C12h12orf76 (similar to human chromosome 12 open reading frame 76) - Rat Genome Database

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Gene: C12h12orf76 (similar to human chromosome 12 open reading frame 76) Rattus norvegicus
Analyze
Symbol: C12h12orf76 (Ensembl: RGD1560398)
Name: similar to human chromosome 12 open reading frame 76 (Ensembl:RGD1560398)
RGD ID: 1560398
Description: Predicted to be located in membrane. Orthologous to human C12orf76 (chromosome 12 open reading frame 76); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; paracetamol; tetrachloromethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498192; RGD1560398; RGD1560398; uncharacterized protein C12orf76 homolog; uncharacterized protein LOC498192; uncharacterized protein RGD1560398
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,452,148 - 47,456,832 (+)NCBIGRCr8
mRatBN7.21241,791,339 - 41,796,200 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,791,359 - 41,796,200 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,959,554 - 42,964,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,573,132 - 43,577,784 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,633,622 - 42,638,274 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,551,749 - 47,556,597 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,551,935 - 47,555,589 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,345,290 - 49,350,123 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,079,302 - 43,083,714 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1243,406,871 - 43,411,718 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
C12h12orf76
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81247,452,148 - 47,456,832 (+)NCBIGRCr8
mRatBN7.21241,791,339 - 41,796,200 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1241,791,359 - 41,796,200 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,959,554 - 42,964,206 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01243,573,132 - 43,577,784 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,633,622 - 42,638,274 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,551,749 - 47,556,597 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,551,935 - 47,555,589 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01249,345,290 - 49,350,123 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,079,302 - 43,083,714 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1243,406,871 - 43,411,718 (+)NCBICelera
Cytogenetic Map12q16NCBI
C12orf76
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812110,041,177 - 110,073,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12110,027,028 - 110,073,636 (-)EnsemblGRCh38hg38GRCh38
GRCh3712110,478,982 - 110,511,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612108,963,366 - 108,989,883 (-)NCBINCBI36Build 36hg18NCBI36
Celera12110,103,217 - 110,129,734 (-)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12107,494,988 - 107,521,516 (-)NCBIHuRef
CHM1_112110,446,778 - 110,473,305 (-)NCBICHM1_1
T2T-CHM13v2.012110,016,870 - 110,049,334 (-)NCBIT2T-CHM13v2.0
1500011B03Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395114,946,257 - 114,952,037 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5114,946,257 - 114,961,529 (-)EnsemblGRCm39 Ensembl
GRCm385114,808,196 - 114,813,976 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5114,808,196 - 114,823,468 (-)EnsemblGRCm38mm10GRCm38
MGSCv375115,258,205 - 115,263,985 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365115,258,205 - 115,263,985 (-)NCBIMGSCv36mm8
Celera5111,906,373 - 111,912,155 (-)NCBICelera
Cytogenetic Map5FNCBI
LOC100981975
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210118,116,967 - 118,140,248 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112118,112,541 - 118,136,653 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012107,603,458 - 107,649,324 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112111,011,517 - 111,030,557 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12110,998,926 - 111,035,322 (-)Ensemblpanpan1.1panPan2
LOC102152728
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12617,127,123 - 17,132,938 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,669,277 - 18,674,903 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02617,471,758 - 17,477,387 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12618,878,836 - 18,884,457 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02617,461,552 - 17,467,176 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02617,479,000 - 17,484,628 (+)NCBIUU_Cfam_GSD_1.0
LOC100517973
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11440,943,932 - 40,950,610 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21443,461,576 - 43,468,246 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH12orf76
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,280,363 - 105,306,748 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037139,814,515 - 139,838,712 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in C12h12orf76
51 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:83
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000056932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
RH143018  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21241,792,598 - 41,792,849 (+)MAPPERmRatBN7.2
Rnor_6.01247,552,992 - 47,553,242NCBIRnor6.0
Rnor_5.01249,346,518 - 49,346,768UniSTSRnor5.0
RGSC_v3.41243,080,530 - 43,080,780UniSTSRGSC3.4
Celera1243,408,113 - 43,408,363UniSTS
RH 3.4 Map12779.73UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 74 2 6 2
Low 3 41 56 40 19 40 6 9 33 35 9 6
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000056932   ⟹   ENSRNOP00000053770
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1247,551,935 - 47,555,589 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114141   ⟹   ENSRNOP00000088363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1241,791,359 - 41,796,200 (+)Ensembl
RefSeq Acc Id: NM_001417147   ⟹   NP_001404076
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81247,452,148 - 47,456,832 (+)NCBI
mRatBN7.21241,791,513 - 41,796,200 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001404076 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13922 (Get FASTA)   NCBI Sequence Viewer  
  EDM13923 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088363.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000053770   ⟸   ENSRNOT00000056932
RefSeq Acc Id: ENSRNOP00000088363   ⟸   ENSRNOT00000114141
RefSeq Acc Id: NP_001404076   ⟸   NM_001417147
- Peptide Label: precursor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZH37-F1-model_v2 AlphaFold D3ZH37 1-72 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698711
Promoter ID:EPDNEW_R9231
Type:initiation region
Name:RGD1560398_1
Description:RGD1560398
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01247,551,931 - 47,551,991EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560398 AgrOrtholog
BioCyc Gene G2FUF-18961 BioCyc
Ensembl Genes ENSRNOG00000037566 Ensembl
  ENSRNOG00000069648 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000114141.1 UniProtKB/TrEMBL
KEGG Report rno:498192 UniProtKB/TrEMBL
NCBI Gene 498192 ENTREZGENE
PhenoGen C12h12orf76 PhenoGen
RatGTEx ENSRNOG00000037566 RatGTEx
  ENSRNOG00000069648 RatGTEx
UniProt A0A8I6A9N4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C12h12orf76  similar to human chromosome 12 open reading frame 76  RGD1560398  RGD1560398  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1560398  RGD1560398   RGD1560398_predicted  RGD1560398 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560398_predicted  RGD1560398 (predicted)  LOC498192  LOC498192  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498192  LOC498192      Symbol and Name status set to provisional 70820 PROVISIONAL