Ccdc22 (coiled-coil domain containing 22)

Gene: Ccdc22 (coiled-coil domain containing 22) Rattus norvegicus

Analyze

Symbol:

Ccdc22

Name:

coiled-coil domain containing 22

RGD ID:

1560910

Description:

Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including positive regulation of ubiquitin-dependent protein catabolic process; regulation of canonical NF-kappaB signal transduction; and vesicle-mediated transport to the plasma membrane. Predicted to be located in centrosome. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 2. Orthologous to human CCDC22 (coiled-coil domain containing 22); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Coiled-coil domain-containing protein 22; LOC317381; RGD1560910; similar to DXImx40e protein

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CCDC22 (coiled-coil domain containing 22)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ccdc22 (coiled-coil domain containing 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ccdc22 (coiled-coil domain containing 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CCDC22 (coiled-coil domain containing 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CCDC22 (coiled-coil domain containing 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ccdc22 (coiled-coil domain containing 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CCDC22 (coiled-coil domain containing 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CCDC22 (coiled-coil domain containing 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ccdc22 (coiled-coil domain containing 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	POFUT2 (protein O-fucosyltransferase 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CCDC22 (coiled-coil domain containing 22)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ccdc22 (coiled-coil domain containing 22)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ccdc22 (coiled-coil domain containing 22)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9951	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	R08E3.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ccdc22	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	17,570,184 - 17,582,130 (+)	NCBI		GRCr8
mRatBN7.2	X	14,898,296 - 14,910,244 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	14,898,296 - 14,910,244 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	19,712,643 - 19,724,567 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	20,358,569 - 20,370,493 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	16,623,713 - 16,635,641 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	15,742,978 - 15,754,925 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	15,742,978 - 15,754,925 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	16,534,513 - 16,546,460 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	26,939,045 - 26,951,756 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	14,981,697 - 14,993,611 (+)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

congenital disorder of glycosylation type IIm (ISO)

genetic disease (ISO)

immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome (ISO)

intellectual disability (ISO)

neurodegeneration with brain iron accumulation 5 (ISO)

Ritscher-Schinzel syndrome (ISO)

Ritscher-Schinzel syndrome 1 (ISO)

Ritscher-Schinzel syndrome 2 (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked epilepsy with variable learning disabilities and behavior disorders (ISO)

X-linked severe congenital neutropenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

atrazine (EXP)

auramine O (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

C60 fullerene (EXP)

cyclosporin A (ISO)

diazinon (ISO)

finasteride (EXP)

folic acid (ISO)

furan (EXP)

gentamycin (EXP)

ivermectin (ISO)

ozone (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

pirinixic acid (ISO)

tamibarotene (ISO)

tetrachloromethane (ISO)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endocytic recycling (ISO,ISS)

Golgi to plasma membrane transport (ISO)

intracellular copper ion homeostasis (ISO)

negative regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of ubiquitin-dependent protein catabolic process (IBA,IEA,ISO)

protein transport (IEA)

Cellular Component

centrosome (ISO,ISS)

endosome (IEA)

Molecular Function

cullin family protein binding (IBA,IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:23563313	PMID:25355947	PMID:28892079

Genomics

Comparative Map Data

Ccdc22
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	17,570,184 - 17,582,130 (+)	NCBI		GRCr8
mRatBN7.2	X	14,898,296 - 14,910,244 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	14,898,296 - 14,910,244 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	19,712,643 - 19,724,567 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	20,358,569 - 20,370,493 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	16,623,713 - 16,635,641 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	15,742,978 - 15,754,925 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	15,742,978 - 15,754,925 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	16,534,513 - 16,546,460 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	26,939,045 - 26,951,756 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	14,981,697 - 14,993,611 (+)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

CCDC22
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	49,235,470 - 49,250,520 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	49,235,470 - 49,250,520 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	49,091,930 - 49,106,981 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	48,978,885 - 48,994,341 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	48,848,381 - 48,863,351	NCBI
Celera	X	52,557,382 - 52,572,443 (-)	NCBI		Celera
Cytogenetic Map	X	p11.23	NCBI
HuRef	X	46,748,323 - 46,763,422 (+)	NCBI		HuRef
CHM1_1	X	49,124,228 - 49,139,289 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	48,646,429 - 48,662,382 (+)	NCBI		T2T-CHM13v2.0

Ccdc22
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	7,460,048 - 7,471,659 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	7,460,048 - 7,471,756 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	7,593,809 - 7,605,420 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	7,593,809 - 7,605,517 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	7,170,935 - 7,182,546 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	6,750,770 - 6,762,351 (-)	NCBI		MGSCv36	mm8
Celera	X	3,866,265 - 3,877,962 (+)	NCBI		Celera
Cytogenetic Map	X	A1.1	NCBI
cM Map	X	3.42	NCBI

Ccdc22
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955543	718,996 - 733,753 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955543	719,185 - 731,788 (+)	NCBI	ChiLan1.0	ChiLan1.0

CCDC22
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	50,727,511 - 50,742,431 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	50,730,750 - 50,745,810 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	41,535,439 - 41,550,547 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	49,387,980 - 49,402,742 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	49,387,980 - 49,402,742 (+)	Ensembl	panpan1.1		panPan2

CCDC22
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	42,329,320 - 42,343,270 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	42,328,755 - 42,343,270 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	16,708,063 - 16,721,934 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	42,471,025 - 42,484,896 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	42,470,447 - 42,484,887 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	42,454,985 - 42,468,855 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	42,442,443 - 42,456,314 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	42,537,397 - 42,551,268 (+)	NCBI		UU_Cfam_GSD_1.0

Ccdc22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	34,867,310 - 34,877,919 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936721	1,107,866 - 1,118,050 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936721	1,107,697 - 1,118,313 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCDC22
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	43,285,246 - 43,303,864 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	43,285,232 - 43,303,865 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	48,133,195 - 48,151,807 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCDC22
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	46,330,215 - 46,349,978 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	46,335,095 - 46,353,583 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666076	11,891,024 - 11,911,267 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ccdc22
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624893	971,645 - 998,886 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624893	971,688 - 1,008,460 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ccdc22
14 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	260
Count of miRNA genes:	171
Interacting mature miRNAs:	203
Transcripts:	ENSRNOT00000015546
Prediction methods:	Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	43491017	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1447972	20991088	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1448129	31706553	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1623715	22646544	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	2927898	47927898	Rat
10755455	Coatc13	Coat color QTL 13		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	4406000	49406000	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	4494549	49494549	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat

Markers in Region

RH136802

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	14,909,682 - 14,909,827 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	15,754,364 - 15,754,508	NCBI	Rnor6.0
Rnor_5.0	X	16,545,899 - 16,546,043	UniSTS	Rnor5.0
RGSC_v3.4	X	26,951,195 - 26,951,339	UniSTS	RGSC3.4
Celera	X	14,993,050 - 14,993,194	UniSTS
RH 3.4 Map	X	167.4	UniSTS
Cytogenetic Map	X	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	28	38	24	17	24			65	32	33	11
Low	2	15	19	17	2	17	8	11	9	3	8		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001135837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000015546 ⟹ ENSRNOP00000015547

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	14,898,296 - 14,910,244 (+)	Ensembl
Rnor_6.0 Ensembl	X	15,742,978 - 15,754,925 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108125 ⟹ ENSRNOP00000082270

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	14,899,348 - 14,910,244 (+)	Ensembl

RefSeq Acc Id:

NM_001135837 ⟹ NP_001129309

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	17,570,184 - 17,582,130 (+)	NCBI
mRatBN7.2	X	14,898,296 - 14,910,244 (+)	NCBI
Rnor_6.0	X	15,742,978 - 15,754,925 (+)	NCBI
Rnor_5.0	X	16,534,513 - 16,546,460 (+)	NCBI
RGSC_v3.4	X	26,939,045 - 26,951,756 (+)	RGD
Celera	X	14,981,697 - 14,993,611 (+)	RGD

Sequence:

show sequence

TACACTTCCCAATGTTCCTCGCGCGGCACGTGACGCTCTGTCCTCGGCGCGCTGAGAGCAGTTA
CTACAACGTTGCTCCACTTTCTCTGACCTGGTCCTAGACCCAGCCCCGGAGTTAGAATTAACTC
CACCATGGAGGAGGCTGACCGAATCCTCATCCATTCCTTGCGCCAGGCGGGCACGGCAGTTCCT
CCAGAAGTGCAGACTCTTCGAGCTTTCACCACGGAGCTGGTTGTAGAGGCTGTGGTCCGATGCC
TTCGAGTGATCAATCCTGATGTGGGCTCTGGCCTCAGTCACTTGCTACCACCAGCCATGTCTGC
CCGCTTCCGCCTGGCCATGAGTCTGGCTCAGGCCTGCATGGACCTGGGCTATCCCTTGGAGCTT
GGCTATCAGAACTTCCTCTATCCCAGTGAGCCTGACCTCCGAGACCTACTTCTCTTCTTGGCTG
AGCGGCTACCCACCGATGCTTCTGAGGATGCAGACCAGCCTGCAGGTGACTCGGCTATTTTCCT
TCGGGCCATTGGGAGCCAAATCCGGGACCAGCTGGCCCTGCCCTGGGTCCCACCTCTCCTTCGA
ACTCCCAAGGTGCAGCGTCTCCAGGGCTCAGCCCTCCAGCAAGCATTCCACTCCAGCAGGTTGG
TTCTGCCTGAATTGAATTGCCGAGGAGAGCCACGGGAGTTCCAGGCCAGTCCCCTGCTGCTACC
AGCCCCCTCACAGGTGCCCCAGCTTCTGGGGAGGGCAGCCTCGCTCCTTGAACACCATGCCATC
CAGCTCTGCCAGCATGTGAACAGGGATTGCCCAGGAGATGAAGACCGAGTGCGCTGGGCATCCC
GCCTCCCATCCCAGGAGGATCCCCGGGCTCCACAGCAGAGACTGCACAAGCAGCTGATTGAACA
TCTGCGTCAAAGCTGGGGCCCACTTGGAGCCCCGACACAAGTCCGAGACCTAGGAGAGATGCTA
CAGGCCTGGGGTGCTAAGGCTATGACTGGCGTGCCCAAAGGCTCCCGCTTCACCCATTCAGAGA
AGTTTACCTTCCATCTGGAGCCCCAGGTCCAGGCAGCTCAGGTGGCAGATATACCAGCTGCCTC
TCAAAGGCCTGAACAGGACACACGGGCAGCTCAAGAGGAGGAGTTAGAGTCCCTCCGGGAGCAG
CTGGCGAGTGTGAACCACAACATTGAAGAGGTTGAAGCTAACATGAAGAGCCTGGGAATGAACC
TTGTGCAGGTGGAAACTGAGTGTCGACAAAGTGAACTCAGCGTGGCTGAGCAGGAGCAAGCCCT
GCGCCTGAAGAGCAGGACGGTGGAGCTGCTGCCTGATGGGGCTGCCAACCTCACCAAGCTGCAG
CTTGTGGTGGAGAGTAGTGCTCAGAGGCTCATTCATCTAGCAAGTCAGTGGGAGAAGCACCGGG
TCCCACTTCTTGCTGAGTATCGCCACCTCAGGAAACTCCAGGATTGTAGGGAGCTGGAATCATC
TCGAAGACTGGTAGAAATCCAGGAGCTGCACCAGAGTGTGCGAGCGGCTGCAGAAGAGGCTCGC
AGGAAGGAGGAGGTCTATAAGCAGTTGGTATCAGAGCTGGAAACCCTGCCAAAAGATGTATCCC
GCCTGGCCTATACCCAGCGCATCCTGGAGATTGTGGGCAACATCCGGAAGCAGAAGGAAGAGAT
CACTAAAATCTTGTCAGACACAAAGGAACTTCAGAAGGAAATCAACTCTCTCTCTGGGAAGCTG
GACCGGACATTTGCAGTGACTGATGAGCTTGTGTTCAAGGATGCTAAGAAGGATGATGCTGTTC
GGAAAGCCTACAAATATCTAGCTGCTCTGCATGAGAATTGCAGCCAGCTCATCCAGACCATTGA
GGACACGGGCACTATCATGAGGGAAGTTCGAGATCTTGAGGAGCAGATTGAGACAGAGATGGGC
AAGAAGACTTTGAGCAACCTGGAGAAGATCTGTGAGGACTACCGAGCCCTTCGCCAGGAGAATG
CTGGCCTCTTGGGCCGGGTCCGAGAGGTCTAGAGCCCTGATGGATGTCTCCTAAGCACAGGCAG
GAATTTGGGGGTACTGGAGACCGTGCTGAAGCACTTGGCTCTAGCACTCTCTTCAATTTGGTAT
CCACTTTCTCCTGTTGGGACCTTAAACCCAGCTGTCTGCTTATCTGTTCCCATATCTGATCAGG
GTGATTGTCCAGCTTGACCACAGTTTATTGGATGGGCACTGGGGACCAGGGGCCTTGGATTCCA
AATAAAAGAGAAGTTCTTCTGTGGGCCACGCTTAGGCATGGATTGGGGCTTGGGGGTAGGGGAC
TGGGGTTAGTGGCAAGTGATACATGGGGTACATTTTGGAAAGTCGGTGTGTATTCATGGAACTC
AGGAGATACGGTGGAGGGGCTGCATGTGTGTACATGTACACGTGTGCGTTCTGACAAGCTGTGT
CTGACTTGATATTTTTTGGGCATTACTAGAGGCTACGTATGATCAGTTATGCCTGTGTGGTTTT
CTGGGATGCTAATTCTGAAGGTTCCAGCGCTGCTCCTGTACGAGGGTCTGCATCTACACCCCTG
CTATGTGTCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001129309	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL83846	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015547
	ENSRNOP00000015547.4
	ENSRNOP00000082270.1
	ENSRNOP00055038868
	ENSRNOP00060042344
	ENSRNOP00065013753
GenBank Protein	P86182	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001129309 ⟸ NM_001135837

- UniProtKB:

A6KP98 (UniProtKB/Swiss-Prot), P86182 (UniProtKB/Swiss-Prot), A0A8I5ZUM8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEEADRILIHSLRQAGTAVPPEVQTLRAFTTELVVEAVVRCLRVINPDVGSGLSHLLPPAMSAR
FRLAMSLAQACMDLGYPLELGYQNFLYPSEPDLRDLLLFLAERLPTDASEDADQPAGDSAIFLR
AIGSQIRDQLALPWVPPLLRTPKVQRLQGSALQQAFHSSRLVLPELNCRGEPREFQASPLLLPA
PSQVPQLLGRAASLLEHHAIQLCQHVNRDCPGDEDRVRWASRLPSQEDPRAPQQRLHKQLIEHL
RQSWGPLGAPTQVRDLGEMLQAWGAKAMTGVPKGSRFTHSEKFTFHLEPQVQAAQVADIPAASQ
RPEQDTRAAQEEELESLREQLASVNHNIEEVEANMKSLGMNLVQVETECRQSELSVAEQEQALR
LKSRTVELLPDGAANLTKLQLVVESSAQRLIHLASQWEKHRVPLLAEYRHLRKLQDCRELESSR
RLVEIQELHQSVRAAAEEARRKEEVYKQLVSELETLPKDVSRLAYTQRILEIVGNIRKQKEEIT
KILSDTKELQKEINSLSGKLDRTFAVTDELVFKDAKKDDAVRKAYKYLAALHENCSQLIQTIED
TGTIMREVRDLEEQIETEMGKKTLSNLEKICEDYRALRQENAGLLGRVREV

hide sequence

RefSeq Acc Id:

ENSRNOP00000015547 ⟸ ENSRNOT00000015546

RefSeq Acc Id:

ENSRNOP00000082270 ⟸ ENSRNOT00000108125

Protein Domains

CCDC22 coiled-coil CCDC22 N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P86182-F1-model_v2	AlphaFold	P86182	1-627	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701749

Promoter ID:

EPDNEW_R12273

Type:

initiation region

Name:

Ccdc22_1

Description:

coiled-coil domain containing 22

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	15,743,017 - 15,743,077	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560910	AgrOrtholog
BioCyc Gene	G2FUF-2905	BioCyc
Ensembl Genes	ENSRNOG00000010846	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055027276	UniProtKB/Swiss-Prot
	ENSRNOG00060029248	UniProtKB/Swiss-Prot
	ENSRNOG00065011134	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000015546	ENTREZGENE
	ENSRNOT00000015546.5	UniProtKB/Swiss-Prot
	ENSRNOT00000108125.1	UniProtKB/TrEMBL
	ENSRNOT00055047288	UniProtKB/Swiss-Prot
	ENSRNOT00060050903	UniProtKB/Swiss-Prot
	ENSRNOT00065018029	UniProtKB/Swiss-Prot
InterPro	CCDC22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CCDC22_CC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CCDC22_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:317381	UniProtKB/Swiss-Prot
NCBI Gene	317381	ENTREZGENE
PANTHER	COILED-COIL DOMAIN-CONTAINING PROTEIN 22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR15668	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	CCDC22_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DUF812	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ccdc22	PhenoGen
RatGTEx	ENSRNOG00000010846	RatGTEx
	ENSRNOG00055027276	RatGTEx
	ENSRNOG00060029248	RatGTEx
	ENSRNOG00065011134	RatGTEx
UniProt	A0A8I5ZUM8	ENTREZGENE, UniProtKB/TrEMBL
	A6KP98	ENTREZGENE
	CCD22_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A6KP98	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Ccdc22	coiled-coil domain containing 22	Ccdc22_predicted	coiled-coil domain containing 22 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Ccdc22_predicted	coiled-coil domain containing 22 (predicted)	RGD1560910_predicted	similar to DXImx40e protein (predicted)	Symbol and Name updated	1299863	APPROVED
2006-03-07	RGD1560910_predicted	similar to DXImx40e protein (predicted)	LOC317381	similar to DXImx40e protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC317381	similar to DXImx40e protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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