Ndufb4l1 (NADH:ubiquinone oxidoreductase subunit B4-like 1) - Rat Genome Database

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Gene: Ndufb4l1 (NADH:ubiquinone oxidoreductase subunit B4-like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Ndufb4l1
Name: NADH:ubiquinone oxidoreductase subunit B4-like 1
RGD ID: 1560413
Description: Orthologous to human NDUFB4 (NADH:ubiquinone oxidoreductase subunit B4); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC501886; NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4-like 1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1, pseudogene 1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like; Ndufb4l1-ps1; RGD1560413; similar to NADH:ubiquinone oxidoreductase B15 subunit
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8146,670,467 - 6,670,862 (+)NCBIGRCr8
mRatBN7.2146,365,872 - 6,366,282 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl146,365,869 - 6,366,261 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0147,949,217 - 7,949,662 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0147,922,243 - 7,922,662 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,547,679 - 7,548,068 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera146,504,808 - 6,505,253 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation

Genomics

Variants

.
Variants in Ndufb4l1
4 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1438130749088978Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14121760611030812Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat


Expression


Sequence


Ensembl Acc Id: ENSRNOT00000044617   ⟹   ENSRNOP00000051237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl146,365,869 - 6,366,261 (+)Ensembl
Rnor_6.0 Ensembl147,949,239 - 7,949,631 (+)Ensembl
RefSeq Acc Id: XM_039092541   ⟹   XP_038948469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8146,670,467 - 6,670,862 (+)NCBI
mRatBN7.2146,365,872 - 6,366,282 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038948469 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051237.3
RefSeq Acc Id: XP_038948469   ⟸   XM_039092541
- UniProtKB: D3ZV29 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000051237   ⟸   ENSRNOT00000044617

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZV29-F1-model_v2 AlphaFold D3ZV29 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560413 AgrOrtholog
BioCyc Gene G2FUF-16481 BioCyc
Ensembl Genes ENSRNOG00000034289 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044617.4 UniProtKB/TrEMBL
InterPro NADH_UbQ_OxRdtase_NDUFB4_su UniProtKB/TrEMBL
NCBI Gene 501886 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4 UniProtKB/TrEMBL
  PTHR15469 UniProtKB/TrEMBL
Pfam NDUF_B4 UniProtKB/TrEMBL
PhenoGen Ndufb4l1 PhenoGen
RatGTEx ENSRNOG00000034289 RatGTEx
UniProt D3ZV29 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-28 Ndufb4l1  NADH:ubiquinone oxidoreductase subunit B4-like 1  Ndufb4l1  NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4-like 1  Name changed 629549 APPROVED
2022-04-28 Ndufb4l1  NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4-like 1  Ndufb4l1-ps1  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1, pseudogene 1  Name and Symbol changed 629549 APPROVED
2018-11-05 Ndufb4l1-ps1  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1, pseudogene 1  Ndufb4l1  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1  Name and Symbol changed 629549 APPROVED
2010-04-23 Ndufb4l1  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1  RGD1560413  similar to NADH:ubiquinone oxidoreductase B15 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560413  similar to NADH:ubiquinone oxidoreductase B15 subunit   RGD1560413_predicted  similar to NADH:ubiquinone oxidoreductase B15 subunit (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560413_predicted  similar to NADH:ubiquinone oxidoreductase B15 subunit (predicted)  LOC501886  similar to NADH:ubiquinone oxidoreductase B15 subunit  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC501886  similar to NADH:ubiquinone oxidoreductase B15 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL