Gprasp2 (G protein-coupled receptor associated sorting protein 2) - Rat Genome Database

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Gene: Gprasp2 (G protein-coupled receptor associated sorting protein 2) Rattus norvegicus
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Symbol: Gprasp2
Name: G protein-coupled receptor associated sorting protein 2
RGD ID: 1561019
Description: Predicted to enable G protein-coupled receptor binding activity and amyloid-beta binding activity. Predicted to act upstream of or within hematopoietic stem cell homeostasis. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in X-linked deafness 7. Orthologous to several human genes including GPRASP2 (G protein-coupled receptor associated sorting protein 2); INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G-protein coupled receptor-associated sorting protein 2; LOC317405; RGD1561019; similar to hypothetical protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,609,304 - 103,615,450 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX103,501,226 - 103,641,988 (+)EnsemblGRCr8
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,817,593 - 98,824,402 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX100,952,521 - 100,958,667 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,463,129 - 104,469,275 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,014,745 - 102,020,891 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,357,240 - 106,363,455 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,360,393 - 106,363,300 (+)Ensemblrn6Rnor6.0
Rnor_5.0X106,756,768 - 106,762,718 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X123,118,497 - 123,121,360 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX100,321,098 - 100,327,315 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
cytosol  (IBA)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9173930   PMID:15086532   PMID:15302935  


Genomics

Comparative Map Data
Gprasp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X103,609,304 - 103,615,450 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX103,501,226 - 103,641,988 (+)EnsemblGRCr8
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,817,593 - 98,824,402 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX100,952,521 - 100,958,667 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X104,463,129 - 104,469,275 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X102,014,745 - 102,020,891 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,357,240 - 106,363,455 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,360,393 - 106,363,300 (+)Ensemblrn6Rnor6.0
Rnor_5.0X106,756,768 - 106,762,718 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X123,118,497 - 123,121,360 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX100,321,098 - 100,327,315 (-)NCBICelera
Cytogenetic MapXq32NCBI
GPRASP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X102,712,448 - 102,717,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX102,712,056 - 102,717,733 (+)Ensemblhg38GRCh38
GRCh37X101,967,376 - 101,972,661 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X101,853,996 - 101,859,317 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X101,773,484 - 101,778,805NCBI
CeleraX102,406,295 - 102,412,645 (+)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX91,633,603 - 91,638,248 (+)NCBIHuRef
CHM1_1X101,859,769 - 101,865,326 (+)NCBICHM1_1
T2T-CHM13v2.0X101,157,397 - 101,162,682 (+)NCBIT2T-CHM13v2.0
Gprasp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X134,739,786 - 134,745,480 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX134,739,783 - 134,745,479 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X135,839,034 - 135,844,730 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX135,839,034 - 135,844,730 (+)Ensemblmm10GRCm38
MGSCv37X132,373,573 - 132,379,269 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X131,185,420 - 131,191,092 (+)NCBIMGSCv36mm8
CeleraX119,145,876 - 119,161,315 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.3NCBI
Gprasp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955548172,755 - 175,280 (+)Ensembl
ChiLan1.0NW_004955548172,442 - 202,686 (+)NCBIChiLan1.0ChiLan1.0
GPRASP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X102,206,303 - 102,324,184 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X102,209,908 - 102,572,924 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X91,823,866 - 91,941,726 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X102,316,104 - 102,321,658 (+)NCBIPanPan1.1PanPan1.1panPan2
GPRASP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X76,653,500 - 76,658,182 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX76,653,842 - 76,656,418 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0X77,825,145 - 77,828,251 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX77,736,671 - 77,828,242 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X75,375,200 - 75,378,306 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X77,038,127 - 77,041,233 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X76,748,174 - 76,751,280 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101970136
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,223,263 - 62,340,686 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368131,134,762 - 1,137,290 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049368131,134,420 - 1,139,513 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPRASP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX83,803,177 - 83,892,475 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X83,811,733 - 83,892,476 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,751,989 - 97,832,439 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPRASP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X90,692,724 - 90,698,316 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606515,531,213 - 15,536,492 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gprasp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X87,657,929 - 87,661,121 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gprasp2
12 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:39
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000004260
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
RH78520  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X98,823,350 - 98,823,509 (+)MAPPERmRatBN7.2
Rnor_6.0X106,362,992 - 106,363,150NCBIRnor6.0
Rnor_5.0X106,757,072 - 106,757,231NCBIRnor5.0
RGSC_v3.4X123,120,897 - 123,121,055UniSTSRGSC3.4
Cytogenetic MapXq35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000004260   ⟹   ENSRNOP00000004260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,511,442 - 103,616,021 (+)Ensembl
mRatBN7.2 EnsemblX98,817,661 - 98,824,402 (+)Ensembl
Rnor_6.0 EnsemblX106,360,393 - 106,363,300 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100404   ⟹   ENSRNOP00000086355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,608,997 - 103,616,305 (+)Ensembl
mRatBN7.2 EnsemblX98,818,247 - 98,824,402 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111785   ⟹   ENSRNOP00000097842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,609,233 - 103,641,988 (+)Ensembl
mRatBN7.2 EnsemblX98,817,593 - 98,824,402 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000125354   ⟹   ENSRNOP00000099923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,609,115 - 103,621,195 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129101   ⟹   ENSRNOP00000105354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,608,290 - 103,641,988 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143993   ⟹   ENSRNOP00000106309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,608,997 - 103,616,305 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000155473   ⟹   ENSRNOP00000111032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,609,115 - 103,638,251 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000156229   ⟹   ENSRNOP00000111861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,609,223 - 103,641,988 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160966   ⟹   ENSRNOP00000099501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,501,226 - 103,641,988 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000161818   ⟹   ENSRNOP00000108250
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX103,556,318 - 103,638,251 (+)Ensembl
RefSeq Acc Id: NM_001401157   ⟹   NP_001388086
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,609,304 - 103,615,450 (+)NCBI
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBI
RefSeq Acc Id: NM_001401158   ⟹   NP_001388087
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,609,304 - 103,615,450 (+)NCBI
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBI
RefSeq Acc Id: NM_001401159   ⟹   NP_001388088
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X103,609,304 - 103,615,450 (+)NCBI
mRatBN7.2X98,817,668 - 98,823,814 (+)NCBI
Ensembl Acc Id: ENSRNOP00000004260   ⟸   ENSRNOT00000004260
Ensembl Acc Id: ENSRNOP00000097842   ⟸   ENSRNOT00000111785
Ensembl Acc Id: ENSRNOP00000086355   ⟸   ENSRNOT00000100404
RefSeq Acc Id: NP_001388087   ⟸   NM_001401158
- UniProtKB: D4A542 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388086   ⟸   NM_001401157
- UniProtKB: D4A542 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001388088   ⟸   NM_001401159
- UniProtKB: D4A542 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099501   ⟸   ENSRNOT00000160966
Ensembl Acc Id: ENSRNOP00000105354   ⟸   ENSRNOT00000129101
Ensembl Acc Id: ENSRNOP00000108250   ⟸   ENSRNOT00000161818
Ensembl Acc Id: ENSRNOP00000106309   ⟸   ENSRNOT00000143993
Ensembl Acc Id: ENSRNOP00000099923   ⟸   ENSRNOT00000125354
Ensembl Acc Id: ENSRNOP00000111861   ⟸   ENSRNOT00000156229
Ensembl Acc Id: ENSRNOP00000111032   ⟸   ENSRNOT00000155473
Protein Domains
Armadillo repeat-containing

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A542-F1-model_v2 AlphaFold D4A542 1-836 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561019 AgrOrtholog
BioCyc Gene G2FUF-1645 BioCyc
Ensembl Genes ENSRNOG00000037658 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004260.8 UniProtKB/TrEMBL
  ENSRNOT00000100404.2 UniProtKB/TrEMBL
  ENSRNOT00000111785 ENTREZGENE
  ENSRNOT00000111785.2 UniProtKB/TrEMBL
  ENSRNOT00000125354 ENTREZGENE
  ENSRNOT00000125354.1 UniProtKB/TrEMBL
  ENSRNOT00000129101.1 UniProtKB/TrEMBL
  ENSRNOT00000143993.1 UniProtKB/TrEMBL
  ENSRNOT00000155473 ENTREZGENE
  ENSRNOT00000155473.1 UniProtKB/TrEMBL
  ENSRNOT00000156229.1 UniProtKB/TrEMBL
  ENSRNOT00000160966.1 UniProtKB/TrEMBL
  ENSRNOT00000161818.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  BHLHb9/GASP-1/GASP-2 UniProtKB/TrEMBL
  DUF634 UniProtKB/TrEMBL
NCBI Gene 317405 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR-ASSOCIATED SORTING PROTEIN 2 UniProtKB/TrEMBL
  PTHR46414 UniProtKB/TrEMBL
Pfam DUF634 UniProtKB/TrEMBL
PhenoGen Gprasp2 PhenoGen
RatGTEx ENSRNOG00000037658 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt D4A542 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-28 Gprasp2  G protein-coupled receptor associated sorting protein 2  RGD1561019_predicted  similar to hypothetical protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561019_predicted  similar to hypothetical protein (predicted)  LOC317405  similar to hypothetical protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317405  similar to hypothetical protein      Symbol and Name status set to provisional 70820 PROVISIONAL