Arid3c (AT-rich interaction domain 3C) - Rat Genome Database

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Pathways
Gene: Arid3c (AT-rich interaction domain 3C) Rattus norvegicus
Analyze
Symbol: Arid3c
Name: AT-rich interaction domain 3C
RGD ID: 1560943
Description: Predicted to enable DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Predicted to be involved in macrophage differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and membrane raft. Predicted to be active in nucleus. Orthologous to human ARID3C (AT-rich interaction domain 3C); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: AT rich interactive domain 3C (BRIGHT-like); AT-rich interactive domain-containing protein 3C; LOC502946; RGD1560943; similar to hypothetical LOC496519
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,685,511 - 61,692,821 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl561,685,511 - 61,692,821 (-)EnsemblGRCr8
mRatBN7.2556,889,649 - 56,896,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,890,042 - 56,895,888 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,869,550 - 58,875,393 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,688,382 - 60,694,225 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,674,253 - 60,680,097 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,107,182 - 58,114,632 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,107,707 - 58,113,553 (-)Ensemblrn6Rnor6.0
Rnor_5.0562,631,772 - 62,637,618 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4559,148,421 - 59,154,267 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera555,484,083 - 55,489,929 (-)NCBICelera
Cytogenetic Map5q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
membrane raft  (IEA,ISO)
nucleus  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21955986  


Genomics

Comparative Map Data
Arid3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,685,511 - 61,692,821 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl561,685,511 - 61,692,821 (-)EnsemblGRCr8
mRatBN7.2556,889,649 - 56,896,959 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,890,042 - 56,895,888 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,869,550 - 58,875,393 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,688,382 - 60,694,225 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,674,253 - 60,680,097 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,107,182 - 58,114,632 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,107,707 - 58,113,553 (-)Ensemblrn6Rnor6.0
Rnor_5.0562,631,772 - 62,637,618 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4559,148,421 - 59,154,267 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera555,484,083 - 55,489,929 (-)NCBICelera
Cytogenetic Map5q22NCBI
ARID3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38934,621,049 - 34,633,011 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl934,621,049 - 34,629,066 (-)Ensemblhg38GRCh38
GRCh37934,621,046 - 34,629,063 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,611,455 - 34,618,011 (-)NCBIBuild 36Build 36hg18NCBI36
Celera934,552,959 - 34,559,515 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef934,575,737 - 34,582,294 (-)NCBIHuRef
CHM1_1934,621,235 - 34,627,787 (-)NCBICHM1_1
T2T-CHM13v2.0934,639,596 - 34,650,042 (-)NCBIT2T-CHM13v2.0
Arid3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39441,723,830 - 41,731,226 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl441,723,836 - 41,731,142 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38441,723,831 - 41,731,142 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl441,723,836 - 41,731,142 (-)Ensemblmm10GRCm38
MGSCv37441,670,868 - 41,678,174 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36441,912,903 - 41,918,863 (-)NCBIMGSCv36mm8
Celera441,384,044 - 41,391,382 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map422.01NCBI
Arid3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,504,032 - 1,510,590 (+)Ensembl
ChiLan1.0NW_0049554721,503,448 - 1,510,965 (+)NCBIChiLan1.0ChiLan1.0
ARID3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,974,694 - 89,982,711 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,975,061 - 89,989,017 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,457,638 - 34,466,425 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,267,063 - 35,275,057 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,267,063 - 35,275,057 (-)EnsemblpanPan2panpan1.1
ARID3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,294,605 - 51,301,979 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,295,030 - 51,301,547 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1149,922,506 - 49,930,320 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01152,234,892 - 52,242,709 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,235,759 - 52,242,279 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,897,603 - 50,905,422 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01150,765,803 - 50,773,609 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,530,526 - 51,538,340 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arid3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,157,164 - 166,165,371 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365242,705,121 - 2,711,557 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365242,705,112 - 2,711,557 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARID3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,172,871 - 32,180,604 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11032,171,233 - 32,187,239 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,312,954 - 36,321,471 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARID3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11245,981,575 - 45,998,777 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,982,439 - 45,985,880 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603843,098,375 - 43,115,838 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arid3c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473639,016,483 - 39,023,668 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473639,016,483 - 39,023,701 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Arid3c
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v113,821,227 - 3,827,339 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Arid3c
61 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:69
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000046589
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 16 95 25 35 8 82 8 3 158 105 2 87 43 55 27 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000046589   ⟹   ENSRNOP00000039046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,685,511 - 61,692,821 (-)Ensembl
mRatBN7.2 Ensembl556,890,042 - 56,895,888 (-)Ensembl
Rnor_6.0 Ensembl558,107,707 - 58,113,553 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110095   ⟹   ENSRNOP00000085659
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl561,685,512 - 61,692,821 (-)Ensembl
mRatBN7.2 Ensembl556,890,042 - 56,895,888 (-)Ensembl
RefSeq Acc Id: NM_001173981   ⟹   NP_001167452
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8561,685,511 - 61,692,821 (-)NCBI
mRatBN7.2556,889,649 - 56,896,959 (-)NCBI
Rnor_6.0558,107,707 - 58,113,553 (-)NCBI
Rnor_5.0562,631,772 - 62,637,618 (-)NCBI
Celera555,484,083 - 55,489,929 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001167452 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98688 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039046
  ENSRNOP00000039046.2
  ENSRNOP00000085659.1
RefSeq Acc Id: NP_001167452   ⟸   NM_001173981
- UniProtKB: D3ZQB1 (UniProtKB/TrEMBL),   A0A8I6A250 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039046   ⟸   ENSRNOT00000046589
Ensembl Acc Id: ENSRNOP00000085659   ⟸   ENSRNOT00000110095
Protein Domains
ARID   REKLES

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQB1-F1-model_v2 AlphaFold D3ZQB1 1-410 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560943 AgrOrtholog
BioCyc Gene G2FUF-41544 BioCyc
Ensembl Genes ENSRNOG00000013416 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046589 ENTREZGENE
  ENSRNOT00000046589.4 UniProtKB/TrEMBL
  ENSRNOT00000110095.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.60 UniProtKB/TrEMBL
InterPro ARI3A/B/C UniProtKB/TrEMBL
  ARID/BRIGHT_DNA-bd UniProtKB/TrEMBL
  ARID_dom_sf UniProtKB/TrEMBL
  REKLES_domain UniProtKB/TrEMBL
KEGG Report rno:502946 UniProtKB/TrEMBL
NCBI Gene 502946 ENTREZGENE
PANTHER AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3C UniProtKB/TrEMBL
  PTHR15348 UniProtKB/TrEMBL
Pfam ARID UniProtKB/TrEMBL
PhenoGen Arid3c PhenoGen
PROSITE ARID UniProtKB/TrEMBL
  REKLES UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013416 RatGTEx
SMART ARID UniProtKB/TrEMBL
  BRIGHT UniProtKB/TrEMBL
Superfamily-SCOP ARID UniProtKB/TrEMBL
UniProt A0A8I6A250 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQB1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Arid3c  AT-rich interaction domain 3C  Arid3c  AT rich interactive domain 3C (BRIGHT-like)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Arid3c  AT rich interactive domain 3C (BRIGHT-like)  RGD1560943  RGD1560943  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560943  RGD1560943   RGD1560943_predicted  RGD1560943 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560943_predicted  RGD1560943 (predicted)  LOC502946  similar to Hypothetical LOC496519  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC502946  similar to Hypothetical LOC496519      Symbol and Name status set to provisional 70820 PROVISIONAL