Itgax (integrin subunit alpha X) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Itgax (integrin subunit alpha X) Rattus norvegicus
Analyze
Symbol: Itgax
Name: integrin subunit alpha X
RGD ID: 1561123
Description: Predicted to enable receptor tyrosine kinase binding activity and signaling receptor activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; positive regulation of endothelial tube morphogenesis; and positive regulation of myelination. Predicted to act upstream of or within defense response to virus. Predicted to be located in external side of plasma membrane. Predicted to be part of integrin alphaX-beta2 complex. Predicted to be active in cell surface. Orthologous to human ITGAX (integrin subunit alpha X); PARTICIPATES IN integrin mediated signaling pathway; tuberculosis pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: integrin alpha X; integrin alpha-X; integrin, alpha X; LOC499271; RGD1561123; similar to mFLJ00114 protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,140,089 - 192,171,151 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,149,905 - 192,171,151 (+)EnsemblGRCr8
mRatBN7.21182,709,653 - 182,740,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,719,609 - 182,740,698 (+)EnsemblmRatBN7.2
Rnor_6.01199,555,560 - 199,576,948 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,555,722 - 199,576,932 (+)Ensemblrn6Rnor6.0
Rnor_5.01206,583,608 - 206,604,971 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,396,184 - 187,416,273 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,365,552 - 180,386,832 (+)NCBICelera
Cytogenetic Map1q37NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bryostatin  (ISO)
bryostatin 1  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
cyproconazole  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP)
diquat  (ISO)
endosulfan  (EXP)
epoxiconazole  (EXP)
estrone  (EXP)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gardiquimod  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
GSK-J4  (ISO)
GW 4064  (ISO)
heparin  (ISO)
imiquimod  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
irinotecan  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
S-nitrosoglutathione  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triprolidine  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
trovafloxacin  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vitamin D  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
Additional References at PubMed
PMID:1385153   PMID:10648399   PMID:12801066   PMID:14609575   PMID:14643301   PMID:14990792   PMID:15210787   PMID:17277142   PMID:18984740   PMID:19234460   PMID:19723499   PMID:19946888  
PMID:20563599   PMID:23981064   PMID:24270810   PMID:28963396   PMID:30873824  


Genomics

Comparative Map Data
Itgax
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,140,089 - 192,171,151 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1192,149,905 - 192,171,151 (+)EnsemblGRCr8
mRatBN7.21182,709,653 - 182,740,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,719,609 - 182,740,698 (+)EnsemblmRatBN7.2
Rnor_6.01199,555,560 - 199,576,948 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,555,722 - 199,576,932 (+)Ensemblrn6Rnor6.0
Rnor_5.01206,583,608 - 206,604,971 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,396,184 - 187,416,273 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,365,552 - 180,386,832 (+)NCBICelera
Cytogenetic Map1q37NCBI
ITGAX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,355,176 - 31,382,999 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,355,134 - 31,382,999 (+)Ensemblhg38GRCh38
GRCh371631,366,497 - 31,394,320 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,274,010 - 31,301,819 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341631,274,009 - 31,301,819NCBI
Cytogenetic Map16p11.2NCBI
HuRef1628,926,765 - 28,954,574 (+)NCBIHuRef
CHM1_11632,684,617 - 32,713,005 (+)NCBICHM1_1
T2T-CHM13v2.01631,742,566 - 31,770,400 (+)NCBIT2T-CHM13v2.0
Itgax
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,728,697 - 127,749,829 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,728,719 - 127,749,829 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387128,129,526 - 128,150,657 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,129,547 - 128,150,657 (+)Ensemblmm10GRCm38
MGSCv377135,273,082 - 135,294,171 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367127,920,716 - 127,941,805 (+)NCBIMGSCv36mm8
Celera7127,963,226 - 127,984,316 (+)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.98NCBI
Itgax
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554938,196,593 - 8,220,296 (+)NCBIChiLan1.0ChiLan1.0
ITGAX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,562,273 - 34,592,485 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,363,701 - 39,393,919 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,574,807 - 23,612,638 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,724,539 - 31,754,603 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,724,113 - 31,797,249 (+)EnsemblpanPan2panpan1.1
ITGAX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,898,143 - 16,927,270 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,808,971 - 16,996,286 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha618,487,797 - 18,499,807 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
Dog10K_Boxer_Tasha622,643,925 - 22,660,443 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0617,023,380 - 17,052,559 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,933,693 - 17,052,528 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,826,486 - 16,855,639 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,745,644 - 16,774,812 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,057,566 - 17,086,388 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itgax
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,593,065 - 125,612,720 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365438,424,672 - 8,442,850 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365438,424,095 - 8,442,850 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGAX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1317,178,725 - 17,201,388 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,424,298 - 17,426,519 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITGAX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1528,058,172 - 28,087,253 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl528,058,456 - 28,086,838 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660681,354,348 - 1,384,497 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgax
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,380,399 - 14,395,916 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478214,380,234 - 14,397,552 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Itgax
223 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:84
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000054983
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 148 91 90 59 92 59 6 356 192 11 127 81 92 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000054983   ⟹   ENSRNOP00000051866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,150,063 - 192,171,151 (+)Ensembl
mRatBN7.2 Ensembl1182,719,609 - 182,740,698 (+)Ensembl
Rnor_6.0 Ensembl1199,555,722 - 199,576,932 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099518   ⟹   ENSRNOP00000083288
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1192,149,905 - 192,171,149 (+)Ensembl
mRatBN7.2 Ensembl1182,719,781 - 182,740,698 (+)Ensembl
RefSeq Acc Id: NM_001419757   ⟹   NP_001406686
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,150,049 - 192,171,151 (+)NCBI
mRatBN7.21182,719,607 - 182,740,709 (+)NCBI
RefSeq Acc Id: XM_039101230   ⟹   XP_038957158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,140,089 - 192,171,151 (+)NCBI
mRatBN7.21182,709,653 - 182,740,709 (+)NCBI
RefSeq Acc Id: XM_039101231   ⟹   XP_038957159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,153,645 - 192,171,151 (+)NCBI
mRatBN7.21182,723,203 - 182,740,709 (+)NCBI
RefSeq Acc Id: XM_039101233   ⟹   XP_038957161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,140,089 - 192,154,230 (+)NCBI
mRatBN7.21182,709,653 - 182,724,685 (+)NCBI
RefSeq Acc Id: XM_063271412   ⟹   XP_063127482
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,155,466 - 192,171,151 (+)NCBI
RefSeq Acc Id: XR_005499481
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81192,140,089 - 192,155,425 (+)NCBI
mRatBN7.21182,709,653 - 182,724,981 (+)NCBI
Ensembl Acc Id: ENSRNOP00000051866   ⟸   ENSRNOT00000054983
RefSeq Acc Id: XP_038957158   ⟸   XM_039101230
- Peptide Label: isoform X1
- UniProtKB: A6I9Y3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957161   ⟸   XM_039101233
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038957159   ⟸   XM_039101231
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000083288   ⟸   ENSRNOT00000099518
RefSeq Acc Id: NP_001406686   ⟸   NM_001419757
- Peptide Label: precursor
- UniProtKB: A6I9Y3 (UniProtKB/TrEMBL),   D3ZWZ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127482   ⟸   XM_063271412
- Peptide Label: isoform X3
Protein Domains
VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWZ1-F1-model_v2 AlphaFold D3ZWZ1 1-1182 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561123 AgrOrtholog
BioCyc Gene G2FUF-57312 BioCyc
Ensembl Genes ENSRNOG00000036703 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000054983 ENTREZGENE
  ENSRNOT00000054983.6 UniProtKB/TrEMBL
  ENSRNOT00000099518 ENTREZGENE
  ENSRNOT00000099518.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom UniProtKB/TrEMBL
  ITGAX-like_Ig_3 UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene 499271 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-X UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
  ITGAX-like_Ig_3 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PhenoGen Itgax PhenoGen
PRINTS INTEGRINA UniProtKB/TrEMBL
  VWFADOMAIN UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000036703 RatGTEx
SMART Int_alpha UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A8I5ZWP3_RAT UniProtKB/TrEMBL
  A6I9Y3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWZ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itgax  integrin subunit alpha X  Itgax  integrin, alpha X  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Itgax  integrin, alpha X  Itgax  integrin alpha X  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Itgax  integrin alpha X  RGD1561123_predicted  similar to mFLJ00114 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561123_predicted  similar to mFLJ00114 protein (predicted)  LOC499271  similar to mFLJ00114 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499271  similar to mFLJ00114 protein      Symbol and Name status set to provisional 70820 PROVISIONAL