Gprasp2 (G protein-coupled receptor associated sorting protein 2) - Rat Genome Database

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Gene: Gprasp2 (G protein-coupled receptor associated sorting protein 2) Rattus norvegicus
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Symbol: Gprasp2
Name: G protein-coupled receptor associated sorting protein 2
RGD ID: 1561019
Description: Predicted to enable G protein-coupled receptor binding activity and amyloid-beta binding activity. Predicted to act upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in X-linked deafness 7. Orthologous to several human genes including GPRASP2 (G protein-coupled receptor associated sorting protein 2); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein coupled receptor-associated sorting protein 2; LOC317405; RGD1561019; similar to hypothetical protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,609,304 - 103,615,450 (+)NCBIGRCr8
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,817,593 - 98,824,402 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX100,952,521 - 100,958,667 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,463,129 - 104,469,275 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,014,745 - 102,020,891 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,357,240 - 106,363,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,360,393 - 106,363,300 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X106,756,768 - 106,762,718 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X123,118,497 - 123,121,360 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX100,321,098 - 100,327,315 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9173930   PMID:15086532   PMID:15302935  


Genomics

Comparative Map Data
Gprasp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,609,304 - 103,615,450 (+)NCBIGRCr8
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,817,593 - 98,824,402 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX100,952,521 - 100,958,667 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,463,129 - 104,469,275 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,014,745 - 102,020,891 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,357,240 - 106,363,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,360,393 - 106,363,300 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X106,756,768 - 106,762,718 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X123,118,497 - 123,121,360 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX100,321,098 - 100,327,315 (-)NCBICelera
Cytogenetic MapXq32NCBI
GPRASP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X102,712,448 - 102,717,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX102,712,445 - 102,717,733 (+)EnsemblGRCh38hg38GRCh38
GRCh37X101,967,376 - 101,972,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X101,853,996 - 101,859,317 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X101,773,484 - 101,778,805NCBI
CeleraX102,406,295 - 102,412,645 (+)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX91,633,603 - 91,638,248 (+)NCBIHuRef
CHM1_1X101,859,769 - 101,865,326 (+)NCBICHM1_1
T2T-CHM13v2.0X101,157,397 - 101,162,682 (+)NCBIT2T-CHM13v2.0
Gprasp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X134,739,786 - 134,745,480 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX134,739,783 - 134,745,479 (+)EnsemblGRCm39 Ensembl
GRCm38X135,839,034 - 135,844,730 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX135,839,034 - 135,844,730 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X132,373,573 - 132,379,269 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X131,185,420 - 131,191,092 (+)NCBIMGSCv36mm8
CeleraX119,145,876 - 119,161,315 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.3NCBI
Gprasp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955548172,755 - 175,280 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955548172,442 - 202,686 (+)NCBIChiLan1.0ChiLan1.0
GPRASP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X102,206,303 - 102,324,184 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X102,209,908 - 102,572,924 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X91,823,866 - 91,941,726 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X102,316,104 - 102,321,658 (+)NCBIpanpan1.1PanPan1.1panPan2
GPRASP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X76,653,500 - 76,658,182 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX76,653,842 - 76,656,418 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.0X77,825,145 - 77,828,251 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX77,736,671 - 77,828,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X75,375,200 - 75,378,306 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X77,038,127 - 77,041,233 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X76,748,174 - 76,751,280 (+)NCBIUU_Cfam_GSD_1.0
LOC101970136
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,223,263 - 62,340,686 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368131,134,762 - 1,137,290 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368131,134,420 - 1,139,513 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPRASP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX83,803,177 - 83,892,475 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X83,811,733 - 83,892,476 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,751,989 - 97,832,439 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPRASP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X90,692,724 - 90,698,316 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606515,531,213 - 15,536,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gprasp2
14 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:39
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000004260
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat

Markers in Region
RH78520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X98,823,350 - 98,823,509 (+)MAPPERmRatBN7.2
Rnor_6.0X106,362,992 - 106,363,150NCBIRnor6.0
Rnor_5.0X106,757,072 - 106,757,231NCBIRnor5.0
RGSC_v3.4X123,120,897 - 123,121,055UniSTSRGSC3.4
Cytogenetic MapXq35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 20 6 9 6 74 26 34 10
Low 3 17 37 35 10 35 8 11 9 7 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004260   ⟹   ENSRNOP00000004260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,817,661 - 98,824,402 (+)Ensembl
Rnor_6.0 EnsemblX106,360,393 - 106,363,300 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100404   ⟹   ENSRNOP00000086355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,818,247 - 98,824,402 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111785   ⟹   ENSRNOP00000097842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,817,593 - 98,824,402 (+)Ensembl
RefSeq Acc Id: NM_001401157   ⟹   NP_001388086
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,609,304 - 103,615,450 (+)NCBI
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBI
RefSeq Acc Id: NM_001401158   ⟹   NP_001388087
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,609,304 - 103,615,450 (+)NCBI
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBI
RefSeq Acc Id: NM_001401159   ⟹   NP_001388088
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,609,304 - 103,615,450 (+)NCBI
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000004260   ⟸   ENSRNOT00000004260
RefSeq Acc Id: ENSRNOP00000097842   ⟸   ENSRNOT00000111785
RefSeq Acc Id: ENSRNOP00000086355   ⟸   ENSRNOT00000100404
RefSeq Acc Id: NP_001388087   ⟸   NM_001401158
- UniProtKB: D4A542 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388086   ⟸   NM_001401157
- UniProtKB: D4A542 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388088   ⟸   NM_001401159
- UniProtKB: D4A542 (UniProtKB/TrEMBL)
Protein Domains
Armadillo repeat-containing

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A542-F1-model_v2 AlphaFold D4A542 1-836 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561019 AgrOrtholog
BioCyc Gene G2FUF-1645 BioCyc
Ensembl Genes ENSRNOG00000037658 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004260 ENTREZGENE
  ENSRNOT00000004260.7 UniProtKB/TrEMBL
  ENSRNOT00000100404 ENTREZGENE
  ENSRNOT00000100404.1 UniProtKB/TrEMBL
  ENSRNOT00000111785 ENTREZGENE
  ENSRNOT00000111785.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  BHLHb9/GASP-1/GASP-2 UniProtKB/TrEMBL
  DUF634 UniProtKB/TrEMBL
NCBI Gene 317405 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 2 UniProtKB/TrEMBL
  PTHR46414 UniProtKB/TrEMBL
Pfam DUF634 UniProtKB/TrEMBL
PhenoGen Gprasp2 PhenoGen
RatGTEx ENSRNOG00000037658 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt D4A542 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Gprasp2  G protein-coupled receptor associated sorting protein 2  RGD1561019_predicted  similar to hypothetical protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561019_predicted  similar to hypothetical protein (predicted)  LOC317405  similar to hypothetical protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317405  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL