Lbhd2 (LBH domain containing 2) - Rat Genome Database

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Gene: Lbhd2 (LBH domain containing 2) Rattus norvegicus
Analyze
Symbol: Lbhd2
Name: LBH domain containing 2
RGD ID: 1560608
Description: Orthologous to human LBHD2 (LBH domain containing 2); INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC500724; LBH domain-containing protein 2; LOC500724; RGD1560608; similar to novel protein; uncharacterized protein LOC500724
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,263,383 - 136,268,422 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6136,263,572 - 136,268,422 (+)EnsemblGRCr8
mRatBN7.26130,442,388 - 130,447,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,442,388 - 130,447,229 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6130,612,362 - 130,617,217 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,908,350 - 130,913,205 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,272,495 - 130,277,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06135,856,218 - 135,861,059 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,856,218 - 135,861,059 (+)Ensemblrn6Rnor6.0
Rnor_5.06144,554,563 - 144,559,562 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46136,162,243 - 136,167,084 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6127,999,177 - 128,004,018 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Lbhd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,263,383 - 136,268,422 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6136,263,572 - 136,268,422 (+)EnsemblGRCr8
mRatBN7.26130,442,388 - 130,447,229 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,442,388 - 130,447,229 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6130,612,362 - 130,617,217 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06130,908,350 - 130,913,205 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,272,495 - 130,277,336 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06135,856,218 - 135,861,059 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6135,856,218 - 135,861,059 (+)Ensemblrn6Rnor6.0
Rnor_5.06144,554,563 - 144,559,562 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46136,162,243 - 136,167,084 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6127,999,177 - 128,004,018 (+)NCBICelera
Cytogenetic Map6q32NCBI
LBHD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814103,084,210 - 103,090,027 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14103,084,210 - 103,090,027 (+)Ensemblhg38GRCh38
GRCh3714103,550,547 - 103,556,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map14q32.32NCBI
CHM1_114103,488,342 - 103,494,151 (+)NCBICHM1_1
T2T-CHM13v2.01497,320,461 - 97,326,278 (+)NCBIT2T-CHM13v2.0
Lbhd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,368,485 - 111,378,526 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,373,243 - 111,378,524 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812111,402,049 - 111,412,092 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,406,809 - 111,412,090 (+)Ensemblmm10GRCm38
MGSCv3712112,645,020 - 112,650,288 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612111,854,623 - 111,859,900 (+)NCBIMGSCv36mm8
Celera12112,596,929 - 112,602,196 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.98NCBI
LBHD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215104,237,500 - 104,245,005 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114103,453,998 - 103,461,461 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01483,705,828 - 83,712,039 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114103,519,924 - 103,525,795 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14103,521,713 - 103,525,567 (+)EnsemblpanPan2panpan1.1
LBHD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1870,935,313 - 70,939,013 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,447,587 - 70,451,297 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0871,212,177 - 71,215,887 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl871,211,104 - 71,215,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1870,875,765 - 70,879,476 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0870,940,515 - 70,944,229 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0871,340,511 - 71,344,225 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lbhd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086403,102,374 - 3,107,677 (-)NCBIHiC_Itri_2
LBHD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605368,252,698 - 68,258,585 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lbhd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247341,594,785 - 1,601,245 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lbhd2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17128,981,187 - 128,986,083 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lbhd2
273 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:122
Interacting mature miRNAs:131
Transcripts:ENSRNOT00000066715
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6131392689143944780Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
BE120929  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,446,999 - 130,447,163 (+)MAPPERmRatBN7.2
Rnor_6.06135,860,830 - 135,860,993NCBIRnor6.0
Rnor_5.06144,554,641 - 144,554,804UniSTSRnor5.0
RGSC_v3.46136,166,855 - 136,167,018UniSTSRGSC3.4
Celera6128,003,789 - 128,003,952UniSTS
RH 3.4 Map6780.81UniSTS
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 5 19 116 57 56 26 25 26 4 167 63 1 98 69 75 30 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000066715   ⟹   ENSRNOP00000062808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6136,263,581 - 136,268,422 (+)Ensembl
mRatBN7.2 Ensembl6130,442,388 - 130,447,229 (+)Ensembl
Rnor_6.0 Ensembl6135,856,218 - 135,861,059 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000173652   ⟹   ENSRNOP00000105946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6136,263,572 - 136,268,422 (+)Ensembl
RefSeq Acc Id: NM_001109280   ⟹   NP_001102750
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,263,581 - 136,268,422 (+)NCBI
mRatBN7.26130,442,388 - 130,447,229 (+)NCBI
Rnor_6.06135,856,218 - 135,861,059 (+)NCBI
Rnor_5.06144,554,563 - 144,559,562 (-)NCBI
RGSC_v3.46136,162,243 - 136,167,084 (+)RGD
Celera6127,999,177 - 128,004,018 (+)RGD
Sequence:
RefSeq Acc Id: XM_063262342   ⟹   XP_063118412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,263,383 - 136,268,381 (+)NCBI
RefSeq Acc Id: XM_063262344   ⟹   XP_063118414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,263,383 - 136,268,381 (+)NCBI
RefSeq Acc Id: XM_063262345   ⟹   XP_063118415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,265,237 - 136,268,381 (+)NCBI
RefSeq Acc Id: NP_001102750   ⟸   NM_001109280
- UniProtKB: D3ZC31 (UniProtKB/TrEMBL),   A6KBQ6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062808   ⟸   ENSRNOT00000066715
RefSeq Acc Id: XP_063118412   ⟸   XM_063262342
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063118414   ⟸   XM_063262344
- Peptide Label: isoform X1
- UniProtKB: A6KBQ6 (UniProtKB/TrEMBL),   D3ZC31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118415   ⟸   XM_063262345
- Peptide Label: isoform X1
- UniProtKB: A6KBQ6 (UniProtKB/TrEMBL),   D3ZC31 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105946   ⟸   ENSRNOT00000173652
Protein Domains
LBH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZC31-F1-model_v2 AlphaFold D3ZC31 1-119 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560608 AgrOrtholog
BioCyc Gene G2FUF-35852 BioCyc
Ensembl Genes ENSRNOG00000043137 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066715 ENTREZGENE
  ENSRNOT00000066715.3 UniProtKB/TrEMBL
  ENSRNOT00000173652.1 UniProtKB/TrEMBL
InterPro LBH_dom UniProtKB/TrEMBL
  LBH_dom_prot UniProtKB/TrEMBL
KEGG Report rno:500724 UniProtKB/TrEMBL
NCBI Gene 500724 ENTREZGENE
PANTHER LBH DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
  PTHR14987 UniProtKB/TrEMBL
Pfam Lbh UniProtKB/TrEMBL
PhenoGen Lbhd2 PhenoGen
RatGTEx ENSRNOG00000043137 RatGTEx
UniProt A0ABK0LLT7_RAT UniProtKB/TrEMBL
  A6KBQ6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZC31 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Lbhd2  LBH domain containing 2  RGD1560608  similar to novel protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560608  similar to novel protein   RGD1560608_predicted  similar to novel protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560608_predicted  similar to novel protein (predicted)  LOC500724  similar to novel protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500724  similar to novel protein      Symbol and Name status set to provisional 70820 PROVISIONAL