Ccdc22 (CCC complex scaffolding subunit CCDC22) - Rat Genome Database

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Gene: Ccdc22 (CCC complex scaffolding subunit CCDC22) Rattus norvegicus
Analyze
Symbol: Ccdc22
Name: CCC complex scaffolding subunit CCDC22 (Ensembl:coiled-coil domain containing 22)
RGD ID: 1560910
Description: Predicted to enable cullin family protein binding activity. Predicted to be involved in several processes, including intracellular copper ion homeostasis; regulation of canonical NF-kappaB signal transduction; and vesicle-mediated transport to the plasma membrane. Predicted to be located in centrosome. Human ortholog(s) of this gene implicated in Ritscher-Schinzel syndrome 2. Orthologous to human CCDC22 (coiled-coil domain containing 22); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: coiled-coil domain containing 22; Coiled-coil domain-containing protein 22; LOC317381; RGD1560910; similar to DXImx40e protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,570,184 - 17,582,130 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX17,535,659 - 17,582,130 (+)EnsemblGRCr8
mRatBN7.2X14,898,296 - 14,910,244 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,898,296 - 14,910,244 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX19,712,643 - 19,724,567 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,358,569 - 20,370,493 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,623,713 - 16,635,641 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,742,978 - 15,754,925 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,742,978 - 15,754,925 (+)Ensemblrn6Rnor6.0
Rnor_5.0X16,534,513 - 16,546,460 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X26,939,045 - 26,951,756 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX14,981,697 - 14,993,611 (+)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO,ISS)
endosome  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23563313   PMID:25355947   PMID:28892079  


Genomics

Comparative Map Data
Ccdc22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,570,184 - 17,582,130 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX17,535,659 - 17,582,130 (+)EnsemblGRCr8
mRatBN7.2X14,898,296 - 14,910,244 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,898,296 - 14,910,244 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX19,712,643 - 19,724,567 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,358,569 - 20,370,493 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,623,713 - 16,635,641 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,742,978 - 15,754,925 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,742,978 - 15,754,925 (+)Ensemblrn6Rnor6.0
Rnor_5.0X16,534,513 - 16,546,460 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X26,939,045 - 26,951,756 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX14,981,697 - 14,993,611 (+)NCBICelera
Cytogenetic MapXq12NCBI
CCDC22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X49,235,470 - 49,250,520 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX49,235,444 - 49,250,526 (+)Ensemblhg38GRCh38
GRCh37X49,091,930 - 49,106,981 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,978,885 - 48,994,341 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X48,848,381 - 48,863,351NCBI
CeleraX52,557,382 - 52,572,443 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,748,323 - 46,763,422 (+)NCBIHuRef
CHM1_1X49,124,228 - 49,139,289 (+)NCBICHM1_1
T2T-CHM13v2.0X48,646,429 - 48,662,382 (+)NCBIT2T-CHM13v2.0
Ccdc22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,460,048 - 7,471,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,460,048 - 7,471,756 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X7,593,809 - 7,605,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,593,809 - 7,605,517 (-)Ensemblmm10GRCm38
MGSCv37X7,170,935 - 7,182,546 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X6,750,770 - 6,762,351 (-)NCBIMGSCv36mm8
CeleraX3,866,265 - 3,877,962 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.42NCBI
Ccdc22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543718,996 - 733,753 (+)Ensembl
ChiLan1.0NW_004955543719,185 - 731,788 (+)NCBIChiLan1.0ChiLan1.0
CCDC22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,727,511 - 50,742,431 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,730,750 - 50,745,810 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,535,439 - 41,550,547 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X49,387,980 - 49,402,742 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,387,980 - 49,402,742 (+)EnsemblpanPan2panpan1.1
CCDC22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,329,320 - 42,343,270 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,328,755 - 42,343,270 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX16,708,063 - 16,721,934 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,471,025 - 42,484,896 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,470,447 - 42,484,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,454,985 - 42,468,855 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,442,443 - 42,456,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,537,397 - 42,551,268 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccdc22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,867,310 - 34,877,919 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367211,107,866 - 1,118,050 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367211,107,697 - 1,118,313 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCDC22
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,285,246 - 43,303,864 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X43,285,232 - 43,303,865 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,133,195 - 48,151,807 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCDC22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,330,215 - 46,349,978 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX46,335,095 - 46,353,583 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607611,891,024 - 11,911,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccdc22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893971,645 - 998,886 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624893971,688 - 1,008,460 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ccdc22
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X14,529,557 - 14,542,882 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ccdc22
62 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:260
Count of miRNA genes:171
Interacting mature miRNAs:203
Transcripts:ENSRNOT00000015546
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X400149324470521Rat

Markers in Region
RH136802  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,909,682 - 14,909,827 (+)MAPPERmRatBN7.2
Rnor_6.0X15,754,364 - 15,754,508NCBIRnor6.0
Rnor_5.0X16,545,899 - 16,546,043UniSTSRnor5.0
RGSC_v3.4X26,951,195 - 26,951,339UniSTSRGSC3.4
CeleraX14,993,050 - 14,993,194UniSTS
RH 3.4 MapX167.4UniSTS
Cytogenetic MapXq13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000015546   ⟹   ENSRNOP00000015547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX17,535,659 - 17,582,130 (+)Ensembl
mRatBN7.2 EnsemblX14,898,296 - 14,910,244 (+)Ensembl
Rnor_6.0 EnsemblX15,742,978 - 15,754,925 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108125   ⟹   ENSRNOP00000082270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX17,571,236 - 17,582,130 (+)Ensembl
mRatBN7.2 EnsemblX14,899,348 - 14,910,244 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153858   ⟹   ENSRNOP00000107853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX17,540,499 - 17,582,130 (+)Ensembl
RefSeq Acc Id: NM_001135837   ⟹   NP_001129309
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,570,184 - 17,582,130 (+)NCBI
mRatBN7.2X14,898,296 - 14,910,244 (+)NCBI
Rnor_6.0X15,742,978 - 15,754,925 (+)NCBI
Rnor_5.0X16,534,513 - 16,546,460 (+)NCBI
RGSC_v3.4X26,939,045 - 26,951,756 (+)RGD
CeleraX14,981,697 - 14,993,611 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001129309 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015547.4
  ENSRNOP00000082270
GenBank Protein P86182 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001129309   ⟸   NM_001135837
- UniProtKB: A6KP98 (UniProtKB/Swiss-Prot),   P86182 (UniProtKB/Swiss-Prot),   A0A8I5ZUM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015547   ⟸   ENSRNOT00000015546
Ensembl Acc Id: ENSRNOP00000082270   ⟸   ENSRNOT00000108125
Ensembl Acc Id: ENSRNOP00000107853   ⟸   ENSRNOT00000153858
Protein Domains
CCDC22 coiled-coil   CCDC22 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P86182-F1-model_v2 AlphaFold P86182 1-627 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701749
Promoter ID:EPDNEW_R12273
Type:initiation region
Name:Ccdc22_1
Description:coiled-coil domain containing 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,743,017 - 15,743,077EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560910 AgrOrtholog
BioCyc Gene G2FUF-2905 BioCyc
Ensembl Genes ENSRNOG00000010846 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015546.5 UniProtKB/Swiss-Prot
  ENSRNOT00000108125 ENTREZGENE
InterPro CCDC22 UniProtKB/Swiss-Prot
  CCDC22_CC UniProtKB/Swiss-Prot
  CCDC22_N UniProtKB/Swiss-Prot
KEGG Report rno:317381 UniProtKB/Swiss-Prot
NCBI Gene 317381 ENTREZGENE
PANTHER COILED-COIL DOMAIN-CONTAINING PROTEIN 22 UniProtKB/Swiss-Prot
  PTHR15668 UniProtKB/Swiss-Prot
Pfam CCDC22_N UniProtKB/Swiss-Prot
  DUF812 UniProtKB/Swiss-Prot
PhenoGen Ccdc22 PhenoGen
RatGTEx ENSRNOG00000010846 RatGTEx
UniProt A0A8I5ZUM8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LSQ9_RAT UniProtKB/TrEMBL
  A6KP98 ENTREZGENE
  CCD22_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A6KP98 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-11-13 Ccdc22  CCC complex scaffolding subunit CCDC22  Ccdc22  coiled-coil domain containing 22  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ccdc22  coiled-coil domain containing 22   Ccdc22_predicted  coiled-coil domain containing 22 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ccdc22_predicted  coiled-coil domain containing 22 (predicted)  RGD1560910_predicted  similar to DXImx40e protein (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560910_predicted  similar to DXImx40e protein (predicted)  LOC317381  similar to DXImx40e protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317381  similar to DXImx40e protein      Symbol and Name status set to provisional 70820 PROVISIONAL