Rhoxl (reproductive homeobox like) - Rat Genome Database

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Pathways
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Gene: Rhoxl (reproductive homeobox like) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rhoxl (Ensembl: RGD1560927)
Name: reproductive homeobox like (Ensembl:RGD1560927)
RGD ID: 1560927
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II; INTERACTS WITH 17beta-estradiol 3-benzoate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC501507; LOC108348152; LOC501507; RGD1560927; RGD1560927; rhox homeobox family member 2-like; uncharacterized protein LOC501507
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X121,308,351 - 121,309,782 (-)NCBIGRCr8
mRatBN7.2X116,442,675 - 116,444,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX116,441,825 - 116,444,081 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX118,545,972 - 118,547,403 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,115,114 - 122,116,545 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,661,172 - 119,662,603 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,820,065 - 123,823,065 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,821,637 - 123,823,056 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,530,740 - 124,532,993 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X124,616,505 - 124,618,777 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X7,709,805 - 7,712,512 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX115,669,192 - 115,671,412 (-)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Rhoxl
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000061499
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system nervous system renal system reproductive system
High
Medium
Low 19
Below cutoff 4 2 2 2 13 5 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061499   ⟹   ENSRNOP00000058217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX116,441,825 - 116,444,081 (-)Ensembl
Rnor_6.0 EnsemblX124,530,740 - 124,532,993 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085845   ⟹   ENSRNOP00000074208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,821,737 - 123,822,950 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092694   ⟹   ENSRNOP00000075850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,821,637 - 123,823,056 (-)Ensembl
RefSeq Acc Id: NR_173353
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X121,308,351 - 121,309,782 (-)NCBI
mRatBN7.2X116,442,675 - 116,444,106 (-)NCBI
Protein Sequences
GenBank Protein EDM10842 (Get FASTA)   NCBI Sequence Viewer  
  EDM10843 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058217.3
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000075850   ⟸   ENSRNOT00000092694
RefSeq Acc Id: ENSRNOP00000058217   ⟸   ENSRNOT00000061499
RefSeq Acc Id: ENSRNOP00000074208   ⟸   ENSRNOT00000085845

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZNR0-F1-model_v2 AlphaFold D3ZNR0 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560927 AgrOrtholog
BioCyc Gene G2FUF-1291 BioCyc
Ensembl Genes ENSRNOG00000040008 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000054164 Ensembl
Ensembl Transcript ENSRNOT00000061499.4 UniProtKB/TrEMBL
InterPro Homeobox_dom UniProtKB/TrEMBL
KEGG Report rno:501507 UniProtKB/TrEMBL
NCBI Gene 501507 ENTREZGENE
PhenoGen Rhoxl PhenoGen
RatGTEx ENSRNOG00000040008 RatGTEx
  ENSRNOG00000054164 RatGTEx
UniProt D3ZNR0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Rhoxl  reproductive homeobox like  RGD1560927  RGD1560927  Symbol and Name Changed 1299863 APPROVED
2021-03-09 RGD1560927  RGD1560927  LOC108348152  rhox homeobox family member 2-like  Data merged from RGD:11409898 737654 PROVISIONAL
2016-08-02 LOC108348152  rhox homeobox family member 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1560927  RGD1560927   RGD1560927_predicted  RGD1560927 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560927_predicted  RGD1560927 (predicted)  LOC501507  LOC501507  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501507  LOC501507      Symbol and Name status set to provisional 70820 PROVISIONAL