Try5 (trypsin 5) - Rat Genome Database

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Gene: Try5 (trypsin 5) Rattus norvegicus
Analyze
Symbol: Try5
Name: trypsin 5
RGD ID: 1560283
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in acrosomal vesicle. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human PRSS1 (serine protease 1); PRSS2 (serine protease 2); and PRSS3 (serine protease 3); INTERACTS WITH silicon dioxide; 1,2-dichloroethane (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: anionic trypsin-2; anionic trypsin-2-like; LOC100365995; LOC103690254; LOC362348; rCG28262-like; RGD1560283; similar to trypsinogen 8; trypsin-4
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8471,180,421 - 71,183,695 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2470,213,760 - 70,217,034 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl470,213,756 - 70,217,051 (-)EnsemblmRatBN7.2
Rnor_6.0470,625,196 - 70,628,470 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl470,625,245 - 70,628,470 (-)Ensemblrn6Rnor6.0
Rnor_5.04135,339,963 - 135,351,521 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4469,022,611 - 69,025,885 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera465,183,478 - 65,185,744 (-)NCBICelera
Cytogenetic Map4q23NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9419241  


Genomics

Comparative Map Data
Try5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8471,180,421 - 71,183,695 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.2470,213,760 - 70,217,034 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl470,213,756 - 70,217,051 (-)EnsemblmRatBN7.2
Rnor_6.0470,625,196 - 70,628,470 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl470,625,245 - 70,628,470 (-)Ensemblrn6Rnor6.0
Rnor_5.04135,339,963 - 135,351,521 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4469,022,611 - 69,025,885 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera465,183,478 - 65,185,744 (-)NCBICelera
Cytogenetic Map4q23NCBI
Try5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39641,288,166 - 41,291,644 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl641,288,167 - 41,293,775 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38641,311,232 - 41,314,710 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl641,311,233 - 41,316,841 (-)Ensemblmm10GRCm38
MGSCv37641,261,231 - 41,264,709 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36641,261,232 - 41,264,707 (-)NCBIMGSCv36mm8
Celera641,265,880 - 41,269,358 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map619.43NCBI

Variants

.
Variants in Try5
11 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46796011273752811Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
1 7 1 1 13 23 30 9 103 9 2 128 111 2 7 2 9 21

Sequence


Ensembl Acc Id: ENSRNOT00000029319   ⟹   ENSRNOP00000035514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl470,625,245 - 70,628,470 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112096   ⟹   ENSRNOP00000079246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl470,213,756 - 70,217,051 (-)Ensembl
RefSeq Acc Id: XM_008762925   ⟹   XP_008761147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8471,180,421 - 71,183,695 (-)NCBI
mRatBN7.2470,213,760 - 70,217,034 (-)NCBI
Rnor_6.0470,625,196 - 70,628,470 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063286941   ⟹   XP_063143011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8471,180,421 - 71,183,695 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008761147 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143011 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000079246
  ENSRNOP00000079246.1
RefSeq Acc Id: XP_008761147   ⟸   XM_008762925
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZME9 (UniProtKB/TrEMBL),   A6IF27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035514   ⟸   ENSRNOT00000029319
Ensembl Acc Id: ENSRNOP00000079246   ⟸   ENSRNOT00000112096
RefSeq Acc Id: XP_063143011   ⟸   XM_063286941
- Peptide Label: isoform X2
- UniProtKB: A6IF27 (UniProtKB/TrEMBL)
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7D9-F1-model_v2 AlphaFold D4A7D9 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692998
Promoter ID:EPDNEW_R3520
Type:single initiation site
Name:Try5_1
Description:trypsin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0470,628,483 - 70,628,543EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560283 AgrOrtholog
BioCyc Gene G2FUF-45123 BioCyc
Ensembl Genes ENSRNOG00000045612 Ensembl
  ENSRNOG00000070063 Ensembl
  ENSRNOG00000089144 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112096 ENTREZGENE
  ENSRNOT00000112096.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Serine_Proteases_S1 UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:103690254 UniProtKB/TrEMBL
NCBI Gene Try5 ENTREZGENE
PANTHER PROTEASE, SERINE 1 (TRYPSIN 1)-RELATED UniProtKB/TrEMBL
  TRYPSIN-1 UniProtKB/TrEMBL
  TRYPSIN-RELATED UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/TrEMBL
PhenoGen Try5 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045612 RatGTEx
  ENSRNOG00000070063 RatGTEx
  ENSRNOG00000089144 RatGTEx
SMART Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
UniProt A0A8I5ZME9 ENTREZGENE, UniProtKB/TrEMBL
  A6IF27 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Try5  trypsin 5  Try5  trypsin 5  Data merged from RGD:149736261 737654 PROVISIONAL
2021-08-09 Try5  trypsin 5      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Try5  trypsin 5  LOC100365995  rCG28262-like  Data merged from RGD:2317994 737654 PROVISIONAL
2015-11-09 try5  trypsin 5  LOC103690254  anionic trypsin-2-like  Data merged from RGD:9119525 737654 APPROVED
2015-11-09 Try5  trypsin 5  try5  trypsin 5  Symbol and Type changed (type changed from [null] to [allele]) 629549 APPROVED
2014-08-25 LOC103690254  anionic trypsin-2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-09-17 try5  trypsin 5  RGD1560283  similar to trypsinogen 8   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100365995  rCG28262-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1560283  similar to trypsinogen 8   RGD1560283_predicted  similar to trypsinogen 8 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560283_predicted  similar to trypsinogen 8 (predicted)  LOC362348  similar to trypsinogen 8  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362348  similar to trypsinogen 8      Symbol and Name status set to provisional 70820 PROVISIONAL