Lyg1 (lysozyme G1) - Rat Genome Database

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Gene: Lyg1 (lysozyme G1) Rattus norvegicus
Analyze
Symbol: Lyg1
Name: lysozyme G1
RGD ID: 1560332
Description: Predicted to enable lysozyme activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be active in extracellular region. Orthologous to human LYG1 (lysozyme g1); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 3-isobutyl-1-methyl-7H-xanthine (ortholog).
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC100910070; LOC503254; lysozyme G-like 1; lysozyme g-like protein 1; lysozyme g-like protein 1-like; RGD1560332; similar to Lysozyme g-like protein 1 precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8947,666,938 - 47,678,687 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl947,666,938 - 47,678,687 (-)EnsemblGRCr8
mRatBN7.2940,171,123 - 40,182,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl940,171,123 - 40,182,869 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx948,666,912 - 48,678,657 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0953,789,667 - 53,801,416 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0952,071,849 - 52,083,602 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0944,527,596 - 44,539,320 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl944,527,742 - 44,534,041 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl944,605,304 - 44,617,210 (-)Ensemblrn6Rnor6.0
Rnor_5.0944,224,976 - 44,236,700 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4936,886,224 - 36,897,973 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera937,924,707 - 37,936,457 (-)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12574869  


Genomics

Comparative Map Data
Lyg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8947,666,938 - 47,678,687 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl947,666,938 - 47,678,687 (-)EnsemblGRCr8
mRatBN7.2940,171,123 - 40,182,869 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl940,171,123 - 40,182,869 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx948,666,912 - 48,678,657 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0953,789,667 - 53,801,416 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0952,071,849 - 52,083,602 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0944,527,596 - 44,539,320 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl944,527,742 - 44,534,041 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl944,605,304 - 44,617,210 (-)Ensemblrn6Rnor6.0
Rnor_5.0944,224,976 - 44,236,700 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4936,886,224 - 36,897,973 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera937,924,707 - 37,936,457 (-)NCBICelera
Cytogenetic Map9q21NCBI
LYG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38299,284,238 - 99,304,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl299,284,238 - 99,306,110 (-)Ensemblhg38GRCh38
GRCh37299,900,701 - 99,921,238 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36299,267,133 - 99,284,071 (-)NCBIBuild 36Build 36hg18NCBI36
Celera294,105,373 - 94,122,311 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef293,666,154 - 93,683,093 (-)NCBIHuRef
CHM1_1299,905,527 - 99,922,458 (-)NCBICHM1_1
T2T-CHM13v2.0299,742,858 - 99,763,389 (-)NCBIT2T-CHM13v2.0
Lyg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39137,985,819 - 37,996,840 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl137,985,817 - 37,996,840 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38137,946,738 - 37,957,759 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl137,946,736 - 37,957,759 (-)Ensemblmm10GRCm38
MGSCv37138,003,583 - 38,014,604 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36137,891,276 - 37,902,305 (-)NCBIMGSCv36mm8
Celera137,729,312 - 37,740,893 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map116.29NCBI
Lyg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554705,563,287 - 5,571,872 (-)Ensembl
ChiLan1.0NW_0049554705,563,298 - 5,571,836 (-)NCBIChiLan1.0ChiLan1.0
LYG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21229,108,787 - 29,156,239 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A29,111,547 - 29,158,526 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A99,993,738 - 100,014,140 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A100,214,192 - 100,234,941 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A100,214,192 - 100,234,941 (-)EnsemblpanPan2panpan1.1
LYG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11043,407,780 - 43,419,610 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1043,408,598 - 43,419,765 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1043,323,582 - 43,359,327 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01044,271,672 - 44,307,204 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1044,280,233 - 44,291,421 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11043,982,501 - 44,018,098 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01044,265,748 - 44,301,230 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01044,449,726 - 44,485,256 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lyg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629285,036,252 - 85,050,487 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366611,527,259 - 1,533,110 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366611,524,677 - 1,533,110 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100522987
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1354,969,575 - 54,975,633 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2357,604,886 - 57,610,944 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LYG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1142,986,476 - 3,006,837 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl142,986,634 - 3,005,561 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041170,587,589 - 170,599,901 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lyg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247494,230,089 - 4,242,362 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247494,229,975 - 4,246,943 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lyg1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v14114,135,174 - 114,146,909 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lyg1
91 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:96
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000025068, ENSRNOT00000074343
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303170Bp332Blood pressure QTL 3323.730.027arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)9671488884474983Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9534647950346479Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)94002992585029925Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9875049253750492Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)93125043268875676Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)94445825699506504Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)92956766474567664Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)94445825685262605Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92956766483835942Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)94172029586720295Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9621499551214995Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9875049253750492Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)944458256121768150Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)93125043265651574Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9534647950416711Rat
1581517Bp284Blood pressure QTL 284arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)93922018684220186Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)92103143049025574Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)94002992585029925Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9621499551214995Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)93496059079960590Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)93145606157460683Rat


Expression

RNA-SEQ Expression

ectoderm
nervous system
1 1

Sequence


Ensembl Acc Id: ENSRNOT00000025068   ⟹   ENSRNOP00000025065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl944,527,742 - 44,534,041 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074343   ⟹   ENSRNOP00000067882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl947,666,938 - 47,678,687 (-)Ensembl
mRatBN7.2 Ensembl940,171,123 - 40,182,869 (-)Ensembl
Rnor_6.0 Ensembl944,605,304 - 44,617,210 (-)Ensembl
RefSeq Acc Id: NM_001098838   ⟹   NP_001092308
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8947,666,938 - 47,678,687 (-)NCBI
mRatBN7.2940,171,123 - 40,182,869 (-)NCBI
Rnor_6.0944,527,596 - 44,539,320 (-)NCBI
Rnor_5.0944,224,976 - 44,236,700 (-)NCBI
RGSC_v3.4936,886,224 - 36,897,973 (-)RGD
Celera937,924,707 - 37,936,457 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001092308 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL99220 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067882
  ENSRNOP00000067882.1
RefSeq Acc Id: NP_001092308   ⟸   NM_001098838
- Peptide Label: precursor
- UniProtKB: D3ZZJ5 (UniProtKB/TrEMBL),   A6INI9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025065   ⟸   ENSRNOT00000025068
Ensembl Acc Id: ENSRNOP00000067882   ⟸   ENSRNOT00000074343

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZJ5-F1-model_v2 AlphaFold D3ZZJ5 1-197 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560332 AgrOrtholog
BioCyc Gene G2FUF-27774 BioCyc
Ensembl Genes ENSRNOG00000018534 Ensembl
  ENSRNOG00000047233 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074343 ENTREZGENE
  ENSRNOT00000074343.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.530.10 UniProtKB/TrEMBL
InterPro Glyco_hydro_23 UniProtKB/TrEMBL
  Lysozyme-like_dom UniProtKB/TrEMBL
KEGG Report rno:503254 UniProtKB/TrEMBL
NCBI Gene 503254 ENTREZGENE
PANTHER LYSOZYME G FAMILY MEMBER UniProtKB/TrEMBL
  LYSOZYME G-LIKE PROTEIN 1 UniProtKB/TrEMBL
PhenoGen Lyg1 PhenoGen
PIRSF Lysozyme_g UniProtKB/TrEMBL
PRINTS LYSOZYMEG UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018534 RatGTEx
  ENSRNOG00000047233 RatGTEx
Superfamily-SCOP SSF53955 UniProtKB/TrEMBL
UniProt A6INI9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZJ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Lyg1  lysozyme G1  LOC100910070  lysozyme g-like protein 1-like  Data merged from RGD:6500517 737654 PROVISIONAL
2016-01-26 Lyg1  lysozyme G1  Lyg1  lysozyme G-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910070  lysozyme g-like protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-28 Lyg1  lysozyme G-like 1  RGD1560332_predicted  similar to Lysozyme g-like protein 1 precursor (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1560332_predicted  similar to Lysozyme g-like protein 1 precursor (predicted)  LOC503254  similar to Lysozyme g-like protein 1 precursor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC503254  similar to Lysozyme g-like protein 1 precursor      Symbol and Name status set to provisional 70820 PROVISIONAL