Itln1 (intelectin 1) - Rat Genome Database

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Gene: Itln1 (intelectin 1) Rattus norvegicus
Analyze
Symbol: Itln1
Name: intelectin 1
RGD ID: 1561048
Description: Predicted to enable calcium ion binding activity; identical protein binding activity; and oligosaccharide binding activity. Predicted to be involved in several processes, including positive regulation of glucose import; protein homotrimerization; and response to nematode. Predicted to be located in brush border membrane and membrane raft. Predicted to be part of receptor complex. Predicted to be active in extracellular space. Orthologous to several human genes including ITLN1 (intelectin 1); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: intelectin 1 (galactofuranose binding); intelectin 1 (galactofuranose binding)-like; intelectin-1; LOC498284; MGC124684; similar to intelectin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,464,641 - 86,490,655 (+)NCBIGRCr8
mRatBN7.21383,932,234 - 83,958,243 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,948,124 - 83,958,227 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,453,887 - 86,463,994 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,852,107 - 87,862,214 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,087,662 - 85,097,769 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,919,570 - 89,929,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,919,667 - 89,929,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,546,165 - 94,556,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,445,119 - 87,455,226 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1383,578,295 - 83,588,402 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. The relationship of novel adipokines, RBP4 and omentin-1, with carotid atherosclerosis severity and vulnerability. Kadoglou NP, etal., Atherosclerosis. 2014 Aug;235(2):606-12. doi: 10.1016/j.atherosclerosis.2014.05.957. Epub 2014 Jun 8.
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. Relationship of ANGPTL6 With Neonatal Glucose Homeostasis and Fat Mass Is Disrupted in Gestational Diabetic Pregnancies. Valencia-Martínez A, etal., J Clin Endocrinol Metab. 2022 Sep 28;107(10):e4078-e4085. doi: 10.1210/clinem/dgac414.
Additional References at PubMed
PMID:16531507   PMID:16866365   PMID:17420014   PMID:19056867   PMID:23376485   PMID:23382219   PMID:25002582   PMID:25869566   PMID:26144294   PMID:26148048   PMID:28017783   PMID:30794687  
PMID:33739937  


Genomics

Comparative Map Data
Itln1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,464,641 - 86,490,655 (+)NCBIGRCr8
mRatBN7.21383,932,234 - 83,958,243 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,948,124 - 83,958,227 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,453,887 - 86,463,994 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,852,107 - 87,862,214 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,087,662 - 85,097,769 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,919,570 - 89,929,774 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,919,667 - 89,929,770 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,546,165 - 94,556,303 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,445,119 - 87,455,226 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1383,578,295 - 83,588,402 (+)NCBICelera
Cytogenetic Map13q24NCBI
ITLN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,876,540 - 160,885,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,876,540 - 160,885,180 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,846,330 - 160,854,970 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,112,954 - 159,121,584 (-)NCBINCBI36Build 36hg18NCBI36
Build 341157,659,404 - 157,668,033NCBI
Celera1133,914,518 - 133,923,141 (-)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,202,640 - 132,211,271 (-)NCBIHuRef
CHM1_11162,241,723 - 162,250,352 (-)NCBICHM1_1
T2T-CHM13v2.01160,013,580 - 160,022,212 (-)NCBIT2T-CHM13v2.0
Itln1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,345,691 - 171,362,893 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1171,345,690 - 171,362,862 (-)EnsemblGRCm39 Ensembl
GRCm381171,518,123 - 171,535,325 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,518,122 - 171,535,294 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,448,254 - 173,465,424 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361173,354,798 - 173,371,968 (-)NCBIMGSCv36mm8
Celera1174,384,162 - 174,390,323 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.49NCBI
Itln1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495546812,568,465 - 12,573,663 (-)NCBIChiLan1.0ChiLan1.0
ITLN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,962,311 - 88,972,593 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,703,069 - 88,712,799 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,233,093 - 136,242,888 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,156,335 - 140,165,211 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,156,335 - 140,165,211 (-)Ensemblpanpan1.1panPan2
Itln1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,983,119 - 6,990,790 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936903191,836 - 199,448 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITLN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,051,929 - 3,088,690 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,078,856 - 3,089,055 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660382,119,371 - 2,129,068 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itln1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624794419,503 - 434,139 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itln1
549 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:33
Interacting mature miRNAs:33
Transcripts:ENSRNOT00000006196
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High 1
Medium 2
Low 6 1
Below cutoff 1 8 1 9 1 18 4 16 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006196   ⟹   ENSRNOP00000006196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1383,948,124 - 83,958,227 (+)Ensembl
Rnor_6.0 Ensembl1389,919,667 - 89,929,770 (+)Ensembl
RefSeq Acc Id: NM_001034946   ⟹   NP_001030118
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,480,548 - 86,490,655 (+)NCBI
mRatBN7.21383,948,124 - 83,958,231 (+)NCBI
Rnor_6.01389,919,667 - 89,929,774 (+)NCBI
Rnor_5.01394,546,165 - 94,556,303 (+)NCBI
RGSC_v3.41387,445,119 - 87,455,226 (+)RGD
Celera1383,578,295 - 83,588,402 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598901   ⟹   XP_017454390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,464,659 - 86,490,655 (+)NCBI
mRatBN7.21383,932,234 - 83,958,243 (+)NCBI
Rnor_6.01389,919,570 - 89,929,774 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090984   ⟹   XP_038946912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,464,659 - 86,490,655 (+)NCBI
mRatBN7.21383,932,234 - 83,958,243 (+)NCBI
RefSeq Acc Id: XM_063272546   ⟹   XP_063128616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81386,464,641 - 86,490,655 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001030118   ⟸   NM_001034946
- Peptide Label: precursor
- UniProtKB: Q499T8 (UniProtKB/TrEMBL),   E9PT30 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454390   ⟸   XM_017598901
- Peptide Label: isoform X1
- UniProtKB: A6JG02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000006196   ⟸   ENSRNOT00000006196
RefSeq Acc Id: XP_038946912   ⟸   XM_039090984
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128616   ⟸   XM_063272546
- Peptide Label: isoform X1
Protein Domains
Fibrinogen C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PT30-F1-model_v2 AlphaFold E9PT30 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699010
Promoter ID:EPDNEW_R9535
Type:single initiation site
Name:Itln1_1
Description:intelectin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01389,919,656 - 89,919,716EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561048 AgrOrtholog
BioCyc Gene G2FUF-17362 BioCyc
Ensembl Genes ENSRNOG00000004678 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006196 ENTREZGENE
  ENSRNOT00000006196.5 UniProtKB/TrEMBL
Gene3D-CATH 3.90.215.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7931002 IMAGE-MGC_LOAD
InterPro Fibrinogen-like_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C UniProtKB/TrEMBL
  Fibrinogen_a/b/g_C_1 UniProtKB/TrEMBL
KEGG Report rno:498284 UniProtKB/TrEMBL
MGC_CLONE MGC:124684 IMAGE-MGC_LOAD
NCBI Gene 498284 ENTREZGENE
PANTHER INTELECTIN UniProtKB/TrEMBL
  INTELECTIN-1A-RELATED UniProtKB/TrEMBL
Pfam Fibrinogen_C UniProtKB/TrEMBL
PhenoGen Itln1 PhenoGen
PROSITE FIBRINOGEN_C_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004678 RatGTEx
Superfamily-SCOP Fibrinogen_a/b/g_C UniProtKB/TrEMBL
UniProt A6JG02 ENTREZGENE, UniProtKB/TrEMBL
  E9PT30 ENTREZGENE, UniProtKB/TrEMBL
  Q499T8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Itln1  intelectin 1  Itln1  intelectin 1 (galactofuranose binding)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Itln1  intelectin 1 (galactofuranose binding)  LOC100363780  intelectin 1 (galactofuranose binding)-like  Data merged from RGD:2322372 1643240 APPROVED
2010-05-06 LOC100363780  intelectin 1 (galactofuranose binding)-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-05 Itln1  intelectin 1 (galactofuranose binding)  LOC498284  similar to intelectin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC498284  similar to intelectin      Symbol and Name status set to provisional 70820 PROVISIONAL