Ftl1l1 (ferritin light chain 1 like 1) - Rat Genome Database

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Gene: Ftl1l1 (ferritin light chain 1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ftl1l1 (Ensembl: AABR07041778.1)
Name: ferritin light chain 1 like 1
RGD ID: 1561055
Description: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain); INTERACTS WITH ammonium chloride; bisphenol A; rotenone.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ferritin light chain 1-like; ferritin light chain 1-like 1; LOC501644; RGD1561055; similar to Ferritin light chain 2 (Ferritin L subunit 2) (Ferritin subunit LG)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X136,686,721 - 136,687,633 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX136,686,719 - 136,687,636 (-)EnsemblGRCr8
GRCr8 Ensembl263,270,578 - 63,305,917 (-)EnsemblGRCr8
mRatBN7.2X131,765,928 - 131,766,840 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,765,916 - 131,766,839 (-)EnsemblmRatBN7.2
Rnor_6.0X139,475,498 - 139,476,412 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X139,523,381 - 139,524,288 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X139,087,895 - 139,088,446 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX130,680,998 - 130,681,912 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ftl1l1
11 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 11 62 34 30 18 64 18 6 155 88 1 54 36 48 12 9 9

Sequence


RefSeq Acc Id: NM_001408864   ⟹   NP_001395793
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X136,686,721 - 136,687,633 (-)NCBI
mRatBN7.2X131,765,928 - 131,766,840 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001395793 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067402
  ENSRNOP00000067402.1
  ENSRNOP00000090717.1
  ENSRNOP00000102077.1
  ENSRNOP00000109088.1
RefSeq Acc Id: NP_001395793   ⟸   NM_001408864
- UniProtKB: M0RCS3 (UniProtKB/TrEMBL),   A0A8I6GIG4 (UniProtKB/TrEMBL)
Protein Domains
Ferritin-like diiron

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCS3-F1-model_v2 AlphaFold M0RCS3 1-183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561055 AgrOrtholog
BioCyc Gene G2FUF-1036 BioCyc
Ensembl Genes ENSRNOG00000034150 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000065602 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049856 ENTREZGENE
  ENSRNOT00000049856.7 UniProtKB/TrEMBL
  ENSRNOT00000096014.2 UniProtKB/TrEMBL
  ENSRNOT00000148687.1 UniProtKB/TrEMBL
  ENSRNOT00000153469.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.10 UniProtKB/TrEMBL
InterPro Ferritin UniProtKB/TrEMBL
  Ferritin-like UniProtKB/TrEMBL
  Ferritin-like_diiron UniProtKB/TrEMBL
  Ferritin-like_SF UniProtKB/TrEMBL
  Ferritin_CS UniProtKB/TrEMBL
  Ferritin_DPS_dom UniProtKB/TrEMBL
NCBI Gene 501644 ENTREZGENE
PANTHER FERRITIN LIGHT CHAIN UniProtKB/TrEMBL
  PTHR11431 UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/TrEMBL
PhenoGen Ftl1l1 PhenoGen
PROSITE FERRITIN_1 UniProtKB/TrEMBL
  FERRITIN_2 UniProtKB/TrEMBL
  FERRITIN_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034150 RatGTEx
  ENSRNOG00000065602 RatGTEx
Superfamily-SCOP SSF47240 UniProtKB/TrEMBL
UniProt A0A8I6GIG4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L171_RAT UniProtKB/TrEMBL
  M0RCS3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-02-03 Ftl1l1  ferritin light chain 1 like 1  Ftl1l1  ferritin light chain 1-like 1  Name changed 629549 APPROVED
2013-12-02 Ftl1l1  ferritin light chain 1-like 1  RGD1561055  similar to Ferritin light chain 2 (Ferritin L subunit 2) (Ferritin subunit LG)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1561055  similar to Ferritin light chain 2 (Ferritin L subunit 2) (Ferritin subunit LG)   RGD1561055_predicted  similar to Ferritin light chain 2 (Ferritin L subunit 2) (Ferritin subunit LG) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561055_predicted  similar to Ferritin light chain 2 (Ferritin L subunit 2) (Ferritin subunit LG) (predicted)  LOC501644  similar to Ferritin light chain 2 (Ferritin L subunit 2) (Ferritin subunit LG)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501644  similar to Ferritin light chain 2 (Ferritin L subunit 2) (Ferritin subunit LG)      Symbol and Name status set to provisional 70820 PROVISIONAL