Klhl34 (kelch-like family member 34) - Rat Genome Database

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Pathways
Gene: Klhl34 (kelch-like family member 34) Rattus norvegicus
Analyze
Symbol: Klhl34
Name: kelch-like family member 34
RGD ID: 1560439
Description: Orthologous to human KLHL34 (kelch like family member 34); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; paracetamol; 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kelch-like 34; kelch-like 34 (Drosophila); kelch-like protein 34; LOC302703; RGD1560439; similar to hypothetical protein FLJ34960
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X40,966,366 - 40,969,121 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX40,965,659 - 40,968,796 (-)EnsemblGRCr8
mRatBN7.2X37,151,298 - 37,154,053 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX37,151,592 - 37,153,529 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX38,338,155 - 38,340,910 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X41,805,347 - 41,808,102 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X39,490,064 - 39,492,819 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X39,952,576 - 39,956,856 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX39,954,904 - 39,956,841 (-)Ensemblrn6Rnor6.0
Rnor_5.0X40,262,136 - 40,266,740 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X58,443,590 - 58,445,527 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX37,782,912 - 37,787,192 (-)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22664934  


Genomics

Comparative Map Data
Klhl34
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X40,966,366 - 40,969,121 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX40,965,659 - 40,968,796 (-)EnsemblGRCr8
mRatBN7.2X37,151,298 - 37,154,053 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX37,151,592 - 37,153,529 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX38,338,155 - 38,340,910 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X41,805,347 - 41,808,102 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X39,490,064 - 39,492,819 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X39,952,576 - 39,956,856 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX39,954,904 - 39,956,841 (-)Ensemblrn6Rnor6.0
Rnor_5.0X40,262,136 - 40,266,740 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X58,443,590 - 58,445,527 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX37,782,912 - 37,787,192 (-)NCBICelera
Cytogenetic MapXq21NCBI
KLHL34
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X21,654,690 - 21,658,330 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX21,654,690 - 21,658,330 (-)Ensemblhg38GRCh38
GRCh37X21,672,808 - 21,676,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X21,583,530 - 21,586,369 (-)NCBIBuild 36Build 36hg18NCBI36
CeleraX25,794,508 - 25,797,347 (-)NCBICelera
Cytogenetic MapXp22.12NCBI
HuRefX19,415,982 - 19,418,607 (-)NCBIHuRef
CHM1_1X21,704,026 - 21,706,865 (-)NCBICHM1_1
T2T-CHM13v2.0X21,238,012 - 21,241,652 (-)NCBIT2T-CHM13v2.0
Klhl34
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X156,600,919 - 156,603,658 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX156,601,431 - 156,603,365 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X157,818,435 - 157,821,060 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX157,818,435 - 157,820,369 (+)Ensemblmm10GRCm38
MGSCv37X154,256,367 - 154,258,301 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X153,162,191 - 153,165,165 (+)NCBIMGSCv36mm8
CeleraX141,068,737 - 141,070,671 (+)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX72.76NCBI
Klhl34
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555091,988,613 - 1,990,553 (-)Ensembl
ChiLan1.0NW_0049555091,985,511 - 1,990,569 (-)NCBIChiLan1.0ChiLan1.0
KLHL34
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X23,462,556 - 23,469,630 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X23,465,946 - 23,469,584 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X14,285,938 - 14,291,694 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X21,640,814 - 21,644,494 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX21,641,967 - 21,643,901 (-)EnsemblpanPan2panpan1.1
KLHL34
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X17,464,569 - 17,467,749 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX17,465,756 - 17,467,711 (-)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.0X17,422,652 - 17,427,179 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX17,425,206 - 17,427,161 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X17,456,923 - 17,461,452 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X17,478,642 - 17,483,162 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X17,538,546 - 17,543,067 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klhl34
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X10,429,005 - 10,434,672 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366242,721,201 - 2,727,123 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL34
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX17,839,245 - 17,841,191 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X17,838,070 - 17,841,718 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KLHL34
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X20,119,366 - 20,125,858 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX20,120,936 - 20,122,867 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605621,983,390 - 21,987,933 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl34
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248296,559,206 - 6,561,143 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248296,557,889 - 6,563,799 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Klhl34
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X36,689,428 - 36,694,876 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klhl34
16 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:29
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000050708
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2447036044931007Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X400149344939387Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2447036045082063Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X197044046970440Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X811148653111486Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 64 87 36 38 9 15 9 6 173 108 9 69 39 73 29 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000050708   ⟹   ENSRNOP00000051191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX40,965,659 - 40,968,796 (-)Ensembl
mRatBN7.2 EnsemblX37,151,592 - 37,153,529 (-)Ensembl
Rnor_6.0 EnsemblX39,954,904 - 39,956,841 (-)Ensembl
RefSeq Acc Id: NM_001401129   ⟹   NP_001388058
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X40,966,366 - 40,969,121 (-)NCBI
mRatBN7.2X37,151,298 - 37,154,053 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001388058 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051191.4
Ensembl Acc Id: ENSRNOP00000051191   ⟸   ENSRNOT00000050708
RefSeq Acc Id: NP_001388058   ⟸   NM_001401129
- UniProtKB: D3ZY10 (UniProtKB/TrEMBL),   A6IPP2 (UniProtKB/TrEMBL)
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZY10-F1-model_v2 AlphaFold D3ZY10 1-645 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560439 AgrOrtholog
BioCyc Gene G2FUF-2471 BioCyc
Ensembl Genes ENSRNOG00000024479 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050708.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
  Potassium Channel Kv1.1, Chain A UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Kelch-like_gigaxonin UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
NCBI Gene 302703 ENTREZGENE
PANTHER KELCH-LIKE PROTEIN 34 UniProtKB/TrEMBL
  LD33804P UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_KLHDC2_KLHL20_DRC7 UniProtKB/TrEMBL
PhenoGen Klhl34 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024479 RatGTEx
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniProt A6IPP2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZY10 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Klhl34  kelch-like family member 34  Klhl34  kelch-like 34 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Klhl34  kelch-like 34 (Drosophila)  RGD1560439_predicted  similar to hypothetical protein FLJ34960 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560439_predicted  similar to hypothetical protein FLJ34960 (predicted)  LOC302703  similar to hypothetical protein FLJ34960  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC302703  similar to hypothetical protein FLJ34960      Symbol and Name status set to provisional 70820 PROVISIONAL