similar to RIKEN cDNA 4432406C05
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8107,489,599 - 7,492,917 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl107,489,567 - 7,493,201 (+)EnsemblGRCr8
mRatBN7.2106,982,938 - 6,986,256 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl106,982,916 - 6,986,256 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1011,689,084 - 11,692,402 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01011,185,515 - 11,188,833 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0106,836,807 - 6,840,124 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0107,077,488 - 7,080,806 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl107,077,488 - 7,080,798 (+)Ensemblrn6Rnor6.0
Rnor_5.0105,878,822 - 5,882,140 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4107,022,562 - 7,025,880 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera105,978,294 - 5,981,613 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Tmem186
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8107,489,599 - 7,492,917 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl107,489,567 - 7,493,201 (+)EnsemblGRCr8
mRatBN7.2106,982,938 - 6,986,256 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl106,982,916 - 6,986,256 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1011,689,084 - 11,692,402 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01011,185,515 - 11,188,833 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0106,836,807 - 6,840,124 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0107,077,488 - 7,080,806 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl107,077,488 - 7,080,798 (+)Ensemblrn6Rnor6.0
Rnor_5.0105,878,822 - 5,882,140 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4107,022,562 - 7,025,880 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera105,978,294 - 5,981,613 (+)NCBICelera
Cytogenetic Map10q12NCBI
TMEM186
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38168,795,180 - 8,797,639 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl168,780,384 - 8,797,763 (-)Ensemblhg38GRCh38
GRCh37168,889,037 - 8,891,496 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36168,796,822 - 8,798,991 (-)NCBIBuild 36Build 36hg18NCBI36
Celera169,058,430 - 9,060,897 (-)NCBICelera
Cytogenetic Map16p13.2NCBI
HuRef168,811,482 - 8,813,949 (-)NCBIHuRef
CHM1_1168,888,938 - 8,891,405 (-)NCBICHM1_1
T2T-CHM13v2.0168,827,933 - 8,830,391 (-)NCBIT2T-CHM13v2.0
Tmem186
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39168,451,595 - 8,455,575 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl168,451,093 - 8,455,576 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38168,633,731 - 8,637,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl168,633,229 - 8,637,712 (-)Ensemblmm10GRCm38
MGSCv37168,633,824 - 8,637,794 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36168,549,052 - 8,553,022 (-)NCBIMGSCv36mm8
Celera169,278,986 - 9,282,956 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map164.24NCBI
Tmem186
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554429,411,908 - 9,417,324 (+)Ensembl
ChiLan1.0NW_0049554429,411,849 - 9,414,017 (+)NCBIChiLan1.0ChiLan1.0
TMEM186
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,334,831 - 9,337,117 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11613,117,643 - 13,121,755 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0167,728,655 - 7,731,232 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,969,078 - 8,971,654 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,969,078 - 8,971,654 (-)EnsemblpanPan2panpan1.1
TMEM186
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha634,761,955 - 34,768,481 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0633,570,003 - 33,576,527 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl633,570,136 - 33,576,377 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1633,372,329 - 33,378,855 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0633,242,177 - 33,248,698 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0633,663,998 - 33,670,525 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem186
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344109,781,837 - 109,785,242 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365307,623,191 - 7,630,592 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365307,626,747 - 7,630,581 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM186
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl333,892,598 - 33,897,719 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1333,892,515 - 33,895,527 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2334,621,626 - 34,623,842 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM186
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.158,387,046 - 8,388,551 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl58,387,808 - 8,388,449 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606821,831,192 - 21,833,771 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem186
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248246,202,263 - 6,214,120 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem186
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1913,397,537 - 13,402,312 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem186
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:568
Count of miRNA genes:263
Interacting mature miRNAs:327
Transcripts:ENSRNOT00000030290
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000030290   ⟹   ENSRNOP00000062154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl107,489,567 - 7,493,201 (+)Ensembl
mRatBN7.2 Ensembl106,982,916 - 6,986,256 (+)Ensembl
Rnor_6.0 Ensembl107,077,488 - 7,080,798 (+)Ensembl
RefSeq Acc Id: NM_001025756   ⟹   NP_001020927
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8107,489,599 - 7,492,917 (+)NCBI
mRatBN7.2106,982,938 - 6,986,256 (+)NCBI
Rnor_6.0107,077,488 - 7,080,806 (+)NCBI
Rnor_5.0105,878,822 - 5,882,140 (+)NCBI
RGSC_v3.4107,022,562 - 7,025,880 (+)RGD
Celera105,978,294 - 5,981,613 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020927 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98933 (Get FASTA)   NCBI Sequence Viewer  
  EDL96242 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062154
  ENSRNOP00000062154.1
GenBank Protein Q4KLZ1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020927   ⟸   NM_001025756
- UniProtKB: Q4KLZ1 (UniProtKB/Swiss-Prot),   A6K4M0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062154   ⟸   ENSRNOT00000030290

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLZ1-F1-model_v2 AlphaFold Q4KLZ1 1-216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696953
Promoter ID:EPDNEW_R7478
Type:single initiation site
Name:Tmem186_1
Description:transmembrane protein 186
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0107,077,618 - 7,077,678EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561167 AgrOrtholog
BioCyc Gene G2FUF-26095 BioCyc
Ensembl Genes ENSRNOG00000027087 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000030290 ENTREZGENE
  ENSRNOT00000030290.3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7386881 IMAGE-MGC_LOAD
InterPro Tmem186 UniProtKB/Swiss-Prot
KEGG Report rno:497863 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114379 IMAGE-MGC_LOAD
NCBI Gene 497863 ENTREZGENE
PANTHER PTHR13603 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 186 UniProtKB/Swiss-Prot
PhenoGen Tmem186 PhenoGen
RatGTEx ENSRNOG00000027087 RatGTEx
UniProt A6K4M0 ENTREZGENE, UniProtKB/TrEMBL
  Q4KLZ1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Tmem186  transmembrane protein 186  MGC114379  similar to RIKEN cDNA 4432406C05  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 MGC114379  similar to RIKEN cDNA 4432406C05      Symbol and Name status set to provisional 70820 PROVISIONAL