Myl6b (myosin light chain 6B) - Rat Genome Database

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Gene: Myl6b (myosin light chain 6B) Rattus norvegicus
Analyze
Symbol: Myl6b
Name: myosin light chain 6B
RGD ID: 1560334
Description: Orthologous to human MYL6B (myosin light chain 6B); INTERACTS WITH 17beta-estradiol; 3H-1,2-dithiole-3-thione; acetamide.
Type: pseudo
RefSeq Status: INFERRED
Previously known as: LOC317454; myosin, light chain 6B, alkali, smooth muscle and non-muscle; RGD1560334; similar to Myosin light chain 1 slow a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X44,450,733 - 44,451,711 (+)NCBIGRCr8
mRatBN7.2X40,572,012 - 40,572,991 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX41,884,439 - 41,885,417 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X45,351,761 - 45,352,739 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X43,036,349 - 43,037,327 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X43,831,778 - 43,833,044 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X44,137,223 - 44,138,007 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X62,058,731 - 62,059,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX41,236,615 - 41,237,881 (+)NCBICelera
Cytogenetic MapXq21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
genetic disease  (ISO)
Keloid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:23533145  


Genomics

Comparative Map Data
Myl6b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X44,450,733 - 44,451,711 (+)NCBIGRCr8
mRatBN7.2X40,572,012 - 40,572,991 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX41,884,439 - 41,885,417 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X45,351,761 - 45,352,739 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X43,036,349 - 43,037,327 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X43,831,778 - 43,833,044 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X44,137,223 - 44,138,007 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X62,058,731 - 62,059,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX41,236,615 - 41,237,881 (+)NCBICelera
Cytogenetic MapXq21NCBI
MYL6B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,152,587 - 56,157,982 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,152,256 - 56,159,647 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,546,371 - 56,551,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,832,602 - 54,838,038 (+)NCBINCBI36Build 36hg18NCBI36
Celera1256,198,479 - 56,203,915 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,585,256 - 53,590,830 (+)NCBIHuRef
CHM1_11256,513,584 - 56,519,154 (+)NCBICHM1_1
T2T-CHM13v2.01256,120,192 - 56,125,594 (+)NCBIT2T-CHM13v2.0
Myl6b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,330,026 - 128,334,554 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,330,026 - 128,334,554 (-)EnsemblGRCm39 Ensembl
GRCm3810128,494,157 - 128,498,685 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,494,157 - 128,498,685 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,931,213 - 127,935,741 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,897,106 - 127,901,634 (-)NCBIMGSCv36mm8
Celera10130,886,257 - 130,890,611 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.77NCBI
Myl6b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,755,936 - 3,760,414 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,755,936 - 3,760,414 (+)NCBIChiLan1.0ChiLan1.0
MYL6B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,174,424 - 38,180,021 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,171,192 - 38,176,751 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,757,712 - 32,763,287 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,008,519 - 33,013,816 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,008,519 - 33,013,816 (-)Ensemblpanpan1.1panPan2
MYL6B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110472,415 - 476,738 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10472,515 - 476,719 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10535,915 - 541,802 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010481,070 - 486,960 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10481,463 - 489,494 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110458,530 - 464,414 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010701,626 - 707,492 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010825,656 - 831,542 (+)NCBIUU_Cfam_GSD_1.0
Myl6b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,303,346 - 58,307,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646562,844 - 566,882 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646562,854 - 566,894 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYL6B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,556,061 - 21,558,758 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,554,351 - 21,558,995 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,255,205 - 23,259,847 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103238506
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,090,775 - 52,098,694 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037193,885,609 - 193,891,947 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myl6b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,850,374 - 11,853,904 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,850,368 - 11,854,475 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myl6b
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:8
Count of miRNA genes:8
Interacting mature miRNAs:8
Transcripts:ENSRNOT00000048453
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_001057245   ⟹   XP_001057245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
CeleraX41,236,615 - 41,237,399 (+)NCBI
RefSeq Acc Id: XM_228900   ⟹   XP_228900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_5.0X44,137,223 - 44,138,007 (+)NCBI
RGSC_v3.4X62,058,731 - 62,059,471 (+)RGD

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560334 AgrOrtholog
BioCyc Gene G2FUF-2428 BioCyc
NCBI Gene 317454 ENTREZGENE
PhenoGen Myl6b PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Myl6b  myosin light chain 6B  Myl6b  myosin, light chain 6B, alkali, smooth muscle and non-muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-09 Myl6b  myosin, light chain 6B, alkali, smooth muscle and non-muscle  RGD1560334  similar to Myosin light chain 1 slow a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560334  similar to Myosin light chain 1 slow a   RGD1560334_predicted  similar to Myosin light chain 1 slow a (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560334_predicted  similar to Myosin light chain 1 slow a (predicted)  LOC317454  similar to Myosin light chain 1 slow a  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC317454  similar to Myosin light chain 1 slow a      Symbol and Name status set to provisional 70820 PROVISIONAL