Bbln (bublin coiled coil protein) - Rat Genome Database

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Gene: Bbln (bublin coiled coil protein) Rattus norvegicus
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Symbol: Bbln
Name: bublin coiled coil protein
RGD ID: 1561113
Description: Predicted to enable molecular adaptor activity. Predicted to be involved in intermediate filament bundle assembly. Predicted to act upstream of or within several processes, including apoptotic signaling pathway; bone resorption; and multinuclear osteoclast differentiation. Predicted to be located in cell junction; polymeric cytoskeletal fiber; and subapical part of cell. Orthologous to human BBLN (bublin coiled coil protein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; cyclosporin A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC499780; RGD1561113; similar to Hypothetical UPF0184 protein C9orf16 homolog; UPF0184 protein C9orf16 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,072,325 - 36,075,070 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,072,328 - 36,075,093 (-)EnsemblGRCr8
mRatBN7.2315,674,577 - 15,677,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,674,580 - 15,677,374 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx318,743,395 - 18,746,140 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,328,389 - 27,331,134 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,579,249 - 25,581,994 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,408,076 - 11,410,907 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,408,348 - 11,410,732 (-)Ensemblrn6Rnor6.0
Rnor_5.0316,756,949 - 16,759,766 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4311,505,289 - 11,508,067 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera310,417,463 - 10,420,299 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Bbln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,072,325 - 36,075,070 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl336,072,328 - 36,075,093 (-)EnsemblGRCr8
mRatBN7.2315,674,577 - 15,677,322 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,674,580 - 15,677,374 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx318,743,395 - 18,746,140 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,328,389 - 27,331,134 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,579,249 - 25,581,994 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,408,076 - 11,410,907 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,408,348 - 11,410,732 (-)Ensemblrn6Rnor6.0
Rnor_5.0316,756,949 - 16,759,766 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4311,505,289 - 11,508,067 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera310,417,463 - 10,420,299 (-)NCBICelera
Cytogenetic Map3p12NCBI
BBLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389128,160,265 - 128,163,924 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9128,160,265 - 128,163,924 (+)Ensemblhg38GRCh38
GRCh379130,922,544 - 130,926,203 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,962,360 - 129,966,028 (+)NCBIBuild 36Build 36hg18NCBI36
Build 349128,002,188 - 128,005,756NCBI
Celera9101,573,422 - 101,577,094 (+)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,536,165 - 100,539,842 (+)NCBIHuRef
CHM1_19131,073,538 - 131,077,222 (+)NCBICHM1_1
T2T-CHM13v2.09140,367,336 - 140,371,004 (+)NCBIT2T-CHM13v2.0
Bbln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,269,120 - 32,271,877 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,267,109 - 32,271,950 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38232,379,101 - 32,381,915 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,377,097 - 32,381,938 (-)Ensemblmm10GRCm38
MGSCv37232,234,621 - 32,237,435 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36232,201,117 - 32,203,893 (-)NCBIMGSCv36mm8
Celera232,084,510 - 32,087,324 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Bbln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955570708,747 - 712,573 (+)Ensembl
ChiLan1.0NW_004955570709,009 - 712,573 (+)NCBIChiLan1.0ChiLan1.0
BBLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,188,647 - 11,192,389 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,190,995 - 11,194,693 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0999,281,258 - 99,284,930 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,951,037 - 127,954,779 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,951,037 - 127,954,779 (+)EnsemblpanPan2panpan1.1
BBLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,319,943 - 55,323,429 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,319,952 - 55,323,609 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha954,514,712 - 54,518,191 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0956,242,129 - 56,245,618 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,242,138 - 56,245,573 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,001,995 - 55,005,474 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,316,714 - 55,320,191 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,408,405 - 55,411,894 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bbln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,960,249 - 195,963,538 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,728,778 - 15,732,065 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,728,776 - 15,732,065 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BBLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11268,616,040 - 268,619,638 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,606,324 - 302,610,207 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BBLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,965,505 - 9,969,443 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660796,263,521 - 6,267,529 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bbln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,672,541 - 6,676,216 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247606,672,541 - 6,676,186 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Bbln
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v153,249,514 - 3,252,356 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bbln
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:62
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000034930
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
AI008323  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,674,645 - 15,674,777 (+)MAPPERmRatBN7.2
Rnor_6.0311,408,148 - 11,408,279NCBIRnor6.0
Rnor_5.0316,757,018 - 16,757,149UniSTSRnor5.0
RGSC_v3.4311,505,361 - 11,505,492UniSTSRGSC3.4
Celera310,417,535 - 10,417,666UniSTS
RH 3.4 Map360.7UniSTS
Cytogenetic Map3p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000034930   ⟹   ENSRNOP00000031226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl336,072,328 - 36,075,093 (-)Ensembl
mRatBN7.2 Ensembl315,674,580 - 15,677,374 (-)Ensembl
Rnor_6.0 Ensembl311,408,348 - 11,410,732 (-)Ensembl
RefSeq Acc Id: NM_001399481   ⟹   NP_001386410
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,072,325 - 36,075,070 (-)NCBI
mRatBN7.2315,674,577 - 15,677,322 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386410 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93239 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031226.4
Ensembl Acc Id: ENSRNOP00000031226   ⟸   ENSRNOT00000034930
RefSeq Acc Id: NP_001386410   ⟸   NM_001399481

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZBT2-F1-model_v2 AlphaFold D3ZBT2 1-83 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691989
Promoter ID:EPDNEW_R2509
Type:initiation region
Name:RGD1561113_1
Description:similar to Hypothetical UPF0184 protein C9orf16 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,410,831 - 11,410,891EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561113 AgrOrtholog
BioCyc Gene G2FUF-50142 BioCyc
Ensembl Genes ENSRNOG00000022681 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034930.7 UniProtKB/TrEMBL
NCBI Gene 499780 ENTREZGENE
PhenoGen Bbln PhenoGen
RatGTEx ENSRNOG00000022681 RatGTEx
UniProt D3ZBT2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-28 Bbln  bublin coiled coil protein  RGD1561113  similar to Hypothetical UPF0184 protein C9orf16 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 RGD1561113  similar to Hypothetical UPF0184 protein C9orf16 homolog  LOC100365430  hypothetical LOC100365430  Data merged from RGD:2319050 1643240 APPROVED
2010-05-05 LOC100365430  hypothetical LOC100365430      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1561113  similar to Hypothetical UPF0184 protein C9orf16 homolog   RGD1561113_predicted  similar to Hypothetical UPF0184 protein C9orf16 homolog (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 RGD1561113_predicted  similar to Hypothetical UPF0184 protein C9orf16 homolog (predicted)  LOC687732  similar to Hypothetical UPF0184 protein C9orf16 homolog  Data merged from RGD:1597553 1643240 APPROVED
2006-11-20 LOC687732  similar to Hypothetical UPF0184 protein C9orf16 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1561113_predicted  similar to Hypothetical UPF0184 protein C9orf16 homolog (predicted)  LOC499780  similar to Hypothetical UPF0184 protein C9orf16 homolog  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499780  similar to Hypothetical UPF0184 protein C9orf16 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL