Vom2r68 (vomeronasal 2 receptor, 68) - Rat Genome Database

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Gene: Vom2r68 (vomeronasal 2 receptor, 68) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Vom2r68
Name: vomeronasal 2 receptor, 68
RGD ID: 1560816
Description: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane; INTERACTS WITH amitrole; cadmium dichloride; methimazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC501881; RGD1560816; similar to putative pheromone receptor; vomeronasal 2 receptor 68
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr814449,671 - 456,533 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl14449,670 - 456,533 (-)EnsemblGRCr8
mRatBN7.214434,685 - 441,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl14434,183 - 441,863 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14458,065 - 464,938 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0141,759,848 - 1,766,721 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014456,527 - 463,394 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd14450,712 - 457,579 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive14449,615 - 456,482 (-)NCBILyon_Normotensive
Lyon_Hypertensive14448,581 - 455,448 (-)NCBILyon_Hypertensive
F344_StmMcwi14624,754 - 631,598 (-)NCBIF344_StmMcwi
Rnor_6.0141,106,463 - 1,113,322 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl141,106,463 - 1,113,322 (+)Ensemblrn6Rnor6.0
Rnor_5.0141,106,281 - 1,113,140 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.414628,951 - 635,811 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera14327,478 - 334,328 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17382427  


Genomics

Variants

.
Variants in Vom2r68
196 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:56
Interacting mature miRNAs:59
Transcripts:ENSRNOT00000044004
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat


Expression

RNA-SEQ Expression

endoderm
mesenchyme
renal system
reproductive system
respiratory system
1 2 2 11 1

Sequence


Ensembl Acc Id: ENSRNOT00000044004   ⟹   ENSRNOP00000042077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl141,106,463 - 1,113,322 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000045104   ⟹   ENSRNOP00000039766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl14449,670 - 456,533 (-)Ensembl
mRatBN7.2 Ensembl14434,183 - 441,863 (-)Ensembl
RefSeq Acc Id: NM_001419219   ⟹   NP_001406148
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814449,671 - 456,533 (-)NCBI
mRatBN7.214434,685 - 441,547 (-)NCBI
Dahl_SR_JrHsd14450,712 - 457,579 (-)NCBI
Lyon_Normotensive14449,615 - 456,482 (-)NCBI
Lyon_Hypertensive14448,581 - 455,448 (-)NCBI
F344_StmMcwi14624,754 - 631,598 (-)NCBI
RefSeq Acc Id: XM_017599338   ⟹   XP_017454827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814449,671 - 456,533 (-)NCBI
mRatBN7.214434,685 - 441,547 (-)NCBI
Rnor_6.0141,106,463 - 1,113,322 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092333   ⟹   XP_038948261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814449,671 - 456,533 (-)NCBI
mRatBN7.214434,685 - 441,547 (-)NCBI
RefSeq Acc Id: XM_063273501   ⟹   XP_063129571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr814449,671 - 456,533 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001406148 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454827 (Get FASTA)   NCBI Sequence Viewer  
  XP_038948261 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129571 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039766
  ENSRNOP00000039766.5
RefSeq Acc Id: XP_017454827   ⟸   XM_017599338
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000042077   ⟸   ENSRNOT00000044004
RefSeq Acc Id: XP_038948261   ⟸   XM_039092333
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000039766   ⟸   ENSRNOT00000045104
RefSeq Acc Id: NP_001406148   ⟸   NM_001419219
- Peptide Label: precursor
- UniProtKB: F1LNQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129571   ⟸   XM_063273501
- Peptide Label: isoform X2
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A754-F1-model_v2 AlphaFold D4A754 1-850 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560816 AgrOrtholog
BioCyc Gene G2FUF-16707 BioCyc
Ensembl Genes ENSRNOG00000033073 Ensembl
  ENSRNOG00000066418 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000045104 ENTREZGENE
  ENSRNOT00000045104.6 UniProtKB/TrEMBL
Gene3D-CATH 2.10.50.30 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_9-Cys_dom UniProtKB/TrEMBL
  GPCR_3_9-Cys_sf UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_Ca_sens_rcpt-rel UniProtKB/TrEMBL
  GPCR_3_vmron_rcpt_2 UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
NCBI Gene 501881 ENTREZGENE
PANTHER PTHR24061 UniProtKB/TrEMBL
  VOMERONASAL 2, RECEPTOR 16 UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  NCD3G UniProtKB/TrEMBL
PhenoGen Vom2r68 PhenoGen
PRINTS GPCRMGR UniProtKB/TrEMBL
  VOMERONASL2R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033073 RatGTEx
  ENSRNOG00000066418 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt F1LNQ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-23 Vom2r68  vomeronasal 2 receptor, 68  RGD1560816  similar to putative pheromone receptor   Symbol and Name updated 1299863 APPROVED
2008-04-30 RGD1560816  similar to putative pheromone receptor   RGD1560816_predicted  similar to putative pheromone receptor (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560816_predicted  similar to putative pheromone receptor (predicted)  LOC501881  similar to putative pheromone receptor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501881  similar to putative pheromone receptor      Symbol and Name status set to provisional 70820 PROVISIONAL