Arfgef1 (ADP ribosylation factor guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Arfgef1 (ADP ribosylation factor guanine nucleotide exchange factor 1) Rattus norvegicus
Analyze
Symbol: Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
RGD ID: 1560793
Description: Predicted to enable guanyl-nucleotide exchange factor activity; myosin binding activity; and protein kinase A regulatory subunit binding activity. Involved in neuron projection development and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in trans-Golgi network. Orthologous to human ARFGEF1 (ADP ribosylation factor guanine nucleotide exchange factor 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ADP-ribosylation factor guanine nucleotide-exchange factor 1; ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited); BIG1; brefeldin A-inhibited GEP 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; LOC312915; RGD1560793; similar to brefeldin A-inhibited guanine nucleotide-exchange protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8513,764,507 - 13,859,237 (+)NCBIGRCr8
mRatBN7.258,982,061 - 9,076,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl58,981,540 - 9,076,326 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,137,964 - 11,230,261 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0512,761,387 - 12,855,480 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0512,472,621 - 12,564,922 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.058,666,046 - 8,760,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl58,666,200 - 8,760,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,474,381 - 13,568,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.458,498,644 - 8,592,918 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera58,494,495 - 8,587,878 (+)NCBICelera
Cytogenetic Map5q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. Saeki N, etal., J Biol Chem. 2005 Mar 18;280(11):10128-34. Epub 2005 Jan 11.
6. Localization of large ADP-ribosylation factor-guanine nucleotide exchange factors to different Golgi compartments: evidence for distinct functions in protein traffic. Zhao X, etal., Mol Biol Cell. 2002 Jan;13(1):119-33.
7. BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways. Zhou C, etal., Neuroscience. 2013 Dec 19;254:361-8. doi: 10.1016/j.neuroscience.2013.09.045. Epub 2013 Oct 1.
Additional References at PubMed
PMID:10716990   PMID:12571360   PMID:14973189   PMID:17227842   PMID:18292223   PMID:20360857   PMID:22084092   PMID:22871113   PMID:23220274   PMID:24198228  


Genomics

Comparative Map Data
Arfgef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8513,764,507 - 13,859,237 (+)NCBIGRCr8
mRatBN7.258,982,061 - 9,076,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl58,981,540 - 9,076,326 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,137,964 - 11,230,261 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0512,761,387 - 12,855,480 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0512,472,621 - 12,564,922 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.058,666,046 - 8,760,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl58,666,200 - 8,760,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,474,381 - 13,568,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.458,498,644 - 8,592,918 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera58,494,495 - 8,587,878 (+)NCBICelera
Cytogenetic Map5q11NCBI
ARFGEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38867,173,511 - 67,343,781 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl867,173,511 - 67,343,781 (-)EnsemblGRCh38hg38GRCh38
GRCh37868,109,893 - 68,256,016 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36868,272,451 - 68,418,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 34868,272,450 - 68,418,466NCBI
Celera864,103,297 - 64,249,319 (-)NCBICelera
Cytogenetic Map8q13.2NCBI
HuRef863,601,813 - 63,748,371 (-)NCBIHuRef
CHM1_1868,165,896 - 68,311,968 (-)NCBICHM1_1
T2T-CHM13v2.0867,599,967 - 67,770,273 (-)NCBIT2T-CHM13v2.0
Arfgef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39110,207,732 - 10,303,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl110,207,796 - 10,302,895 (-)EnsemblGRCm39 Ensembl
GRCm38110,137,507 - 10,232,670 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl110,137,571 - 10,232,670 (-)EnsemblGRCm38mm10GRCm38
MGSCv37110,127,588 - 10,222,751 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36110,122,721 - 10,218,159 (-)NCBIMGSCv36mm8
Celera110,111,100 - 10,206,279 (-)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.36NCBI
Arfgef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544411,986,595 - 12,110,172 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544411,986,595 - 12,110,172 (+)NCBIChiLan1.0ChiLan1.0
ARFGEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2782,934,778 - 83,078,661 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1858,577,096 - 58,720,869 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0863,740,512 - 63,884,189 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1865,402,117 - 65,546,014 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl865,403,386 - 65,545,789 (-)Ensemblpanpan1.1panPan2
ARFGEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12916,712,872 - 16,852,478 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2916,708,820 - 16,852,844 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2917,028,251 - 17,168,331 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02916,793,854 - 16,933,903 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2916,793,352 - 16,934,175 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12916,825,243 - 16,966,723 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,925,119 - 17,065,181 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02917,182,796 - 17,322,945 (-)NCBIUU_Cfam_GSD_1.0
Arfgef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,870,517 - 67,978,189 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364966,807,403 - 6,914,987 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364966,807,388 - 6,914,960 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARFGEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl467,465,529 - 67,613,611 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1467,465,517 - 67,613,611 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2473,526,804 - 73,674,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARFGEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1863,058,504 - 63,204,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl863,057,200 - 63,204,292 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603978,298,523 - 78,446,510 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arfgef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474424,011,136 - 24,143,202 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474424,010,609 - 24,144,474 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arfgef1
446 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:129
Count of miRNA genes:101
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000007766
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat

Markers in Region
BE114642  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.259,045,367 - 9,045,519 (+)MAPPERmRatBN7.2
Rnor_6.058,729,509 - 8,729,660NCBIRnor6.0
Rnor_5.0513,537,846 - 13,537,997UniSTSRnor5.0
RGSC_v3.458,561,946 - 8,562,097UniSTSRGSC3.4
Celera58,556,939 - 8,557,090UniSTS
RH 3.4 Map555.3UniSTS
Cytogenetic Map5q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 52 36 19 36 8 10 74 35 41 11 8
Low 3 5 5 5 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007766   ⟹   ENSRNOP00000007766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl58,982,061 - 9,076,312 (+)Ensembl
Rnor_6.0 Ensembl58,666,200 - 8,760,458 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095352   ⟹   ENSRNOP00000089172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl58,981,540 - 9,076,326 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110006   ⟹   ENSRNOP00000076394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl58,982,726 - 9,076,326 (+)Ensembl
RefSeq Acc Id: NM_001277056   ⟹   NP_001263985
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8513,764,975 - 13,859,237 (+)NCBI
mRatBN7.258,982,061 - 9,076,326 (+)NCBI
Rnor_6.058,666,200 - 8,760,458 (+)NCBI
Rnor_5.0513,474,381 - 13,568,680 (+)NCBI
Celera58,494,495 - 8,587,878 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017593322   ⟹   XP_017448811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8513,764,507 - 13,858,252 (+)NCBI
mRatBN7.258,982,180 - 9,074,896 (+)NCBI
Rnor_6.058,666,046 - 8,759,039 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063287518   ⟹   XP_063143588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8513,764,507 - 13,854,282 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001263985   ⟸   NM_001277056
- UniProtKB: D4A631 (UniProtKB/Swiss-Prot),   A0A8I6GGZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448811   ⟸   XM_017593322
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q3C5 (UniProtKB/TrEMBL),   A0A8I6GGZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007766   ⟸   ENSRNOT00000007766
RefSeq Acc Id: ENSRNOP00000089172   ⟸   ENSRNOT00000095352
RefSeq Acc Id: ENSRNOP00000076394   ⟸   ENSRNOT00000110006
RefSeq Acc Id: XP_063143588   ⟸   XM_063287518
- Peptide Label: isoform X2
Protein Domains
SEC7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A631-F1-model_v2 AlphaFold D4A631 1-1846 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693533
Promoter ID:EPDNEW_R4058
Type:single initiation site
Name:Arfgef1_1
Description:ADP ribosylation factor guanine nucleotide exchange factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.058,666,295 - 8,666,355EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560793 AgrOrtholog
BioCyc Gene G2FUF-42212 BioCyc
Ensembl Genes ENSRNOG00000005703 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055017515 UniProtKB/Swiss-Prot
  ENSRNOG00060009967 UniProtKB/Swiss-Prot
  ENSRNOG00065017598 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007766.8 UniProtKB/TrEMBL
  ENSRNOT00000095352 ENTREZGENE
  ENSRNOT00000095352.1 UniProtKB/TrEMBL
  ENSRNOT00000110006.1 UniProtKB/TrEMBL
  ENSRNOT00055029654 UniProtKB/Swiss-Prot
  ENSRNOT00060017074 UniProtKB/Swiss-Prot
  ENSRNOT00065029809 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1000.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.220.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DCB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7/BIG1-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:312915 UniProtKB/Swiss-Prot
NCBI Gene 312915 ENTREZGENE
PANTHER BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYL-NUCLEOTIDE EXCHANGE FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BIG2_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DCB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUF1981 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sec7_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arfgef1 PhenoGen
PROSITE SEC7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005703 RatGTEx
  ENSRNOG00055017515 RatGTEx
  ENSRNOG00060009967 RatGTEx
  ENSRNOG00065017598 RatGTEx
SMART Sec7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y4E2_RAT UniProtKB/TrEMBL
  A0A8I6GGZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q3C5 ENTREZGENE, UniProtKB/TrEMBL
  BIG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Arfgef1  ADP ribosylation factor guanine nucleotide exchange factor 1  Arfgef1  ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arfgef1  ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)   Arfgef1_predicted  ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Arfgef1_predicted  ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) (predicted)  RGD1560793_predicted  similar to brefeldin A-inhibited guanine nucleotide-exchange protein 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560793_predicted  similar to brefeldin A-inhibited guanine nucleotide-exchange protein 1 (predicted)  LOC312915  similar to brefeldin A-inhibited guanine nucleotide-exchange protein 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC312915  similar to brefeldin A-inhibited guanine nucleotide-exchange protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL