Ftl1l5 (ferritin light chain 1 like 5) - Rat Genome Database

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Gene: Ftl1l5 (ferritin light chain 1 like 5) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ftl1l5 (Ensembl: AC115277.1)
Name: ferritin light chain 1 like 5
RGD ID: 1560687
Description: Predicted to enable ferric iron binding activity and ferrous iron binding activity. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain); INTERACTS WITH bisphenol A; lidocaine; rotenone.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ferritin light chain 1-like; LOC500804; RGD1560687; similar to Ferritin light chain (Ferritin L subunit)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8712,295,404 - 12,871,512 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl263,270,578 - 63,305,917 (-)EnsemblGRCr8
GRCr8 Ensembl712,870,798 - 12,871,349 (+)EnsemblGRCr8
mRatBN7.2712,220,109 - 12,221,018 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl261,543,323 - 61,578,556 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl712,220,103 - 12,221,023 (+)EnsemblmRatBN7.2
Rnor_6.0715,362,899 - 15,386,478 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0715,527,742 - 15,551,320 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4713,799,349 - 13,799,900 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera710,290,947 - 10,314,410 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)
lidocaine  (EXP)
rotenone  (EXP)
testosterone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Ftl1l5
6021 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:45
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000042108
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 1 18 69 34 30 18 64 18 6 170 97 4 62 42 51 12 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000042108   ⟹   ENSRNOP00000065071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl712,220,103 - 12,221,023 (+)Ensembl
Rnor_6.0 Ensembl715,385,868 - 15,386,419 (+)Ensembl
RefSeq Acc Id: XM_039080052   ⟹   XP_038935980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,295,404 - 12,871,512 (+)NCBI
mRatBN7.2712,220,109 - 12,221,018 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038935980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065071
  ENSRNOP00000065071.1
  ENSRNOP00000090717.1
  ENSRNOP00000102077.1
  ENSRNOP00000109088.1
RefSeq Acc Id: XP_038935980   ⟸   XM_039080052
- UniProtKB: M0R6L9 (UniProtKB/TrEMBL),   A0A8I6GIG4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000065071   ⟸   ENSRNOT00000042108
Protein Domains
Ferritin-like diiron

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R6L9-F1-model_v2 AlphaFold M0R6L9 1-183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560687 AgrOrtholog
BioCyc Gene G2FUF-34786 BioCyc
Ensembl Genes ENSRNOG00000004662 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000065602 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042108 ENTREZGENE
  ENSRNOT00000042108.7 UniProtKB/TrEMBL
  ENSRNOT00000096014.2 UniProtKB/TrEMBL
  ENSRNOT00000148687.1 UniProtKB/TrEMBL
  ENSRNOT00000153469.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.10 UniProtKB/TrEMBL
InterPro Ferritin UniProtKB/TrEMBL
  Ferritin-like UniProtKB/TrEMBL
  Ferritin-like_diiron UniProtKB/TrEMBL
  Ferritin-like_SF UniProtKB/TrEMBL
  Ferritin_CS UniProtKB/TrEMBL
  Ferritin_DPS_dom UniProtKB/TrEMBL
NCBI Gene 500804 ENTREZGENE
PANTHER FERRITIN LIGHT CHAIN UniProtKB/TrEMBL
  PTHR11431 UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/TrEMBL
PhenoGen Ftl1l5 PhenoGen
PROSITE FERRITIN_1 UniProtKB/TrEMBL
  FERRITIN_2 UniProtKB/TrEMBL
  FERRITIN_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004662 RatGTEx
  ENSRNOG00000065602 RatGTEx
Superfamily-SCOP SSF47240 UniProtKB/TrEMBL
UniProt A0A8I6GIG4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L171_RAT UniProtKB/TrEMBL
  M0R6L9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Ftl1l5  ferritin light chain 1 like 5  RGD1560687  similar to Ferritin light chain (Ferritin L subunit)  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1560687  similar to Ferritin light chain (Ferritin L subunit)   RGD1560687_predicted  similar to Ferritin light chain (Ferritin L subunit) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560687_predicted  similar to Ferritin light chain (Ferritin L subunit) (predicted)  LOC500804  similar to Ferritin light chain (Ferritin L subunit)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500804  similar to Ferritin light chain (Ferritin L subunit)      Symbol and Name status set to provisional 70820 PROVISIONAL