Stfa2l2 (stefin A2-like 2) - Rat Genome Database

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Gene: Stfa2l2 (stefin A2-like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Stfa2l2
Name: stefin A2-like 2
RGD ID: 1560676
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in peeling skin syndrome 4. Orthologous to human CSTA (cystatin A); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498087; RGD1560676; similar to stefin A2; stefin A2; stefin A2-like 3; stefin-2; Stfa2; Stfa2l3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,003,490 - 78,005,912 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1178,003,545 - 78,005,913 (+)EnsemblGRCr8
mRatBN7.21164,498,151 - 64,500,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,498,206 - 64,500,574 (+)EnsemblmRatBN7.2
Rnor_6.01167,451,583 - 67,454,007 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01170,540,416 - 70,542,837 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41166,357,714 - 66,360,075 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1163,967,872 - 64,002,487 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Variants

.
Variants in Stfa2l2
31 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
5 1 12 34 41 76 63 11 25 8 11 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000098787   ⟹   ENSRNOP00000091715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1178,003,545 - 78,005,913 (+)Ensembl
mRatBN7.2 Ensembl1164,498,206 - 64,500,574 (+)Ensembl
RefSeq Acc Id: XM_006248415   ⟹   XP_006248477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81178,003,490 - 78,005,912 (+)NCBI
mRatBN7.21164,498,151 - 64,500,576 (+)NCBI
Rnor_6.01167,451,583 - 67,454,007 (+)NCBI
Rnor_5.01170,540,416 - 70,542,837 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001417729 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248477 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000091715
  ENSRNOP00000091715.1
RefSeq Acc Id: XP_006248477   ⟸   XM_006248415
- Sequence:
Ensembl Acc Id: ENSRNOP00000091715   ⟸   ENSRNOT00000098787
Protein Domains
Cystatin

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560676 AgrOrtholog
BioCyc Gene G2FUF-21223 BioCyc
Ensembl Genes ENSRNOG00000063669 Ensembl
  ENSRNOG00000076506 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000098787 ENTREZGENE
  ENSRNOT00000098787.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.10 UniProtKB/TrEMBL
InterPro Cystatin_dom UniProtKB/TrEMBL
  Cystatin_sf UniProtKB/TrEMBL
  Prot_inh_cystat_CS UniProtKB/TrEMBL
  Prot_inh_stefin UniProtKB/TrEMBL
NCBI Gene 498087 ENTREZGENE
PANTHER CYSTATIN-A UniProtKB/TrEMBL
  PTHR11414 UniProtKB/TrEMBL
Pfam Cystatin UniProtKB/TrEMBL
PhenoGen Stfa2l2 PhenoGen
PRINTS STEFINA UniProtKB/TrEMBL
PROSITE CYSTATIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000063669 RatGTEx
  ENSRNOG00000076506 RatGTEx
SMART SM00043 UniProtKB/TrEMBL
Superfamily-SCOP SSF54403 UniProtKB/TrEMBL
UniProt A0A8I6GJV2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-22 Stfa2l2  stefin A2-like 2  Stfa2l2  stefin A2-like 2  Data merged from RGD:149736207 737654 PROVISIONAL
2021-08-09 Stfa2l2  stefin A2-like 2      Symbol and Name status set to provisional 45752 PROVISIONAL
2015-11-06 Stfa2l2  stefin A2-like 2  Stfa2l3  stefin A2-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-18 Stfa2l3  stefin A2-like 3  RGD1560676_predicted  similar to stefin A2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560676_predicted  similar to stefin A2 (predicted)  LOC498087  similar to stefin A2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498087  similar to stefin A2      Symbol and Name status set to provisional 70820 PROVISIONAL