Stard8 (StAR-related lipid transfer domain containing 8) - Rat Genome Database

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Pathways
Gene: Stard8 (StAR-related lipid transfer domain containing 8) Rattus norvegicus
Analyze
Symbol: Stard8
Name: StAR-related lipid transfer domain containing 8
RGD ID: 1560770
Description: Predicted to enable GTPase activator activity. Predicted to be involved in actin cytoskeleton organization and regulation of Rho protein signal transduction. Orthologous to human STARD8 (StAR related lipid transfer domain containing 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC312113; RGD1560770; similar to START domain containing 8; StAR-related lipid transfer (START) domain containing 8; stAR-related lipid transfer protein 8; START domain containing 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X68,119,276 - 68,236,247 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX68,119,644 - 68,236,246 (+)EnsemblGRCr8
mRatBN7.2X64,079,079 - 64,196,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX64,124,574 - 64,196,052 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX65,665,621 - 65,679,569 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X69,165,962 - 69,179,914 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X66,726,912 - 66,740,854 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X68,713,157 - 68,785,046 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX68,713,123 - 68,785,052 (+)Ensemblrn6Rnor6.0
Rnor_5.0X69,587,772 - 69,659,522 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X87,088,565 - 87,102,511 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX64,551,816 - 64,565,762 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090  


Genomics

Comparative Map Data
Stard8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X68,119,276 - 68,236,247 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX68,119,644 - 68,236,246 (+)EnsemblGRCr8
mRatBN7.2X64,079,079 - 64,196,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX64,124,574 - 64,196,052 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX65,665,621 - 65,679,569 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X69,165,962 - 69,179,914 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X66,726,912 - 66,740,854 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X68,713,157 - 68,785,046 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX68,713,123 - 68,785,052 (+)Ensemblrn6Rnor6.0
Rnor_5.0X69,587,772 - 69,659,522 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X87,088,565 - 87,102,511 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX64,551,816 - 64,565,762 (+)NCBICelera
Cytogenetic MapXq22NCBI
STARD8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X68,647,666 - 68,725,836 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX68,647,666 - 68,725,842 (+)Ensemblhg38GRCh38
GRCh37X67,867,508 - 67,945,678 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X67,784,236 - 67,862,403 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X67,650,531 - 67,728,698NCBI
CeleraX68,220,334 - 68,298,611 (+)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX61,695,452 - 61,772,608 (+)NCBIHuRef
CHM1_1X67,760,683 - 67,838,871 (+)NCBICHM1_1
T2T-CHM13v2.0X67,081,162 - 67,159,288 (+)NCBIT2T-CHM13v2.0
Stard8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X98,046,539 - 98,118,334 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX98,046,854 - 98,118,334 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X99,002,933 - 99,074,728 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX99,003,248 - 99,074,728 (+)Ensemblmm10GRCm38
MGSCv37X96,237,920 - 96,270,067 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X95,245,384 - 95,277,447 (+)NCBIMGSCv36mm8
CeleraX85,983,748 - 86,015,610 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.19NCBI
Stard8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554758,245,754 - 8,278,319 (+)Ensembl
ChiLan1.0NW_0049554758,203,624 - 8,278,319 (+)NCBIChiLan1.0ChiLan1.0
STARD8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X68,299,028 - 68,377,083 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X68,302,603 - 68,380,880 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X57,890,362 - 57,968,391 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X67,955,393 - 68,031,958 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX67,954,883 - 68,031,958 (+)EnsemblpanPan2panpan1.1
STARD8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X53,128,122 - 53,211,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX53,128,095 - 53,210,852 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX43,953,760 - 44,036,713 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X54,087,072 - 54,170,149 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX54,086,983 - 54,169,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X52,061,722 - 52,144,669 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X53,390,428 - 53,473,431 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X53,314,126 - 53,397,128 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Stard8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X48,876,064 - 48,953,571 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936777323,367 - 358,243 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936777316,332 - 358,241 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STARD8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX54,773,171 - 54,856,711 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X54,773,189 - 54,856,716 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X61,989,481 - 62,001,599 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STARD8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X58,487,688 - 58,569,710 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX58,556,806 - 58,566,551 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666065342,579 - 420,535 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stard8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248911,508,980 - 1,547,811 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248911,509,113 - 1,540,416 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Stard8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X57,034,084 - 57,072,301 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Stard8
255 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:186
Count of miRNA genes:125
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000043872
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 82 59 6 346 182 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000043872   ⟹   ENSRNOP00000042131
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX68,164,817 - 68,236,246 (+)Ensembl
mRatBN7.2 EnsemblX64,124,574 - 64,196,052 (+)Ensembl
Rnor_6.0 EnsemblX68,771,100 - 68,785,046 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000075995   ⟹   ENSRNOP00000067895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,782,872 - 68,783,725 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076690   ⟹   ENSRNOP00000067952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,713,123 - 68,776,156 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077039   ⟹   ENSRNOP00000068015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,752,597 - 68,783,944 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081662   ⟹   ENSRNOP00000070263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX68,774,699 - 68,785,052 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000123604   ⟹   ENSRNOP00000104319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX68,119,644 - 68,236,245 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143878   ⟹   ENSRNOP00000109884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX68,205,288 - 68,236,246 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153437   ⟹   ENSRNOP00000111209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX68,204,202 - 68,236,246 (+)Ensembl
RefSeq Acc Id: NM_001107849   ⟹   NP_001101319
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X68,204,224 - 68,235,677 (+)NCBI
mRatBN7.2X64,164,037 - 64,195,484 (+)NCBI
Rnor_6.0X68,771,100 - 68,785,046 (+)NCBI
Rnor_5.0X69,587,772 - 69,659,522 (+)NCBI
RGSC_v3.4X87,088,565 - 87,102,511 (+)RGD
CeleraX64,551,816 - 64,565,762 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257074   ⟹   XP_006257136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X68,164,740 - 68,236,247 (+)NCBI
mRatBN7.2X64,124,555 - 64,195,530 (+)NCBI
Rnor_6.0X68,713,157 - 68,784,234 (+)NCBI
Rnor_5.0X69,587,772 - 69,659,522 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099690   ⟹   XP_038955618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X68,204,730 - 68,236,247 (+)NCBI
mRatBN7.2X64,164,545 - 64,196,052 (+)NCBI
RefSeq Acc Id: XM_039099691   ⟹   XP_038955619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X68,119,276 - 68,236,247 (+)NCBI
mRatBN7.2X64,079,079 - 64,195,530 (+)NCBI
RefSeq Acc Id: NP_001101319   ⟸   NM_001107849
- UniProtKB: A6IQ62 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257136   ⟸   XM_006257074
- Peptide Label: isoform X2
- UniProtKB: D4A5B9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042131   ⟸   ENSRNOT00000043872
Ensembl Acc Id: ENSRNOP00000068015   ⟸   ENSRNOT00000077039
Ensembl Acc Id: ENSRNOP00000067895   ⟸   ENSRNOT00000075995
Ensembl Acc Id: ENSRNOP00000070263   ⟸   ENSRNOT00000081662
Ensembl Acc Id: ENSRNOP00000067952   ⟸   ENSRNOT00000076690
RefSeq Acc Id: XP_038955619   ⟸   XM_039099691
- Peptide Label: isoform X3
- UniProtKB: A6IQ62 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955618   ⟸   XM_039099690
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000109884   ⟸   ENSRNOT00000143878
Ensembl Acc Id: ENSRNOP00000111209   ⟸   ENSRNOT00000153437
Ensembl Acc Id: ENSRNOP00000104319   ⟸   ENSRNOT00000123604
Protein Domains
Rho-GAP   START

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5B9-F1-model_v2 AlphaFold D4A5B9 1-1014 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701861
Promoter ID:EPDNEW_R12381
Type:single initiation site
Name:Stard8_1
Description:StAR-related lipid transfer domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12382  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X68,713,141 - 68,713,201EPDNEW
RGD ID:13701862
Promoter ID:EPDNEW_R12382
Type:initiation region
Name:Stard8_2
Description:StAR-related lipid transfer domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R12381  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X68,752,629 - 68,752,689EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560770 AgrOrtholog
BioCyc Gene G2FUF-2156 BioCyc
Ensembl Genes ENSRNOG00000033883 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043872 ENTREZGENE
  ENSRNOT00000043872.6 UniProtKB/TrEMBL
  ENSRNOT00000123604 ENTREZGENE
  ENSRNOT00000123604.1 UniProtKB/TrEMBL
  ENSRNOT00000143878 ENTREZGENE
  ENSRNOT00000143878.1 UniProtKB/TrEMBL
  ENSRNOT00000153437 ENTREZGENE
  ENSRNOT00000153437.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.2070 UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/TrEMBL
  3.30.530.20 UniProtKB/TrEMBL
InterPro Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  START-like_dom UniProtKB/TrEMBL
  START_lipid-bd UniProtKB/TrEMBL
NCBI Gene 312113 ENTREZGENE
PANTHER RHO-TYPE GTPASE ACTIVATING PROTEIN UniProtKB/TrEMBL
  STAR-RELATED LIPID TRANSFER PROTEIN 8 UniProtKB/TrEMBL
Pfam RhoGAP UniProtKB/TrEMBL
  START UniProtKB/TrEMBL
PhenoGen Stard8 PhenoGen
PROSITE RHOGAP UniProtKB/TrEMBL
  START UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033883 RatGTEx
SMART RhoGAP UniProtKB/TrEMBL
  START UniProtKB/TrEMBL
Superfamily-SCOP Bet v1-like UniProtKB/TrEMBL
  Rho_GAP UniProtKB/TrEMBL
  SSF47769 UniProtKB/TrEMBL
UniProt A0ABK0L489_RAT UniProtKB/TrEMBL
  A0ABK0LXN4_RAT UniProtKB/TrEMBL
  A0ABK0M4L4_RAT UniProtKB/TrEMBL
  A6IQ62 ENTREZGENE, UniProtKB/TrEMBL
  D4A5B9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Stard8  StAR-related lipid transfer domain containing 8  Stard8  StAR-related lipid transfer (START) domain containing 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Stard8  StAR-related lipid transfer (START) domain containing 8  Stard8  START domain containing 8   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Stard8  START domain containing 8   Stard8_predicted  START domain containing 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Stard8_predicted  START domain containing 8 (predicted)  RGD1560770_predicted  similar to START domain containing 8 (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560770_predicted  similar to START domain containing 8 (predicted)  LOC312113  similar to START domain containing 8  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC312113  similar to START domain containing 8      Symbol and Name status set to provisional 70820 PROVISIONAL