Hapstr2 (HUWE1 associated protein modifying stress responses 2) - Rat Genome Database

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Gene: Hapstr2 (HUWE1 associated protein modifying stress responses 2) Rattus norvegicus
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Symbol: Hapstr2
Name: HUWE1 associated protein modifying stress responses 2
RGD ID: 1560171
Description: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein stabilization. Predicted to be located in nucleus. Orthologous to human HAPSTR2 (HUWE1 associated protein modifying stress responses 2); INTERACTS WITH azoxystrobin; chlorpyrifos; coumarin.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: HUWE1-associated protein modifying stress responses 2; LOC367949; RGD1560171; similar to PRO0149 protein; UPF0472 protein C16orf72
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X143,958,364 - 143,960,399 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX143,958,032 - 143,960,240 (+)EnsemblGRCr8
mRatBN7.2X138,922,089 - 138,924,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX138,922,100 - 138,922,918 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX141,140,731 - 141,142,766 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X144,681,719 - 144,683,754 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X142,237,417 - 142,239,452 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X143,681,714 - 143,683,171 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX143,682,099 - 143,682,917 (-)Ensemblrn6Rnor6.0
Rnor_5.0X143,708,152 - 143,709,595 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X146,111,116 - 146,112,319 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX134,991,265 - 134,992,668 (+)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Hapstr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X143,958,364 - 143,960,399 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX143,958,032 - 143,960,240 (+)EnsemblGRCr8
mRatBN7.2X138,922,089 - 138,924,124 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX138,922,100 - 138,922,918 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX141,140,731 - 141,142,766 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X144,681,719 - 144,683,754 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X142,237,417 - 142,239,452 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X143,681,714 - 143,683,171 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX143,682,099 - 143,682,917 (-)Ensemblrn6Rnor6.0
Rnor_5.0X143,708,152 - 143,709,595 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X146,111,116 - 146,112,319 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX134,991,265 - 134,992,668 (+)NCBICelera
Cytogenetic MapXq36NCBI
HAPSTR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X140,091,678 - 140,092,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX140,091,678 - 140,092,911 (+)Ensemblhg38GRCh38
GRCh37X139,173,837 - 139,175,070 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic MapXq27.1NCBI
HuRefX128,439,954 - 128,441,198 (+)NCBIHuRef
CHM1_1X139,085,182 - 139,086,426 (+)NCBICHM1_1
T2T-CHM13v2.0X138,403,603 - 138,404,836 (+)NCBIT2T-CHM13v2.0
Gm715
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X59,591,614 - 59,592,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX59,591,614 - 59,592,823 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X60,548,008 - 60,549,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX60,548,019 - 60,548,849 (+)Ensemblmm10GRCm38
MGSCv37X57,801,189 - 57,802,392 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X56,808,673 - 56,809,882 (+)NCBIMGSCv36mm8
CeleraX46,986,276 - 46,987,479 (+)NCBICelera
Cytogenetic MapXA6NCBI
cM MapX33.5NCBI
Hapstr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554895,211,935 - 5,212,187 (-)NCBIChiLan1.0ChiLan1.0
HAPSTR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X139,539,387 - 139,542,111 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X139,542,988 - 139,545,708 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X129,241,811 - 129,243,106 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X139,493,100 - 139,494,361 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX139,493,157 - 139,493,978 (+)EnsemblpanPan2panpan1.1
HAPSTR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X110,022,431 - 110,023,770 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX95,839,737 - 95,841,033 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X112,006,461 - 112,007,757 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.1X109,138,604 - 109,139,897 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X111,323,532 - 111,324,825 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X111,002,673 - 111,003,969 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hapstr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X108,062,346 - 108,064,863 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365137,550,020 - 7,552,271 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAPSTR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX114,686,461 - 114,687,291 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X114,686,410 - 114,687,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X130,958,338 - 130,959,756 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HAPSTR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X115,170,535 - 115,172,391 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666139124,201 - 125,785 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hapstr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248086,604,193 - 6,607,266 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hapstr2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X119,623,377 - 119,625,447 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hapstr2
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:20
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000064172
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat

Markers in Region
RH128284  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X138,922,906 - 138,923,093 (-)MAPPERmRatBN7.2
Rnor_6.0X143,681,924 - 143,682,110NCBIRnor6.0
Rnor_5.0X143,708,362 - 143,708,548UniSTSRnor5.0
RGSC_v3.4X146,111,923 - 146,112,109UniSTSRGSC3.4
CeleraX134,992,272 - 134,992,458UniSTS
Cytogenetic MapXq36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 4 59 127 36 39 18 12 18 6 188 92 8 115 63 90 21 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000064172   ⟹   ENSRNOP00000062957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX143,958,032 - 143,960,240 (+)Ensembl
mRatBN7.2 EnsemblX138,922,100 - 138,922,918 (+)Ensembl
Rnor_6.0 EnsemblX143,682,099 - 143,682,917 (-)Ensembl
RefSeq Acc Id: NM_001401189   ⟹   NP_001388118
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X143,958,364 - 143,960,399 (+)NCBI
mRatBN7.2X138,922,089 - 138,924,124 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388118 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062957
  ENSRNOP00000062957.2
Ensembl Acc Id: ENSRNOP00000062957   ⟸   ENSRNOT00000064172
RefSeq Acc Id: NP_001388118   ⟸   NM_001401189
- UniProtKB: F1LW04 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LW04-F1-model_v2 AlphaFold F1LW04 1-272 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560171 AgrOrtholog
BioCyc Gene G2FUF-871 BioCyc
Ensembl Genes ENSRNOG00000043487 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064172 ENTREZGENE
  ENSRNOT00000064172.4 UniProtKB/TrEMBL
InterPro C16orf72-like UniProtKB/TrEMBL
  DUF4588 UniProtKB/TrEMBL
NCBI Gene 367949 ENTREZGENE
PANTHER PTHR31624 UniProtKB/TrEMBL
  SIMILAR TO PRO0149 PROTEIN UniProtKB/TrEMBL
Pfam DUF4588 UniProtKB/TrEMBL
PhenoGen Hapstr2 PhenoGen
RatGTEx ENSRNOG00000043487 RatGTEx
UniProt F1LW04 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-09 Hapstr2  HUWE1 associated protein modifying stress responses 2  RGD1560171  similar to PRO0149 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560171  similar to PRO0149 protein   RGD1560171_predicted  similar to PRO0149 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560171_predicted  similar to PRO0149 protein (predicted)  LOC367949  similar to PRO0149 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC367949  similar to PRO0149 protein      Symbol and Name status set to provisional 70820 PROVISIONAL