Defa7 (defensin alpha 7) - Rat Genome Database

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Gene: Defa7 (defensin alpha 7) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Defa7 (Ensembl: Np4)
Name: defensin alpha 7 (Ensembl:defensin NP-4 precursor)
RGD ID: 1560529
Description: Predicted to be involved in defense response to bacterium; defense response to fungus; and killing of cells of another organism. Predicted to be located in extracellular space; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; decabromodiphenyl ether; tetrachloromethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha-defensin 7
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81677,121,608 - 77,133,013 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1677,121,639 - 77,122,502 (-)EnsemblGRCr8
mRatBN7.21670,419,152 - 70,430,555 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1670,419,277 - 70,420,046 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1675,692,984 - 75,693,753 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01679,146,396 - 79,147,165 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01674,395,818 - 74,396,587 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01675,414,786 - 75,415,555 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01675,029,574 - 75,030,343 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41675,101,479 - 75,102,248 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1668,291,841 - 68,292,610 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Defa7
39 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:58
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000029297
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165942871491442908Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165942871491442908Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165942871491442908Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164909919691442908Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)167523528581732231Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat


Expression

RNA-SEQ Expression

appendage
ectoderm
mesenchyme
mesoderm
musculoskeletal system
nervous system
reproductive system
1 5 5 5 6 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000029297   ⟹   ENSRNOP00000037267
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1670,419,277 - 70,420,046 (-)Ensembl
RefSeq Acc Id: NR_172012
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81677,121,608 - 77,133,013 (-)NCBI
mRatBN7.21670,419,152 - 70,430,555 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001028247 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT68750 (Get FASTA)   NCBI Sequence Viewer  
  AAT68758 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000037267.3
Ensembl Acc Id: ENSRNOP00000037267   ⟸   ENSRNOT00000029297
Protein Domains
Mammalian defensins

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560529 AgrOrtholog
BioCyc Gene G2FUF-10832 BioCyc
Ensembl Genes ENSRNOG00000028707 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029297.5 UniProtKB/TrEMBL
InterPro Alpha-defensin UniProtKB/TrEMBL
  Defensin_beta/neutrophil UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
  Mammalian_defensins UniProtKB/TrEMBL
NCBI Gene 613222 ENTREZGENE
PANTHER DEFENSIN ALPHA 10-RELATED UniProtKB/TrEMBL
  PTHR11876 UniProtKB/TrEMBL
Pfam Defensin_1 UniProtKB/TrEMBL
  Defensin_propep UniProtKB/TrEMBL
PhenoGen Defa7 PhenoGen
PIRSF Alpha-defensin UniProtKB/TrEMBL
PROSITE DEFENSIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028707 RatGTEx
SMART Defensin_propep UniProtKB/TrEMBL
  DEFSN UniProtKB/TrEMBL
Superfamily-SCOP Defensin-like UniProtKB/TrEMBL
UniProt F1LQB7 ENTREZGENE, UniProtKB/TrEMBL
  Q4JEI7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Defa7  defensin alpha 7      Symbol and Name status set to provisional 70820 PROVISIONAL