Wwc3 (WWC family member 3) - Rat Genome Database

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Gene: Wwc3 (WWC family member 3) Rattus norvegicus
Analyze
Symbol: Wwc3
Name: WWC family member 3
RGD ID: 1560666
Description: Predicted to enable kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of organ growth; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hippo signaling. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human WWC3 (WWC family member 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC317439; RGD1560666; similar to KIAA1280 protein
RGD Orthologs
Human
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X27,146,018 - 27,263,446 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX27,145,812 - 27,263,446 (+)EnsemblGRCr8
mRatBN7.2X23,584,204 - 23,701,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX23,584,424 - 23,700,513 (+)EnsemblmRatBN7.2
Rnor_6.0X24,872,496 - 24,988,671 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX24,891,156 - 24,988,741 (+)Ensemblrn6Rnor6.0
Rnor_5.0X25,285,806 - 25,399,864 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X44,209,446 - 44,326,141 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX24,016,315 - 24,130,906 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24682284   PMID:29393412  


Genomics

Comparative Map Data
Wwc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X27,146,018 - 27,263,446 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX27,145,812 - 27,263,446 (+)EnsemblGRCr8
mRatBN7.2X23,584,204 - 23,701,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX23,584,424 - 23,700,513 (+)EnsemblmRatBN7.2
Rnor_6.0X24,872,496 - 24,988,671 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX24,891,156 - 24,988,741 (+)Ensemblrn6Rnor6.0
Rnor_5.0X25,285,806 - 25,399,864 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X44,209,446 - 44,326,141 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX24,016,315 - 24,130,906 (+)NCBICelera
Cytogenetic MapXq13NCBI
WWC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X10,015,254 - 10,144,474 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX10,015,254 - 10,144,474 (+)Ensemblhg38GRCh38
GRCh37X9,983,294 - 10,112,514 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X9,943,795 - 10,072,518 (+)NCBIBuild 36Build 36hg18NCBI36
CeleraX14,155,064 - 14,283,798 (+)NCBICelera
Cytogenetic MapXp22.2NCBI
HuRefX7,861,614 - 7,942,180 (+)NCBIHuRef
CHM1_1X10,014,187 - 10,142,938 (+)NCBICHM1_1
T2T-CHM13v2.0X9,597,786 - 9,727,019 (+)NCBIT2T-CHM13v2.0
Wwc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555443,012,474 - 3,126,518 (-)Ensembl
ChiLan1.0NW_0049555443,012,602 - 3,126,518 (-)NCBIChiLan1.0ChiLan1.0
WWC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X11,817,013 - 11,946,745 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X11,820,777 - 11,950,408 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X2,645,114 - 2,774,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X9,946,561 - 10,027,781 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX9,946,558 - 10,027,781 (+)EnsemblpanPan2panpan1.1
WWC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X6,716,428 - 6,836,381 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX6,716,357 - 6,834,146 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX6,672,442 - 6,792,352 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X6,663,033 - 6,783,024 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX6,662,086 - 6,783,017 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X6,653,536 - 6,773,455 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X6,688,729 - 6,808,638 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X6,679,128 - 6,799,042 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wwc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X19,357 - 130,180 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647019,351 - 130,180 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647019,357 - 127,591 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WWC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX6,815,202 - 6,930,934 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X6,815,648 - 6,930,939 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X7,165,920 - 7,330,740 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WWC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X8,471,537 - 8,600,474 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX8,471,578 - 8,600,516 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666237558 - 78,336 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wwc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248824,161,485 - 4,271,362 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248824,161,565 - 4,270,837 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Wwc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X27,464,577 - 27,574,385 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wwc3
432 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:109
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000059295, ENSRNOT00000071173
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat

Markers in Region
DXMco1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X27,159,480 - 27,159,684 (+)Marker Load Pipeline
mRatBN7.2X23,597,894 - 23,598,098 (+)MAPPERmRatBN7.2
Rnor_6.0X24,885,623 - 24,885,826NCBIRnor6.0
Rnor_5.0X25,298,800 - 25,299,003UniSTSRnor5.0
RGSC_v3.4X44,223,229 - 44,223,433RGDRGSC3.4
RGSC_v3.4X44,223,230 - 44,223,433UniSTSRGSC3.4
CeleraX24,028,041 - 24,028,244UniSTS
RGSC_v3.1X44,276,698 - 44,276,902RGD
Cytogenetic MapXq21UniSTS
RH130302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X23,701,555 - 23,701,748 (+)MAPPERmRatBN7.2
Rnor_6.0X24,988,363 - 24,988,555NCBIRnor6.0
Rnor_5.0X25,399,556 - 25,399,748UniSTSRnor5.0
RGSC_v3.4X44,327,846 - 44,328,038UniSTSRGSC3.4
CeleraX24,130,598 - 24,130,790UniSTS
Cytogenetic MapXq21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071173   ⟹   ENSRNOP00000065846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX27,145,812 - 27,263,446 (+)Ensembl
mRatBN7.2 EnsemblX23,584,424 - 23,700,513 (+)Ensembl
Rnor_6.0 EnsemblX24,891,156 - 24,988,741 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131278   ⟹   ENSRNOP00000099111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX27,164,406 - 27,263,446 (+)Ensembl
RefSeq Acc Id: NM_001427611   ⟹   NP_001414540
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X27,146,018 - 27,263,446 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001414540 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90595 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065846
  ENSRNOP00000065846.4
  ENSRNOP00000099111.1
Ensembl Acc Id: ENSRNOP00000065846   ⟸   ENSRNOT00000071173
RefSeq Acc Id: NP_001414540   ⟸   NM_001427611
- UniProtKB: M0R8P6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099111   ⟸   ENSRNOT00000131278

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8P6-F1-model_v2 AlphaFold M0R8P6 1-1126 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560666 AgrOrtholog
BioCyc Gene G2FUF-2686 BioCyc
Ensembl Genes ENSRNOG00000024250 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071173 ENTREZGENE
  ENSRNOT00000071173.4 UniProtKB/TrEMBL
  ENSRNOT00000131278.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2_WWC UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
  WWC/KIBRA_Hippo_Reg UniProtKB/TrEMBL
NCBI Gene 317439 ENTREZGENE
PANTHER BOMB/KIRA PROTEINS UniProtKB/TrEMBL
  PROTEIN WWC3 UniProtKB/TrEMBL
Pfam PF00397 UniProtKB/TrEMBL
  WWC1 UniProtKB/TrEMBL
PhenoGen Wwc3 PhenoGen
PROSITE PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024250 RatGTEx
SMART SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A0ABK0LCN8_RAT UniProtKB/TrEMBL
  M0R8P6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-26 Wwc3  WWC family member 3  RGD1560666  similar to KIAA1280 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560666  similar to KIAA1280 protein   RGD1560666_predicted  similar to KIAA1280 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560666_predicted  similar to KIAA1280 protein (predicted)  LOC317439  similar to KIAA1280 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317439  similar to KIAA1280 protein      Symbol and Name status set to provisional 70820 PROVISIONAL