Rfx8 (regulatory factor X8) - Rat Genome Database

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Pathways
Gene: Rfx8 (regulatory factor X8) Rattus norvegicus
Analyze
Symbol: Rfx8
Name: regulatory factor X8
RGD ID: 1560724
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human RFX8 (regulatory factor X8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA-binding protein RFX8; LOC501127; LOC501128; regulatory factor X 8; RFX family member 8, lacking RFX DNA binding domain; RFX gene family member 8, lacking RFX DNA binding domain; RGD1560724; RGD1565676; similar to FLJ42986 protein; similar to regulatory factor X domain containing 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,453,282 - 49,517,123 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl949,453,289 - 49,515,134 (-)EnsemblGRCr8
mRatBN7.2941,957,589 - 42,021,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,957,596 - 42,021,848 (-)EnsemblmRatBN7.2
Rnor_6.0946,414,407 - 46,476,076 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,414,564 - 46,475,040 (-)Ensemblrn6Rnor6.0
Rnor_5.0946,101,244 - 46,162,933 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4938,842,636 - 38,902,600 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera939,706,648 - 39,768,709 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Rfx8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8949,453,282 - 49,517,123 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl949,453,289 - 49,515,134 (-)EnsemblGRCr8
mRatBN7.2941,957,589 - 42,021,432 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,957,596 - 42,021,848 (-)EnsemblmRatBN7.2
Rnor_6.0946,414,407 - 46,476,076 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl946,414,564 - 46,475,040 (-)Ensemblrn6Rnor6.0
Rnor_5.0946,101,244 - 46,162,933 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4938,842,636 - 38,902,600 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera939,706,648 - 39,768,709 (-)NCBICelera
Cytogenetic Map9q22NCBI
RFX8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382101,397,359 - 101,475,112 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2101,397,359 - 101,475,112 (-)Ensemblhg38GRCh38
GRCh372102,013,821 - 102,091,574 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362101,392,873 - 101,457,169 (-)NCBIBuild 36Build 36hg18NCBI36
Celera296,217,462 - 96,291,111 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef295,777,628 - 95,854,810 (-)NCBIHuRef
CHM1_12102,017,897 - 102,095,115 (-)NCBICHM1_1
T2T-CHM13v2.02101,856,061 - 101,933,872 (-)NCBIT2T-CHM13v2.0
Rfx8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39139,704,459 - 39,760,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl139,704,461 - 39,760,157 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38139,665,299 - 39,720,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl139,665,301 - 39,720,997 (-)Ensemblmm10GRCm38
MGSCv37139,722,146 - 39,777,834 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36139,609,847 - 39,665,539 (-)NCBIMGSCv36mm8
Celera139,463,844 - 39,494,609 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map118.41NCBI
Rfx8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554707,128,322 - 7,191,393 (-)Ensembl
ChiLan1.0NW_0049554707,128,811 - 7,191,466 (-)NCBIChiLan1.0ChiLan1.0
RFX8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21226,752,260 - 26,829,423 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A26,754,992 - 26,832,184 (+)NCBINHGRI_mPanPan1
PanPan1.12A102,373,895 - 102,450,759 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A102,373,895 - 102,443,339 (-)EnsemblpanPan2panpan1.1
RFX8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11041,464,882 - 41,521,157 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1041,464,820 - 41,520,988 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1041,390,216 - 41,446,317 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01042,332,535 - 42,388,886 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1042,144,936 - 42,389,052 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11042,047,443 - 42,103,777 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01042,329,717 - 42,385,850 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01042,519,425 - 42,575,775 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rfx8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629290,867,246 - 90,937,268 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936713195,816 - 260,179 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936713195,795 - 260,143 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RFX8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl352,841,111 - 52,909,214 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1352,841,215 - 52,909,209 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2355,387,460 - 55,455,537 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RFX8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,097,386 - 5,174,563 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,097,572 - 5,174,130 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041172,763,930 - 172,841,772 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rfx8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247496,077,966 - 6,134,381 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247496,076,640 - 6,134,330 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rfx8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14115,916,749 - 115,977,797 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rfx8
595 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:144
Count of miRNA genes:114
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000047654
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
BE116648  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2941,990,253 - 41,990,403 (+)MAPPERmRatBN7.2
Rnor_6.0946,446,051 - 46,446,200NCBIRnor6.0
Rnor_5.0946,132,915 - 46,133,064UniSTSRnor5.0
RGSC_v3.4938,873,611 - 38,873,760UniSTSRGSC3.4
Celera939,738,651 - 39,738,800UniSTS
RH 3.4 Map9388.3UniSTS
Cytogenetic Map9q21UniSTS
AI454710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2941,962,397 - 41,962,549 (+)MAPPERmRatBN7.2
Rnor_6.0946,419,216 - 46,419,367NCBIRnor6.0
Rnor_5.0946,106,053 - 46,106,204UniSTSRnor5.0
RGSC_v3.4938,847,445 - 38,847,596UniSTSRGSC3.4
Celera939,711,855 - 39,712,006UniSTS
RH 3.4 Map9388.4UniSTS
Cytogenetic Map9q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 36 59 6 299 136 11 140 80 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000078196   ⟹   ENSRNOP00000072601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl949,453,289 - 49,514,771 (-)Ensembl
mRatBN7.2 Ensembl941,957,596 - 42,021,848 (-)Ensembl
Rnor_6.0 Ensembl946,414,564 - 46,475,040 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108584   ⟹   ENSRNOP00000085957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl949,453,289 - 49,515,134 (-)Ensembl
mRatBN7.2 Ensembl941,957,596 - 42,021,848 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000161743   ⟹   ENSRNOP00000110617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl949,453,289 - 49,515,134 (-)Ensembl
RefSeq Acc Id: XM_039084546   ⟹   XP_038940474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,453,282 - 49,517,123 (-)NCBI
mRatBN7.2941,957,589 - 42,021,432 (-)NCBI
RefSeq Acc Id: XM_039084547   ⟹   XP_038940475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8949,453,282 - 49,517,123 (-)NCBI
mRatBN7.2941,957,589 - 42,021,432 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038940474 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940475 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99188 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072601.3
  ENSRNOP00000085957
  ENSRNOP00000085957.2
  ENSRNOP00000110617
  ENSRNOP00000110617.1
Ensembl Acc Id: ENSRNOP00000072601   ⟸   ENSRNOT00000078196
RefSeq Acc Id: XP_038940475   ⟸   XM_039084547
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GDI7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940474   ⟸   XM_039084546
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K3E1 (UniProtKB/TrEMBL),   A0A8I6GDI7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085957   ⟸   ENSRNOT00000108584
Ensembl Acc Id: ENSRNOP00000110617   ⟸   ENSRNOT00000161743

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3E1-F1-model_v2 AlphaFold A0A0G2K3E1 1-597 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696629
Promoter ID:EPDNEW_R7152
Type:initiation region
Name:Rfx8_1
Description:RFX family member 8, lacking RFX DNA binding domain
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0946,475,100 - 46,475,160EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560724 AgrOrtholog
BioCyc Gene G2FUF-27737 BioCyc
Ensembl Genes ENSRNOG00000058243 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078196.3 UniProtKB/TrEMBL
  ENSRNOT00000108584 ENTREZGENE
  ENSRNOT00000108584.2 UniProtKB/TrEMBL
  ENSRNOT00000161743 ENTREZGENE
  ENSRNOT00000161743.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro RFX-like UniProtKB/TrEMBL
  RFX1-4/6/8-like_BCD UniProtKB/TrEMBL
  RFX_DNA-bd UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene 501127 ENTREZGENE
PANTHER DNA-BINDING PROTEIN RFX8 UniProtKB/TrEMBL
  PTHR12619 UniProtKB/TrEMBL
Pfam BCD_RFX UniProtKB/TrEMBL
  RFX_DNA_binding UniProtKB/TrEMBL
PhenoGen Rfx8 PhenoGen
PROSITE RFX_DBD UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058243 RatGTEx
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A0G2K3E1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GDI7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M522_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-09-08 Rfx8  regulatory factor X8  Rfx8  RFX family member 8, lacking RFX DNA binding domain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Rfx8  RFX family member 8, lacking RFX DNA binding domain  RGD1565676  similar to regulatory factor X domain containing 1  Data merged from RGD:1565676 737654 PROVISIONAL
2012-11-21 Rfx8  RFX family member 8, lacking RFX DNA binding domain  Rfx8  RFX gene family member 8, lacking RFX DNA binding domain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-11 Rfx8  RFX gene family member 8, lacking RFX DNA binding domain  Rfx8  regulatory factor X 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Rfx8  regulatory factor X 8  RGD1560724  similar to FLJ42986 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565676  similar to regulatory factor X domain containing 1   RGD1565676_predicted  similar to regulatory factor X domain containing 1 (predicted)  'predicted' is removed 2292626 APPROVED
2008-04-30 RGD1560724  similar to FLJ42986 protein   RGD1560724_predicted  similar to FLJ42986 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565676_predicted  similar to regulatory factor X domain containing 1 (predicted)  LOC501128  similar to regulatory factor X domain containing 1  Symbol and Name status set to approved 1299863 APPROVED
2006-03-07 RGD1560724_predicted  similar to FLJ42986 protein (predicted)  LOC501127  similar to FLJ42986 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501128  similar to regulatory factor X domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-02-09 LOC501127  similar to FLJ42986 protein      Symbol and Name status set to provisional 70820 PROVISIONAL