Prrg3 (proline rich and Gla domain 3) - Rat Genome Database

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Gene: Prrg3 (proline rich and Gla domain 3) Rattus norvegicus
Analyze
Symbol: Prrg3
Name: proline rich and Gla domain 3
RGD ID: 1560309
Description: Predicted to enable calcium ion binding activity. Predicted to be active in extracellular space. Orthologous to human PRRG3 (proline rich and Gla domain 3); INTERACTS WITH bisphenol A; ozone; paraquat.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: LOC102546678; LOC293935; proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane); RGD1560309; similar to Gm368 protein; transmembrane gamma-carboxyglutamic acid protein 3; transmembrane gamma-carboxyglutamic acid protein 3-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X154,711,246 - 154,731,359 (+)NCBIGRCr8
mRatBN7.2X149,666,498 - 149,689,353 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX149,670,257 - 149,677,373 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01669,954,910 - 69,966,733 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,285,579 - 69,287,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1669,959,803 - 69,965,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01669,624,916 - 69,635,722 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X157,599,863 - 157,604,493NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapXq37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Prrg3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X154,711,246 - 154,731,359 (+)NCBIGRCr8
mRatBN7.2X149,666,498 - 149,689,353 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX149,670,257 - 149,677,373 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01669,954,910 - 69,966,733 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,285,579 - 69,287,538 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1669,959,803 - 69,965,224 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01669,624,916 - 69,635,722 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X157,599,863 - 157,604,493NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Cytogenetic MapXq37NCBI
PRRG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X151,694,607 - 151,705,924 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX151,694,607 - 151,705,924 (+)EnsemblGRCh38hg38GRCh38
GRCh37X150,863,079 - 150,874,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X150,617,435 - 150,620,669 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X150,537,346 - 150,540,581NCBI
CeleraX151,115,147 - 151,118,431 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX139,720,484 - 139,726,675 (+)NCBIHuRef
CHM1_1X150,738,686 - 150,745,019 (+)NCBICHM1_1
T2T-CHM13v2.0X149,962,930 - 149,974,244 (+)NCBIT2T-CHM13v2.0
Prrg3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X71,005,769 - 71,016,328 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX71,006,230 - 71,016,328 (+)EnsemblGRCm39 Ensembl
GRCm38X71,962,164 - 71,972,722 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX71,962,624 - 71,972,722 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X69,208,360 - 69,218,067 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X68,215,741 - 68,225,448 (+)NCBIMGSCv36mm8
CeleraX62,941,143 - 62,950,854 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.15NCBI
Prrg3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554987,217,544 - 7,227,699 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554987,217,550 - 7,227,685 (+)NCBIChiLan1.0ChiLan1.0
PRRG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X151,762,920 - 151,773,849 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X151,766,525 - 151,777,454 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X141,274,802 - 141,286,081 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X151,233,013 - 151,238,962 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX151,232,966 - 151,238,962 (+)Ensemblpanpan1.1panPan2
PRRG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X119,649,964 - 119,661,042 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX119,651,112 - 119,656,019 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX105,033,125 - 105,044,138 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X121,870,925 - 121,881,939 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX121,871,376 - 121,881,936 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X118,590,936 - 118,601,945 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X121,074,136 - 121,085,140 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X120,956,728 - 120,967,746 (+)NCBIUU_Cfam_GSD_1.0
Prrg3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X117,200,134 - 117,210,897 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367141,050,454 - 1,052,593 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367141,045,541 - 1,055,548 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRRG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX123,085,490 - 123,095,584 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X123,085,511 - 123,095,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X140,727,194 - 140,732,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103232749
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X126,247,468 - 126,257,469 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX126,247,955 - 126,259,518 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606564,015,574 - 64,041,793 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prrg3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248833,012,279 - 3,022,095 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248833,011,450 - 3,022,096 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prrg3
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:146
Count of miRNA genes:89
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000071232, ENSRNOT00000074955
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X126975089152453651Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 8 7 3 3 3 4 4 60 18 27 9 4
Below cutoff 1 31 26 14 14 14 3 6 15 12 10 1 3

Sequence


Ensembl Acc Id: ENSRNOT00000071232   ⟹   ENSRNOP00000064438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl169,285,579 - 69,287,538 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000074955   ⟹   ENSRNOP00000065772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1669,960,082 - 69,961,162 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000093000   ⟹   ENSRNOP00000076043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1669,959,803 - 69,965,224 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106491   ⟹   ENSRNOP00000082649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX149,670,257 - 149,677,373 (+)Ensembl
RefSeq Acc Id: NM_001427169   ⟹   NP_001414098
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,713,096 - 154,722,831 (+)NCBI
RefSeq Acc Id: XM_006253297   ⟹   XP_006253359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,712,582 - 154,722,831 (+)NCBI
mRatBN7.2X149,667,852 - 149,678,062 (+)NCBI
Rnor_6.01669,954,910 - 69,965,370 (-)NCBI
Rnor_5.01669,624,916 - 69,635,722 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008771339   ⟹   XP_008769561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,713,212 - 154,722,831 (+)NCBI
mRatBN7.2X149,668,438 - 149,678,062 (+)NCBI
Rnor_6.01669,954,910 - 69,964,548 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600377   ⟹   XP_017455866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,711,246 - 154,722,831 (+)NCBI
mRatBN7.2X149,666,591 - 149,678,062 (+)NCBI
Rnor_6.01669,954,910 - 69,966,733 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600378   ⟹   XP_017455867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,711,280 - 154,722,831 (+)NCBI
mRatBN7.2X149,666,498 - 149,678,062 (+)NCBI
Rnor_6.01669,954,910 - 69,966,733 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063279841   ⟹   XP_063135911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X154,711,246 - 154,731,359 (+)NCBI
RefSeq Acc Id: XP_006253359   ⟸   XM_006253297
- Peptide Label: isoform X1
- UniProtKB: M0R4Y6 (UniProtKB/TrEMBL),   A6KUL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769561   ⟸   XM_008771339
- Peptide Label: isoform X1
- UniProtKB: M0R4Y6 (UniProtKB/TrEMBL),   A6KUL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455867   ⟸   XM_017600378
- Peptide Label: isoform X1
- UniProtKB: M0R4Y6 (UniProtKB/TrEMBL),   A6KUL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455866   ⟸   XM_017600377
- Peptide Label: isoform X1
- UniProtKB: M0R4Y6 (UniProtKB/TrEMBL),   A6KUL3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064438   ⟸   ENSRNOT00000071232
Ensembl Acc Id: ENSRNOP00000076043   ⟸   ENSRNOT00000093000
Ensembl Acc Id: ENSRNOP00000065772   ⟸   ENSRNOT00000074955
Ensembl Acc Id: ENSRNOP00000082649   ⟸   ENSRNOT00000106491
RefSeq Acc Id: XP_063135911   ⟸   XM_063279841
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001414098   ⟸   NM_001427169
- UniProtKB: A6KUL3 (UniProtKB/TrEMBL),   M0R4Y6 (UniProtKB/TrEMBL)
Protein Domains
Gla

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R4Y6-F1-model_v2 AlphaFold M0R4Y6 1-231 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560309 AgrOrtholog
BioCyc Gene G2FUF-716 BioCyc
Ensembl Genes ENSRNOG00000045663 Ensembl
  ENSRNOG00000047013 Ensembl
  ENSRNOG00000066176 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000106491.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.740.10 UniProtKB/TrEMBL
InterPro Coagulation_fac_subgr_Gla_dom UniProtKB/TrEMBL
  GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  Peptidase_S1_coag_factors UniProtKB/TrEMBL
NCBI Gene 293935 ENTREZGENE
PANTHER COAGULATION FACTOR UniProtKB/TrEMBL
  TRANSMEMBRANE GAMMA-CARBOXYGLUTAMIC ACID PROTEIN 3 UniProtKB/TrEMBL
Pfam Gla UniProtKB/TrEMBL
PhenoGen Prrg3 PhenoGen
PRINTS GLABLOOD UniProtKB/TrEMBL
PROSITE GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045663 RatGTEx
  ENSRNOG00000047013 RatGTEx
  ENSRNOG00000066176 RatGTEx
SMART GLA UniProtKB/TrEMBL
Superfamily-SCOP VitK_dep_GLA UniProtKB/TrEMBL
UniProt A6KUL3 ENTREZGENE, UniProtKB/TrEMBL
  M0R4Y6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Prrg3  proline rich and Gla domain 3  LOC102546678  transmembrane gamma-carboxyglutamic acid protein 3-like  Data merged from RGD:7696879 737654 PROVISIONAL
2016-05-04 Prrg3  proline rich and Gla domain 3  Prrg3  proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102546678  transmembrane gamma-carboxyglutamic acid protein 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Prrg3  proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)   Prrg3_predicted  proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Prrg3_predicted  proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) (predicted)  RGD1560309_predicted  similar to Gm368 protein (predicted)  Symbol and Name updated 1299863 APPROVED
2006-03-07 RGD1560309_predicted  similar to Gm368 protein (predicted)  LOC293935  similar to Gm368 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC293935  similar to Gm368 protein      Symbol and Name status set to provisional 70820 PROVISIONAL