Nemp2 (nuclear envelope integral membrane protein 2) - Rat Genome Database

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Gene: Nemp2 (nuclear envelope integral membrane protein 2) Rattus norvegicus
Analyze
Symbol: Nemp2
Name: nuclear envelope integral membrane protein 2
RGD ID: 1560421
Description: Predicted to be located in nuclear inner membrane. Predicted to be active in nuclear envelope. Orthologous to human NEMP2 (nuclear envelope integral membrane protein 2); INTERACTS WITH acetamide; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC503257; LOC685327; RGD1560421; similar to Protein KIAA0286; similar to RIKEN cDNA 5330401P04; Tmem194b; transmembrane protein 194B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,353,233 - 56,372,586 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl956,353,233 - 56,372,493 (-)EnsemblGRCr8
mRatBN7.2948,861,252 - 48,880,565 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,861,252 - 48,880,512 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx957,403,304 - 57,422,604 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,526,134 - 62,545,434 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,822,129 - 60,841,431 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,713,598 - 53,732,858 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,713,598 - 53,732,858 (-)Ensemblrn6Rnor6.0
Rnor_5.0953,380,915 - 53,400,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4945,848,645 - 45,867,905 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera946,529,998 - 46,549,258 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Nemp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,353,233 - 56,372,586 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl956,353,233 - 56,372,493 (-)EnsemblGRCr8
mRatBN7.2948,861,252 - 48,880,565 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,861,252 - 48,880,512 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx957,403,304 - 57,422,604 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0962,526,134 - 62,545,434 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0960,822,129 - 60,841,431 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0953,713,598 - 53,732,858 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl953,713,598 - 53,732,858 (-)Ensemblrn6Rnor6.0
Rnor_5.0953,380,915 - 53,400,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4945,848,645 - 45,867,905 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera946,529,998 - 46,549,258 (-)NCBICelera
Cytogenetic Map9q22NCBI
NEMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,421,421 - 190,648,785 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,504,338 - 190,534,722 (-)Ensemblhg38GRCh38
GRCh372191,369,064 - 191,399,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,077,313 - 191,108,164 (-)NCBIBuild 36Build 36hg18NCBI36
Celera2184,966,557 - 184,994,411 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2183,231,166 - 183,259,021 (-)NCBIHuRef
CHM1_12191,377,431 - 191,405,282 (-)NCBICHM1_1
T2T-CHM13v2.02190,930,561 - 191,096,453 (-)NCBIT2T-CHM13v2.0
Nemp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,669,850 - 52,691,078 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,669,862 - 52,691,078 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38152,568,535 - 52,651,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,630,703 - 52,651,919 (+)Ensemblmm10GRCm38
MGSCv37152,687,549 - 52,708,763 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36152,575,292 - 52,595,181 (+)NCBIMGSCv36mm8
Celera153,171,476 - 53,192,690 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.99NCBI
Nemp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,596,778 - 8,618,508 (+)Ensembl
ChiLan1.0NW_0049554038,602,056 - 8,620,417 (+)NCBIChiLan1.0ChiLan1.0
NEMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,172,608 - 93,217,039 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,201,714 - 93,232,023 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B77,792,444 - 77,836,649 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B195,709,125 - 195,752,471 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B195,727,677 - 195,744,992 (-)EnsemblpanPan2panpan1.1
NEMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,073,117 - 1,104,249 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,085,482 - 1,096,484 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha372,024,384 - 2,053,286 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.037962,678 - 991,577 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37970,288 - 991,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137972,716 - 1,001,544 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037940,563 - 969,417 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037969,154 - 998,068 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nemp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,167,855 - 149,190,491 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,656,225 - 7,670,225 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,647,575 - 7,670,215 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,097,154 - 95,140,478 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11595,111,131 - 95,513,414 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215106,492,684 - 106,519,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NEMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,007,127 - 76,036,169 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,009,416 - 76,026,235 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040123,436,456 - 123,464,596 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nemp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,540,486 - 5,557,971 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248545,534,535 - 5,562,172 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nemp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14122,720,731 - 122,738,239 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nemp2
132 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:641
Count of miRNA genes:281
Interacting mature miRNAs:356
Transcripts:ENSRNOT00000029204
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)956047863101047863Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)948718864108376862Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)95450650499506504Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat

Markers in Region
RH132026  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,861,323 - 48,861,533 (+)MAPPERmRatBN7.2
Rnor_6.0953,713,670 - 53,713,879NCBIRnor6.0
Rnor_5.0953,380,987 - 53,381,196UniSTSRnor5.0
RGSC_v3.4945,848,717 - 45,848,926UniSTSRGSC3.4
Celera946,530,070 - 46,530,279UniSTS
Cytogenetic Map9q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000029204   ⟹   ENSRNOP00000032860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl956,353,233 - 56,372,493 (-)Ensembl
mRatBN7.2 Ensembl948,861,252 - 48,880,512 (-)Ensembl
Rnor_6.0 Ensembl953,713,598 - 53,732,858 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113308   ⟹   ENSRNOP00000079039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,862,406 - 48,880,512 (-)Ensembl
RefSeq Acc Id: NM_001134642   ⟹   NP_001128114
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,353,233 - 56,372,493 (-)NCBI
mRatBN7.2948,861,252 - 48,880,512 (-)NCBI
Rnor_6.0953,713,598 - 53,732,858 (-)NCBI
Rnor_5.0953,380,915 - 53,400,175 (-)NCBI
RGSC_v3.4945,848,645 - 45,867,905 (-)RGD
Celera946,529,998 - 46,549,258 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084132   ⟹   XP_038940060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,355,244 - 56,372,586 (-)NCBI
mRatBN7.2948,863,430 - 48,880,565 (-)NCBI
RefSeq Acc Id: XM_039084133   ⟹   XP_038940061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,358,801 - 56,372,586 (-)NCBI
mRatBN7.2948,866,820 - 48,880,558 (-)NCBI
RefSeq Acc Id: NP_001128114   ⟸   NM_001134642
- Peptide Label: precursor
- UniProtKB: P0C8N6 (UniProtKB/Swiss-Prot),   A6INV9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032860   ⟸   ENSRNOT00000029204
RefSeq Acc Id: XP_038940060   ⟸   XM_039084132
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038940061   ⟸   XM_039084133
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G4K5 (UniProtKB/TrEMBL),   A6INW2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079039   ⟸   ENSRNOT00000113308

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C8N6-F1-model_v2 AlphaFold P0C8N6 1-421 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696654
Promoter ID:EPDNEW_R7179
Type:multiple initiation site
Name:Nemp2_1
Description:nuclear envelope integral membrane protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0953,732,863 - 53,732,923EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560421 AgrOrtholog
BioCyc Gene G2FUF-27613 BioCyc
Ensembl Genes ENSRNOG00000012924 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000029204 ENTREZGENE
  ENSRNOT00000029204.4 UniProtKB/Swiss-Prot
InterPro NEMP_fam UniProtKB/Swiss-Prot
KEGG Report rno:503257 UniProtKB/Swiss-Prot
NCBI Gene 503257 ENTREZGENE
PANTHER NUCLEAR ENVELOPE INTEGRAL MEMBRANE PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR13598 UniProtKB/Swiss-Prot
Pfam NEMP UniProtKB/Swiss-Prot
PhenoGen Nemp2 PhenoGen
RatGTEx ENSRNOG00000012924 RatGTEx
UniProt A0A8I6G4K5 ENTREZGENE
  A6INV9 ENTREZGENE, UniProtKB/TrEMBL
  A6INW2 ENTREZGENE, UniProtKB/TrEMBL
  NEMP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Nemp2  nuclear envelope integral membrane protein 2  LOC685327  similar to Protein KIAA0286  Data merged from RGD:1595121 737654 PROVISIONAL
2015-06-08 Nemp2  nuclear envelope integral membrane protein 2  Tmem194b  transmembrane protein 194B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-16 Tmem194b  transmembrane protein 194B   RGD1560421  similar to RIKEN cDNA 5330401P04   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560421  similar to RIKEN cDNA 5330401P04   RGD1560421_predicted  similar to RIKEN cDNA 5330401P04 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 LOC685327  similar to Protein KIAA0286  LOC682855  similar to Protein KIAA0286  Data merged from RGD:1593993 1643240 APPROVED
2006-11-20 LOC685327  similar to Protein KIAA0286      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682855  similar to Protein KIAA0286      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1560421_predicted  similar to RIKEN cDNA 5330401P04 (predicted)  LOC503257  similar to RIKEN cDNA 5330401P04  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC503257  similar to RIKEN cDNA 5330401P04      Symbol and Name status set to provisional 70820 PROVISIONAL