Fmnl2 (formin-like 2) - Rat Genome Database

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Gene: Fmnl2 (formin-like 2) Rattus norvegicus
Analyze
Symbol: Fmnl2
Name: formin-like 2
RGD ID: 1560248
Description: Predicted to enable actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to be active in cytosol. Orthologous to human FMNL2 (formin like 2); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: formin-like protein 2; LOC499797; RGD1560248; similar to formin-like 2 isoform B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8357,758,236 - 58,033,832 (+)NCBIGRCr8
mRatBN7.2337,348,791 - 37,624,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl337,348,574 - 37,624,754 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0338,400,409 - 38,677,637 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl338,559,914 - 38,675,878 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0343,498,605 - 43,774,803 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4334,371,529 - 34,655,033 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera335,487,885 - 35,763,621 (+)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
heptachlor  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
N-nitrosodimethylamine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
PD 0325901  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21834987   PMID:25468996   PMID:25931508  


Genomics

Comparative Map Data
Fmnl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8357,758,236 - 58,033,832 (+)NCBIGRCr8
mRatBN7.2337,348,791 - 37,624,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl337,348,574 - 37,624,754 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0338,400,409 - 38,677,637 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl338,559,914 - 38,675,878 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0343,498,605 - 43,774,803 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4334,371,529 - 34,655,033 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera335,487,885 - 35,763,621 (+)NCBICelera
Cytogenetic Map3q12NCBI
FMNL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382152,335,174 - 152,649,826 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2152,335,174 - 152,649,826 (+)EnsemblGRCh38hg38GRCh38
GRCh372153,191,688 - 153,506,340 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362152,899,997 - 153,214,594 (+)NCBINCBI36Build 36hg18NCBI36
Build 342153,017,258 - 153,331,854NCBI
Celera2146,806,351 - 147,120,796 (+)NCBICelera
Cytogenetic Map2q23.3NCBI
HuRef2145,077,831 - 145,392,715 (+)NCBIHuRef
CHM1_12153,197,750 - 153,512,372 (+)NCBICHM1_1
T2T-CHM13v2.02152,787,273 - 153,102,389 (+)NCBIT2T-CHM13v2.0
Fmnl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39252,747,743 - 53,023,816 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl252,747,872 - 53,023,816 (+)EnsemblGRCm39 Ensembl
GRCm38252,857,717 - 53,134,202 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl252,857,860 - 53,133,804 (+)EnsemblGRCm38mm10GRCm38
MGSCv37252,716,902 - 52,993,236 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36252,679,877 - 52,956,211 (+)NCBIMGSCv36mm8
Celera254,599,738 - 54,875,813 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map230.69NCBI
Fmnl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544017,948,713 - 18,071,652 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544017,925,982 - 18,077,176 (+)NCBIChiLan1.0ChiLan1.0
FMNL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21355,020,262 - 55,334,157 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B55,035,259 - 55,349,145 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B39,635,721 - 39,949,803 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B156,874,405 - 157,188,035 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B156,874,912 - 157,188,035 (+)Ensemblpanpan1.1panPan2
LOC476151
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11953,582,159 - 53,645,901 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1953,386,346 - 53,644,600 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2628,013,402 - 28,274,303 (-)NCBIDog10K_Boxer_Tasha
Fmnl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303116,314,467 - 116,592,589 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646925,027,040 - 25,302,795 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646925,024,190 - 25,303,260 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FMNL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1560,053,877 - 60,384,655 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11560,054,300 - 60,384,666 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21566,699,415 - 67,030,586 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FMNL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11037,757,033 - 38,081,750 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040161,485,522 - 161,801,835 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fmnl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248664,436,967 - 4,738,979 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248664,434,956 - 4,738,599 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fmnl2
1384 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:290
Count of miRNA genes:175
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000006433, ENSRNOT00000059388, ENSRNOT00000073604, ENSRNOT00000075441
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat

Markers in Region
D3Rat118  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2337,507,660 - 37,507,860 (+)MAPPERmRatBN7.2
Rnor_6.0338,560,561 - 38,560,760NCBIRnor6.0
Rnor_5.0343,657,808 - 43,658,007UniSTSRnor5.0
RGSC_v3.4334,539,427 - 34,539,627RGDRGSC3.4
RGSC_v3.4334,539,428 - 34,539,627UniSTSRGSC3.4
RGSC_v3.1334,435,799 - 34,435,999RGD
Celera335,646,812 - 35,647,011UniSTS
FHH x ACI Map327.9UniSTS
FHH x ACI Map327.9RGD
Cytogenetic Map3q12UniSTS
RH142401  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2337,624,395 - 37,624,595 (+)MAPPERmRatBN7.2
Rnor_6.0338,677,287 - 38,677,486NCBIRnor6.0
Rnor_5.0343,774,453 - 43,774,652UniSTSRnor5.0
RGSC_v3.4334,656,602 - 34,656,801UniSTSRGSC3.4
Celera335,763,271 - 35,763,470UniSTS
RH 3.4 Map3455.4UniSTS
Cytogenetic Map3q12UniSTS
AI179941  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2337,624,397 - 37,624,595 (+)MAPPERmRatBN7.2
Rnor_6.0338,677,289 - 38,677,486NCBIRnor6.0
Rnor_5.0343,774,455 - 43,774,652UniSTSRnor5.0
RGSC_v3.4334,656,604 - 34,656,801UniSTSRGSC3.4
Celera335,763,273 - 35,763,470UniSTS
RH 3.4 Map1791.5UniSTS
Cytogenetic Map3q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 23 7 19 7 1 1 74 34 35 11 1
Low 1 43 34 34 34 7 10 1 6 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001066238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006224439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001837106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001842676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000085545   ⟹   ENSRNOP00000071681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl337,348,574 - 37,624,754 (+)Ensembl
Rnor_6.0 Ensembl338,559,914 - 38,675,878 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096662   ⟹   ENSRNOP00000092053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl337,348,574 - 37,624,754 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116367   ⟹   ENSRNOP00000089390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl337,348,574 - 37,624,754 (+)Ensembl
RefSeq Acc Id: XM_008761822   ⟹   XP_008760044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,033,832 (+)NCBI
mRatBN7.2337,349,157 - 37,622,898 (+)NCBI
Rnor_6.0338,400,411 - 38,677,637 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761823   ⟹   XP_008760045
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,033,832 (+)NCBI
mRatBN7.2337,349,157 - 37,622,827 (+)NCBI
Rnor_6.0338,400,411 - 38,677,637 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592149   ⟹   XP_017447638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,033,832 (+)NCBI
mRatBN7.2337,349,157 - 37,624,746 (+)NCBI
Rnor_6.0338,400,411 - 38,677,637 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039106784   ⟹   XP_038962712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,033,832 (+)NCBI
mRatBN7.2337,348,792 - 37,624,746 (+)NCBI
RefSeq Acc Id: XM_039106785   ⟹   XP_038962713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,033,832 (+)NCBI
mRatBN7.2337,348,791 - 37,624,746 (+)NCBI
RefSeq Acc Id: XM_039106786   ⟹   XP_038962714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,032,011 (+)NCBI
mRatBN7.2337,348,791 - 37,624,746 (+)NCBI
RefSeq Acc Id: XM_039106787   ⟹   XP_038962715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,033,832 (+)NCBI
mRatBN7.2337,348,791 - 37,624,746 (+)NCBI
RefSeq Acc Id: XM_039106788   ⟹   XP_038962716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,028,801 (+)NCBI
mRatBN7.2337,349,157 - 37,619,681 (+)NCBI
RefSeq Acc Id: XM_039106789   ⟹   XP_038962717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,033,832 (+)NCBI
mRatBN7.2337,348,792 - 37,624,746 (+)NCBI
RefSeq Acc Id: XM_039106790   ⟹   XP_038962718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,033,832 (+)NCBI
mRatBN7.2337,348,793 - 37,624,746 (+)NCBI
RefSeq Acc Id: XM_063284876   ⟹   XP_063140946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8357,758,236 - 58,030,392 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008760045   ⟸   XM_008761823
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_008760044   ⟸   XM_008761822
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AKV5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447638   ⟸   XM_017592149
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K132 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071681   ⟸   ENSRNOT00000085545
RefSeq Acc Id: XP_038962714   ⟸   XM_039106786
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038962713   ⟸   XM_039106785
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038962715   ⟸   XM_039106787
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038962712   ⟸   XM_039106784
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962717   ⟸   XM_039106789
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038962718   ⟸   XM_039106790
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038962716   ⟸   XM_039106788
- Peptide Label: isoform X7
- UniProtKB: A0A8I6AV50 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000092053   ⟸   ENSRNOT00000096662
RefSeq Acc Id: ENSRNOP00000089390   ⟸   ENSRNOT00000116367
RefSeq Acc Id: XP_063140946   ⟸   XM_063284876
- Peptide Label: isoform X3
Protein Domains
DAD   FH2   GBD/FH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K132-F1-model_v2 AlphaFold A0A0G2K132 1-1038 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560248 AgrOrtholog
BioCyc Gene G2FUF-49720 BioCyc
Ensembl Genes ENSRNOG00000055567 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085545.2 UniProtKB/TrEMBL
  ENSRNOT00000096662.1 UniProtKB/TrEMBL
  ENSRNOT00000116367.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.2220 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  DAD_dom UniProtKB/TrEMBL
  Drf_FH3 UniProtKB/TrEMBL
  Drf_GTPase-bd UniProtKB/TrEMBL
  FH2_actin-bd UniProtKB/TrEMBL
  FH2_Formin_sf UniProtKB/TrEMBL
  FMNL UniProtKB/TrEMBL
  GTPase-bd/formin_homology_3 UniProtKB/TrEMBL
NCBI Gene 499797 ENTREZGENE
PANTHER PTHR45857 UniProtKB/TrEMBL
  PTHR45857:SF5 UniProtKB/TrEMBL
Pfam Drf_FH3 UniProtKB/TrEMBL
  Drf_GBD UniProtKB/TrEMBL
  FH2 UniProtKB/TrEMBL
PhenoGen Fmnl2 PhenoGen
PRINTS WILMSTUMOUR UniProtKB/TrEMBL
PROSITE DAD UniProtKB/TrEMBL
  FH2 UniProtKB/TrEMBL
  GBD_FH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000055567 RatGTEx
SMART Drf_FH3 UniProtKB/TrEMBL
  Drf_GBD UniProtKB/TrEMBL
  FH2 UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Formin homology 2 domain (FH2 domain) UniProtKB/TrEMBL
UniProt A0A0G2K132 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKV5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AV50 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Fmnl2  formin-like 2  RGD1560248  similar to formin-like 2 isoform B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560248  similar to formin-like 2 isoform B   RGD1560248_predicted  similar to formin-like 2 isoform B (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560248_predicted  similar to formin-like 2 isoform B (predicted)  LOC499797  similar to formin-like 2 isoform B  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499797  similar to formin-like 2 isoform B      Symbol and Name status set to provisional 70820 PROVISIONAL