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Gene: Amer3 (APC membrane recruitment protein 3) Rattus norvegicus

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Symbol:

Amer3

Name:

APC membrane recruitment protein 3

RGD ID:

1560420

Description:

Predicted to enable beta-catenin binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Orthologous to human AMER3 (APC membrane recruitment protein 3); INTERACTS WITH bisphenol A; 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ortholog); 2,2',4,4',5,5'-hexachlorobiphenyl (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Fam123c; family with sequence similarity 123C; LOC501122; RGD1560420; similar to RIKEN cDNA 9430069J07 gene

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AMER3 (APC membrane recruitment protein 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Amer3 (APC membrane recruitment 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Amer3 (APC membrane recruitment protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AMER3 (APC membrane recruitment protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AMER3 (APC membrane recruitment protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Amer3 (APC membrane recruitment protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	AMER3 (APC membrane recruitment protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AMER3 (APC membrane recruitment protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Amer3 (APC membrane recruitment protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Amer3 (APC membrane recruitment protein 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SFRP5 (secreted frizzled related protein 5)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	AMER3 (APC membrane recruitment protein 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Amer3 (APC membrane recruitment 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	amer3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	amer3	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	amer3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	amer3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	44,286,274 - 44,298,246 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	44,268,722 - 44,351,398 (+)	Ensembl				GRCr8
mRatBN7.2	9	36,790,355 - 36,802,341 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	36,790,932 - 36,802,419 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	45,287,877 - 45,299,262 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	50,419,049 - 50,430,431 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	48,700,966 - 48,712,348 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	41,089,417 - 41,101,108 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	41,096,835 - 41,099,189 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	40,759,302 - 40,770,856 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	33,332,869 - 33,335,223 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	34,576,198 - 34,586,661 (+)	NCBI		Celera
Cytogenetic Map	9	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

esophageal atresia/tracheoesophageal fistula (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,4,4'-trichlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

Aflatoxin B2 alpha (ISO)

aflatoxin M1 (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

copper(II) sulfate (ISO)

dibutyl phthalate (ISO)

methapyrilene (ISO)

PCB138 (ISO)

pirinixic acid (ISO)

rotenone (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

triptonide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of canonical Wnt signaling pathway (IBA)

Wnt signaling pathway (IEA)

Cellular Component

nuclear body (ISO)

plasma membrane (IBA,IEA)

Molecular Function

beta-catenin binding (IBA)

lipid binding (IEA)

phosphatidylinositol-4,5-bisphosphate binding (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Amer3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	44,286,274 - 44,298,246 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	9	44,268,722 - 44,351,398 (+)	Ensembl				GRCr8
mRatBN7.2	9	36,790,355 - 36,802,341 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	36,790,932 - 36,802,419 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	9	45,287,877 - 45,299,262 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	50,419,049 - 50,430,431 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	48,700,966 - 48,712,348 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	41,089,417 - 41,101,108 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	41,096,835 - 41,099,189 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	9	40,759,302 - 40,770,856 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	9	33,332,869 - 33,335,223 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	9	34,576,198 - 34,586,661 (+)	NCBI		Celera
Cytogenetic Map	9	q21	NCBI

AMER3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	130,755,540 - 130,768,134 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	130,755,540 - 130,768,134 (+)	Ensembl			hg38	GRCh38
GRCh37	2	131,513,113 - 131,525,707 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	131,229,547 - 131,242,177 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	2	125,047,974 - 125,060,604 (-)	NCBI		Celera
Cytogenetic Map	2	q21.1	NCBI
HuRef	2	123,586,259 - 123,598,889 (+)	NCBI		HuRef
CHM1_1	2	131,517,083 - 131,529,713 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	131,189,705 - 131,202,299 (+)	NCBI		T2T-CHM13v2.0

Amer3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	34,617,988 - 34,630,025 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	34,618,738 - 34,630,025 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	34,578,907 - 34,590,944 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	34,579,657 - 34,590,944 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	34,636,538 - 34,647,789 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	34,524,273 - 34,535,487 (+)	NCBI		MGSCv36	mm8
Celera	1	34,345,622 - 34,356,836 (+)	NCBI		Celera
Cytogenetic Map	1	B	NCBI
cM Map	1	13.34	NCBI

Amer3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955459	267,754 - 277,422 (+)	NCBI	ChiLan1.0	ChiLan1.0

AMER3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	44,874,912 - 44,885,928 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	44,889,887 - 44,900,903 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	29,429,382 - 29,440,406 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	131,515,406 - 131,527,622 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	131,521,603 - 131,524,188 (+)	Ensembl			panPan2	panpan1.1

AMER3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	19	20,444,794 - 20,455,969 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	19	20,450,384 - 20,452,789 (+)	Ensembl			canFam3	CanFam3.1
ROS_Cfam_1.0	19	21,767,141 - 21,778,279 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	19	21,766,706 - 21,775,711 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	19	20,408,233 - 20,419,367 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	19	20,668,504 - 20,679,638 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	19	21,709,925 - 21,721,063 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Amer3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	100,373,849 - 100,383,953 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936469	41,238,646 - 41,244,623 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936469	41,234,187 - 41,244,603 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AMER3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	57,038,328 - 57,044,524 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	15	57,035,442 - 57,047,427 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	156,704,675 - 156,714,569 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AMER3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666037	410,471 - 421,307 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Amer3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624732	14,798,872 - 14,809,682 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Amer3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	4	110,809,917 - 110,821,749 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Amer3
123 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	54
Count of miRNA genes:	51
Interacting mature miRNAs:	54
Transcripts:	ENSRNOT00000033700
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303170	Bp332	Blood pressure QTL 332	3.73	0.027	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	9	6714888	84474983	Rat
631211	Bw4	Body weight QTL4	5.31		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	9	5346479	50346479	Rat
7411571	Bw138	Body weight QTL 138	14.3	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	9	40029925	85029925	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	8750492	53750492	Rat
1300180	Bw14	Body weight QTL 14	3.776		body mass (VT:0001259)	body weight (CMO:0000012)	9	31250432	68875676	Rat
61450	Ciaa3	CIA Autoantibody QTL 3	6.5		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	9	29567664	74567664	Rat
70186	Niddm26	Non-insulin dependent diabetes mellitus QTL 26	3.87		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	9	29567664	83835942	Rat
70218	Cm28	Cardiac mass QTL 28	8.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	9	41720295	86720295	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	496645	45496645	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	6214995	51214995	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	8750492	53750492	Rat
7207805	Bmd88	Bone mineral density QTL 88	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	9	31250432	65651574	Rat
61425	Cia15	Collagen induced arthritis QTL 15	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	9	5346479	50416711	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	496645	45496645	Rat
1600365	Mcs20	Mammary carcinoma susceptibility QTL 20	3		mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	9	21031430	49025574	Rat
1581517	Bp284	Blood pressure QTL 284			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	9	39220186	84220186	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	496645	45496645	Rat
7411656	Foco26	Food consumption QTL 26	9.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	40029925	85029925	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	6214995	51214995	Rat
1598823	Memor16	Memory QTL 16	1.9		exploratory behavior trait (VT:0010471)	difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	9	31456061	57460683	Rat
1641894	Alcrsp12	Alcohol response QTL 12			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	34960590	79960590	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	1	5	126	28	12	5	4	5	2	58	25	2	108	17	40	7	11	11

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001399352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001055491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006226789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006244725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063267585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033700 ⟹ ENSRNOP00000037826

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	44,268,722 - 44,298,756 (+)	Ensembl
mRatBN7.2 Ensembl	9	36,790,932 - 36,802,419 (+)	Ensembl
Rnor_6.0 Ensembl	9	41,096,835 - 41,099,189 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000144984 ⟹ ENSRNOP00000107825

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	44,268,921 - 44,298,887 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000153073 ⟹ ENSRNOP00000106776

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	44,285,989 - 44,351,398 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000167928 ⟹ ENSRNOP00000109696

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	9	44,285,989 - 44,299,463 (+)	Ensembl

RefSeq Acc Id:

NM_001399352 ⟹ NP_001386281

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	44,286,870 - 44,298,246 (+)	NCBI
mRatBN7.2	9	36,790,959 - 36,802,341 (+)	NCBI

RefSeq Acc Id:

XM_006244725 ⟹ XP_006244787

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	44,286,274 - 44,298,246 (+)	NCBI
mRatBN7.2	9	36,790,355 - 36,802,341 (+)	NCBI
Rnor_6.0	9	41,089,417 - 41,101,108 (+)	NCBI
Rnor_5.0	9	40,759,302 - 40,770,856 (+)	NCBI

Sequence:

show sequence

GAAATCAGCTCCAAGAAGGGGACATAAGGAAGATCCTAGACTACCCCACTTTGCCTCCCCACAT
CGACTTGCTCCTTTTTCAAGCCTCAGAACCCAGAGTCTTCAGTAGAACTTCTAGAGAGGCTGCG
TGTGACATCGTCTTTTGGAGAGAGCTGGAGTCAGCGGGCCCTGGACCTTCGGGATGCAAGAGGG
CGGGGCACCCACACCTGTAGTGTCCGGATACACCGGACGCCTCGGACTGGGGACCACAGGGGTT
TAGGGATGCAAAACCCACAGCATTATGGGAGCATCTAGGTGGGCAGAAGGAGAGAGATAGAACA
AAGCCAGCAATTCTTGGCGACGGCGGCGCAGTGGCGGCAGAGTCCCCTCGCTCCTCCGCTGCTC
GCCAGCGTCCTCCGGTCCCCGCCCTCCCAAGCGCGGCGGAGCTCCGGCTGGTGGTGCCCGCGGG
TGCCCGGAGGCCCGCCCCCCACGGCGGCGCGGAACCTGGAGCTGGCCGTGGTGCTGACGCGAGG
CTCGGGCGCGCACTCGCTGCCTGGCTCGGGCAGGGCCGCGCCCTGCGACACTCCCCAGCCCCGG
CGAGAGGAGAACCCATCGGGTCTAAAGCACCAAAGTCCAGCAAGATTTGTGAGCAGGGGCGGGC
TGGCCTTTCAGAGCCCACAGACTTTACAATTTTGCACAGTGGCAAGAAGATAACATGGAGCTGA
GGAGAGGAAAGACCTTTATCAAATCTAGTGTGCAGATTTCCCACGAGAAACTCATAGACTCCCC
AGCCAAGGAGGACCCAGACACTTGGTCACTCTCACTGGGAGAGCAGCAGAGAGCCCATGGCGAG
AGGAGCTCCCAAACAAGTCCCTGTGCCCAAGGGTATGGCCGATGCCCCAACAAAGAGGTACTGT
CTGACCCAGAAGGGGGTCCCGTGCCCCTCTGTGGAAACACTTTCAAGTTGGTGCGCAAGAGTAA
GACACATGACAATGTTCCAGGGGCTGTGAAGGCAGCAGCCCCCACAGGGCAAATGGTAGGTAGC
ACAAGCTTCACAGAGACCCCAGGAGGTCAGCGTATGATTGACTACCGCCACTTTGTGCCCCAGA
TGCCCTTCGTGCCAGCTGTGGCTAAGAGCATCCCAAGAAAAAGGATTTCCCTGAAAAGGTCCAA
GAAGTGCTTTCGAAACCTATTTCACATGCGCAGAAGCAAGACTGAGAACTTGGCCTCGCTCTCA
GCCAAGGGGAAGAACCTCTCCCCTCCCGGGGTCCCAGCGCAGCAAGGCAAGCCCTTCTTCTCCA
TGGGTGAGGGGCTGGGGCTGGACAGCCTATGCCAGGACCTGTCTGACAGTGAGTTTCTACATGA
CTCGCCCTTTGACCTCTGCAGCGCCCTGTGTGAGGATGTGGCCTCACTGAAAAGCTTCGATTCA
CTTACAGGTTGTGGGGAGATCTTTGCAGATGGGAGCTCGGTGCCATCTGTGGAGTTGAAGGACG
GCCCAGAGAGCCCAGCCCATTCACCGCAGGCTCTGGACAGCAAGACTCCCTGTGGCCCCTCCCA
GGGTAGTATGGAACAGCTGATGTCACCTGCCCAGAATGAAGCATCAGACTTCACCAAGTTCTGG
GACAGTGTGAATCGCTCTGTGCAGCAGCAGCAGCGTGCCCTGCTGGGCCCGTGGTTGATGAGTC
CCCAGGGAACAGAAACAGACCAACCCAGGCTGGACTCATCTGGGTTAGCTGAACTGCCCCTGTT
CCCTTGCAGGGGTCCCCCCAGTGGCTCCAAAGCCAGCTCCATAGACACAGGTACCCCCAAAAGT
GAACAGCCTGAATCTGTGTCCACAAGCGATGAAGGTTACTATGATTCCTTCTCACCAGGCCTCG
AGGAGGAGAAGAAGGAAGCTGCGAGCCCAGCCACGCCTGCAGCCGCTTTCCCCAGGGACAGCTA
CAGTGGGGACGCCCTCTATGAACTCTTCTATGACCCCAGCGAGGCTCCTGTTGGCCCAATCCTG
GATGATGACTGTGTGTCTGAGAGTCTCTCAGGACCTGCCTTGGGGACTCCGTTGTCTATGTGCA
GCTTTCGCGTGGGGGCAGAGGAGAACCTGGCCCCAGCGCCAGGCCCTGACTTGCTCAGTCAGGG
CTTCCTACAGAGTACCTGGAAGGGCAAGGAATGTTTGCTGAAGCTCTGTGACACAGAACTTGCT
ATCACCATGGGCATTGTCAACTGGCTGCGCAGAACCCCACAGGCCACTGCCCCTACCCCTGCAT
CTACCCCTGCCTCTACCCCTGCCATTGTCCTTCGGGAGCCCGCTGCCCCACCTGACCCCCATAG
AGTCCTCAGAGGAACATCAGCAGATATGAAAGGCAGGGAAGACCAGGCCTTAGACATGGGTAAG
GATGTGCAATGCTTTTCACCCAGTAGGCAGGTGCCCTGGGCGCATTCAGGAACCAAAGACTTGC
TTATTAGAGAGCGGGAAGTCCAAGGGGAGCCCGCAAGGGGTATAAATACCCCATCTAAAGATGG
ATCTCTAGAGGAAGGAACACAAAATGTCTCCGAAGGCCGGTCCTCCTCGGAAGTAACCACTACA
ACAAGCATTTCCAGGAATAGCAAAGCTGTAAACACTGCCACCCGTCTCAGTTCTCAGAAGGAAC
TCGGGACACCTGGGAACCTGAGGTGTTCTCAAGGTTCCTTAAGACCAGGGCCTGGAGGAAGTGC
TCTTGATCCAGGGCCCATGCTTGTGGGCTGTGTGGCAGCCCTGCAAATCTATCCAGACAGCCAT
TCTCCTAGACAGGATAAGGGCAATGGGCTCCTCTGGAAGCCTCAGGCTTGGGGTCCTAACGCTG
TGCTAAAGAAACCTACAAGCAGCAAACGCAATGAAGCAGCTGCCTGTGGCCTCTCCTCCTCAGC
CAGCCCACAAGACCAGAGATGTCATGACCTCTTCCTAGACCTGAACCAACTCACCTTGGAACCC
TCCAGGCTAGGTACCCAAGCCTGTGCCTCTGTGGACAGCCTGCCTCAGCAGCTCTGCCCCAGGG
CTCCAGAGCAAGTGCCACATAGGGGTTCAGTGGGGTCCTGAGCCACTCTGGGCCCCCAATGTCC
AGCCTCTGTGGCTATTTCCCAGAAATCCTGAGGCTTTCTTTGGACAGTGAGCAGTGGTAAGTCA
CTCCTTCCCCAGGAGTGGGCCAGGAAATGTGGCCACGGCCTTCTGAATGGACTTCTTGTGGATA
ACCAGAAGAGCGGGCTAACAAGGTGACCATGGCGCAGGTTCACCTACAGAATGGACGCACACTA
TTCAGGAACTGCATATGCATGACCTCATTCAGGAGAACCCTGGAAGGACCAGAATCTTTGTCTT
TATTATTTTTTTTCTGGCGTGAGGCTTGTGTTTGGGGTAGAGATGGTCGAGATCAGGTATGTGG
GGAGGGGGGATGGGGATGAGATGAGGGGATCATTGCCTGAGCCCGGGGCTAGAGACTGCTGGGA
GCTGTCTATGCTTAGCTGCCCCTCATGTCACAAGGACAGTTGATGGCCAGCAAGCAGTTCGTGG
TGTAAATGAAGACAGGGGTAGCCGTTTCATCTGTTTGAGGATAAGAGCCACGGCTCAGGAGGCG
GAAAACCTCATGGGGTTGAGTTGACAAGGACCCACTGGCTTCATCCAAGCCTACTCGTTACCAG
GATGGGAGACTGCCACACACTACAGCATCCCAGTGCTTCTGTTCAGGAACAACAAGGACCAGCA
AGAACCTGGAGCTGCCAGCATGGTGTAAGAGCACAGCTTTGCCAGGGCTGACCAGACCCTGCCT
GGTCAGTAGGTTCTGTCATAGGTAATTCTGTGCATTCCCTTCAGTTTGATCTCTGAAGCCTTGG
GTGGGTAAAAGCCCACTGTTTTCCCCACGTCTGCCATTCTGCCTTGGAGTTGCAAAGGCCTTGT
CTTCTGCCCTTTCCACTCCCAGCATGGCCACCTCTTCTCCAGGGAGCTCTCTGAAAGATGCCGG
GCTCACCACCCCTAACACAAAAGCAACACATGCACCAAACCCAGACATTCAGAATCAGGAAAGG
ACCTGCTGGATGCTGTCCCCATGAAGTGTAGAAATCTCTTCTGACCCAGCAAGAGGCCCAGGGA
GAGAGGGCCCATCCTCACTGCCAGGGATTTGATTCTACCTCAGCAAAAATAACACAGTGGTAGA
CAGAGGATGAGGACTTGACAGGTAGCTGTAAAATTTGTCACCAGGATCTTGCTTGCAGGCACAC
TGCTGGAGAGGCCACACTTCATACAGAGCTTCCGAGGAGAGGTGCAGGAATTCCAGACAAGCAC
TGAAGTCCCATTAGTAACATGTGTTCAAGGGCCGAGTGCTTCACTTCAGGCTAGAAAGTGTCTT
GTGATCTCTGGCATCAACAGTTCTCTAAGGCTGCTTGCTGTGTGTGAGACGAGGGCCGTAGGTT
AAAAGCAGACACCAAGGTTGTGGCCGTGTGCATCTGGAATCAAGGAAGCACACGGCCATTCACC
TGGGCATCCATGTGTCCTTCTCCTAGAACCCAGACCCCATCGTGACTTCATAATGACATCACTG
AGCCTGGCTCTGAATAAGTGACAAGTAGAAGACCATTCTGCATGACCCCTGCAGCAGTCTGAGG
TAAATTACGCTCATTTCAGACCTGGGGAGCAGGCACAGCTTGTGGGACCTTTCTGTGGACATAC
ACATGTAGGGTAGGCAGGTAGGGCGTTCGGATCCCGTCCATACCTTAGTACAAAAGCTCTACTA
TGCAGTCGGTTCTGGAACATTCCACTGGTCTTCCGCAGCCGATACTCCCAGAGCCTTCAGCCCT
TTCTTCTTCCAGGTCACAGATGCCTGAACACCCCAGGGTGCCAACCACATGTCTCTATGAGCAG
GCTGAGAGCTCAGTAAGGAGGCCACCCAACCCCAGTCACAGCCTTTGGGCTTTGTACTGTACTT
GACAGAGAAAGTGCTCAGTAAATACTTTTTTTTGAAAGAA

hide sequence

RefSeq Acc Id:

XM_063267585 ⟹ XP_063123655

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	44,290,043 - 44,298,246 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001386281	(Get FASTA)	NCBI Sequence Viewer
	XP_006244787	(Get FASTA)	NCBI Sequence Viewer
	XP_063123655	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000037826.4
	ENSRNOP00000106776.1
	ENSRNOP00000107825.1
	ENSRNOP00000109696
	ENSRNOP00000109696.1

RefSeq Acc Id:	XP_006244787 ⟸ XM_006244725
- Peptide Label:	isoform X1
- UniProtKB:	D3ZHS8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MELRRGKTFIKSSVQISHEKLIDSPAKEDPDTWSLSLGEQQRAHGERSSQTSPCAQGYGRCPNK EVLSDPEGGPVPLCGNTFKLVRKSKTHDNVPGAVKAAAPTGQMVGSTSFTETPGGQRMIDYRHF VPQMPFVPAVAKSIPRKRISLKRSKKCFRNLFHMRRSKTENLASLSAKGKNLSPPGVPAQQGKP FFSMGEGLGLDSLCQDLSDSEFLHDSPFDLCSALCEDVASLKSFDSLTGCGEIFADGSSVPSVE LKDGPESPAHSPQALDSKTPCGPSQGSMEQLMSPAQNEASDFTKFWDSVNRSVQQQQRALLGPW LMSPQGTETDQPRLDSSGLAELPLFPCRGPPSGSKASSIDTGTPKSEQPESVSTSDEGYYDSFS PGLEEEKKEAASPATPAAAFPRDSYSGDALYELFYDPSEAPVGPILDDDCVSESLSGPALGTPL SMCSFRVGAEENLAPAPGPDLLSQGFLQSTWKGKECLLKLCDTELAITMGIVNWLRRTPQATAP TPASTPASTPAIVLREPAAPPDPHRVLRGTSADMKGREDQALDMGKDVQCFSPSRQVPWAHSGT KDLLIREREVQGEPARGINTPSKDGSLEEGTQNVSEGRSSSEVTTTTSISRNSKAVNTATRLSS QKELGTPGNLRCSQGSLRPGPGGSALDPGPMLVGCVAALQIYPDSHSPRQDKGNGLLWKPQAWG PNAVLKKPTSSKRNEAAACGLSSSASPQDQRCHDLFLDLNQLTLEPSRLGTQACASVDSLPQQL CPRAPEQVPHRGSVGS hide sequence

Ensembl Acc Id:

ENSRNOP00000037826 ⟸ ENSRNOT00000033700

RefSeq Acc Id:	NP_001386281 ⟸ NM_001399352
- UniProtKB:	D3ZHS8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063123655 ⟸ XM_063267585
- Peptide Label:	isoform X1
- UniProtKB:	D3ZHS8 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000106776 ⟸ ENSRNOT00000153073

Ensembl Acc Id:

ENSRNOP00000109696 ⟸ ENSRNOT00000167928

Ensembl Acc Id:

ENSRNOP00000107825 ⟸ ENSRNOT00000144984

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZHS8-F1-model_v2	AlphaFold	D3ZHS8	1-784	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1560420	AgrOrtholog
BioCyc Gene	G2FUF-27854	BioCyc
Ensembl Genes	ENSRNOG00000023603	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000033700.6	UniProtKB/TrEMBL
	ENSRNOT00000144984.1	UniProtKB/TrEMBL
	ENSRNOT00000153073.1	UniProtKB/TrEMBL
	ENSRNOT00000167928	ENTREZGENE
	ENSRNOT00000167928.1	UniProtKB/TrEMBL
InterPro	WTX_protein	UniProtKB/TrEMBL
NCBI Gene	501122	ENTREZGENE
PANTHER	APC MEMBRANE RECRUITMENT PROTEIN 3	UniProtKB/TrEMBL
	PTHR22237	UniProtKB/TrEMBL
Pfam	WTX	UniProtKB/TrEMBL
PhenoGen	Amer3	PhenoGen
RatGTEx	ENSRNOG00000023603	RatGTEx
UniProt	D3ZHS8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-12-18	Amer3	APC membrane recruitment protein 3	Fam123c	family with sequence similarity 123C	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-07	Fam123c	family with sequence similarity 123C	RGD1560420_predicted	similar to RIKEN cDNA 9430069J07 gene (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1560420_predicted	similar to RIKEN cDNA 9430069J07 gene (predicted)	LOC501122	similar to RIKEN cDNA 9430069J07 gene	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC501122	similar to RIKEN cDNA 9430069J07 gene			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar