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Gene: Rufy4 (RUN and FYVE domain containing 4) Rattus norvegicus

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Symbol:

Rufy4

Name:

RUN and FYVE domain containing 4

RGD ID:

1560678

Description:

Predicted to enable dynactin binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including positive regulation of bone resorption; positive regulation of transport; and vacuole organization. Predicted to be located in endolysosome. Predicted to be active in autophagosome. Orthologous to human RUFY4 (RUN and FYVE domain containing 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dioxygen.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC301510; RGD1560678; RUN and FYVE domain-containing protein 4; similar to FLJ46536 protein

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RUFY4 (RUN and FYVE domain containing 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL
Mus musculus (house mouse):	Rufy4 (RUN and FYVE domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rufy4 (RUN and FYVE domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RUFY4 (RUN and FYVE domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RUFY4 (RUN and FYVE domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rufy4 (RUN and FYVE domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RUFY4 (RUN and FYVE domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RUFY4 (RUN and FYVE domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rufy4 (RUN and FYVE domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rufy4 (RUN and FYVE domain containing 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RUFY4 (RUN and FYVE domain containing 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rufy4 (RUN and FYVE domain containing 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100486003	Alliance	DIOPT (OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	LOC100486003	Alliance	DIOPT (OrthoInspector\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,152,139 - 83,172,683 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	83,154,445 - 83,172,897 (+)	Ensembl				GRCr8
mRatBN7.2	9	75,702,937 - 75,727,719 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	75,703,750 - 75,723,525 (+)	Ensembl				mRatBN7.2
Rnor_6.0	9	81,401,080 - 81,422,016 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	81,402,124 - 81,421,990 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	81,166,869 - 81,187,696 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	73,446,811 - 73,464,490 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	73,280,221 - 73,301,145 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

carbon nanotube (ISO)

D-glucose (ISO)

dioxygen (EXP)

ethylparaben (ISO)

glucose (ISO)

glyphosate (EXP)

mono(2-ethylhexyl) phthalate (ISO)

ozone (ISO)

PCB138 (ISO)

perfluorooctane-1-sulfonic acid (ISO)

tetraphene (ISO)

trichloroethene (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome assembly (IBA,IEA,ISO)

autophagy (IEA)

cellular response to interleukin-4 (IEA,ISO)

multivesicular body-lysosome fusion (IEA,ISO)

positive regulation of bone resorption (IEA,ISO)

positive regulation of exocytosis (IEA,ISO)

positive regulation of macroautophagy (IBA,IEA,ISO)

positive regulation of retrograde axon cargo transport (IEA,ISO)

Cellular Component

autophagosome (IBA,IEA,ISO)

cytoplasmic vesicle (IEA)

endolysosome (IEA,ISO)

lysosome (IEA)

Molecular Function

dynactin binding (IEA,ISO)

metal ion binding (IEA)

phosphatidylinositol-3-phosphate binding (IBA,IEA,ISO)

protein binding (ISO)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:26416964

Genomics

Comparative Map Data

Rufy4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	83,152,139 - 83,172,683 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	83,154,445 - 83,172,897 (+)	Ensembl				GRCr8
mRatBN7.2	9	75,702,937 - 75,727,719 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	75,703,750 - 75,723,525 (+)	Ensembl				mRatBN7.2
Rnor_6.0	9	81,401,080 - 81,422,016 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	81,402,124 - 81,421,990 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	81,166,869 - 81,187,696 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	73,446,811 - 73,464,490 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	73,280,221 - 73,301,145 (+)	NCBI		Celera
Cytogenetic Map	9	q33	NCBI

RUFY4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	218,034,934 - 218,090,652 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	218,034,960 - 218,090,584 (+)	Ensembl			hg38	GRCh38
GRCh37	2	218,899,657 - 218,955,307 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	218,646,285 - 218,663,108 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	2	212,667,545 - 212,721,497 (+)	NCBI		Celera
Cytogenetic Map	2	q35	NCBI
HuRef	2	210,753,571 - 210,795,629 (+)	NCBI		HuRef
HuRef	2	210,806,734 - 210,808,063 (+)	NCBI		HuRef
CHM1_1	2	218,906,131 - 218,961,799 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	218,519,258 - 218,576,350 (+)	NCBI		T2T-CHM13v2.0

Rufy4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	74,163,768 - 74,187,389 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	74,164,700 - 74,187,382 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	74,124,433 - 74,148,230 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	74,125,541 - 74,148,223 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	74,172,115 - 74,194,804 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	74,058,748 - 74,081,430 (+)	NCBI		MGSCv36	mm8
Celera	1	74,686,822 - 74,709,585 (+)	NCBI		Celera
Cytogenetic Map	1	C3	NCBI
cM Map	1	38.38	NCBI

Rufy4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	15,242,954 - 15,257,976 (-)	Ensembl
ChiLan1.0	NW_004955453	15,243,125 - 15,259,086 (-)	NCBI	ChiLan1.0	ChiLan1.0

RUFY4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	120,704,607 - 120,726,807 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	120,719,574 - 120,741,774 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	105,331,522 - 105,353,934 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	223,930,456 - 223,952,939 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	223,932,041 - 223,952,939 (+)	Ensembl			panPan2	panpan1.1

RUFY4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	37	24,809,365 - 24,830,254 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	37	24,809,359 - 24,829,724 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	37	25,629,499 - 25,650,965 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	37	24,825,220 - 24,846,781 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	37	24,827,074 - 24,845,718 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	37	24,730,722 - 24,752,283 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	37	24,665,154 - 24,686,674 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	37	24,684,349 - 24,705,920 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rufy4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	174,312,123 - 174,333,037 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936569	657,071 - 675,292 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936569	654,904 - 676,012 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RUFY4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	120,192,235 - 120,213,462 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	120,193,657 - 120,213,625 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	133,247,484 - 133,269,106 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RUFY4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	103,958,208 - 103,979,948 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	103,958,495 - 103,979,410 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666040	95,415,317 - 95,437,513 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rufy4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624823	6,908,636 - 6,925,863 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624823	6,908,113 - 6,927,724 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rufy4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	147,578,825 - 147,597,064 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rufy4
128 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	45
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000046019
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631656	Bp108	Blood pressure QTL 108	5.97	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	56047863	101047863	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
1582203	Gluco19	Glucose level QTL 19	3.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	63376862	108376862	Rat
724515	Uae16	Urinary albumin excretion QTL 16	8		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	65657365	108376720	Rat
61352	Bp34	Blood pressure QTL 34	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	82168823	86720295	Rat
8662828	Vetf6	Vascular elastic tissue fragility QTL 6	3.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	9	44458256	99506504	Rat
1598834	Memor11	Memory QTL 11	2.5		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	9	44458256	85262605	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
724544	Uae9	Urinary albumin excretion QTL 9	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	9	64220169	109220169	Rat
1578760	Cm53	Cardiac mass QTL 53	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	64220169	109220169	Rat
2290450	Scl57	Serum cholesterol level QTL 57	4.15		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	9	44458256	121768150	Rat
1581580	Uae34	Urinary albumin excretion QTL 34			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	64220169	109220169	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
1300134	Bp185	Blood pressure QTL 185	3.73		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	68875497	121768150	Rat
1354626	Bvd1	Brain ventricular dilatation QTL 1	3.73	0.001	brain ventricle morphology trait (VT:0000822)	hydrocephalus severity score (CMO:0001881)	9	83161999	118999486	Rat
731164	Uae25	Urinary albumin excretion QTL 25	3.5	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	9	48718864	108376862	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1578757	Pur6	Proteinuria QTL 6	3.3	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	9	64220169	109220169	Rat
4889943	Bss90	Bone structure and strength QTL 90	4.1		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	9	54506504	99506504	Rat

Markers in Region

D9Rat90

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	9	83,161,999 - 83,162,207 (+)	Marker Load Pipeline
mRatBN7.2	9	75,712,843 - 75,713,051 (+)	MAPPER	mRatBN7.2
Rnor_6.0	9	81,411,073 - 81,411,292	NCBI	Rnor6.0
Rnor_5.0	9	81,176,785 - 81,177,004	UniSTS	Rnor5.0
RGSC_v3.4	9	73,454,285 - 73,454,505	RGD	RGSC3.4
RGSC_v3.4	9	73,454,286 - 73,454,505	UniSTS	RGSC3.4
Celera	9	73,290,214 - 73,290,421	UniSTS
RGSC_v3.1	9	73,601,268 - 73,601,487	RGD
RH 3.4 Map	9	698.4	RGD
RH 3.4 Map	9	698.4	UniSTS
RH 2.0 Map	9	772.6	RGD
SHRSP x BN Map	9	51.1998	RGD
FHH x ACI Map	9	49.02	RGD
Cytogenetic Map	9	q33	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
15	3	50	132	57	56	25	72	25	6	272	152	11	104	78	82	31	9	9

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001431248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431249	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001431251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006226876	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006245288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017596824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017603884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039084637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268159	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063268160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000046019 ⟹ ENSRNOP00000042319

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	83,154,445 - 83,172,897 (+)	Ensembl
mRatBN7.2 Ensembl	9	75,703,750 - 75,723,525 (+)	Ensembl
Rnor_6.0 Ensembl	9	81,402,124 - 81,421,769 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083595 ⟹ ENSRNOP00000069107

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	9	81,403,270 - 81,421,990 (+)	Ensembl

RefSeq Acc Id:

XM_006245288 ⟹ XP_006245350

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	83,152,139 - 83,172,683 (+)	NCBI
mRatBN7.2	9	75,702,937 - 75,727,719 (+)	NCBI
Rnor_6.0	9	81,401,080 - 81,422,016 (+)	NCBI
Rnor_5.0	9	81,166,869 - 81,187,696 (+)	NCBI

Sequence:

show sequence

CTGCGACGTGGGGAGAAGGGCAACGCCCCCGGCCCGCCCCGTCGGGAGTCCGCCTCCGCCTCCG
CTACCGCTCCGCCAGGCAGTGGGAGTGCGGGGGCCCGGCCAGGGGCGGTGACACGGACGCTGGA
GGCAGTCTGTAGGGAGGGGACCCGAGGGCGCGGGAACCCGGGAGGGGCTGTGGCGGAATCCCCG
AGACTGGCTGAGCTGGGAGCGCGTGAAAGAGAGCAACGCCGTGACTAGTGAATGACTGAGAGAC
TGACACCAGAGAAGAGATCTGAAGGGACAGAAACGATGGCACGGAGGACAAGGGGGGCCCAGGG
GTAGATCCGGCTCTGCACTGGGAAGAAGGGCGGGACGTGGAGCAGAGAACAGCAGTCACCAGGA
CCAACCGCCCCATGTCAGACTGGCATAGAAAAAGGATGACCCCAGCACCAGAAAGCTGAGTGAA
GTCAGCGAAAGAGGCCACCCTACACCGAGCAGCCCACCTGAGGTTTCCATCCCGGGGAAGTGGG
TACCAGGACTGGAAGGAAGGTACCCCGACACTGGCCGGGATCCCGCTGCTGGCTGGGTCTAGAC
CCTCACCCATCTGTATGTAAGGAAAGCAAGCAGCCGAGCCCAGAGAATCACAGGAGGTCACCTT
ACTTTCAAGTCTCCATGGCAGAAAAGGAAACCATCCTCAAGATCAGCAGGAACTTGAAAAATGC
TGTCTCTGCCATCCTCCAGGGATATGGGGACGGGCAGGGGCCAGTGACAGACACAAGTGCCGAG
CTACACAGACTCTGTGGCTGCCTGGAGCTGCTCCTGCAGTTTGACCAGAAAGAGCAGAGGAGCT
TCCTGGGGGCTCGGAAGGATTACTGGGACTTCCTGTTCACTGCCCTTCGGCGGCAGCGGGGATA
CACAGAGCAGATGAACTTCATATGCTCACAGGACAAGCTGAAGACCTCGCTAGGAAAAGGCCGT
GCCTTTATCCGACTCTGCCTTGCCCATGGACAGCTGGCTGAGTCCATGCAGCTGTGCCTCCTGA
ACCCACAACTCACCAGGGAATGGTATGGCCCTCGGAGCCCTCTGCTGTGCCCTGAGCTCCAGGG
AGACATCTTGGACTCTCTCTATACCCTCAATGGAGTTGCCTTCAACCTGGACCTGCAACGGCCA
GACCTGGATGAAGCCTGGCCCATGTTCTCAGAATCCCACTATTCCAGTCCCAGCCGGACCCGGG
AAAGAAGACCCAGAAAACCCAAAGGTTTTCCAGAGGAGGTGAGATGCTCCAAGGGACAGCAGCT
GCAGGGACCAGAGGCTGGAGGAACCAGCTGTCTTCAAGATGCAACCACAGAAGACCTCCCACCT
GACCTCCGTACCCCCTTGCAGCAAGACCATCTTCCCACCTTTCTGGAAGAGAAGAGGGAGGATT
CCAGAAGCCTCAGTTGTCCCCAGAGCATTTGGGAAACAGGAAGGGAAGGATTTCGGCTAGACCA
GGAGGGAGGCCCAAAGACCAGGAAATTGCTGGAAAACTCAACAGCCAGCATCCAGCAACAGAAG
GGTGGGGCTAAGGATGTTCAAATGCAGCTGACAGGAAGGAAAGATGAAGGAAAAGGAAGTCTGC
CAGGGACGGAAGGTCGGAAAACAACAGAAGGGATCCAGGAAAGGGCAACAGATTGGAACCATGC
CCAGGAGCTGCTGGCCCCCAGCCTTCAGGGAAGGGAAGAAGATGCAGAGTTGGGATACAGGCAT
GGGTGGGATCAGCCTGGTGCTCTGGGGCAATCCTGGGTCCTGGGATCAAAGAAAGGTCCCACCA
CAGGGAAGCCACAAGAGTGGACAGGAGTAACCCGTGCAACCGTGCAGAAGGATCAAACAGAAGT
GCCCTTGCAGCAGGAGGTGATCAAGGAGCCTGGGTACGGCCTCCAGCTGACAGAGGTACAGGCC
CAGTGTCAAGAGCAGCTGCAGGCCCAGGAAGGAGAACTACAGGCACTCCAGGAGCAGCTCAGCA
GGTGTCAGGAAGAAAGAGCCCTGCTACAAGCAATGCTGGAACAGAAGCAGCAGGAGGCTGAGAG
GAGGGCTGCCATGTATGAGAAGGAGCTTGAAGGACAGAGGGACCTGGTCCAGGCCATGAAAAGG
AGGGTGTTGGAACTGATTCAGGAGAAGGACCACCAATGGCAGAGACTCCAACAGCTGTCTACTG
TGACCCCTGGACACTGCATGGGCTGCAACAAGGTCTTTAGGCGGCTGTCTCGGCGGTATCCTTG
CAGGCTCTGTGGAGGCCTGGTTTGCCATGCCTGCTCTGTAGACTACAAGAAGAGAGAGCGTTGC
TGCCCAGCCTGTGCCCAGCAGGAAGAAATCCAGGTCACCTGACCAAGATAGCACAAGGAACCTA
AGACCAGCCAGCCCACCAGCTCACTCTCGTCATTCCTCTTCCCAACCCTGGTGTCTGACTACTT
TTCTCTTCTGGGAGCTGGTGAGCTGTGACCCCAGCACTGCTGTGGAGGACCAGAGGGAACAGCT
GGCAGTCCACAGAGAGGCCTAGCTCTGCCTTTCTCGTGCAAGGGGCTGAGTGGAATGTGCCCAC
AGCTCTAGAAGCATTGTGTCTGATGAGGAAGACATGCTGTAACCTCTTTGTAAAGTCCCTTGAA
GCACAGTGAGTCATGACCATGAATAAGAGCAGCCCAGGGCTCAGCTGTTTCCAAGCCACACTCT
CCCTCCCCCATCACCTATAAGGAGGGAAGCCCAAATTCACTGGGCTCTTCAGGAACCTTCCCTC
TGATCTCCTTCCAGGATCATTGTCTTGTCTCATGTCTCACAGATTTACTGACGTGTGGTTGACA
TATAAAAACATTGTGTAAGTATGATGAGTTTTTAACTTTAATACACACCTATAAAGCCATCTCC
AAACACAGGCATCAGATCCAAGGCTTCCGCAACCGTCCTCCAGCTCCCGCCTCCATGCCGAGGC
AACCACTGACCCTGCCTCATATTACCTGGAAGCACAGCCGCTTCCTAGAAATCTGTAGTAGAAA
TGAAATTGTACAGTTCACTCTATTATTGCTACCTCAACACTGCATAATTGGTTTGAGATTTGTC
TAAGTATTGTGTG

hide sequence

RefSeq Acc Id:

XM_039084637 ⟹ XP_038940565

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	83,152,139 - 83,172,683 (+)	NCBI
mRatBN7.2	9	75,702,937 - 75,727,719 (+)	NCBI

RefSeq Acc Id:

XM_063268159 ⟹ XP_063124229

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	83,152,139 - 83,172,683 (+)	NCBI

RefSeq Acc Id:

XM_063268160 ⟹ XP_063124230

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	83,152,697 - 83,172,683 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001418177	(Get FASTA)	NCBI Sequence Viewer
	NP_001418178	(Get FASTA)	NCBI Sequence Viewer
	NP_001418179	(Get FASTA)	NCBI Sequence Viewer
	NP_001418180	(Get FASTA)	NCBI Sequence Viewer
	XP_006245350	(Get FASTA)	NCBI Sequence Viewer
	XP_038940565	(Get FASTA)	NCBI Sequence Viewer
	XP_063124229	(Get FASTA)	NCBI Sequence Viewer
	XP_063124230	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL75334	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000042319
	ENSRNOP00000042319.7

RefSeq Acc Id:

XP_006245350 ⟸ XM_006245288

- Sequence:

show sequence

MAEKETILKISRNLKNAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQRSFLGAR
KDYWDFLFTALRRQRGYTEQMNFICSQDKLKTSLGKGRAFIRLCLAHGQLAESMQLCLLNPQLT
REWYGPRSPLLCPELQGDILDSLYTLNGVAFNLDLQRPDLDEAWPMFSESHYSSPSRTRERRPR
KPKGFPEEVRCSKGQQLQGPEAGGTSCLQDATTEDLPPDLRTPLQQDHLPTFLEEKREDSRSLS
CPQSIWETGREGFRLDQEGGPKTRKLLENSTASIQQQKGGAKDVQMQLTGRKDEGKGSLPGTEG
RKTTEGIQERATDWNHAQELLAPSLQGREEDAELGYRHGWDQPGALGQSWVLGSKKGPTTGKPQ
EWTGVTRATVQKDQTEVPLQQEVIKEPGYGLQLTEVQAQCQEQLQAQEGELQALQEQLSRCQEE
RALLQAMLEQKQQEAERRAAMYEKELEGQRDLVQAMKRRVLELIQEKDHQWQRLQQLSTVTPGH
CMGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPACAQQEEIQVT

hide sequence

Ensembl Acc Id:

ENSRNOP00000042319 ⟸ ENSRNOT00000046019

Ensembl Acc Id:

ENSRNOP00000069107 ⟸ ENSRNOT00000083595

RefSeq Acc Id:	XP_038940565 ⟸ XM_039084637
- UniProtKB:	F1M513 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063124229 ⟸ XM_063268159
- UniProtKB:	F1M513 (UniProtKB/TrEMBL)

RefSeq Acc Id:

XP_063124230 ⟸ XM_063268160

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2JUI2-F1-model_v2	AlphaFold	A0A0G2JUI2	1-563	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560678	AgrOrtholog
BioCyc Gene	G2FUF-27150	BioCyc
Ensembl Genes	ENSRNOG00000032991	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000046019	ENTREZGENE
	ENSRNOT00000046019.7	UniProtKB/TrEMBL
Gene3D-CATH	1.20.58.900	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	RUFY4	UniProtKB/TrEMBL
	Run	UniProtKB/TrEMBL
	Run_dom_sf	UniProtKB/TrEMBL
	Znf_FYVE-rel	UniProtKB/TrEMBL
	Znf_FYVE_PHD	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
KEGG Report	rno:301510	UniProtKB/TrEMBL
NCBI Gene	301510	ENTREZGENE
PANTHER	PTHR47732	UniProtKB/TrEMBL
	RUN AND FYVE DOMAIN-CONTAINING PROTEIN 4	UniProtKB/TrEMBL
Pfam	RUFY4	UniProtKB/TrEMBL
	RUN	UniProtKB/TrEMBL
PhenoGen	Rufy4	PhenoGen
PROSITE	RUN	UniProtKB/TrEMBL
	ZF_FYVE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000032991	RatGTEx
Superfamily-SCOP	FYVE_PHD_ZnF	UniProtKB/TrEMBL
	SSF140741	UniProtKB/TrEMBL
UniProt	F1M513	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-28	Rufy4	RUN and FYVE domain containing 4	RGD1560678_predicted	similar to FLJ46536 protein (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1560678_predicted	similar to FLJ46536 protein (predicted)	LOC301510	similar to FLJ46536 protein	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC301510	similar to FLJ46536 protein			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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