Pgk1l1 (phosphoglycerate kinase 1 like 1) - Rat Genome Database

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Gene: Pgk1l1 (phosphoglycerate kinase 1 like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Pgk1l1
Name: phosphoglycerate kinase 1 like 1
RGD ID: 1560402
Description: Predicted to enable ADP binding activity; ATP binding activity; and phosphoglycerate kinase activity. Predicted to be involved in gluconeogenesis and glycolytic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hemolytic anemia and phosphoglycerate kinase 1 deficiency. Orthologous to human PGK1 (phosphoglycerate kinase 1); PARTICIPATES IN gluconeogenesis pathway; glycolysis pathway; glycolysis/gluconeogenesis pathway; INTERACTS WITH bisphenol A; lead diacetate; trichloroethene.
Type: protein-coding (Ensembl: processed_pseudogene)
RefSeq Status: MODEL
Previously known as: LOC499525; phosphoglycerate kinase 1-like; RGD1560402; similar to Phosphoglycerate kinase 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8244,487,980 - 44,489,330 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl244,488,018 - 44,489,235 (+)EnsemblGRCr8
mRatBN7.2242,754,605 - 42,755,929 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl242,754,639 - 42,755,856 (+)EnsemblmRatBN7.2
Rnor_6.0242,726,747 - 42,728,100 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl242,726,809 - 42,728,026 (+)Ensemblrn6Rnor6.0
Rnor_5.0261,775,473 - 61,776,789 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4242,481,803 - 42,483,020 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera238,546,762 - 38,548,113 (+)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Pgk1l1
4 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:87
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000036860
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
9590080Insglur4Insulin/glucose ratio QTL 428.70.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)2615276751152767Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9685065Swd6Spike wave discharge measurement QTL 65.80.01brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge rate (CMO:0001739)24095742350526673Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358144538110Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)2573632550736325Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 11 45 111 77 75 45 58 45 6 250 133 8 92 49 61 30 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000036860   ⟹   ENSRNOP00000065201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl244,488,018 - 44,489,235 (+)Ensembl
mRatBN7.2 Ensembl242,754,639 - 42,755,856 (+)Ensembl
Rnor_6.0 Ensembl242,726,809 - 42,728,026 (+)Ensembl
RefSeq Acc Id: XM_039103506   ⟹   XP_038959434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8244,487,980 - 44,489,330 (+)NCBI
mRatBN7.2242,754,605 - 42,755,929 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038959434 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073614.2
Ensembl Acc Id: ENSRNOP00000065201   ⟸   ENSRNOT00000036860
RefSeq Acc Id: XP_038959434   ⟸   XM_039103506
- UniProtKB: M0R6Y8 (UniProtKB/TrEMBL),   A0A096MJL6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R6Y8-F1-model_v2 AlphaFold M0R6Y8 1-395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560402 AgrOrtholog
BioCyc Gene G2FUF-54431 BioCyc
Ensembl Genes ENSRNOG00000026928 Ensembl, ENTREZGENE
  ENSRNOG00000058249 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036860 ENTREZGENE
  ENSRNOT00000085653.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1260 UniProtKB/TrEMBL
InterPro Phosphoglycerate_kinase UniProtKB/TrEMBL
  Phosphoglycerate_kinase_N UniProtKB/TrEMBL
  Phosphoglycerate_kinase_sf UniProtKB/TrEMBL
NCBI Gene 499525 ENTREZGENE
PANTHER PHOSPHOGLYCERATE KINASE 1 UniProtKB/TrEMBL
  PTHR11406 UniProtKB/TrEMBL
Pfam PGK UniProtKB/TrEMBL
PhenoGen Pgk1l1 PhenoGen
PIRSF Pgk UniProtKB/TrEMBL
PRINTS PHGLYCKINASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026928 RatGTEx
  ENSRNOG00000058249 RatGTEx
Superfamily-SCOP SSF53748 UniProtKB/TrEMBL
UniProt A0A096MJL6 ENTREZGENE, UniProtKB/TrEMBL
  M0R6Y8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Pgk1l1  phosphoglycerate kinase 1 like 1  RGD1560402  similar to Phosphoglycerate kinase 1  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1560402  similar to Phosphoglycerate kinase 1   RGD1560402_predicted  similar to Phosphoglycerate kinase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560402_predicted  similar to Phosphoglycerate kinase 1 (predicted)  LOC499525  similar to Phosphoglycerate kinase 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499525  similar to Phosphoglycerate kinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL