Tpi1l1 (triosephosphate isomerase 1 like 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tpi1l1 (triosephosphate isomerase 1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tpi1l1
Name: triosephosphate isomerase 1 like 1
RGD ID: 1560534
Description: Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and triosephosphate isomerase deficiency. Orthologous to human TPI1 (triosephosphate isomerase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC094212.1; LOC500959; triosephosphate isomerase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8831,923,596 - 31,931,244 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl831,923,232 - 31,931,327 (-)EnsemblGRCr8
mRatBN7.2823,647,760 - 23,654,967 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl823,647,764 - 23,655,504 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx827,706,793 - 27,707,577 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0826,004,079 - 26,004,863 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0823,873,462 - 23,874,246 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd831,949,180 - 31,949,964 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive834,105,811 - 34,106,595 (-)NCBILyon_Normotensive
Lyon_Hypertensive832,680,547 - 32,681,331 (-)NCBILyon_Hypertensive
F344_StmMcwi824,020,235 - 24,021,019 (-)NCBIF344_StmMcwi
Rnor_6.0826,341,789 - 26,342,573 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl826,341,732 - 26,345,754 (-)NCBIrn6Rnor6.0
Rnor_5.0826,363,796 - 26,364,580 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4824,852,575 - 24,853,359 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera825,217,433 - 25,218,217 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Tpi1l1
30 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 46 65 135 93 11 45 35 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000091773   ⟹   ENSRNOP00000070014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl831,923,642 - 31,931,271 (-)Ensembl
mRatBN7.2 Ensembl823,647,764 - 23,655,504 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136992   ⟹   ENSRNOP00000102104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl831,923,439 - 31,931,099 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000137431   ⟹   ENSRNOP00000105024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl831,923,706 - 31,930,611 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143390   ⟹   ENSRNOP00000099247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl831,923,670 - 31,931,327 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000149546   ⟹   ENSRNOP00000105930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl831,923,956 - 31,930,304 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000151482   ⟹   ENSRNOP00000104877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl831,923,232 - 31,930,848 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000161730   ⟹   ENSRNOP00000107941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl831,923,561 - 31,928,009 (-)Ensembl
RefSeq Acc Id: NM_001033072   ⟹   NP_001028244
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8831,924,153 - 31,924,937 (-)NCBI
mRatBN7.2823,648,317 - 23,649,101 (-)NCBI
Dahl_SR_JrHsd831,949,180 - 31,949,964 (-)NCBI
Lyon_Normotensive834,105,811 - 34,106,595 (-)NCBI
Lyon_Hypertensive832,680,547 - 32,681,331 (-)NCBI
F344_StmMcwi824,020,235 - 24,021,019 (-)NCBI
Rnor_6.0826,341,789 - 26,342,573 (-)NCBI
Rnor_5.0826,363,796 - 26,364,580 (-)NCBI
RGSC_v3.4824,852,575 - 24,853,359 (-)RGD
Celera825,217,433 - 25,218,217 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081927   ⟹   XP_038937855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8831,923,596 - 31,931,244 (-)NCBI
mRatBN7.2823,647,760 - 23,654,967 (-)NCBI
RefSeq Acc Id: XM_063265962   ⟹   XP_063122032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8831,923,596 - 31,931,242 (-)NCBI
RefSeq Acc Id: NP_001028244   ⟸   NM_001033072
- UniProtKB: Q6SA19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038937855   ⟸   XM_039081927
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000070014   ⟸   ENSRNOT00000091773
RefSeq Acc Id: XP_063122032   ⟸   XM_063265962
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000102104   ⟸   ENSRNOT00000136992
Ensembl Acc Id: ENSRNOP00000107941   ⟸   ENSRNOT00000161730
Ensembl Acc Id: ENSRNOP00000099247   ⟸   ENSRNOT00000143390
Ensembl Acc Id: ENSRNOP00000105024   ⟸   ENSRNOT00000137431
Ensembl Acc Id: ENSRNOP00000104877   ⟸   ENSRNOT00000151482
Ensembl Acc Id: ENSRNOP00000105930   ⟸   ENSRNOT00000149546

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JWU1-F1-model_v2 AlphaFold A0A0G2JWU1 1-253 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560534 AgrOrtholog
BioCyc Gene G2FUF-31333 BioCyc
BioCyc Pathway ANAGLYCOLYSIS-PWY [glycolysis III (from glucose)] BioCyc
  PWY66-373 [sucrose degradation V (sucrose alpha-glucosidase)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image ANAGLYCOLYSIS-PWY BioCyc
  PWY66-373 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000055222 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091773.3 UniProtKB/TrEMBL
  ENSRNOT00000136992.1 UniProtKB/TrEMBL
  ENSRNOT00000137431.1 UniProtKB/TrEMBL
  ENSRNOT00000143390.1 UniProtKB/TrEMBL
  ENSRNOT00000149546 ENTREZGENE
  ENSRNOT00000149546.1 UniProtKB/TrEMBL
  ENSRNOT00000151482.1 UniProtKB/TrEMBL
  ENSRNOT00000161730.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  TIM_sf UniProtKB/TrEMBL
  TrioseP_Isoase_bac/euk UniProtKB/TrEMBL
  Triosephosphate_isomerase UniProtKB/TrEMBL
  Triosephosphate_isomerase_AS UniProtKB/TrEMBL
KEGG Report rno:500959 UniProtKB/TrEMBL
NCBI Gene 500959 ENTREZGENE
PANTHER Triophos_ismrse UniProtKB/TrEMBL
  TRIOSEPHOSPHATE ISOMERASE UniProtKB/TrEMBL
Pfam TIM UniProtKB/TrEMBL
PhenoGen Tpi1l1 PhenoGen
PROSITE TIM_1 UniProtKB/TrEMBL
  TIM_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055222 RatGTEx
Superfamily-SCOP Triophos_ismrse UniProtKB/TrEMBL
UniProt A0A0G2JWU1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L547_RAT UniProtKB/TrEMBL
  A0ABK0LJE4_RAT UniProtKB/TrEMBL
  A0ABK0M2V3_RAT UniProtKB/TrEMBL
  Q6SA19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Tpi1l1  triosephosphate isomerase 1 like 1  LOC500959  triosephosphate isomerase  Symbol and Name Changed 1299863 APPROVED
2022-06-02 LOC500959  triosephosphate isomerase  AC094212.1    Data merged from RGD:15009298 737654 PROVISIONAL
2019-11-08 AC094212.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2006-02-09 LOC500959  triosephosphate isomerase      Symbol and Name status set to provisional 70820 PROVISIONAL