Rps12l4 (ribosomal protein S12-like 4) - Rat Genome Database

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Gene: Rps12l4 (ribosomal protein S12-like 4) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rps12l4
Name: ribosomal protein S12-like 4
RGD ID: 1561102
Description: Predicted to be a structural constituent of ribosome. Predicted to be involved in maintenance of translational fidelity and ribosomal small subunit biogenesis. Predicted to be part of cytosolic small ribosomal subunit; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; furan.
Type: protein-coding
RefSeq Status: PREDICTED
Previously known as: hypothetical protein LOC299713; LOC299713; RGD1561102; similar to ribosomal protein S12; uncharacterized protein LOC299713
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8725,006,242 - 25,007,029 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl725,005,384 - 25,008,327 (-)EnsemblGRCr8
mRatBN7.2723,118,845 - 23,119,632 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl723,118,845 - 23,119,632 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx725,113,407 - 25,114,194 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0727,276,109 - 27,276,896 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0727,053,147 - 27,053,934 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0729,281,252 - 29,282,039 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl729,281,252 - 29,282,039 (-)Ensemblrn6Rnor6.0
Rnor_5.0729,383,629 - 29,384,416 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4725,402,762 - 25,403,549 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera720,277,965 - 20,278,752 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
translation  (IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Rps12l4
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:96
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000067777
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)72154197735707405Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72092049437412865Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 61 155 91 90 59 69 59 6 322 163 10 133 76 83 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000067777   ⟹   ENSRNOP00000063201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl723,118,845 - 23,119,632 (-)Ensembl
Rnor_6.0 Ensembl729,281,252 - 29,282,039 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000164906   ⟹   ENSRNOP00000105104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl725,005,384 - 25,008,327 (-)Ensembl
RefSeq Acc Id: NM_001106777   ⟹   NP_001100247
RefSeq Status: PREDICTED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8725,006,242 - 25,007,029 (-)NCBI
mRatBN7.2723,118,845 - 23,119,632 (-)NCBI
Rnor_6.0729,281,252 - 29,282,039 (-)NCBI
Rnor_5.0729,383,629 - 29,384,416 (-)NCBI
RGSC_v3.4725,402,762 - 25,403,549 (-)RGD
Celera720,277,965 - 20,278,752 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100247 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM16998 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000092043.1
  ENSRNOP00000105104
  ENSRNOP00000105104.1
RefSeq Acc Id: NP_001100247   ⟸   NM_001106777
- UniProtKB: D3ZV36 (UniProtKB/TrEMBL),   A6IFQ0 (UniProtKB/TrEMBL),   A0A8I6ACY4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063201   ⟸   ENSRNOT00000067777
Ensembl Acc Id: ENSRNOP00000105104   ⟸   ENSRNOT00000164906
Protein Domains
Ribosomal protein eL8/eL30/eS12/Gadd45

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZV36-F1-model_v2 AlphaFold D3ZV36 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561102 AgrOrtholog
BioCyc Gene G2FUF-34500 BioCyc
Ensembl Genes ENSRNOG00000016411 UniProtKB/TrEMBL
  ENSRNOG00000043412 Ensembl
  ENSRNOG00000080274 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000115390.2 UniProtKB/TrEMBL
  ENSRNOT00000164906 ENTREZGENE
  ENSRNOT00000164906.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1330.30 UniProtKB/TrEMBL
InterPro L30e-like UniProtKB/TrEMBL
  Ribosomal_eS12_CS UniProtKB/TrEMBL
  Ribosomal_L7Ae/L30e/S12e/Gad45 UniProtKB/TrEMBL
  Ribosomal_S12e UniProtKB/TrEMBL
KEGG Report rno:299713 UniProtKB/TrEMBL
NCBI Gene 299713 ENTREZGENE
PANTHER Ribosomal_S12e UniProtKB/TrEMBL
Pfam Ribosomal_L7Ae UniProtKB/TrEMBL
PhenoGen Rps12l4 PhenoGen
PRINTS RIBSOMALS12E UniProtKB/TrEMBL
PROSITE RIBOSOMAL_S12E UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016411 RatGTEx
  ENSRNOG00000043412 RatGTEx
  ENSRNOG00000080274 RatGTEx
Superfamily-SCOP SSF55315 UniProtKB/TrEMBL
UniProt A0A8I6ACY4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJM9_RAT UniProtKB/TrEMBL
  A6IFQ0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZV36 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-07 Rps12l4  ribosomal protein S12-like 4  RGD1561102  similar to ribosomal protein S12  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1561102  similar to ribosomal protein S12   RGD1561102_predicted  similar to ribosomal protein S12 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561102_predicted  similar to ribosomal protein S12 (predicted)  LOC299713  similar to ribosomal protein S12  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC299713  similar to ribosomal protein S12      Symbol and Name status set to provisional 70820 PROVISIONAL